How natalizumab binds and antagonizes α4 integrins

Journal of Biological Chemistry

Volumn 288, Issue 45, 2013, Pages 32314-32325

  Yu, Yamei ^a,b   Schürpf, Thomas ^a   Springer, Timothy A ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACES; CONSERVED REGIONS; DOCKING MODELS; INTEGRINS; LIGAND BINDING; LIGAND-BINDING SITES; MULTIPLE SCLEROSIS; VASCULAR CELL ADHESION;

CELL MEMBRANES; EPITOPES; GLYCOPROTEINS; LIGANDS; PROPELLERS;

ANTIBODIES;

ALPHA4 BETA7 INTEGRIN; ALPHA4 INTEGRIN; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; NATALIZUMAB; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VERY LATE ACTIVATION ANTIGEN 4;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SPECIES DIFFERENCE;

ADHESION; CELL SURFACE; CRYSTAL STRUCTURE; IMMUNOLOGY; INTEGRINS; STRUCTURE;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODIES, NEUTRALIZING; CRYSTALLOGRAPHY, X-RAY; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; INTEGRIN ALPHA4; INTEGRIN ALPHA4BETA1; MICE; MOLECULAR DOCKING SIMULATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84887434165     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.501668     Document Type: Article

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