The molecular mechanisms of zinc neurotoxicity and the pathogenesis of vascular type senile dementia

International Journal of Molecular Sciences

Volumn 14, Issue 11, 2013, Pages 22067-22081

  Mizuno, Dai ^a   Kawahara, Masahiro ^a  

^a MUSASHINO UNIVERSITY   (Japan)

Author keywords

Carnosine; Histidine; Vascular type dementia; Zinc

Indexed keywords

CALCIUM ION; CARNOSINE; DNA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; ZINC ION; ZINC TRANSPORTER; ZINC TRANSPORTER 1;

ALZHEIMER DISEASE; ARC GENE; ARTICLE; BRAIN ISCHEMIA; CALCIUM HOMEOSTASIS; DEGENERATIVE DISEASE; DNA MICROARRAY; ENDOPLASMIC RETICULUM STRESS; GADD34 GENE; GADD45 GENE; GENE; GENE EXPRESSION REGULATION; HUMAN; IN VITRO STUDY; MULTIINFARCT DEMENTIA; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; P8 GENE; PRION DISEASE; SENILE DEMENTIA;

ALZHEIMER DISEASE; CARNOSINE; DEMENTIA, VASCULAR; HISTIDINE; HUMANS; NEURONS; NEUROTOXICITY SYNDROMES; ZINC;

EID: 84887327906     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141122067     Document Type: Article

References (54)

