메뉴 건너뛰기




Volumn 28, Issue 2, 2012, Pages 395-408

Targeted molecular therapies for ovarian cancer: An update and future perspectives (Review)

Author keywords

Checkpoint kinase; Hepetocyte nuclear factor 1 ; Ovarian cancer; Poly (ADP ribose) polymerase; Targeted therapy

Indexed keywords

ABAGOVOMAB; AFLIBERCEPT; ANTINEOPLASTIC AGENT; BAY 86 5321; BEVACIZUMAB; CARBOPLATIN; CATUMAXOMAB; CETUXIMAB; CISPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EOS 200 4; ERLOTINIB; FARLETUZUMAB; GANITUMAB; GEMCITABINE; IMATINIB; LENALIDOMIDE; MAB B43 13; MM 121; MMI 121; OREGOVOMAB; PACLITAXEL; PAZOPANIB; PERTUZUMAB; PLACEBO; PLATINUM; SAR 256212; SORAFENIB; TOPOTECAN; TRASTUZUMAB; TREBANANIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VOLOCIXIMAB;

EID: 84863458937     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.1833     Document Type: Review
Times cited : (15)

References (70)
  • 2
    • 80053246700 scopus 로고    scopus 로고
    • The role of targeted therapy in ovarian cancer
    • Banerjee S and Kaye S: The role of targeted therapy in ovarian cancer. Eur J Cancer 47 (Suppl 3): S116-S130, 2011.
    • (2011) Eur J Cancer , vol.47 , Issue.SUPPL. 3
    • Banerjee, S.1    Kaye, S.2
  • 3
    • 48149110374 scopus 로고    scopus 로고
    • The use of monoclonal antibodies for the treatment of epithelial ovarian cancer
    • Review
    • Oei AL, Sweep FC, Thomas CM, Boerman OC and Massuger LF: The use of monoclonal antibodies for the treatment of epithelial ovarian cancer (Review). Int J Oncol 32: 1145-1157, 2008.
    • (2008) Int J Oncol , vol.32 , pp. 1145-1157
    • Oei, A.L.1    Sweep, F.C.2    Thomas, C.M.3    Boerman, O.C.4    Massuger, L.F.5
  • 4
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • Reichert JM: Antibody-based therapeutics to watch in 2011. MAbs 3: 76-99, 2011.
    • (2011) MAbs , vol.3 , pp. 76-99
    • Reichert, J.M.1
  • 5
    • 79960420158 scopus 로고    scopus 로고
    • Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action
    • Itamochi H: Targeted therapies in epithelial ovarian cancer: molecular mechanisms of action. World J Biol Chem 1: 209-220, 2010.
    • (2010) World J Biol Chem , vol.1 , pp. 209-220
    • Itamochi, H.1
  • 6
    • 56449105264 scopus 로고    scopus 로고
    • Combination gemcitabine, platinum, and bevacizumab for the treatment of recurrent ovarian cancer
    • Richardson DL, Backes FJ, Seamon LG, et al: Combination gemcitabine, platinum, and bevacizumab for the treatment of recurrent ovarian cancer. Gynecol Oncol 111: 461-466, 2008.
    • (2008) Gynecol Oncol , vol.111 , pp. 461-466
    • Richardson, D.L.1    Backes, F.J.2    Seamon, L.G.3
  • 7
    • 56149111692 scopus 로고    scopus 로고
    • Combined oral cyclophosphamide and bevacizumab in heavily pre-treated ovarian cancer
    • Jurado JM, Sánchez A, Pajares B, Pérez E, Alonso L and Alba E: Combined oral cyclophosphamide and bevacizumab in heavily pre-treated ovarian cancer. Clin Transl Oncol 10: 583-586, 2008.
    • (2008) Clin Transl Oncol , vol.10 , pp. 583-586
    • Jurado, J.M.1    Sánchez, A.2    Pajares, B.3    Pérez, E.4    Alonso, L.5    Alba, E.6
  • 8
    • 84855466019 scopus 로고    scopus 로고
    • A phase 3 trial of bevacizumab in ovarian cancer
    • Perren TJ, Swart AM, Pfisterer J, et al: A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 365: 2484-2496, 2011.
