Metabolism of parabens (4-hydroxybenzoic acid esters) by hepatic esterases and UDP-glucuronosyltransferases in man

Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 6, 2010, Pages 568-577

  Abbas, Suzanne ^a   Greige Gerges, Heáleàne ^b   Karam, Nancy ^c   Piet, Marie Heáleàne ^a   Netter, Patrick ^a   Magdalou, Jacques ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b LEBANESE UNIVERSITY   (Lebanon)

^c HOLY SPIRIT UNIVERSITY OF KASLIK USEK   (Lebanon)

Author keywords

4 hydroxybenzoic acid; Esterases; Glucuronidation; Hydrolysis; Man; Parabens; Udpglucuronosyltransferases

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; BENZYL PARABEN; BUTYL PARABEN; ESTERASE; ETHYL PARABEN; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A8; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B17; GLUCURONOSYLTRANSFERASE 2B7; METHYL PARABEN; PROPYL PARABEN; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; BLOOD LEVEL; CHEMICAL ANALYSIS; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME SUBSTRATE; GLUCURONIDATION; HUMAN; HUMAN CELL; HYDROLYSIS; LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; MASS SPECTROMETRY; PH;

EID: 78951483772     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-10-RG-013     Document Type: Article

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