메뉴 건너뛰기




Volumn 54, Issue 12, 2013, Pages 7329-7337

VEGF rescues cigarette smoking-induced human RPE cell death by increasing autophagic flux: Implications of the role of autophagy in advanced age-related macular degeneration

Author keywords

AMD; Autophagy; Cigarette smoke; RPE cells; VEGF

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; VASCULOTROPIN;

EID: 84887331851     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-12149     Document Type: Article
Times cited : (18)

References (34)
  • 1
    • 84863845318 scopus 로고    scopus 로고
    • Mechanisms of age-related macular degeneration
    • Ambati J, Fowler BJ. Mechanisms of age-related macular degeneration. Neuron. 2012;75:26-39.
    • (2012) Neuron. , vol.75 , pp. 26-39
    • Ambati, J.1    Fowler, B.J.2
  • 2
    • 3042662037 scopus 로고    scopus 로고
    • Risk factors for incident age-related macular degeneration: Pooled findings from 3 continents
    • Tomany SC, Wang JJ, Van Leeuwen R, et al. Risk factors for incident age-related macular degeneration: pooled findings from 3 continents. Ophthalmology. 2004;111:1280-1287.
    • (2004) Ophthalmology. , vol.111 , pp. 1280-1287
    • Tomany, S.C.1    Wang, J.J.2    Van Leeuwen, R.3
  • 3
    • 77449104200 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/ Akt
    • Byeon SH, Lee SC, Choi SH, et al. Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/ Akt. Invest Ophthalmol Vis Sci. 2010;51:1190-1197.
    • (2010) Invest Ophthalmol Vis Sci. , vol.51 , pp. 1190-1197
    • Byeon, S.H.1    Lee, S.C.2    Choi, S.H.3
  • 4
    • 0029759549 scopus 로고    scopus 로고
    • A prospective study of cigarette smoking and risk of age-related macular degeneration in men
    • Christen WG, Glynn RJ, Manson JE, Ajani UA, Buring JE. A prospective study of cigarette smoking and risk of age-related macular degeneration in men. JAMA. 1996;276:1147-1151.
    • (1996) JAMA. , vol.276 , pp. 1147-1151
    • Christen, W.G.1    Glynn, R.J.2    Manson, J.E.3    Ajani, U.A.4    Buring, J.E.5
  • 5
    • 29744442338 scopus 로고    scopus 로고
    • Smoking and age related macular degeneration: The number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation
    • Khan JC, Thurlby DA, Shahid H, et al. Smoking and age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation. Br J Ophthalmol. 2006;90:75-80.
    • (2006) Br J Ophthalmol. , vol.90 , pp. 75-80
    • Khan, J.C.1    Thurlby, D.A.2    Shahid, H.3
  • 6
    • 84856534214 scopus 로고    scopus 로고
    • Smoking as a risk factor for choroidal neovascularization secondary to presumed ocular histoplasmosis syndrome
    • Chheda LV, Ferketich AK, Carroll CP, Moyer PD, Kurz DE, Kurz PA. Smoking as a risk factor for choroidal neovascularization secondary to presumed ocular histoplasmosis syndrome. Ophthalmology. 2012;119:333-338.
    • (2012) Ophthalmology. , vol.119 , pp. 333-338
    • Chheda, L.V.1    Ferketich, A.K.2    Carroll, C.P.3    Moyer, P.D.4    Kurz, D.E.5    Kurz, P.A.6
  • 7
    • 79957746980 scopus 로고    scopus 로고
    • Nicotine increases VEGF/PEDF ratio in retinal pigment epithelium: A possible mechanism for CNV in passive smokers with AMD
    • Pons M, Marin-Castano ME. Nicotine increases VEGF/PEDF ratio in retinal pigment epithelium: a possible mechanism for CNV in passive smokers with AMD. Invest Ophthalmol Vis Sci. 2011;52:3842-3853.
    • (2011) Invest Ophthalmol Vis Sci. , vol.52 , pp. 3842-3853
    • Pons, M.1    Marin-Castano, M.E.2
  • 8
    • 84870564051 scopus 로고    scopus 로고
    • Apoptosis and necrosis: Two different outcomes of cigarette smoke condensate-induced endothelial cell death
    • Messner B, Frotschnig S, Steinacher-Nigisch A, et al. Apoptosis and necrosis: two different outcomes of cigarette smoke condensate-induced endothelial cell death. Cell Death Dis. 2012;3:e424.
    • (2012) Cell Death Dis. , vol.3
    • Messner, B.1    Frotschnig, S.2    Steinacher-Nigisch, A.3
  • 10
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell. 2010;40:310-322.
    • (2010) Mol Cell. , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 11
    • 77951214016 scopus 로고    scopus 로고
    • Mammalian autophagy: Core molecular machinery and signaling regulation
    • Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol. 2010;22:124-131.
    • (2010) Curr Opin Cell Biol. , vol.22 , pp. 124-131