    • (2011) N Engl J Med , vol.365 , pp. 2484-2496
    • Perren, T.J.1    Swart, A.M.2    Pfisterer, J.3
  • 9
    • 78649401745 scopus 로고    scopus 로고
    • How to integrate molecular targeted agents in the continuum of care
    • Köhne CH: How to integrate molecular targeted agents in the continuum of care. Ann Oncol 21 (Suppl 7): vii134-vii139, 2010.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 7
    • Köhne, C.H.1
  • 10
    • 69849111795 scopus 로고    scopus 로고
    • Aflibercept in epithelial ovarian carcinoma
    • Moroney JW, Sood AK and Coleman RL: Aflibercept in epithelial ovarian carcinoma. Future Oncol 5: 591-600, 2009.
    • (2009) Future Oncol , vol.5 , pp. 591-600
    • Moroney, J.W.1    Sood, A.K.2    Coleman, R.L.3
  • 11
  • 12
    • 84858336778 scopus 로고    scopus 로고
    • A phase II study of aflibercept in patients with advanced epithelial ovarian cancer and symptomatic malignant ascites
    • Colombo N, Mangili G, Mammoliti S, et al: A phase II study of aflibercept in patients with advanced epithelial ovarian cancer and symptomatic malignant ascites. Gynecol Oncol 125: 42-47, 2012.
    • (2012) Gynecol Oncol , vol.125 , pp. 42-47
    • Colombo, N.1    Mangili, G.2    Mammoliti, S.3
  • 13
    • 81255185158 scopus 로고    scopus 로고
    • Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer
    • Coleman RL, Duska LR, Ramirez PT, et al: Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer. Lancet Oncol 12: 1109-1117, 2011.
    • (2011) Lancet Oncol , vol.12 , pp. 1109-1117
    • Coleman, R.L.1    Duska, L.R.2    Ramirez, P.T.3
  • 14
    • 77955347059 scopus 로고    scopus 로고
    • AMG-386, a selective angiopoietin-1/-2-neutralizing peptibody for the potential treatment of cancer
    • Neal J and Wakelee H: AMG-386, a selective angiopoietin-1/-2-neutralizing peptibody for the potential treatment of cancer. Curr Opin Mol Ther 12: 487-495, 2010.
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 487-495
    • Neal, J.1    Wakelee, H.2
  • 15
    • 84863012011 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase II Study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer
    • Karlan BY, Oza AM, Richardson GE, et al: Randomized, double-blind, placebo-controlled phase II Study of AMG 386 combined with weekly paclitaxel in patients with recurrent ovarian cancer. J Clin Oncol 30: 362-371, 2012.
    • (2012) J Clin Oncol , vol.30 , pp. 362-371
    • Karlan, B.Y.1    Oza, A.M.2    Richardson, G.E.3
  • 16
    • 79959732370 scopus 로고    scopus 로고
    • The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer
    • Yarom N and Jonker DJ: The role of the epidermal growth factor receptor in the mechanism and treatment of colorectal cancer. Discov Med 11: 95-105, 2011.
    • (2011) Discov Med , vol.11 , pp. 95-105
    • Yarom, N.1    Jonker, D.J.2
  • 18
    • 67349095676 scopus 로고    scopus 로고
    • Associations between ERBB2 amplification and progression-free survival and overall survival in advanced stage, suboptimally-resected epithelial ovarian cancers: A Gynecologic Oncology Group Study
    • Farley J, Fuchiuji S, Darcy KM, et al: Associations between ERBB2 amplification and progression-free survival and overall survival in advanced stage, suboptimally-resected epithelial ovarian cancers: a Gynecologic Oncology Group Study. Gynecol Oncol 113: 341-347, 2009.
    • (2009) Gynecol Oncol , vol.113 , pp. 341-347
    • Farley, J.1    Fuchiuji, S.2    Darcy, K.M.3
  • 19
    • 79952316971 scopus 로고    scopus 로고
    • Polyclonal antitumor immunoglobulin may play a role in ovarian cancer adjuvant therapy
    • Tang L and Zhao X: Polyclonal antitumor immunoglobulin may play a role in ovarian cancer adjuvant therapy. Med Hypotheses 76: 530-532, 2011.
    • (2011) Med Hypotheses , vol.76 , pp. 530-532
    • Tang, L.1    Zhao, X.2
  • 20
    • 77949900758 scopus 로고    scopus 로고
    • Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer
    • Makhija S, Amler LC, Glenn D, et al: Clinical activity of gemcitabine plus pertuzumab in platinum-resistant ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. J Clin Oncol 28: 1215-1223, 2010.
