A Novel Hap1-Tsc1 interaction regulates neuronal mTORC1 signaling and morphogenesis in the brain

Journal of Neuroscience

Volumn 33, Issue 46, 2013, Pages 18015-18021

  Mejia, Luis A ^a   Litterman, Nadia ^a   Ikeuchi, Yoshiho ^a,b   De La Torre, Luis Ubieta ^a   Bennett, Eric J ^a   Zhang, Chi ^a   Wade Harpe, J ^a   Bonni, Azad ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUNTINGTIN ASSOCIATED PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; NERVE PROTEIN; PROTEIN S6; TUBEROUS SCLEROSIS COMPLEX 1; TUBEROUS SCLEROSIS COMPLEX 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DOWN REGULATION; ELECTROPORATION; EMBRYO; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MASS SPECTROMETRY; MOUSE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; CELLS, CULTURED; FEMALE; HEK293 CELLS; HUMANS; MALE; MICE; MORPHOGENESIS; MULTIPROTEIN COMPLEXES; NERVE TISSUE PROTEINS; NEURONS; PROTEIN BINDING; RATS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 84887324926     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2290-13.2013     Document Type: Article

References (28)

1. Barnes AP, Polleux F (2009) Establishment of axon-dendrite polarity in developing neurons. Annu Rev Neurosci 32:347-381. CrossRef Medline
2. Bateup HS, Johnson CA, Denefrio CL, Saulnier JL, Kornacker K, Sabatini BL (2013) Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis. Neuron 78:510-522. CrossRef Medline
3. Choi YJ, Di Nardo A, Kramvis I, Meikle L, Kwiatkowski DJ, Sahin M, He X (2008) Tuberous sclerosis complex proteins control axon formation. Genes Dev 22:2485-2495. CrossRef Medline
4. de la Torre-Ubieta L, Bonni A (2011) Transcriptional regulation of neuronal polarity and morphogenesis in the mammalian brain. Neuron 72:22-40. CrossRef Medline
5. de la Torre-Ubieta L, Gaudillière B, Yang Y, Ikeuchi Y, Yamada T, DiBacco S, Stegmüller J, Schüller U, Salih DA, Rowitch D, Brunet A, Bonni A (2010) A FOXO-Pak1 transcriptional pathway controls neuronal polarity. Genes Dev 24:799-813. CrossRef Medline
6. Dibble CC, Elis W, Menon S, Qin W, Klekota J, Asara JM, Finan PM, Kwiatkowski DJ, Murphy LO, Manning BD (2012) TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Mol Cell 47:535-546. CrossRef Medline
7. Dragatsis I, Dietrich P, Zeitlin S (2000) Expression of the Huntingtinassociated protein 1 gene in the developing and adult mouse. Neurosci Lett 282:37-40. CrossRef Medline
8. Feliciano DM, Su T, Lopez J, Platel JC, Bordey A (2011) Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice. J Clin Invest 121:1596-1607. CrossRef Medline
9. Gaudilliere B, Shi Y, Bonni A (2002) RNA interference reveals a requirement for myocyte enhancer factor 2A in activity-dependent neuronal survival. J Biol Chem 277:46442-46446. CrossRef Medline
10. Goto J, Talos DM, Klein P, Qin W, Chekaluk YI, Anderl S, Malinowska IA, Di Nardo A, Bronson RT, Chan JA, Vinters HV, Kernie SG, Jensen FE, Sahin M, Kwiatkowski DJ (2011) Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex. Proc Natl Acad Sci U S A 108:E1070-E1079. CrossRef Medline
11. Guo L, Ying W, Zhang J, Yuan Y, Qian X, Wang J, Yang X, He F (2010) Tandem affinity purification and identification of the human TSC1 protein complex. Acta Biochim Biophys Sin (Shanghai) 42:266-273. CrossRef Medline
12. Han JM, Sahin M (2011) TSC1/TSC2 signaling in the CNS. FEBS Lett 585: 973-980. CrossRef Medline
13. Hodges AK, Li S, Maynard J, Parry L, Braverman R, Cheadle JP, DeClue JE, Sampson JR (2001) Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin. HumMol Genet 10:2899-2905. CrossRef Medline
14. Li XJ, Li SH, Sharp AH, Nucifora FC Jr, Schilling G, Lanahan A, Worley P, Snyder SH, Ross CA (1995) A huntingtin-associated protein enriched in brain with implications for pathology. Nature 378:398-402. CrossRef Medline
15. Li YH, Werner H, Püschel AW (2008) Rheb and mTOR regulate neuronal polarity through Rap1B. J Biol Chem 283:33784-33792. CrossRef Medline
16. Lim ET, Raychaudhuri S, Sanders SJ, Stevens C, Sabo A, MacArthur DG, Neale BM, Kirby A, Ruderfer DM, Fromer M, Lek M, Liu L, Flannick J, Ripke S, Nagaswamy U, Muzny D, Reid JG, Hawes A, Newsham I, Wu Y, et al. (2013) Rare complete knockouts in humans: population distribution and significant role in autism spectrum disorders. Neuron 77:235-242. CrossRef Medline
17. Litterman N, Ikeuchi Y, Gallardo G, O'Connell BC, Sowa ME, Gygi SP, Harper JW, Bonni A (2011) An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. PLoS Biol 9:e1001060. CrossRef Medline
18. Ma XM, Blenis J (2009) Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10:307-318. CrossRef Medline
19. Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC (2002) Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10:151-162. CrossRef Medline
20. Nakashima A, Yoshino K, Miyamoto T, Eguchi S, Oshiro N, Kikkawa U, Yonezawa K (2007) Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex. Biochem Biophys Res Commun 361:218-223. CrossRef Medline
21. Navarro-Quiroga I, Chittajallu R, Gallo V, Haydar TF (2007) Long-term, selective gene expression in developing and adult hippocampal pyramidal neurons using focal in utero electroporation. J Neurosci 27:5007-5011. CrossRef Medline
22. Nellist M, van Slegtenhorst MA, Goedbloed M, van den Ouweland AM, Halley DJ, van der Sluijs P (1999) Characterization of the cytosolic tuberinhamartin complex: tuberin is a cytosolic chaperone for hamartin. J Biol Chem 274:35647-35652. CrossRef Medline
23. Orlova KA, Crino PB (2010) The tuberous sclerosis complex. AnnN Y Acad Sci 1184:87-105. CrossRef Medline
24. Rong J, Li SH, Li XJ (2007) Regulation of intracellular HAP1 trafficking. J Neurosci Res 85:3025-3029. CrossRef Medline
25. Sakai Y, Shaw CA, Dawson BC, Dugas DV, Al-Mohtaseb Z, Hill DE, Zoghbi HY (2011) Protein interactome reveals converging molecular pathways among autism disorders. Sci Transl Med 3:86ra49. CrossRef Medline
26. Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E (2013) Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature 493:411-415. CrossRef Medline
27. Sheng G, Xu X, Lin YF, Wang CE, Rong J, Cheng D, Peng J, Jiang X, Li SH, Li XJ (2008) Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. J Clin Invest 118: 2785-2795. CrossRef Medline
28. Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009) Defining the human deubiquitinating enzyme interaction landscape. Cell 138:389-403. CrossRef Medline