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Volumn 99, Issue , 2013, Pages 132-139

NF-κB, ERK, p38 MAPK and JNK contribute to the initiation and/or maintenance of mechanical allodynia induced by tumor necrosis factor-alpha in the red nucleus

Author keywords

Mitogen activated protein kinase; Nuclear factor kappa B; Rat; Red nucleus; Tumor necrosis factor alpha

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRROLIDINE DITHIOCARBAMATE; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84887328074     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2013.10.008     Document Type: Article
Times cited : (29)

References (50)
  • 2
    • 78650309320 scopus 로고    scopus 로고
    • The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines
    • Austin P.J., Moalem-Taylor G. The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. J. Neuroimmunol. 2010, 229:26-50.
    • (2010) J. Neuroimmunol. , vol.229 , pp. 26-50
    • Austin, P.J.1    Moalem-Taylor, G.2
  • 3
    • 0036957199 scopus 로고    scopus 로고
    • Descending systems contributing to locomotor recovery after mild or moderate spinal cord injury in rats: experimental evidence and a review of literature
    • Basso D.M., Beattie M.S., Bresnahan J.C. Descending systems contributing to locomotor recovery after mild or moderate spinal cord injury in rats: experimental evidence and a review of literature. Restor. Neurol. Neurosci. 2002, 20:189-218.
    • (2002) Restor. Neurol. Neurosci. , vol.20 , pp. 189-218
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 5
    • 0034677593 scopus 로고    scopus 로고
    • Brain-derived TNFα: involvement in neuroplastic changes implicated in the conscious perception of persistent pain
    • Covey W.C., Ignatowski T.A., Knight P.R., Spengler R.N. Brain-derived TNFα: involvement in neuroplastic changes implicated in the conscious perception of persistent pain. Brain Res. 2000, 859:113-122.
    • (2000) Brain Res. , vol.859 , pp. 113-122
    • Covey, W.C.1    Ignatowski, T.A.2    Knight, P.R.3    Spengler, R.N.4
  • 6
    • 33845533191 scopus 로고    scopus 로고
    • Intra- and extraneuronal changes of immunofluorescence staining for TNF-α and TNFR1 in the dorsal root ganglia of rat peripheral neuropathic pain models
    • Dubový P., Jancálek R., Klusáková I., Svízenská I., Pejchalová K. Intra- and extraneuronal changes of immunofluorescence staining for TNF-α and TNFR1 in the dorsal root ganglia of rat peripheral neuropathic pain models. Cell Mol. Neurobiol. 2006, 26:1205-1217.
    • (2006) Cell Mol. Neurobiol. , vol.26 , pp. 1205-1217
    • Dubový, P.1    Jancálek, R.2    Klusáková, I.3    Svízenská, I.4    Pejchalová, K.5
  • 9
    • 34250766660 scopus 로고    scopus 로고
    • Gene transfer to interfere with TNFα signaling in neuropathic pain
    • Hao S., Mata M., Glorioso J.C., Fink D.J. Gene transfer to interfere with TNFα signaling in neuropathic pain. Gene Ther. 2007, 14:1010-1016.
    • (2007) Gene Ther. , vol.14 , pp. 1010-1016
    • Hao, S.1    Mata, M.2    Glorioso, J.C.3    Fink, D.J.4
  • 10
    • 0027025430 scopus 로고
    • The analgesic effect of red nucleus and preliminary research on its mechanism
    • Huang M., Liu M., Li X. The analgesic effect of red nucleus and preliminary research on its mechanism. Zhen Ci Yan Jiu 1992, 17:166-170.
    • (1992) Zhen Ci Yan Jiu , vol.17 , pp. 166-170
    • Huang, M.1    Liu, M.2    Li, X.3
  • 12
    • 77649121128 scopus 로고    scopus 로고
    • Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve
    • Jancálek R., Dubový P., Svízenská I., Klusáková I. Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve. J. Neuroinflamm. 2010, 7:11.
    • (2010) J. Neuroinflamm. , vol.7 , pp. 11
    • Jancálek, R.1    Dubový, P.2    Svízenská, I.3    Klusáková, I.4
  • 13
    • 0037705314 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    • Jin S.X., Zhuang Z.Y., Woolf C.J., Ji R.R. p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain. J. Neurosci. 2003, 23:4017-4022.