    • (2010) J Clin Oncol , vol.28 , pp. 1215-1223
    • Makhija, S.1    Amler, L.C.2    Glenn, D.3
  • 22
    • 77649314140 scopus 로고    scopus 로고
    • An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells
    • Sheng Q, Liu X, Fleming E, et al: An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells. Cancer Cell 17: 298-310, 2010.
    • (2010) Cancer Cell , vol.17 , pp. 298-310
    • Sheng, Q.1    Liu, X.2    Fleming, E.3
  • 23
    • 78049476593 scopus 로고    scopus 로고
    • Farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer: A phase I study
    • Konner JA, Bell-McGuinn KM, Sabbatini P, et al: Farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer: a phase I study. Clin Cancer Res 16: 5288-5295, 2010.
    • (2010) Clin Cancer Res , vol.16 , pp. 5288-5295
    • Konner, J.A.1    Bell-McGuinn, K.M.2    Sabbatini, P.3
  • 24
    • 58549088720 scopus 로고    scopus 로고
    • Oregovomab maintenance monoimmunotherapy does not improve outcomes in advanced ovarian cancer
    • Berek J, Taylor P, McGuire W, Smith LM, Schultes B and Nicodemus CF: Oregovomab maintenance monoimmunotherapy does not improve outcomes in advanced ovarian cancer. J Clin Oncol 27: 418-425, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 418-425
    • Berek, J.1    Taylor, P.2    McGuire, W.3    Smith, L.M.4    Schultes, B.5    Nicodemus, C.F.6
  • 26
    • 79951743656 scopus 로고    scopus 로고
    • Abagovomab: An anti-idiotypic CA-125 targeted immunotherapeutic agent for ovarian cancer
    • Grisham RN, Berek J, Pfisterer J and Sabbatini P: Abagovomab: an anti-idiotypic CA-125 targeted immunotherapeutic agent for ovarian cancer. Immunotherapy 3: 153-162, 2011.
    • (2011) Immunotherapy , vol.3 , pp. 153-162
    • Grisham, R.N.1    Berek, J.2    Pfisterer, J.3    Sabbatini, P.4
  • 27
    • 0035889129 scopus 로고    scopus 로고
    • Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody
    • Ruf P and Lindhofer H: Induction of a long-lasting antitumor immunity by a trifunctional bispecific antibody. Blood 98: 2526-2534, 2001.
    • (2001) Blood , vol.98 , pp. 2526-2534
    • Ruf, P.1    Lindhofer, H.2
  • 28
    • 80052593787 scopus 로고    scopus 로고
    • Intraperitoneal treatment with the trifunctional bispecific antibody Catumaxomab in patients with platinum-resistant epithelial ovarian cancer: A phase IIa study of the AGO Study Group
    • Baumann K, Pfisterer J, Wimberger P, et al: Intraperitoneal treatment with the trifunctional bispecific antibody Catumaxomab in patients with platinum-resistant epithelial ovarian cancer: a phase IIa study of the AGO Study Group. Gynecol Oncol 123: 27-32, 2011.
    • (2011) Gynecol Oncol , vol.123 , pp. 27-32
    • Baumann, K.1    Pfisterer, J.2    Wimberger, P.3
  • 29
    • 79955475569 scopus 로고    scopus 로고
    • A phase II, single-arm study of the anti-á5â1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer
    • Bell-McGuinn KM, Matthews CM, Ho SN, et al: A phase II, single-arm study of the anti-á5â1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer. Gynecol Oncol 121: 273-279, 2011.
    • (2011) Gynecol Oncol , vol.121 , pp. 273-279
    • Bell-McGuinn, K.M.1    Matthews, C.M.2    Ho, S.N.3
  • 30
    • 79951988792 scopus 로고    scopus 로고
    • Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: A gynecologic oncology group trial
    • Matei D, Sill MW, Lankes HA, et al: Activity of sorafenib in recurrent ovarian cancer and primary peritoneal carcinomatosis: a gynecologic oncology group trial. J Clin Oncol 29: 69-75, 2011.
