메뉴 건너뛰기




Volumn 57, Issue 12, 2013, Pages 5931-5939

Multidrug-resistant transporter Mdr1p-mediated uptake of a novel antifungal compound

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; FLUCONAZOLE; ITRACONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; 1,3 BENZODIOXOLE DERIVATIVE; FUNGAL PROTEIN; MOLECULAR LIBRARY; MULTIDRUG RESISTANCE PROTEIN; NSC156627; QUINOLIZINE DERIVATIVE; TRANSCRIPTION FACTOR;

EID: 84887421426     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01504-13     Document Type: Article
Times cited : (23)

References (49)
  • 2
    • 33646850399 scopus 로고    scopus 로고
    • Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus
    • Chauhan N, Latge JP, Calderone R. 2006. Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus. Nat. Rev. Microbiol. 4:435-444.
    • (2006) Nat. Rev. Microbiol. , vol.4 , pp. 435-444
    • Chauhan, N.1    Latge, J.P.2    Calderone, R.3
  • 4
    • 0035310920 scopus 로고    scopus 로고
    • Estimating the cost of nosocomial candidemia in the united states
    • Miller LG, Hajjeh RA, Edwards JE, Jr. 2001. Estimating the cost of nosocomial candidemia in the united states. Clin. Infect. Dis. 32:1110.
    • (2001) Clin. Infect. Dis. , vol.32 , pp. 1110
    • Miller, L.G.1    Hajjeh, R.A.2    Edwards Jr., J.E.3
  • 8
    • 0030757227 scopus 로고    scopus 로고
    • Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    • White TC. 1997. Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 41:1482-1487.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 1482-1487
    • White, T.C.1
  • 9
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White TC, Marr KA, Bowden RA. 1998. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin. Microbiol. Rev. 11:382-402.
    • (1998) Clin. Microbiol. Rev. , vol.11 , pp. 382-402
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 10
    • 65749096905 scopus 로고    scopus 로고
    • Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance
    • Tsao S, Rahkhoodaee F, Raymond M. 2009. Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. Antimicrob. Agents Chemother. 53:1344-1352.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 1344-1352
    • Tsao, S.1    Rahkhoodaee, F.2    Raymond, M.3
  • 11
    • 21344451158 scopus 로고    scopus 로고
    • Evolution of antifungal-drug resistance: Mechanisms and pathogen fitness
    • Anderson JB. 2005. Evolution of antifungal-drug resistance: mechanisms and pathogen fitness. Nat. Rev. Microbiol. 3:547-556.
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 547-556
    • Anderson, J.B.1
  • 13
    • 39149087719 scopus 로고    scopus 로고
    • The evolution of fungal drug resistance: Modulating the trajectory from genotype to phenotype
    • Cowen LE. 2008. The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. Nat. Rev. Microbiol. 6:187-198.
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 187-198
    • Cowen, L.E.1
  • 14
    • 37349095258 scopus 로고    scopus 로고
    • The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans
    • doi:10.1371/journal.ppat.0030164
    • Morschhauser J, Barker KS, Liu TT, Bla BWJ, Homayouni R, Rogers PD. 2007. The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans. PLoS Pathog. 3:e164. doi:10.1371/journal.ppat.0030164.
    • (2007) PLoS Pathog. , vol.3
    • Morschhauser, J.1    Barker, K.S.2    Liu, T.T.3    Bla, B.W.J.4    Homayouni, R.5    Rogers, P.D.6
  • 15
    • 33745630119 scopus 로고    scopus 로고
    • Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolate
    • Hiller D, Stahl S, Morschhauser J. 2006. Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolate. Antimicrob. Agents Chemother. 50: 2300-2308.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 2300-2308
    • Hiller, D.1    Stahl, S.2    Morschhauser, J.3
  • 16
    • 33846025066 scopus 로고    scopus 로고
    • Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans, a major facilitator transporter involved in azole resistance
    • Rognon B, Kozovska Z, Coste AT, Pardini G, Sanglard D. 2006. Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans, a major facilitator transporter involved in azole resistance. Microbiology 152:3701-3722.