    • (2003) J. Neurosci. , vol.23 , pp. 4017-4022
    • Jin, S.X.1    Zhuang, Z.Y.2    Woolf, C.J.3    Ji, R.R.4
  • 14
    • 30644463076 scopus 로고    scopus 로고
    • Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-α
    • Jin X., Gereau R.W. Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-α. J. Neurosci. 2006, 26:246-255.
    • (2006) J. Neurosci. , vol.26 , pp. 246-255
    • Jin, X.1    Gereau, R.W.2
  • 15
    • 68349129916 scopus 로고    scopus 로고
    • Nerve growth factor of red nucleus involvement in pain induced by spared nerve injury of the rat sciatic nerve
    • Jing Y.Y., Wang J.Y., Li X.L., Wang Z.H., Pei L., Pan M.M., Dong X.P., Fan G.X., Yuan Y.K. Nerve growth factor of red nucleus involvement in pain induced by spared nerve injury of the rat sciatic nerve. Neurochem. Res. 2009, 34:1612-1618.
    • (2009) Neurochem. Res. , vol.34 , pp. 1612-1618
    • Jing, Y.Y.1    Wang, J.Y.2    Li, X.L.3    Wang, Z.H.4    Pei, L.5    Pan, M.M.6    Dong, X.P.7    Fan, G.X.8    Yuan, Y.K.9
  • 16
    • 0037043149 scopus 로고    scopus 로고
    • Red nucleus projections to distinct motor neuron pools in the rat spinal cord
    • Küchler M., Fouad K., Weinmann O., Schwab M.E., Raineteau O. Red nucleus projections to distinct motor neuron pools in the rat spinal cord. J. Comp. Neurol. 2002, 448:349-359.
    • (2002) J. Comp. Neurol. , vol.448 , pp. 349-359
    • Küchler, M.1    Fouad, K.2    Weinmann, O.3    Schwab, M.E.4    Raineteau, O.5
  • 17
    • 0036800264 scopus 로고    scopus 로고
    • Discharge characteristics of neurons in the red nucleus during voluntary gait modifications: a comparison with the motor cortex
    • Lavoie S., Drew T. Discharge characteristics of neurons in the red nucleus during voluntary gait modifications: a comparison with the motor cortex. J. Neurophysiol. 2002, 88:1791-1814.
    • (2002) J. Neurophysiol. , vol.88 , pp. 1791-1814
    • Lavoie, S.1    Drew, T.2
  • 18
    • 27644498849 scopus 로고    scopus 로고
    • Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation
    • Ledeboer A., Gamanos M., Lai W., Martin D., Maier S.F., Watkins L.R., Quan N. Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation. Eur. J. Neurosci. 2005, 22:1977-1986.
    • (2005) Eur. J. Neurosci. , vol.22 , pp. 1977-1986
    • Ledeboer, A.1    Gamanos, M.2    Lai, W.3    Martin, D.4    Maier, S.F.5    Watkins, L.R.6    Quan, N.7
  • 19
    • 11244254104 scopus 로고    scopus 로고
    • Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model
    • Lee H.L., Lee K.M., Son S.J., Hwang S.H., Cho H.J. Temporal expression of cytokines and their receptors mRNAs in a neuropathic pain model. Neuroreport 2004, 15:2807-2811.
    • (2004) Neuroreport , vol.15 , pp. 2807-2811
    • Lee, H.L.1    Lee, K.M.2    Son, S.J.3    Hwang, S.H.4    Cho, H.J.5
  • 20
    • 77950801122 scopus 로고    scopus 로고
    • TNF-α and neuropathic pain - a review
    • Leung L., Cahill C.M. TNF-α and neuropathic pain - a review. J. Neuroinflamm. 2010, 7:27.
    • (2010) J. Neuroinflamm. , vol.7 , pp. 27
    • Leung, L.1    Cahill, C.M.2
  • 21
    • 54549120585 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha of red nucleus involved in the development of neuropathic allodynia
    • Li X., Wang J., Wang Z., Dong C., Dong X., Jing Y., Yuan Y., Fan G. Tumor necrosis factor-alpha of red nucleus involved in the development of neuropathic allodynia. Brain Res. Bull. 2008, 77:233-236.
