Low-dose morphine induces hyperalgesia through activation of G αs, protein kinase C, and L-type Ca2+ channels in rats

Journal of Neuroscience Research

Volumn 86, Issue 2, 2008, Pages 471-479

  Esmaeili Mahani, Saeed ^a,b,c   Shimokawa, Noriaki ^c   Javan, Mohammad ^d   Maghsoudi, Nader ^a   Motamedi, Fereshteh ^a   Koibuchi, Noriyuki ^c   Ahmadiani, Abolhasan ^a,d  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID BAHONAR UNIVERSITY OF KERMAN   (Iran)

^c GUNMA UNIVERSITY   (Japan)

^d TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

G protein; Hyperalgesia; L type calcium channel; Morphine; PKA; PKC

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CHELERYTHRINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GUANINE NUCLEOTIDE BINDING PROTEIN; KT 5720; MORPHINE; NIFEDIPINE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; DRUG EFFECT; ENZYME ACTIVATION; HYPERALGESIA; LUMBAR SPINAL CORD; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RAT; TAIL FLICK TEST; WISTAR RAT;

ALKALOIDS; ANALGESICS, OPIOID; ANIMALS; BENZOPHENANTHRIDINES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CARBAZOLES; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GTP-BINDING PROTEINS; HYPERALGESIA; IMMUNOBLOTTING; INDOLES; MALE; MORPHINE; NIFEDIPINE; POLYMERASE CHAIN REACTION; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PYRROLES; RATS; RATS, WISTAR; RNA, MESSENGER; SPINAL CORD;

EID: 38849179484     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21489     Document Type: Article

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