Apelin-13 induces proliferation, migration, and collagen I mRNA expression in human RPE cells via PI3K/Akt and MEK/Erk signaling pathways

Molecular Vision

Volumn 19, Issue , 2013, Pages 2227-2236

  Qin, Dong ^a,b   Zheng, Xiao Xue ^a   Jiang, Yan Rong ^a,b  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APELIN; COLLAGEN TYPE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECOMBINANT APELIN 13; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION; HUMAN; HUMAN CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

CELL MOVEMENT; CELL PROLIFERATION; COLLAGEN TYPE I; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PIGMENT EPITHELIUM OF EYE; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER;

EID: 84887303841     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Gardner TW, Antonetti DA, Barber AJ, LaNoue KF, Nakamura M. New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets. Diabetes Technol Ther 2000; 2:601-8. [PMID: 11469624].
2. Bharti K, Nguyen MT, Skuntz S, Bertuzzi S, Arnheiter H. The other pigment cell: specification and development of the pigmented epithelium of the vertebrate eye. Pigment Cell Res 2006; 19:380-94. [PMID: 16965267].
3. Nowak JZ. Age-related macular degeneration (AMD): pathogenesis and therapy. Pharmacol Rep 2006; 58:353-63. [PMID: 16845209].
4. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev 2005; 85:845-81. [PMID: 15987797].
5. Abe T, Durlu YK, Tamai M. The properties of retinal pigment epithelial cells in proliferative vitreoretinopathy compared with cultured retinal pigment epithelial cells. Exp Eye Res 1996; 63:201-10. [PMID: 8983978].
6. Limb GA, Little BC, Meager A, Ogilvie JA, Wolstencroft RA, Franks WA, Chignell AH, Dumonde DC. Cytokines in proliferative vitreoretinopathy. Eye (Lond) 1991; 5:686-93. [PMID: 1800167].
7. Kenarova B, Voinov L, Apostolov C, Vladimirova R, Misheva A. Levels of some cytokines in subretinal fluid in proliferative vitreoretinopathy and rhegmatogenous retinal detachment. Eur J Ophthalmol 1997; 7:64-7. [PMID: 9101198].
8. Esser P, Heimann K, Bartz-schmidt KU, Fontana A, Schraermeyer U, Thumann G, Weller M. Apoptosis in proliferative vitreoretinal disorders: possible involvement of TGF-beta-induced RPE cell apoptosis. Exp Eye Res 1997; 65:365-78. [PMID: 9299173].
9. Campochiaro PA. Pathogenic mechanisms in proliferative vitreoretinopathy. Arch Ophthalmol 1997; 115:237-41. [PMID: 9046259].
10. Miller H, Miller B, Ryan SJ. The role of retinal pigment epithelium in the involution of subretinal neovascularization. Invest Ophthalmol Vis Sci 1986; 27:1644-52. [PMID: 2429937].
11. Hiscott P, Gray R, Grierson I, Gregor Z. Cytokeratin-containing cells in proliferative diabetic retinopathy membranes. Br J Ophthalmol 1994; 78:219-22. [PMID: 7511932].
12. Slack JL, Liska DJ, Bornstein P. Regulation of expression the type I collagen genes. Am J Med Genet 1993; 45:140-51. [PMID: 8456796].
13. Hamilton CW, Chandler D, Klintworth GK, Machemer R. A transmission and scanning electron microscopic study of surgically excised preretinal membrane proliferations in diabetes mellitus. Am J Ophthalmol 1982; 94:473-88. [PMID: 7137272].
14. Snead DR, James S, Snead MP. Pathological changes in the vitreoretinal junction 1: epiretinal membrane formation. Eye (Lond) 2008; 22:1310-7. [PMID: 18344963].