    • (2006) Microbiology , vol.152 , pp. 3701-3722
    • Rognon, B.1    Kozovska, Z.2    Coste, A.T.3    Pardini, G.4    Sanglard, D.5
  • 18
    • 0034081664 scopus 로고    scopus 로고
    • Targeted gene disruption in Candida albicans wild-type strains: The role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates
    • Wirsching S, Michel S, Morschhauser J. 2000. Targeted gene disruption in Candida albicans wild-type strains: the role of the MDR1 gene in fluconazole resistance of clinical Candida albicans isolates. Mol. Microbiol. 36:856-865.
    • (2000) Mol. Microbiol. , vol.36 , pp. 856-865
    • Wirsching, S.1    Michel, S.2    Morschhauser, J.3
  • 19
    • 33645791257 scopus 로고    scopus 로고
    • Overexpression of the MDR1gene is sufficient to confer increased resistance to toxic compounds in Candida albicans
    • Hiller D, Sanglard D, Morschhauser J. 2006. Overexpression of the MDR1gene is sufficient to confer increased resistance to toxic compounds in Candida albicans. Antimicrob. Agents Chemother. 50:1365-1371.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 1365-1371
    • Hiller, D.1    Sanglard, D.2    Morschhauser, J.3
  • 21
    • 47749142093 scopus 로고    scopus 로고
    • Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains
    • Dunkel N, Blass J, Rogers PD, Morschhauser J. 2008. Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains. Mol. Microbiol. 69:827-840.
    • (2008) Mol. Microbiol. , vol.69 , pp. 827-840
    • Dunkel, N.1    Blass, J.2    Rogers, P.D.3    Morschhauser, J.4
  • 22
    • 84872026338 scopus 로고    scopus 로고
    • Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex i mutants
    • Sun N, Fonzi W, Chen H, She X, Zhang L, Calderone R. 2013. Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants. Antimicrob. Agents Chemother. 57:532-542.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 532-542
    • Sun, N.1    Fonzi, W.2    Chen, H.3    She, X.4    Zhang, L.5    Calderone, R.6
  • 23
    • 84869886429 scopus 로고    scopus 로고
    • Caloric restriction restores the chronological life span of the goa1 null mutant of Candida albicans in spite of high cell levels of ROS
    • Chen H, Calderone R, Sun N, Wang Y, Li D. 2012. Caloric restriction restores the chronological life span of the goa1 null mutant of Candida albicans in spite of high cell levels of ROS. Fungal Genet. Biol. 49:1023-1032.
    • (2012) Fungal Genet. Biol. , vol.49 , pp. 1023-1032
    • Chen, H.1    Calderone, R.2    Sun, N.3    Wang, Y.4    Li, D.5
  • 24
    • 79956059142 scopus 로고    scopus 로고
    • Enzymatic dysfunction of mitochondrial complex i of the Candida albicans goa1 mutant is associated with increased reactive oxidants and cell death
    • Li D, Chen H, Florentino A, Alex D, Sikorski P, Fonzi WA, Calderone R. 2011. Enzymatic dysfunction of mitochondrial complex I of the Candida albicans goa1 mutant is associated with increased reactive oxidants and cell death. Eukaryot. Cell 10:672-682.
    • (2011) Eukaryot. Cell , vol.10 , pp. 672-682
    • Li, D.1    Chen, H.2    Florentino, A.3    Alex, D.4    Sikorski, P.5    Fonzi, W.A.6    Calderone, R.7
  • 26
    • 79251514614 scopus 로고    scopus 로고
    • Methods for using Galleria mellonella as a model host to study fungal pathogenesis
    • Fuchs BB, O'Brien E, Khoury JB, Mylonakis E. 2010. Methods for using Galleria mellonella as a model host to study fungal pathogenesis. Virulence 1:475-482.