    • (2011) J Clin Oncol , vol.29 , pp. 69-75
    • Matei, D.1    Sill, M.W.2    Lankes, H.A.3
  • 31
    • 80052604394 scopus 로고    scopus 로고
    • Sorafenib as a third line therapy in patients with epithelial ovarian cancer or primary peritoneal cancer: A phase II study
    • Bodnar L, Górnas M and Szczylik C: Sorafenib as a third line therapy in patients with epithelial ovarian cancer or primary peritoneal cancer: a phase II study. Gynecol Oncol 123: 33-36, 2011.
    • (2011) Gynecol Oncol , vol.123 , pp. 33-36
    • Bodnar, L.1    Górnas, M.2    Szczylik, C.3
  • 32
    • 81155148279 scopus 로고    scopus 로고
    • Sorafenib in combination with weekly topotecan in recurrent ovarian cancer, a phase I/II study of the Hoosier Oncology Group
    • Ramasubbaiah R, Perkins SM, Schilder J, et al: Sorafenib in combination with weekly topotecan in recurrent ovarian cancer, a phase I/II study of the Hoosier Oncology Group. Gynecol Oncol 123: 499-504, 2011.
    • (2011) Gynecol Oncol , vol.123 , pp. 499-504
    • Ramasubbaiah, R.1    Perkins, S.M.2    Schilder, J.3
  • 33
    • 77956799700 scopus 로고    scopus 로고
    • Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer: A study of the Princess Margaret Hospital Phase II Consortium
    • Welch SA, Hirte HW, Elit L, et al: Sorafenib in combination with gemcitabine in recurrent epithelial ovarian cancer: a study of the Princess Margaret Hospital Phase II Consortium. Int J Gynecol Cancer 20: 787-793, 2010.
    • (2010) Int J Gynecol Cancer , vol.20 , pp. 787-793
    • Welch, S.A.1    Hirte, H.W.2    Elit, L.3
  • 34
    • 77951917301 scopus 로고    scopus 로고
    • Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer
    • Pölcher M, Eckhardt M, Coch C, et al: Sorafenib in combination with carboplatin and paclitaxel as neoadjuvant chemotherapy in patients with advanced ovarian cancer. Cancer Chemother Pharmacol 66: 203-207, 2010.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 203-207
    • Pölcher, M.1    Eckhardt, M.2    Coch, C.3
  • 35
    • 80054688412 scopus 로고    scopus 로고
    • The PACOVAR-trial: A phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer
    • Eichbaum M, Mayer C, Eickhoff R, et al: The PACOVAR-trial: a phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer. BMC Cancer 11: 453, 2011.
    • (2011) BMC Cancer , vol.11 , pp. 453
    • Eichbaum, M.1    Mayer, C.2    Eickhoff, R.3
  • 36
    • 77956649079 scopus 로고    scopus 로고
    • A Phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer
    • Friedlander M, Hancock KC, Rischin D, et al: A Phase II, open-label study evaluating pazopanib in patients with recurrent ovarian cancer. Gynecol Oncol 119: 32-37, 2010.
    • (2010) Gynecol Oncol , vol.119 , pp. 32-37
    • Friedlander, M.1    Hancock, K.C.2    Rischin, D.3
  • 37
    • 46849094734 scopus 로고    scopus 로고
    • Molecular mechanisms of action of imatinib mesylate in human ovarian cancer: A proteomic analysis
    • Patel BB, He YA, Li XM, et al: Molecular mechanisms of action of imatinib mesylate in human ovarian cancer: a proteomic analysis. Cancer Genomics Proteomics 5: 137-149, 2008.
    • (2008) Cancer Genomics Proteomics , vol.5 , pp. 137-149
    • Patel, B.B.1    He, Y.A.2    Li, X.M.3
  • 38
    • 67449136137 scopus 로고    scopus 로고
    • History of aromatase: Saga of an important biological mediator and therapeutic target
    • Santen RJ, Brodie H, Simpson ER, Siiteri PK and Brodie A: History of aromatase: saga of an important biological mediator and therapeutic target. Endocr Rev 30: 343-375, 2009.
    • (2009) Endocr Rev , vol.30 , pp. 343-375
    • Santen, R.J.1    Brodie, H.2    Simpson, E.R.3    Siiteri, P.K.4    Brodie, A.5
  • 39
    • 56749138439 scopus 로고    scopus 로고
    • A phase 2 trial of oral imatinib in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma in second or greater remission
    • Juretzka M, Hensley ML, Tew W, et al: A phase 2 trial of oral imatinib in patients with epithelial ovarian, fallopian tube, or peritoneal carcinoma in second or greater remission. Eur J Gynaecol Oncol 29: 568-572, 2008.