15. Tatemoto K, Hosoya M, Habata Y, Fujii R, Kakegawa T, Zou MX, Kawamata Y, Fukusumi S, Hinuma S, Kitada C, Kurokawa T, Onda H, Fujino M. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 1998; 251:471-6. [PMID: 9792798].
16. Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S, Kitada C, Honda S, Kurokawa T, Onda H, Nishimura O, Fujino M. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem 2000; 275:21061-7. [PMID: 10777510].
17. Langelaan DN, Bebbington EM, Reddy T, Rainey JK. Structural insight into G-protein coupled receptor binding by apelin. Biochemistry 2009; 48:537-48. [PMID: 19123778].
18. Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR, O'Dowd BF. Modification of the terminal residue of apelin-13 antagonizes its hypotensive action Endocrinology 2005; 146:231-6. [PMID: 15486224].
19. Ladeiras-Lopes R, Ferreira-Martins J, Leite-Moreira AF. The apelinergic system: the role played in human physiology and pathology and potential therapeutic applications. Arq Bras Cardiol 2008; 90:343-9. [PMID: 18516406].
20. Masri B, Morin N, Pedebernade L, Knibiehler B, Audigier Y. The apelin receptor is coupled to Gi1 or Gi2 protein and is differently desensitized by apelin fragment. J Biol Chem 2006; 281:18317-26. [PMID: 16679320].
21. De Falco M, De Luca L, Onori N, Cavallotti I, Artigiano F, Esposito V, De Luca B, Laforgia V, Groeger AM, De Luca A. Apelin expression in normal human tissues. In Vivo 2002; 16:333-6. [PMID: 12494873].
22. Habata Y, Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Hinuma S, Kitada C, Nishizawa N, Murosaki S, Kurokawa T, Onda H, Tatemoto K, Fujino M. Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. Biochim Biophys Acta 1999; 1452:25-35. [PMID: 10525157].
23. Kawamata Y, Habata Y, Fukusumi S, Hosoya M, Fujii R, Hinuma S, Nishizawa N, Kitada C, Onda H, Nishimura O, Fujino M. Molecular properties of apelin: tissue distribution and receptor binding. Biochim Biophys Acta 2001; 1538:162-71. [PMID: 11336787].
24. Shirasuna K, Shimizu T, Sayama K, Asahi T, Sasaki M, Berisha B, Schams D, Miyamoto A. Expression and localization of apelin and its receptor APJ in the bovine corpus luteum during the estrous cycle and prostaglandin F2alpha-induced luteolysis. Reproduction 2008; 135:519-25. [PMID: 18367512].
25. De Falco M, Fedele V, Russo T, Virgilio F, Sciarrillo R, Leone S, Laforgia V, De Luca A. Distribution of apelin, the endogenous ligand of APJ receptor, in the lizard Podarcis sicula. J Mol Histol 2004; 35:521-7. [PMID: 15571329].
26. Barnes G, Japp AG, Newby DE. Translation promise of apelin-APJ system. Heart 2010; 96:1011-6. [PMID: 20584856].
27. Kasai A, Ishimaru Y, Kinjo T, Satooka T, Matsumoto N, Yoshioka Y, Yamamuro A, Gomi F, Shintani N, Baba A, Maeda S. Apelin is crucial factor for hypoxia-induced retinal angiogenesis. Arterioscler Thromb Vasc Biol 2010; 30:2182-7. [PMID: 20705920].
28. Tao Y, Lu Q, Jiang YR, Qian J, Wang JY, Gao L, Jonas JB. Apelin in plasma and vitreous and in fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 2010; 51:4237-42. [PMID: 20220056].
29. Masri B, Morin N, Cornu M, Knibiehler B, Audigier Y. Apelin (65-67) activates p70S6 kinase and is mitogenic for umbilical endothelial cells. FASEB J 2004; 18:1909-11. [PMID: 15385434].
30. Lu Q, Jiang YR, Qian J, Tao Y. Apelin-13 regulates proliferation, migration and survival of retinal Müller cells under hypoxia. Diabetes Res Clin Pract 2013; 99:158-67. [PMID: 23332048].
