New aminopyrimidine derivatives as inhibitors of the TAM family

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 789-801

  Traoré, Ténin ^a   Cavagnino, Andrea ^b   Saettel, Nicolas ^a   Radvanyi, François ^a   Piguel, Sandrine ^a,d   Bernard Pierrot, Isabelle ^a   Stoven, Véronique ^b,c   Legraverend, Michel ^a  

^a CNRS   (France)

^b PSL RESEARCH UNIVERSITY   (France)

^c INSERM U900   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

Docking; Met inhibitors; Molecular modeling; Pyrimidine synthesis; TAM inhibitors; Type 2 inhibitors

Indexed keywords

BMS 777607; N [3 FLUORO 4 [6 (2 MORPHOLINOETHYLAMINO)PYRIMIDIN 4 YLOXY]PHENYL] 1 (4 FLUOROPHENYL) 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBOXAMIDE; N [4 (2 AMINOPYRIMIDIN 4 YLOXY) 3 FLUOROPHENYL] 1 (4 FLUORPHENYL) 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBOXAMIDE; N [4 (6 AMINOPYRIMIDIN 4 YLOXY) 3 FLUOROPHENYL] 1 (2 METHYL 4 FLUORO PHENYL) 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBOXAMIDE; N [4 (6 AMINOPYRIMIDIN 4 YLOXY) 3 FLUOROPHENYL] 1 (4 FLUOROPHENYL) 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBOXAMIDE; N [4 (6 AMINOPYRIMIDIN 4 YLOXY)PHENYL] 1 (4 FLUOROPHENYL) 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBOXAMIDE; PROTEIN INHIBITOR; PROTEIN KINASE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION;

DOCKING; MET INHIBITORS; MOLECULAR MODELING; PYRIMIDINE SYNTHESIS; TAM INHIBITORS; TYPE 2 INHIBITORS;

AMINOPYRIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MET; PYRIDONES; RECEPTOR PROTEIN-TYROSINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887357242     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.037     Document Type: Article

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