Combination of HIF-1α gene transfection and HIF-1-Activated bone marrow-derived angiogenic cell infusion improves burn wound healing in aged mice

Gene Therapy

Volumn 20, Issue 11, 2013, Pages 1070-1076

  Du, J ^a,b   Liu, L ^b   Lay, F ^b   Wang, Q ^b   Dou, C ^b   Zhang, X ^b   Hosseini, S M ^b   Simon, A ^b   Rees, D J ^b   Ahmed, A K ^b   Sebastian, R ^b   Sarkar, K ^b   Milner, S ^b   Marti, G P ^b   Semenza, G L ^b   Harmon, J W ^b  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

angiogenesis; bone marrow derived angiogenic cell (BMDAC); burn wounds; dimethyloxalylglycine (DMOG); hypoxia inducible factor (HIF); plasmid DNA transfection

Indexed keywords

DIMETHYLOXALYLGLYCINE; DNA; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PLASMID DNA; UNCLASSIFIED DRUG;

AGED; AGING; ANGIOGENIC GENE THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BURN; CELL HOMING; CONTROLLED STUDY; DNA TRANSFECTION; ELECTROPORATION; GENE CONSTRUCT; GENE THERAPY; GENETIC TRANSFECTION; HEALING; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PERFUSION; PRIORITY JOURNAL; SKIN BLOOD FLOW; WOUND; WOUND CLOSURE; WOUND HEALING IMPAIRMENT;

MURINAE; MUS;

ADENOVIRIDAE; AGING; ANIMALS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; BURNS; CELLS, CULTURED; COMBINED MODALITY THERAPY; DISEASE MODELS, ANIMAL; FEMALE; GENETIC THERAPY; GENETIC VECTORS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PHYSIOLOGIC; TRANSFECTION; WOUND HEALING;

EID: 84887438427     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2013.32     Document Type: Article

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