Discovery of 3H-Imidazo[4,5-b]pyridines as Potent c-Met Kinase Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem

Volumn 7, Issue 6, 2012, Pages 1057-1070

  Chen, Danqi ^a   Wang, Ying ^a   Ma, Yuchi ^a   Xiong, Bing ^a   Ai, Jing ^a   Chen, Yi ^a   Geng, Meiyu ^a   Shen, Jingkang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

C Met; Hinge binders; Imidazolopyridines; Kinase inhibitors; Structure activity relationships

Indexed keywords

(9H FLUOREN 9 YL)METHYL[4 [(2 AMINO 3 NITROPYRIDIN 4 YL)OXY]PHENYL]CARBAMATE; (9H FLUOREN 9 YL)METHYL[4 [(2,3 DIAMINOPYRIDIN 4 YL)OXY]PHENYL]CARBAMATE; 1 (4 FLUOROPHENYL) 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBOXYLIC ACID; 1 (4 FLUOROPHENYL) 2 OXO N [4 [[2 (THIOPHEN 3 YL) 3H IMIDAZO[4,5-B]PYRIDIN 7 YL]OXY]PHENYL] 1,2 DIHYDROPYRIDINE 3 CARBOXAMIDE; 1 [(4 FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLIC ACID; 2 (4 FLUOROPHENYL) 7 (4 NITROPHENOXY)OXAZOLO[4,5B]PYRIDINE; 2 (4 FLUOROPHENYL)OXAZOLO[4,5 B]PYRIDINE; 2 PHENYL N [[4 [[2 (4 TOLYL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]PHENYL]CARBAMOTHIOYL]ACETAMIDE; 2 PHENYL N [[4 [[2 (PYRIDIN 4 YL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]PHENYL]CARBAMOTHIOYL]ACETAMIDE; 2 PHENYL N [[4 [[2 (THIOPHEN 3 YL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]PHENYL]CARBAMOTHIOYL]ACETAMIDE; 2 PHENYL N [[4 [[2 PHENYL 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]PHENYL]CARBAMOTHIOYL]ACETAMIDE; 3H IMIDAZO[4,5 B]PYRIDINE; 4 (4 AMINOPHENOXY) 3 NITROPYRIDIN 2 AMINE; 4 [(2 PHENYL 3H IMIDAZO[4,5 B]PYRIDIN 7 YL)OXY]ANILINE; 4 [7 (4 AMINOPHENOXY) 3H IMIDAZO[4,5 B]PYRIDIN 2 YL] N,N DIMETHYLANILINE; 4 [[2 (2 CHLOROPHENYL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]ANILINE; 4 [[2 (3,4 DIFLUOROPHENYL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]ANILINE; 4 [[2 (4 FLUOROPHENYL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]ANILINE; 4 [[2 (4 FLUOROPHENYL)OXAZOLO[4,5 B]PYRIDIN 7 YL]OXY]ANILINE; 4 [[2 (4 TOLYL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]ANILINE; 4 [[2 (PYRIDAZIN 4 YL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]ANILINE; 4 [[2 (PYRIDIN 4 YL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]ANILINE; 4 [[2 (THIOPHEN 3 YL) 3H IMIDAZO[4,5 B]PYRIDIN 7 YL]OXY]ANILINE; 4 CHLORO 3 NITROPYRIDIN 2 AMINE; 7 CHLORO 2 (4 FLUOROPHENYL)OXAZOLO[4,5 B]PYRIDINE; ANTINEOPLASTIC AGENT; METHYL 1 (4 FLUOROPHENYL) 2 OXO 1,2 DIHYDROPYRIDINE 3 CARBOXYLATE; N [[4 [[2 (4 FLUOROPHENYL)OXAZOLO[4,5 B]PYRIDIN 7 YL]OXY]PHENYL]CARBAMOTHIOYL] 2 PHENYLACETAMIDE; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; CANCER INHIBITION; CELL ASSAY; CELL STRAIN 3T3; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG METABOLISM; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; IMIDAZOLES; MICE; MICE, NUDE; NIH 3T3 CELLS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-MET; PYRIDINES; PYRIDONES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 84861544849     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200120     Document Type: Article

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