    • (2010) Virulence , vol.1 , pp. 475-482
    • Fuchs, B.B.1    O'Brien, E.2    Khoury, J.B.3    Mylonakis, E.4
  • 27
    • 0031759244 scopus 로고    scopus 로고
    • Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
    • Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhauser J. 1998. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains. Antimicrob. Agents Chemother. 42:3065-3072.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 3065-3072
    • Franz, R.1    Kelly, S.L.2    Lamb, D.C.3    Kelly, D.E.4    Ruhnke, M.5    Morschhauser, J.6
  • 29
    • 78149321014 scopus 로고    scopus 로고
    • Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi
    • doi:10.1371/journal.ppat.1001126
    • Mansfield BE, Oltean HN, Oliver BG, Hoot SJ, Leyde SE, Hedstrom L, White TC. 2010. Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. PLoS Pathog. 6:e1001126. doi:10.1371/journal.ppat. 1001126.
    • (2010) PLoS Pathog. , vol.6
    • Mansfield, B.E.1    Oltean, H.N.2    Oliver, B.G.3    Hoot, S.J.4    Leyde, S.E.5    Hedstrom, L.6    White, T.C.7
  • 31
    • 83755171493 scopus 로고    scopus 로고
    • Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins
    • Kumar R, Chadha S, Saraswat D, Bajwa JS, Li RA, Conti HR, Edgerton M. 2011. Histatin 5 uptake by Candida albicans utilizes polyamine transporters Dur3 and Dur31 proteins. J. Biol. Chem. 286:43748-43758.
    • (2011) J. Biol. Chem. , vol.286 , pp. 43748-43758
    • Kumar, R.1    Chadha, S.2    Saraswat, D.3    Bajwa, J.S.4    Li, R.A.5    Conti, H.R.6    Edgerton, M.7
  • 32
    • 33645980973 scopus 로고    scopus 로고
    • Evolution of gene families: The multidrug resistance transporter genes in five related yeast species
    • Gbelska Y, Krijger JJ, Breunig KD. 2006. Evolution of gene families: the multidrug resistance transporter genes in five related yeast species. FEMS Yeast Res. 6:345-355.
    • (2006) FEMS Yeast Res. , vol.6 , pp. 345-355
    • Gbelska, Y.1    Krijger, J.J.2    Breunig, K.D.3
  • 33
    • 0033572636 scopus 로고    scopus 로고
    • Polyamine transport in bacteria and yeast
    • Igarashi K, Kashiwagi K. 1999. Polyamine transport in bacteria and yeast. Biochem. J. 344:633-642.
    • (1999) Biochem. J. , vol.344 , pp. 633-642
    • Igarashi, K.1    Kashiwagi, K.2
  • 34
    • 0030977164 scopus 로고    scopus 로고
    • The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae
    • Kaouass M, Audette M, Ramotar D, Verma S, De Montigny D, Gamache I, Torossian K, Poulin R. 1997. The STK2 gene, which encodes a putative Ser/Thr protein kinase, is required for high-affinity spermidine transport in Saccharomyces cerevisiae. Mol. Cell. Biol. 17:2994-3004.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2994-3004
    • Kaouass, M.1    Audette, M.2    Ramotar, D.3    Verma, S.4    De Montigny, D.5    Gamache, I.6    Torossian, K.7    Poulin, R.8
  • 36
    • 0035088330 scopus 로고    scopus 로고
    • In search of natural substrates and inhibitors of MDR pumps
    • Lewis K. 2001. In search of natural substrates and inhibitors of MDR pumps. J. Mol. Microbiol. Biotechnol. 3:247-254.
    • (2001) J. Mol. Microbiol. Biotechnol. , vol.3 , pp. 247-254
    • Lewis, K.1
  • 38
    • 84857173900 scopus 로고    scopus 로고
    • The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates
    • Holmes AR, Keniya MV, Ivnitski-Steele I, Monk BC, Lamping E, Sklar LA, Cannon RD. 2012. The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates. Antimicrob. Agents Chemother. 56:1508-1515.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 1508-1515
    • Holmes, A.R.1    Keniya, M.V.2    Ivnitski-Steele, I.3    Monk, B.C.4    Lamping, E.5    Sklar, L.A.6    Cannon, R.D.7
  • 39
    • 84875192043 scopus 로고    scopus 로고
    • Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)
    • Tan KW, Li Y, Paxton JW, Birch NP, Scheepens A. 2013. Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2). Food Chem. 138:2267-2274.
