Comparative study of the hydrolytic metabolism of methyl-, ethyl-, propyl-, butyl-, heptyl-and dodecylparaben by microsomes of various rat and human tissues

Xenobiotica

Volumn 43, Issue 12, 2013, Pages 1064-1072

  Ozaki, Hitomi ^a   Sugihara, Kazumi ^b   Watanabe, Yoko ^a,c   Fujino, Chieri ^c   Uramaru, Naoto ^c   Sone, Tomomichi ^d   Ohta, Shigeru ^a   Kitamura, Shigeyuki ^c  

^a HIROSHIMA UNIVERSITY   (Japan)

^b HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^c NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

^d SETSUNAN UNIVERSITY   (Japan)

Author keywords

Carboxylesterase; Hydrolytic metabolism; Paraben; Rat and human liver microsomes; Rat and human small intestine microsomes; Substrate specificity

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; BIS(4 NITROPHENYL) PHOSPHATE; BUTYL PARABEN; CARBOXYLESTERASE; CARBOXYLESTERASE 1; CARBOXYLESTERASE 2; DODECYLPARABEN; ETHYL PARABEN; HEPTYL PARABEN; HYDROLASE; ISOENZYME; METHYL PARABEN; PROPYL PARABEN; TRITON X 100; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL STRAIN COS1; COLUMN CHROMATOGRAPHY; COMPARATIVE STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; HYDROLYSIS; LIVER MICROSOME; MALE; MICROSOME; NONHUMAN; PROTEIN EXPRESSION; RAT; SMALL INTESTINE;

ANIMALS; BIOCATALYSIS; CARBOXYLESTERASE; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; HYDROLYSIS; ISOENZYMES; MALE; METABOLIC NETWORKS AND PATHWAYS; MICROSOMES; ORGAN SPECIFICITY; PARABENS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SUBSTRATE SPECIFICITY;

EID: 84887233674     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2013.802059     Document Type: Article

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