    • Yang, Z.1    Klionsky, D.J.2
  • 12
    • 84860261634 scopus 로고    scopus 로고
    • Autophagy in toxicology: Selfconsumption in times of stress and plenty
    • Bolt AM, Klimecki WT. Autophagy in toxicology: selfconsumption in times of stress and plenty. J Appl Toxicol. 2012;32:465-479.
    • (2012) J Appl Toxicol. , vol.32 , pp. 465-479
    • Bolt, A.M.1    Klimecki, W.T.2
  • 13
    • 65449121080 scopus 로고    scopus 로고
    • Changes in retinal pigment epithelium related to cigarette smoke: Possible relevance to smoking as a risk factor for agerelated macular degeneration
    • Wang AL, Lukas TJ, Yuan M, Du N, Handa JT, Neufeld AH. Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for agerelated macular degeneration. PLoS One. 2009;4:e5304.
    • (2009) PLoS One. , vol.4
    • Wang, A.L.1    Lukas, T.J.2    Yuan, M.3    Du, N.4    Handa, J.T.5    Neufeld, A.H.6
  • 14
    • 0642364450 scopus 로고    scopus 로고
    • Disruption of vascular endothelial homeostasis by tobacco smoke: Impact on atherosclerosis
    • Bernhard D, Pfister G, Huck CW, et al. Disruption of vascular endothelial homeostasis by tobacco smoke: impact on atherosclerosis. FASEB J. 2003;17:2302-2304.
    • (2003) FASEB J. , vol.17 , pp. 2302-2304
    • Bernhard, D.1    Pfister, G.2    Huck, C.W.3
  • 15
    • 80052895371 scopus 로고    scopus 로고
    • Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells
    • Csordas A, Kreutmayer S, Ploner C, et al. Cigarette smoke extract induces prolonged endoplasmic reticulum stress and autophagic cell death in human umbilical vein endothelial cells. Cardiovasc Res. 2011;92:141-148.
    • (2011) Cardiovasc Res. , vol.92 , pp. 141-148
    • Csordas, A.1    Kreutmayer, S.2    Ploner, C.3
  • 16
    • 41549108838 scopus 로고    scopus 로고
    • Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smokemediated oxidative stress in human lung epithelial cells
    • Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smokemediated oxidative stress in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2008;294:L478-L488.
    • (2008) Am J Physiol Lung Cell Mol Physiol. , vol.294
    • Kode, A.1    Rajendrasozhan, S.2    Caito, S.3    Yang, S.R.4    Megson, I.L.5    Rahman, I.6
  • 17
    • 37349110028 scopus 로고    scopus 로고
    • Study of 99mTc-annexin V uptake in apoptotic cell models of Parkinson's disease
    • Cao W, Huang J, Wu J, et al. Study of 99mTc-annexin V uptake in apoptotic cell models of Parkinson's disease. Nucl Med Commun. 2007;28:895-901.
    • (2007) Nucl Med Commun. , vol.28 , pp. 895-901
    • Cao, W.1    Huang, J.2    Wu, J.3
  • 18
    • 80052773862 scopus 로고    scopus 로고
    • Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome system
    • Kim SY, Lee JH, Huh JW, et al. Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome system. J Biol Chem. 2011;286:31932-31943.
    • (2011) J Biol Chem. , vol.286 , pp. 31932-31943
    • Kim, S.Y.1    Lee, J.H.2    Huh, J.W.3
  • 19
    • 66349110062 scopus 로고    scopus 로고
    • ARPE-19 retinal pigment epithelial cells are highly resistant to oxidative stress and exercise strict control over their lysosomal redox-active iron
    • Kurz T, Karlsson M, Brunk UT, Nilsson SE, Frennesson C. ARPE-19 retinal pigment epithelial cells are highly resistant to oxidative stress and exercise strict control over their lysosomal redox-active iron. Autophagy. 2009;5:494-501.
    • (2009) Autophagy. , vol.5 , pp. 494-501
    • Kurz, T.1    Karlsson, M.2    Brunk, U.T.3    Nilsson, S.E.4    Frennesson, C.5
  • 21
    • 84865029396 scopus 로고    scopus 로고
    • Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF
    • Medici D, Olsen BR. Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF. PLoS One. 2012;7:e42913.
    • (2012) PLoS One. , vol.7
    • Medici, D.1    Olsen, B.R.2
  • 22
    • 49649105189 scopus 로고    scopus 로고
    • Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
    • Stahl A, Paschek L, Martin G, et al. Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro. FEBS Lett. 2008; 582:3097-3102.
    • (2008) FEBS Lett. , vol.582 , pp. 3097-3102
    • Stahl, A.1    Paschek, L.2    Martin, G.3
  • 23
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008;7:3355-3361.
    • (2008) Cell Cycle. , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 24
    • 77951947299 scopus 로고    scopus 로고