    • (2013) Food Chem. , vol.138 , pp. 2267-2274
    • Tan, K.W.1    Li, Y.2    Paxton, J.W.3    Birch, N.P.4    Scheepens, A.5
  • 40
    • 15744391238 scopus 로고    scopus 로고
    • Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation
    • Uemura T, Tachihara K, Tomitori H, Kashiwagi K, Igarashi K. 2005. Characteristics of the polyamine transporter TPO1 and regulation of its activity and cellular localization by phosphorylation. J. Biol. Chem. 280: 9646-9652.
    • (2005) J. Biol. Chem. , vol.280 , pp. 9646-9652
    • Uemura, T.1    Tachihara, K.2    Tomitori, H.3    Kashiwagi, K.4    Igarashi, K.5
  • 44
    • 80055116385 scopus 로고    scopus 로고
    • 2011. Mitochondria and fungal pathogenesis: Drug tolerance, virulence, and potential for antifungal therapy
    • Shingu-Vazquez M, Traven A. 2011. Mitochondria and fungal pathogenesis: drug tolerance, virulence, and potential for antifungal therapy. Eukaryot. Cell 10:1376-1383.
    • Eukaryot. Cell , vol.10 , pp. 1376-1383
    • Shingu-Vazquez, M.1    Traven, A.2
  • 45
    • 34548331719 scopus 로고    scopus 로고
    • Involvement of Candida albicans pyruvate dehydrogenase complex protein X (Pdx1) in filamentation
    • Vellucci VF, Gygax SE, Hostetter MK. 2007. Involvement of Candida albicans pyruvate dehydrogenase complex protein X (Pdx1) in filamentation. Fungal Genet. Biol. 44:979-990.
    • (2007) Fungal Genet. Biol. , vol.44 , pp. 979-990
    • Vellucci, V.F.1    Gygax, S.E.2    Hostetter, M.K.3
  • 46
    • 0027192868 scopus 로고
    • Isogenic strain construction and gene mapping in Candida albicans
    • Fonzi WA, Irwin MY. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
    • (1993) Genetics , vol.134 , pp. 717-728
    • Fonzi, W.A.1    Irwin, M.Y.2
  • 47
    • 77749291956 scopus 로고    scopus 로고
    • Screening for amino acid substitutions in the Candida albicans Erg11 protein of azolesusceptible and azole-resistant clinical isolates: New substitutions and a review of the literature
    • Morio F, Loge C, Besse B, Hennequin C, Le Pape P. 2010. Screening for amino acid substitutions in the Candida albicans Erg11 protein of azolesusceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. Diagn. Microbiol. Infect. Dis. 66:373-384.
    • (2010) Diagn. Microbiol. Infect. Dis. , vol.66 , pp. 373-384
    • Morio, F.1    Loge, C.2    Besse, B.3    Hennequin, C.4    Le Pape, P.5
  • 48
    • 77950180902 scopus 로고    scopus 로고
    • Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection
    • MacCallum DM, Coste A, Ischer F, Jacobsen MD, Odds FC, Sanglard D. 2010. Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection. Antimicrob. Agents Chemother. 54:1476-1483.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1476-1483
    • Maccallum, D.M.1    Coste, A.2    Ischer, F.3    Jacobsen, M.D.4    Odds, F.C.5    Sanglard, D.6
  • 49
    • 47249114532 scopus 로고    scopus 로고
    • Micafungin activity against Candida albicans with diverse azole resistance phenotypes
    • Richards TS, Oliver BG, White TC. 2008. Micafungin activity against Candida albicans with diverse azole resistance phenotypes. J. Antimicrob. Chemother. 62:349-355.
    • (2008) J. Antimicrob. Chemother. , vol.62 , pp. 349-355
    • Richards, T.S.1    Oliver, B.G.2    White, T.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.