    • (2008) Eur J Gynaecol Oncol , vol.29 , pp. 568-572
    • Juretzka, M.1    Hensley, M.L.2    Tew, W.3
  • 40
    • 78149360639 scopus 로고    scopus 로고
    • Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer: A phase II study based on surgical reassessment
    • Blank SV, Christos P, Curtin JP, et al: Erlotinib added to carboplatin and paclitaxel as first-line treatment of ovarian cancer: a phase II study based on surgical reassessment. Gynecol Oncol 119: 451-456, 2010.
    • (2010) Gynecol Oncol , vol.119 , pp. 451-456
    • Blank, S.V.1    Christos, P.2    Curtin, J.P.3
  • 41
    • 45549099056 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: A trial of the Chicago, PMH, and California Phase II Consortia
    • Nimeiri HS, Oza AM, Morgan RJ, et al: Efficacy and safety of bevacizumab plus erlotinib for patients with recurrent ovarian, primary peritoneal, and fallopian tube cancer: a trial of the Chicago, PMH, and California Phase II Consortia. Gynecol Oncol 110: 49-55, 2008.
    • (2008) Gynecol Oncol , vol.110 , pp. 49-55
    • Nimeiri, H.S.1    Oza, A.M.2    Morgan, R.J.3
  • 42
    • 84856702658 scopus 로고    scopus 로고
    • A phase II evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A gynecologic oncology group study
    • Garcia AA, Sill MW, Lankes HA, et al: A phase II evaluation of lapatinib in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A gynecologic oncology group study. Gynecol Oncol 124: 569-574, 2012.
    • (2012) Gynecol Oncol , vol.124 , pp. 569-574
    • Garcia, A.A.1    Sill, M.W.2    Lankes, H.A.3
  • 43
    • 52049112530 scopus 로고    scopus 로고
    • A phase I study of lapatinib in combination with carboplatin in women with platinum sensitive recurrent ovarian carcinoma
    • Kimball KJ, Numnum TM, Kirby TO, et al: A phase I study of lapatinib in combination with carboplatin in women with platinum sensitive recurrent ovarian carcinoma. Gynecol Oncol 111: 95-101, 2008.
    • (2008) Gynecol Oncol , vol.111 , pp. 95-101
    • Kimball, K.J.1    Numnum, T.M.2    Kirby, T.O.3
  • 44
    • 79957697421 scopus 로고    scopus 로고
    • Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma
    • Weroha SJ, Oberg AL, Ziegler KL, et al: Phase II trial of lapatinib and topotecan (LapTop) in patients with platinum-refractory/resistant ovarian and primary peritoneal carcinoma. Gynecol Oncol 122: 116-120, 2011.
    • (2011) Gynecol Oncol , vol.122 , pp. 116-120
    • Weroha, S.J.1    Oberg, A.L.2    Ziegler, K.L.3
  • 45
    • 79958227079 scopus 로고    scopus 로고
    • Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: A systematic review
    • Murphy M and Stordal B: Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: a systematic review. Drug Resist Updat 14: 177-190, 2011.
    • (2011) Drug Resist Updat , vol.14 , pp. 177-190
    • Murphy, M.1    Stordal, B.2
  • 47
    • 77957660865 scopus 로고    scopus 로고
    • Dasatinib induces autophagic cell death in human ovarian cancer
    • Le XF, Mao W, Lu Z, Carter BZ and Bast RC Jr: Dasatinib induces autophagic cell death in human ovarian cancer. Cancer 116: 4980-4990, 2010.
    • (2010) Cancer , vol.116 , pp. 4980-4990
    • Le, X.F.1    Mao, W.2    Lu, Z.3    Carter, B.Z.4    Bast Jr., R.C.5
  • 48
    • 80052010923 scopus 로고    scopus 로고
    • Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: A trial of the NCIC Clinical Trials Group
    • Oza AM, Elit L, Tsao MS, et al: Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol 29: 3278-3285, 2011.
    • (2011) J Clin Oncol , vol.29 , pp. 3278-3285
    • Oza, A.M.1    Elit, L.2    Tsao, M.S.3
  • 49
    • 80052588957 scopus 로고    scopus 로고
    • Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: A Gynecologic Oncology Group study
    • Behbakht K, Sill MW, Darcy KM, et al: Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: a Gynecologic Oncology Group study. Gynecol Oncol 123: 19-26, 2011.