    • Cigarette-smokeinduced oxidative/nitrosative stress impairs VEGF-and fluidshear-stress-mediated signaling in endothelial cells
    • Edirisinghe I, Arunachalam G, Wong C, et al. Cigarette-smokeinduced oxidative/nitrosative stress impairs VEGF-and fluidshear-stress-mediated signaling in endothelial cells. Antioxid Redox Signal. 2010;12:1355-1369.
    • (2010) Antioxid Redox Signal. , vol.12 , pp. 1355-1369
    • Edirisinghe, I.1    Arunachalam, G.2    Wong, C.3
  • 25
    • 33646699515 scopus 로고    scopus 로고
    • Increased serum cadmium and strontium levels in young smokers: Effects on arterial endothelial cell gene transcription
    • Bernhard D, Rossmann A, Henderson B, Kind M, Seubert A, Wick G. Increased serum cadmium and strontium levels in young smokers: effects on arterial endothelial cell gene transcription. Arterioscler Thromb Vasc Biol. 2006;26:833-838.
    • (2006) Arterioscler Thromb Vasc Biol. , vol.26 , pp. 833-838
    • Bernhard, D.1    Rossmann, A.2    Henderson, B.3    Kind, M.4    Seubert, A.5    Wick, G.6
  • 26
    • 80052391019 scopus 로고    scopus 로고
    • Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells
    • Son YO, Wang X, Hitron JA, et al. Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells. Toxicol Appl Pharmacol. 2011; 255:287-296.
    • (2011) Toxicol Appl Pharmacol. , vol.255 , pp. 287-296
    • Son, Y.O.1    Wang, X.2    Hitron, J.A.3
  • 27
    • 73649089980 scopus 로고    scopus 로고
    • ERK and cell death: Mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence
    • Cagnol S, Chambard JC. ERK and cell death: mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. FEBS J. 2010;277:2-21.
    • (2010) FEBS J. , vol.277 , pp. 2-21
    • Cagnol, S.1    Chambard, J.C.2
  • 28
    • 33947502315 scopus 로고    scopus 로고
    • hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways
    • Li H, Wang X, Li N, Qiu J, Zhang Y, Cao X. hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways. J Biol Chem. 2007;282:4943-4950.
    • (2007) J Biol Chem. , vol.282 , pp. 4943-4950
    • Li, H.1    Wang, X.2    Li, N.3    Qiu, J.4    Zhang, Y.5    Cao, X.6
  • 29
    • 34047168720 scopus 로고    scopus 로고
    • Requirement for ERK activity in sodium selenite-induced apoptosis of acute promyelocytic leukemia-derived NB4 cells
    • Han B, Wei W, Hua F, et al. Requirement for ERK activity in sodium selenite-induced apoptosis of acute promyelocytic leukemia-derived NB4 cells. J Biochem Mol Biol. 2007;40: 196-204.
    • (2007) J Biochem Mol Biol. , vol.40 , pp. 196-204
    • Han, B.1    Wei, W.2    Hua, F.3
  • 30
    • 0036727502 scopus 로고    scopus 로고
    • Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation
    • Hecquet C, Lefevre G, Valtink M, Engelmann K, Mascarelli F. Activation and role of MAP kinase-dependent pathways in retinal pigment epithelial cells: ERK and RPE cell proliferation. Invest Ophthalmol Vis Sci. 2002;43:3091-3098.
    • (2002) Invest Ophthalmol Vis Sci. , vol.43 , pp. 3091-3098
    • Hecquet, C.1    Lefevre, G.2    Valtink, M.3    Engelmann, K.4    Mascarelli, F.5
  • 31
    • 3042739490 scopus 로고    scopus 로고
    • Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: Prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2
    • Garg TK, Chang JY. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003;3:5.
    • (2003) BMC Ophthalmol. , vol.3 , pp. 5
    • Garg, T.K.1    Chang, J.Y.2
  • 32
    • 84873409839 scopus 로고    scopus 로고
    • Oncogenic KRAS. and BRAF activation of the MEK/ERK signaling pathway promotes expression of dualspecificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition
    • Cagnol S, Rivard N. Oncogenic KRAS. and BRAF activation of the MEK/ERK signaling pathway promotes expression of dualspecificity phosphatase 4 (DUSP4/MKP2) resulting in nuclear ERK1/2 inhibition. Oncogene. 2013;32:564-576.
    • (2013) Oncogene. , vol.32 , pp. 564-576
    • Cagnol, S.1    Rivard, N.2
  • 33
    • 0033558798 scopus 로고    scopus 로고
    • VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling
    • Gupta K, Kshirsagar S, Li W, et al. VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signaling. Exp Cell Res. 1999;247: 495-504.
    • (1999) Exp Cell Res. , vol.247 , pp. 495-504
    • Gupta, K.1    Kshirsagar, S.2    Li, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.