    • (2008) Brain Res. Bull. , vol.77 , pp. 233-236
    • Li, X.1    Wang, J.2    Wang, Z.3    Dong, C.4    Dong, X.5    Jing, Y.6    Yuan, Y.7    Fan, G.8
  • 22
    • 0026043297 scopus 로고
    • The analgesia effect of red nucleus and strengthening effect thereof to the acupuncture analgesia
    • Liu M., Liu X., Liu B. The analgesia effect of red nucleus and strengthening effect thereof to the acupuncture analgesia. Zhen Ci Yan Jiu 1991, 16:48-53.
    • (1991) Zhen Ci Yan Jiu , vol.16 , pp. 48-53
    • Liu, M.1    Liu, X.2    Liu, B.3
  • 23
    • 33846874140 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK
    • Liu Y.L., Zhou L.J., Hu N.W., Xu J.T., Wu C.Y., Zhang T., Li Y.Y., Liu X.G. Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK. Neuropharmacology 2007, 52:708-715.
    • (2007) Neuropharmacology , vol.52 , pp. 708-715
    • Liu, Y.L.1    Zhou, L.J.2    Hu, N.W.3    Xu, J.T.4    Wu, C.Y.5    Zhang, T.6    Li, Y.Y.7    Liu, X.G.8
  • 25
    • 0034124252 scopus 로고    scopus 로고
    • Red nucleus lesions impair overground locomotion in rats: a kinetic analysis
    • Muir G.D., Whishaw I.Q. Red nucleus lesions impair overground locomotion in rats: a kinetic analysis. Eur. J. Neurosci. 2000, 12:1113-1122.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 1113-1122
    • Muir, G.D.1    Whishaw, I.Q.2
  • 26
    • 80052342708 scopus 로고    scopus 로고
    • Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain
    • Nadeau S., Filali M., Zhang J., Kerr B.J., Rivest S., Soulet D., Iwakura Y., de Rivero Vaccari J.P., Keane R.W., Lacroix S. Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain. J. Neurosci. 2011, 31:12533-12542.
    • (2011) J. Neurosci. , vol.31 , pp. 12533-12542
    • Nadeau, S.1    Filali, M.2    Zhang, J.3    Kerr, B.J.4    Rivest, S.5    Soulet, D.6    Iwakura, Y.7    de Rivero Vaccari, J.P.8    Keane, R.W.9    Lacroix, S.10
  • 28
    • 41949096276 scopus 로고    scopus 로고
    • Transient early expression of TNF-α in sciatic nerve and dorsal root ganglia in a mouse model of painful peripheral neuropathy
    • Sacerdote P., Franchi S., Trovato A.E., Valsecchi A.E., Panerai A.E., Colleoni M. Transient early expression of TNF-α in sciatic nerve and dorsal root ganglia in a mouse model of painful peripheral neuropathy. Neurosci. Lett. 2008, 436:210-213.
    • (2008) Neurosci. Lett. , vol.436 , pp. 210-213
    • Sacerdote, P.1    Franchi, S.2    Trovato, A.E.3    Valsecchi, A.E.4    Panerai, A.E.5    Colleoni, M.6
  • 29
    • 34547666626 scopus 로고    scopus 로고
    • Changes in cortically induced rhythmic jaw movements after lesioning of the red nucleus in rats
    • Satoh Y., Ishizuka K., Murakami T. Changes in cortically induced rhythmic jaw movements after lesioning of the red nucleus in rats. Brain Res. 2007, 1165:60-70.
    • (2007) Brain Res. , vol.1165 , pp. 60-70
    • Satoh, Y.1    Ishizuka, K.2    Murakami, T.3
  • 30
    • 0345701254 scopus 로고    scopus 로고
    • Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    • Schäfers M., Svensson C.I., Sommer C., Sorkin L.S. Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J. Neurosci. 2003, 23:2517-2521.
    • (2003) J. Neurosci. , vol.23 , pp. 2517-2521
    • Schäfers, M.1    Svensson, C.I.2    Sommer, C.3    Sorkin, L.S.4
  • 31
    • 0035860577 scopus 로고    scopus 로고
    • Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy
    • Sommer C., Lindenlaub T., Teuteberg P., Schäfers M., Hartung T., Toyka K.V. Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy. Brain Res. 2001, 913:86-89.