    • (2011) Gynecol Oncol , vol.123 , pp. 19-26
    • Behbakht, K.1    Sill, M.W.2    Darcy, K.M.3
  • 50
    • 77951938324 scopus 로고    scopus 로고
    • A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies
    • Temkin SM, Yamada SD and Fleming GF: A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies. Gynecol Oncol 117: 473-476, 2010.
    • (2010) Gynecol Oncol , vol.117 , pp. 473-476
    • Temkin, S.M.1    Yamada, S.D.2    Fleming, G.F.3
  • 51
    • 80052030314 scopus 로고    scopus 로고
    • Temsirolimus in combination with carboplatin and paclitaxel in patients with advanced solid tumors: A NCIC-CTG, phase I, open-label dose-escalation study (IND 179)
    • Kollmannsberger C, Hirte H, Siu LL, et al: Temsirolimus in combination with carboplatin and paclitaxel in patients with advanced solid tumors: a NCIC-CTG, phase I, open-label dose-escalation study (IND 179). Ann Oncol 23: 238-244, 2012.
    • (2012) Ann Oncol , vol.23 , pp. 238-244
    • Kollmannsberger, C.1    Hirte, H.2    Siu, L.L.3
  • 52
    • 84863338519 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations
    • Janku F, Wheler JJ, Westin SN, et al: PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 30: 777-782, 2012.
    • (2012) J Clin Oncol , vol.30 , pp. 777-782
    • Janku, F.1    Wheler, J.J.2    Westin, S.N.3
  • 53
    • 84857475389 scopus 로고    scopus 로고
    • Loss of BRCA1 protein expression as indicator of the BRCAness phenotype is associated with favorable overall survival after complete resection of sporadic ovarian cancer
    • Radosa MP, Häfner N, Camara O, et al: Loss of BRCA1 protein expression as indicator of the BRCAness phenotype is associated with favorable overall survival after complete resection of sporadic ovarian cancer. Int J Gynecol Cancer 21: 1399-1406, 2011.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 1399-1406
    • Radosa, M.P.1    Häfner, N.2    Camara, O.3
  • 54
    • 78649663174 scopus 로고    scopus 로고
    • BRCA mutations in the management of breast cancer: The state of the art
    • Narod SA: BRCA mutations in the management of breast cancer: the state of the art. Nat Rev Clin Oncol 7: 702-707, 2010.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 702-707
    • Narod, S.A.1
  • 55
    • 84856889082 scopus 로고    scopus 로고
    • The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy
    • Javle M and Curtin NJ: The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy. Ther Adv Med Oncol 3: 257-267, 2011.
    • (2011) Ther Adv Med Oncol , vol.3 , pp. 257-267
    • Javle, M.1    Curtin, N.J.2
  • 56
    • 51449113045 scopus 로고    scopus 로고
    • Targeted therapy for cancer using PARP inhibitors
    • Lord CJ and Ashworth A: Targeted therapy for cancer using PARP inhibitors. Curr Opin Pharmacol 8: 363-369, 2008.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 363-369
    • Lord, C.J.1    Ashworth, A.2
  • 57
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' in sporadic cancers
    • DOI 10.1038/nrc1457
    • Turner N, Tutt A and Ashworth A: Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer 4: 814-819, 2004. (Pubitemid 39331153)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.10 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 58
    • 77956399970 scopus 로고    scopus 로고
    • Small-molecule PARP modulators - Current status and future therapeutic potential
    • Penning TD: Small-molecule PARP modulators - current status and future therapeutic potential. Curr Opin Drug Discov Devel 13: 577-586, 2010.
    • (2010) Curr Opin Drug Discov Devel , vol.13 , pp. 577-586
    • Penning, T.D.1
  • 59
    • 77954032829 scopus 로고    scopus 로고
    • Poly(ADP)-ribose polymerase inhibition: Frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
    • Fong PC, Yap TA, Boss DS, et al: Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J Clin Oncol 28: 2512-2519, 2010.
    • (2010) J Clin Oncol , vol.28 , pp. 2512-2519
    • Fong, P.C.1    Yap, T.A.2    Boss, D.S.3
  • 60
    • 80052389761 scopus 로고    scopus 로고
    • Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: A phase 2, multicentre, open-label, non-randomised study
    • Gelmon KA, Tischkowitz M, Mackay H, et al: Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study. Lancet Oncol 12: 852-861, 2011.
