Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells

Acta Pharmacologica Sinica

Volumn 34, Issue 11, 2013, Pages 1403-1410

  Hou, Li Li ^a   Gao, Chao ^b   Chen, Liang ^a   Hu, Guo Qiang ^a   Xie, Song Qiang ^a  

^a HENAN UNIVERSITY   (China)

^b ZHENGZHOU CHILDREN S HOSPITAL   (China)

Author keywords

3 methyladenine; Akt mTOR signaling pathway; Anticancer drug; Apoptosis; Autophagy; Fucoxanthin; HeLa cells

Indexed keywords

BIOLOGICAL MARKER; FUCOXANTHIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN KINASE B; PROTEIN LC3 II; PROTEIN P53; RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL CYCLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UTERINE CERVIX CANCER; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BLOTTING, WESTERN; CELL CYCLE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLOW CYTOMETRY; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; UTERINE CERVICAL NEOPLASMS; XANTHOPHYLLS;

EID: 84887328958     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.90     Document Type: Article

References (31)

1. Shigetomi H, Higashiura Y, Kajihara H, Kobayashi H. Targeted molecular therapies for ovarian cancer: an update and future perspectives. Oncol Rep 2012; 28: 395-408.
2. Carew JS, Kelly KR, Nawrocki ST. Autophagy as a target for cancer therapy: new developments. Cancer Manag Res 2012; 4: 357-65.
3. Gordy C, He YW. The crosstalk between autophagy and apoptosis: where does this lead? Protein Cell 2012; 3: 17-27.
4. Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B, et al. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 2012; 45: 487-98.
5. Abrahamsen H, Stenmark H, Platta HW. Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression. FEBS Lett 2012; 586: 1584-91.
6. D'Orazio N, Gemello E, Gammone MA, de Girolamo M, Ficoneri C, Riccioni G. Fucoxantin: a treasure from the sea. Mar Drugs 2012; 10: 604-16.
7. Wang J, Chen S, Xu S, Yu X, Ma D, Xu X, et al. In vivo induction of apoptosis by fucoxanthin, a marine carotenoid, associated with down-regulating STAT3/EGFR signaling in sarcoma 180 (S180) xenografts-bearing mice. Mar Drugs 2012; 10: 2055-68.
8. Yu RX, Hu XM, Xu SQ, Jiang ZJ, Yang W. Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway. Eur J Pharmacol 2011; 657: 10-9.
9. Heo SJ, Yoon WJ, Kim KN, Oh C, Choi YU, Yoon KT, et al. Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage. Food Chem Toxicol 2012; 50: 3336-42.
10. Takashima M, Shichiri M, Hagihara Y, Yoshida Y, Niki E. Capacity of fucoxanthin for scavenging peroxyl radicals and inhibition of lipid peroxidation in model systems. Free Radic Res 2012; 46: 1406-12.
11. Xie SQ, Wang JH, Ma HX, Cheng PF, Zhao J, Wang CJ. Polyamine transporter recognization and antitumor effects of anthracenymethyl homospermidine. Toxicology 2009; 263: 127-33.
12. Xie SQ, Zhang YH, Li Q, Xu FH, Miao JW, Zhao J, et al. 3-Nitro-naphthalimide and nitrogen mustard conjugate NNM-25 induces hepatocellular carcinoma apoptosis via PARP-1/p53 pathway. Apoptosis 2012; 17: 725-34.
13. Huang S, Sinicrope FA. Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer. Autophagy 2010; 6: 256-69.
14. Hu D, Wu J, Xu L, Zhang R, Chen L. A method for the establishment of a cell line with stable expression of the GFP-LC3 reporter protein. Mol Med Report 2012; 6: 783-6.
15. Zhang XJ, Chen S, Huang KX, Le WD. Why should autophagic flux be assessed? Acta Pharmacol Sin 2013; 34: 595-9.
16. Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 2007; 72: 29-39. (Pubitemid 46998522)
17. Zou CY, Smith KD, Zhu QS, Liu J, McCutcheon IE, Slopis JM, et al. Dual targeting of AKT and mammalian target of rapamyc, in: a potential therapeutic approach for malignant peripheral nerve sheath tumor. Mol Cancer Ther 2009; 8: 1157-68.
18. Lieberman AP, Puertollano R, Raben N, Slaugenhaupt S, Walkley SU, Ballabio A. Autophagy in lysosomal storage disorders. Autophagy 2012; 8: 719-30.
19. Zhang X, Chen LX, Ouyang L, Cheng Y, Liu B. Plant natural com-pounds: targeting pathways of autophagy as anti-cancer therapeutic agents. Cell Prolif 2012; 45: 466-76.
20. Marquez RT, Xu L. Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/apoptosis toggle switch. Am J Cancer Res 2012; 2: 214-21.
21. Kaushik S, Cuervo AM. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol 2012; 22: 407-17.
22. Hundeshagen P, Hamacher-Brady A, Eils R, Brady NR. Concurrent detection of autolysosome formation and lysosomal degradation by flow cytometry in a high-content screen for inducers of autophagy. BMC Biol 2011; 9: 38.
23. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, et al. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 2010; 465: 942-6.
24. Fu L, Kim YA, Wang X, Wu X, Xue P, Lonial S, et al. Perifosine inhibits mammalion target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy. Cancer Res 2009; 69: 8967-76.
25. Tafuku S, Ishikawa C, Yasumoto T, Mori N. Anti-neoplastic effects of fucoxanthin and its deacetylated product, fucoxanthinol, on Burkitt's and Hodgkin's lymphoma cells. Oncol Rep 2012; 28: 1512-8.
26. Dickstein RJ, Nitti G, Dinney CP, Davies BR, Kamat AM, McConkey DJ. Autophagy limits the cytotoxic effects of the AKT inhibitor AZ7328 in human bladder cancer cells. Cancer Biol Ther 2012; 13: 1325-38.
27. Singh BN, Kumar D, Shankar S, Srivastava RK. Rottlerin induces autophagy which leads to apoptotic cell death through inhibition of PI3K/Akt/mTOR pathway in human pancreatic cancer stem cells. Biochem Pharmacol 2012; 84: 1154-63.
28. Platini F, Pérez-Tomás R, Ambrosio S, Tessitore L. Understanding autophagy in cell death control. Curr Pharm Des 2010; 16: 101-13.
29. Wang WJ, Long LM, Yang N, Zhang QQ, Ji WJ, Zhao JH, et al. NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro. Acta Pharmacol Sin 2013; 34: 681-90.
30. Satomi Y. Fucoxanthin induces GADD45A expression and G1 arrest with SAPK/JNK activation in LNCap human prostate cancer cells. Anticancer Res 2012; 32: 807-13.
31. Yoshiko S, Hoyoku N. Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells. In vivo 2007; 21: 305-9. (Pubitemid 46534285)