    • (2001) Brain Res. , vol.913 , pp. 86-89
    • Sommer, C.1    Lindenlaub, T.2    Teuteberg, P.3    Schäfers, M.4    Hartung, T.5    Toyka, K.V.6
  • 33
    • 0034105825 scopus 로고    scopus 로고
    • Effects of noxious skin heating on spontaneous cell activity in the magnocellular red nucleus of the cat
    • Steffens H., Rathelot J.A., Padel Y. Effects of noxious skin heating on spontaneous cell activity in the magnocellular red nucleus of the cat. Exp. Brain Res. 2000, 131:215-224.
    • (2000) Exp. Brain Res. , vol.131 , pp. 215-224
    • Steffens, H.1    Rathelot, J.A.2    Padel, Y.3
  • 34
    • 17444408199 scopus 로고    scopus 로고
    • Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38
    • Svensson C.I., Schäfers M., Jones T.L., Powell H., Sorkin L.S. Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38. Neurosci. Lett. 2005, 379:209-213.
    • (2005) Neurosci. Lett. , vol.379 , pp. 209-213
    • Svensson, C.I.1    Schäfers, M.2    Jones, T.L.3    Powell, H.4    Sorkin, L.S.5
  • 35
    • 0035857748 scopus 로고    scopus 로고
    • Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain
    • Sweitzer S., Martin D., DeLeo J.A. Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain. Neuroscience 2001, 103:529-539.
    • (2001) Neuroscience , vol.103 , pp. 529-539
    • Sweitzer, S.1    Martin, D.2    DeLeo, J.A.3
  • 36
    • 33645519792 scopus 로고    scopus 로고
    • TNF-alpha and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica
    • Takahashi N., Kikuchi S., Shubayev V.I., Campana W.M., Myers R.R. TNF-alpha and phosphorylation of ERK in DRG and spinal cord: insights into mechanisms of sciatica. Spine 2006, 31:523-529.
    • (2006) Spine , vol.31 , pp. 523-529
    • Takahashi, N.1    Kikuchi, S.2    Shubayev, V.I.3    Campana, W.M.4    Myers, R.R.5
  • 37
    • 45849111819 scopus 로고    scopus 로고
    • Interleukin-1 beta of red nucleus involved in the development of allodynia in spared nerve injury rats
    • Wang Z., Wang J., Li X., Yuan Y., Fan G. Interleukin-1 beta of red nucleus involved in the development of allodynia in spared nerve injury rats. Exp. Brain Res. 2008, 188:379-384.
    • (2008) Exp. Brain Res. , vol.188 , pp. 379-384
    • Wang, Z.1    Wang, J.2    Li, X.3    Yuan, Y.4    Fan, G.5
  • 38
    • 84864334756 scopus 로고    scopus 로고
    • Interleukin-10 of red nucleus plays anti-allodynia effect in neuropathic pain rats with spared nerve injury
    • Wang Z.H., Zeng X.Y., Han S.P., Fan G.X., Wang J.Y. Interleukin-10 of red nucleus plays anti-allodynia effect in neuropathic pain rats with spared nerve injury. Neurochem. Res. 2012, 37:1811-1819.
    • (2012) Neurochem. Res. , vol.37 , pp. 1811-1819
    • Wang, Z.H.1    Zeng, X.Y.2    Han, S.P.3    Fan, G.X.4    Wang, J.Y.5
  • 39
    • 54849416454 scopus 로고    scopus 로고
    • Supraspinal glial-neuronal interactions contribute to descending pain facilitation
    • Wei F., Guo W., Zou S., Ren K., Dubner R. Supraspinal glial-neuronal interactions contribute to descending pain facilitation. J. Neurosci. 2008, 28:10482-10495.
    • (2008) J. Neurosci. , vol.28 , pp. 10482-10495
    • Wei, F.1    Guo, W.2    Zou, S.3    Ren, K.4    Dubner, R.5
  • 40
    • 34248572468 scopus 로고    scopus 로고
    • Peri-sciatic administration of recombinant rat TNF-α induces mechanical allodynia via upregulation of TNF-α in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway
    • Wei X.H., Zang Y., Wu C.Y., Xu J.T., Xin W.J., Liu X.G. Peri-sciatic administration of recombinant rat TNF-α induces mechanical allodynia via upregulation of TNF-α in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway. Exp. Neurol. 2007, 205:471-484.