1. Lee, J.M.; Grabb, M.C.; Zipfel, G.J.; Choi, D.W. Brain tissue responses to ischemia. J. Clin. Invest. 2000, 106, 723-731.
2. De Haan, E.H.; Nys, G.M.; van Zandvoort, M.J. Cognitive function following stroke and vascular cognitive impairment. Curr. Opin. Neurol. 2006, 19, 559-564.
3. 2+: A novel ionic mediator of neural injury in brain disease. Trends Pharmacol. Sci. 2000, 21, 395-401.
4. Kawahara, M.; Kato-Negishi, M.; Kuroda, Y. Pyruvate blocks zinc-induced neurotoxicity in immortalized hypothalamic neurons. Cell Mol. Neurobiol. 2002, 22, 87-93.
5. Koyama, H.; Konoha, K.; Sadakane, Y.; Ohkawara, S.; Kawahara, M. Zinc neurotoxicity and the pathogenesis of vascular-type dementia: Involvement of calcium dyshomeostasis and carnosine. J. Clin. Toxicol. 2011, S3, doi:10.4172/2161-0495.S3-002.
6. Mellon, P.L.; Windle, J.J.; Goldsmith, P.C.; Padula, C.A.; Roberts, J.L.; Weiner, R.I. Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 1990, 5, 1-10.
7. Mahesh, V.B.; Zamorano, P.; De Sevilla, L.; Lewis, D.; Brann, D.W. Characterization of ionotropic glutamate receptors in rat hypothalamus, pituitary and immortalized gonadotropin-releasing hormone (GnRH) neurons (GT1-7 cells). Neuroendocrinology 1999, 69, 397-407.
8. Sadakane, Y.; Konoha, K.; Kawahara, M. Protective activity of mango (Mangifera indica L.) fruit against a zinc-induced neuronal cell death is independent of its antioxidant activity. Trace Nutr. Res. 2005, 22, 73-79.
9. Konoha, K.; Sadakane, Y.; Kawahara, M. Carnosine protects GT1-7 cells against zinc-induced neurotoxicity: A possible candidate for treatment for vascular type of dementia. Trace Nutr. Res. 2006, 23, 56-62.
10. Sadakane, Y.; Konoha, K.; Nagata, T.; Kawahara, M. Protective activity of the extracts from Japanese eel (Anguilla japonica) against zinc-induced neuronal cell death: Carnosine and an unknown substance. Trace Nutr. Res. 2007, 24, 98-105.
11. Sadakane, Y.; Konoha, K.; Nagata, T.; Kawahara, M. Improvement of screening for protective substances against zinc-induced neuronal cell death. Trace Nutr. Res. 2008, 25, 41-45.
12. Kawahara, M.; Konoha, K.; Nagata, T.; Sadakane, Y. Protective substances against zinc-induced neuronal death after ischemia: Carnosine a target for drug of vascular type of dementia. Recent Pat. CNS Drug Discov. 2007, 2, 145-149.
13. Corona, C.; Frazzini, V.; Silvestri, E.; Lattanzio, R.; La Sorda, R.; Piantelli, M.; Canzoniero, L.M.; Ciavardelli, D.; Rizzarelli, E.; Sensi, S.L. Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice. PLoS One 2011, 6, e17971.
14. Kawahara, M.; Koyama, H.; Nagata, T.; Sadakane, Y. Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126. Metallomics 2011, 3, 726-734.
15. Hipkiss, A.R. Carnosine and its possible roles in nutrition and health. Adv. Food Nutr. Res. 2009, 57, 87-154.
16. Hambidge, M. Human zinc deficiency. J. Nutr. 2000, 130, 1344S-1349S.
17. Hirano, T.; Murakami, M.; Fukada, T.; Nishida, K.; Yamasaki, S.; Suzuki, T. Roles of zinc and zinc signaling in immunity: Zinc as an intracellular signaling molecule. Adv. Immunol. 2008, 97, 149-176.
18. Prasad, A.S. Impact of the discovery of human zinc deficiency on health. J. Am. Coll. Nutr. 2009, 28, 257-265.
19. Frederickson, C.J.; Suh, S.W.; Silva, D.; Frederickson, C.J.; Thompson, R.B. Importance of zinc in the central nervous system: The zinc-containing neuron. J. Nutr. 2000, 130, 1471S-1483S.
20. Tamano, H.; Takeda, A. Dynamic action of neurometals at the synapse. Metallomics 2011, 3, 656-661.
21. Koh, J.Y.; Suh, S.W.; Gwag, B.J.; He, Y.Y.; Hsu, C.Y.; Choi, D.W. The role of zinc in selective neuronal death after transient global cerebral ischemia. Science 1996, 272, 1013-1016.
22. Calderone, A.; Jover, T.; Mashiko, T.; Noh, K.M.; Tanaka, H.; Bennett, M.V.; Zukin, R.S. Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death. J. Neurosci. 2004, 24, 9903-9913.
23. Sensi, S.L.; Canzoniero, L.M.; Yu, S.P.; Ying, H.S.; Koh, J.Y.; Kerchner, G.A.; Choi, D.W. Measurement of intracellular free zinc in living cortical neurons: Routes of entry. J. Neurosci. 1997, 17, 9554-9564.
24. 2+-permeable AMPA receptors in neurological disorders. Trends Neurosci. 1997, 20, 464-470.
25. Plum, L.M.; Rink, L.; Haase, H. The essential toxin: Impact of zinc on human health. Int. J. Environ. Res. Public Health 2010, 7, 1342-1365.
26. Weiss, J.H.; Hartley, D.M.; Koh, J.Y.; Choi, D.W. AMPA receptor activation potentiates zinc neurotoxicity. Neuron 1993, 10, 43-49.
27. Zhu, L.; Tang, Y.; Wang, H.D.; Zhang, Z.Y.; Pan, H. Immersion autometallographic demonstration of pathological zinc accumulation in human acute neural diseases. Neurol. Sci. 2012, 33, 855-861.