    • (2011) Lancet Oncol , vol.12 , pp. 852-861
    • Gelmon, K.A.1    Tischkowitz, M.2    Mackay, H.3
  • 61
    • 34547094373 scopus 로고    scopus 로고
    • UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: A study of the Princess Margaret Hospital Phase II consortium
    • DOI 10.1016/j.ygyno.2007.02.018, PII S0090825807001461
    • Welch S, Hirte HW, Carey MS, et al: UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium. Gynecol Oncol 106: 305-310, 2007. (Pubitemid 47096653)
    • (2007) Gynecologic Oncology , vol.106 , Issue.2 , pp. 305-310
    • Welch, S.1    Hirte, H.W.2    Carey, M.S.3    Hotte, S.J.4    Tsao, M.-S.5    Brown, S.6    Pond, G.R.7    Dancey, J.E.8    Oza, A.M.9
  • 62
    • 77953770987 scopus 로고    scopus 로고
    • Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair
    • Morgan MA, Parsels LA, Zhao LP, et al: Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res 70: 4972-4981,2010.
    • (2010) Cancer Res , vol.70 , pp. 4972-4981
    • Morgan, M.A.1    Parsels, L.A.2    Zhao, L.P.3
  • 63
    • 77950846641 scopus 로고    scopus 로고
    • Clear cell carcinoma of the ovary: Potential pathogenic mechanisms
    • Review
    • Kajihara H, Yamada Y, Kanayama S, et al: Clear cell carcinoma of the ovary: potential pathogenic mechanisms (Review). Oncol Rep 23: 1193-1203, 2010.
    • (2010) Oncol Rep , vol.23 , pp. 1193-1203
    • Kajihara, H.1    Yamada, Y.2    Kanayama, S.3
  • 64
    • 84856068168 scopus 로고    scopus 로고
    • Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary
    • Yamada Y, Shigetomi H, Onogi A, et al: Redox-active iron-induced oxidative stress in the pathogenesis of clear cell carcinoma of the ovary. Int J Gynecol Cancer 21: 1200-1207, 2011.
    • (2011) Int J Gynecol Cancer , vol.21 , pp. 1200-1207
    • Yamada, Y.1    Shigetomi, H.2    Onogi, A.3
  • 66
    • 77954121574 scopus 로고    scopus 로고
    • A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer
    • Fang F, Balch C, Schilder J, et al: A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer. Cancer 116: 4043-4053, 2010.
    • (2010) Cancer , vol.116 , pp. 4043-4053
    • Fang, F.1    Balch, C.2    Schilder, J.3
  • 67
    • 43049091153 scopus 로고    scopus 로고
    • A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A Gynecologic Oncology Group study
    • Gynecologic Oncology Group
    • Modesitt SC, Sill M, Hoffman JS, Bender DP and Gynecologic Oncology Group: A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 109: 182-186, 2008.
    • (2008) Gynecol Oncol , vol.109 , pp. 182-186
    • Modesitt, S.C.1    Sill, M.2    Hoffman, J.S.3    Bender, D.P.4
  • 68
    • 77955019276 scopus 로고    scopus 로고
    • Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
    • Tutt A, Robson M, Garber JE, et al: Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 376: 235-244, 2010.
    • (2010) Lancet , vol.376 , pp. 235-244
    • Tutt, A.1    Robson, M.2    Garber, J.E.3
  • 69
    • 80051550209 scopus 로고    scopus 로고
    • Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: Cytoplasmic sequestration of CDK2 by p27
    • Itamochi H, Yoshida T, Walker CL, et al: Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: cytoplasmic sequestration of CDK2 by p27. Gynecol Oncol 122: 641-647, 2011.
    • (2011) Gynecol Oncol , vol.122 , pp. 641-647
    • Itamochi, H.1    Yoshida, T.2    Walker, C.L.3
  • 70
    • 84055193485 scopus 로고    scopus 로고
    • Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1
    • Vance S, Liu E, Zhao L, et al: Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1. Cell Cycle 10: 4321-4329, 2011.
    • (2011) Cell Cycle , vol.10 , pp. 4321-4329
    • Vance, S.1    Liu, E.2    Zhao, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.