31. Kasai A, Shintani N, Oda M, Kakuda M, Hashimoto H, Matsuda T, Hinuma S, Baba A. Apelin is a novel angiogenic factor in retinal endothelial cells. Biochem Biophys Res Commun 2004; 325:395-400. [PMID: 15530405].
32. Paine SK, Basu A, Mondal LK, Sen A, Choudhuri S, Chowdhury IH, Saha A, Bhadhuri G, Mukherjee A, Bhattacharya B. Association of vascular endothelial growth factor, transforming growth factor beta, and interferon gamma gene polymorphisms with proliferative diabetic retinopathy in patients with type 2 diabetes. Mol Vis 2012; 18:2749-57. [PMID: 23213275].
33. Mitamura Y, Okumura A, Harada C, Namekata K, Nakamura K, Tashimo A, Ohtsuka K, Harada T. Activator protein-1 in epiretinal membranes of patients with proliferative diabetic retinopathy. Diabetologia 2006; 49:209-11. [PMID: 16341687].
34. Mitamura Y, Takeuchi S, Matsuda A, Tagawa Y, Mizue Y, Nishihira J. Monocyte chemotactic protein-1 in the vitreous of patients with proliferative diabetic retinopathy. Ophthalmologica 2001; 215:415-8. [PMID: 11741107].
35. Watanabe D, Suzuma K, Matsui S, Kurimoto M, Kiryu J, Kita M, Suzuma I, Ohashi H, Ojima T, Murakami T, Kobayashi T, Masuda S, Nagao M, Yoshimura N, Takagi H. Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. N Engl J Med 2005; 353:782-92. [PMID: 16120858].
36. Yamaji Y, Yoshida S, Ishikawa K, Sengoku A, Sato K, Yoshida A, Kuwahara R, Ohuchida K, Oki E, Enaida H, Fujisawa K, Kono T, Ishibashi T. TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy. Invest Ophthalmol Vis Sci 2008; 49:3151-7. [PMID: 18316703].
37. Hara C, Kasai A, Gomi F, Satooka T, Sakimoto S, Nakai K, Yoshioka Y, Yamamuro A, Maeda S, Nishida K. Laser-induced choroidal neovascularization in mice attenuated by deficiency in the apelin-APJ system. Invest Ophthalmol Vis Sci 2013; 54:4321-9. [PMID: 23722395].
38. Jerdan JA, Michels RG, Glaser BM. Diabetic preretinal membranes. An immunohistochemical study. Arch Ophthalmol 1986; 104:286-90. [PMID: 3947305].
39. Melgar-Lesmes P, Casals G, Pauta M, Ros J, Reichenbach V, Bataller R, Morales-Ruiz M, Jimenez W. Apelin mediates the induction of profibrogenic genes in human stellate cells. Endocrinology 2010; 151:5306-14. [PMID: 20843995].
40. Chung BH, Kim JD, Kim CK, Kim JH, Won MH, Lee HS, Dong MS, Ha KS, Kwon YG, Kim YM. Icariin stimulates angiogenesis by activating the MEK/ERK-and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells. Biochem Biophys Res Commun 2008; 376:404-8. [PMID: 18789310].
41. Lee SJ, Namkoong S, Kim YM, Kim CK, Lee H, Ha KS, Chung HT, Kwon YG, Kim YM. Fractalkine stimulates angiogenesis by activating the Raf-1/MEK/ERK-and PI3K/Akt/ eNOS-dependent signal pathways. Am J Physiol Heart Circ Physiol 2006; 291:H2836-46. [PMID: 16877565].
42. Montaner S, Sodhi A, Pece S, Mesri EA, Gutkind JS. The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor promotes endothelial cell survival through the activation of Akt/protein kinase B. Cancer Res 2001; 61:2641-8. [PMID: 11289142].
43. Defoe DM, Grindstaff RD. Epidermal growth factor stimulation of RPE cell survival: contribution of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. Exp Eye Res 2004; 79:51-9. [PMID: 15183100].
44. Anchan RM, Reh TA, Angello J, Balliet A, Walker M. EGF and TGF-alpha stimulate retinal neuroepithelial cell proliferation in vitro. Neuron 1991; 6:923-36. [PMID: 1711348].