28. Adlard, P.A.; Bush, A.I. Metals and Alzheimer's disease. J. Alzheimers. Dis. 2006, 10, 145-163.
29. 2+-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons. Biophys. J. 1997, 73, 67-75.
30. Lin, H.; Bhatia, R.; Lal, R. Amyloid beta protein forms ion channels: Implications for Alzheimer's disease pathophysiology. FASEB J. 2001, 15, 2433-2444.
31. Leach, S.P.; Salman, M.D.; Hamar, D. Trace elements and prion diseases: A review of the interactions of copper, manganese and zinc with the prion protein. Anim. Health Res. Rev. 2006, 7, 97-105.
32. Valentine, J.S.; Hart, P.J. Misfolded CuZnSOD and amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 2003, 100, 3617-3622.
33. Brewer, G.J. Recognition, diagnosis, and management of Wilson's disease. Proc. Soc. Exp. Biol. Med. 2000, 223, 39-46.
34. Koh, J.Y.; Choi, D.W. Zinc toxicity of cultured cortical neurons: Involvement of N-methyl-D-asparatate receptors. Neuroscience 1994, 4, 1049-1057.
35. 2+ toxicity and modulation by ZnT-1 in PC12 cells. Brain Res. 2000, 886, 99-107.
36. Lee, J.Y.; Kim, Y.H.; Koh, J.Y. Protection by pyruvate against transient forebrain ischemia in rats. J. Neurosci. 2001, 21, RC171.
37. Sheline, C.T.; Behrens, M.M.; Choi, D.W. Zinc-induced cortical neuronal death: Contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis. J. Neurosci. 2000, 20, 3139-3146.
38. 2+ pools. Proc. Natl. Acad. Sci. USA 2003, 100, 6157-6162.
39. Kawahara, M.; Kato-Negishi, M.; Hosoda, R.; Kuroda, Y. Characterization of zinc-induced apoptosis of GT1-7 cells. Biomed. Res. Trace Elements 2002, 13, 280-281.
40. Konoha, K.; Sadakane, Y.; Kawahara, M. Effects of gadolinium and other metal on the neurotoxicity of immortalized hypothalamic neurons induced by zinc. Biomed. Res. Trace Elements 2004, 15, 275-277.
41. 2+ channel and the carboxyl acid group. Neurobiol. Dis. 2001, 8, 774-783.
42. Kawahara, M.; Sadakane, Y.; Koyama, H.; Konoha, K.; Ohkawara, S. D-Histidine and L-histidine attenuate zinc-induced neuronal death in GT1-7 cells. Metallomics 2013, 5, 453-460.
43. Brown, M.K.; Naidoo, N. The endoplasmic reticulum stress response in aging and age-related diseases. Front. Physiol. 2012, 3, 263.
44. Ferreiro, E.; Baldeiras, I.; Ferreira, I.L.; Costa, R.O.; Rego, A.C.; Pereira, C.F.; Oliveira, C.R. Mitochondrial-and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: From pathogenesis to biomarkers. Int. J. Cell Biol. 2012, 2012, doi:10.1155/2012/735206.
45. Roussel, B.D.; Kruppa, A.J.; Miranda, E.; Crowther, D.C.; Lomas, D.A.; Marciniak, S.J. Endoplasmic reticulum dysfunction in neurological disease. Lancet Neurol. 2013, 12, 105-118.
46. Moskalev, A.A.; Smit-McBride, Z.; Shaposhnikov, M.V.; Plyusnina, E.N.; Zhavoronkov, A.; Budovsky, A.; Tacutu, R.; Fraifeld, V.E. Gadd45 proteins: Relevance to aging, longevity and age-related pathologies. Ageing Res. Rev. 2012, 11, 51-66.
47. Van Prooyen, N.; Andresen, V.; Gold, H.; Bialuk, I.; Pise-Masison, C.; Franchini, G. Hijacking the T-cell communication network by the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) p12 and p8 proteins. Mol. Aspects Med. 2010, 31, 333-343.
48. Goruppi, S.; Iovanna, J.L. Stress-inducible protein p8 is involved in several physiological and pathological processes. J. Biol. Chem. 2010, 285, 1577-1581.
49. Onoue, S.; Kumon, Y.; Igase, K.; Ohnishi, T.; Sakanaka, M. Growth arrest and DNA damage-inducible gene 153 increases transiently in the thalamus following focal cerebral infarction. Brain Res. Mol. Brain Res. 2005, 134, 189-197.
50. Kunizuka, H.; Kinouchi, H.; Arai, S.; Izaki, K.; Mikawa, S.; Kamii, H.; Sugawara, T.; Suzuki, A.; Mizoi, K.; Yoshimoto, T. Activation of Arc gene, a dendritic immediate early gene, by middle cerebral artery occlusion in rat brain. Neuroreport 1999, 10, 1717-1722.
51. Rickhag, M.; Teilum, M.; Wieloch, T. Rapid and long-term induction of effector immediate early genes (BDNF, Neuritin and Arc) in peri-infarct cortex and dentate gyrus after ischemic injury in rat brain. Brain Res. 2007, 1151, 203-210.
52. Bonfanti, L.; Peretto, P.; De Marchis, S.; Fasolo, A. Carnosine-related dipeptides in the mammalian brain. Prog. Neurobiol. 1999, 59, 333-353.
53. De Marchis, S.; Modena, C.; Peretto, P.; Giffard, C.; Fasolo, A. Carnosine-like immunoreactivity in the central nervous system of rats during postnatal development. J. Comp. Neurol. 2000, 426, 378-390.
54. Stuerenburg, H.J. The roles of carnosine in aging of skeletal muscle and in neuromuscular disease. Biochemistry (Mosc) 2000, 65, 862-865.