    • (2007) Exp. Neurol. , vol.205 , pp. 471-484
    • Wei, X.H.1    Zang, Y.2    Wu, C.Y.3    Xu, J.T.4    Xin, W.J.5    Liu, X.G.6
  • 41
    • 33847325194 scopus 로고    scopus 로고
    • P38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury
    • Xu J.T., Xin W.J., Wei X.H., Wu C.Y., Ge Y.X., Liu Y.L., Zang Y., Zhang T., Li Y.Y., Liu X.G. p38 activation in uninjured primary afferent neurons and in spinal microglia contributes to the development of neuropathic pain induced by selective motor fiber injury. Exp. Neurol. 2007, 204:355-365.
    • (2007) Exp. Neurol. , vol.204 , pp. 355-365
    • Xu, J.T.1    Xin, W.J.2    Wei, X.H.3    Wu, C.Y.4    Ge, Y.X.5    Liu, Y.L.6    Zang, Y.7    Zhang, T.8    Li, Y.Y.9    Liu, X.G.10
  • 43
    • 57049154549 scopus 로고    scopus 로고
    • Exogenous tumor necrosis factor-α rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn
    • Youn D.H., Wang H., Jeong S.J. Exogenous tumor necrosis factor-α rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn. J. Neurosci. Res. 2008, 86:2867-2875.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 2867-2875
    • Youn, D.H.1    Wang, H.2    Jeong, S.J.3
  • 44
    • 78149466023 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro
    • Zang Y., He X.H., Xin W.J., Pang R.P., Wei X.H., Zhou L.J., Li Y.Y., Liu X.G. Inhibition of NF-kappaB prevents mechanical allodynia induced by spinal ventral root transection and suppresses the re-expression of Nav1.3 in DRG neurons in vivo and in vitro. Brain Res. 2010, 1363:151-158.
    • (2010) Brain Res. , vol.1363 , pp. 151-158
    • Zang, Y.1    He, X.H.2    Xin, W.J.3    Pang, R.P.4    Wei, X.H.5    Zhou, L.J.6    Li, Y.Y.7    Liu, X.G.8
  • 45
    • 79960287548 scopus 로고    scopus 로고
    • Upregulation of Nav1.3 channel induced by rrTNF in cultured adult rat DRG neurons via p38 MAPK and JNK pathways
    • Zang Y., Xin W.J., Pang R.P., Li Y.Y., Liu X.G. Upregulation of Nav1.3 channel induced by rrTNF in cultured adult rat DRG neurons via p38 MAPK and JNK pathways. Chin. J. Physiol. 2011, 54:241-246.
    • (2011) Chin. J. Physiol. , vol.54 , pp. 241-246
    • Zang, Y.1    Xin, W.J.2    Pang, R.P.3    Li, Y.Y.4    Liu, X.G.5
  • 47
    • 21844437380 scopus 로고    scopus 로고
    • Intraneural injection of interleukin-1β and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain
    • Zelenka M., Schäfers M., Sommer C. Intraneural injection of interleukin-1β and tumor necrosis factor-alpha into rat sciatic nerve at physiological doses induces signs of neuropathic pain. Pain 2005, 116:257-263.
    • (2005) Pain , vol.116 , pp. 257-263
    • Zelenka, M.1    Schäfers, M.2    Sommer, C.3
  • 48
    • 14044252008 scopus 로고    scopus 로고
    • ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    • Zhuang Z.Y., Gerner P., Woolf C.J., Ji R.R. ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 2005, 114:149-159.
    • (2005) Pain , vol.114 , pp. 149-159
    • Zhuang, Z.Y.1    Gerner, P.2    Woolf, C.J.3    Ji, R.R.4
  • 49
    • 33645460235 scopus 로고    scopus 로고
    • A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    • Zhuang Z.Y., Wen Y.R., Zhang D.R., Borsello T., Bonny C., Strichartz G.R., Decosterd I., Ji R.R. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. J. Neurosci. 2006, 26:551-560.
    • (2006) J. Neurosci. , vol.26 , pp. 551-560
    • Zhuang, Z.Y.1    Wen, Y.R.2    Zhang, D.R.3    Borsello, T.4    Bonny, C.5    Strichartz, G.R.6    Decosterd, I.7    Ji, R.R.8
  • 50
    • 0020525719 scopus 로고
    • Ethical guideline for investigations of experimental pain in conscious animals
    • Zimmermann M. Ethical guideline for investigations of experimental pain in conscious animals. Pain 1983, 16:109-110.
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


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