Impact of endocrine disrupting chemicals on birth outcomes;Effets des perturbateurs endocriniens sur les marqueurs de la périnatalité

Gynecologie Obstetrique et Fertilite

Volumn 41, Issue 10, 2013, Pages 601-610

  Chen Zee, E ^a   Cornet, P ^a   Lazimi, G ^a   Rondet, C ^a   Lochard, M ^b   Magnier, A M ^a,c   Ibanez, G ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b ICF Environnement   (France)

^c Societe de formation therapeutique du generaliste SFTG   (France)

Author keywords

Birth outcomes; Bisphenol A; Brominated flame retardants; Endocrine disruptors; Parabens; Perfluorinated compounds; Phthalates; Prenatal exposure

Indexed keywords

4 HYDROXYBENZOIC ACID ESTER; 4,4' ISOPROPYLIDENEDIPHENOL; FLAME RETARDANT; PERFLUORO COMPOUND; PHTHALIC ACID;

CORRELATIONAL STUDY; GESTATIONAL AGE; HUMAN; LOW BIRTH WEIGHT; MEDLINE; METHODOLOGY; NEWBORN; POLLUTANT; PREGNANCY OUTCOME; REVIEW;

BIRTH OUTCOMES; BISPHENOL A; BISPHÉNOL A; BROMINATED FLAME RETARDANTS; COMPOSÉS PERFLUORÉS; ENDOCRINE DISRUPTORS; EXPOSITION PRÉNATALE; MARQUEURS DE LA PÉRINATALITÉ; PARABENS; PERFLUORINATED COMPOUNDS; PERTURBATEURS ENDOCRINIENS; PHTALATES; PHTHALATES; PRENATAL EXPOSURE; RETARDATEURS DE FLAMMES BROMÉS;

BENZHYDRYL COMPOUNDS; ENDOCRINE DISRUPTORS; ENVIRONMENTAL POLLUTANTS; FEMALE; FLAME RETARDANTS; FLUOROCARBONS; GESTATIONAL AGE; HEALTH STATUS; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; MALE; PHENOLS; PREGNANCY; PREGNANCY OUTCOME; PREMATURE BIRTH;

EID: 84887221894     PISSN: 12979589     EISSN: 17696682     Source Type: Journal    
DOI: 10.1016/j.gyobfe.2013.08.012     Document Type: Article

References (120)

1. Commission Européenne. European Workshop on the impact of endocrine disrupters on human health and wildlife, 2-4 December, 1996.
2. R.T. Zoeller, T.R. Brown, L.L. Doan, A.C. Gore, N.E. Skakkebaek, and A.M. Soto Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society Endocrinology 153 9 2012 4097 4110
3. Comité de la prévention et de la précaution. Les perturbateurs endocriniens: quels risques ? 2003.
4. L.N. Vandenberg, R. Hauser, M. Marcus, N. Olea, and W.V. Welshons Human exposure to bisphenol A (BPA) Reprod Toxicol 24 2 2007 139 177
5. ANSES. Effets sanitaires du bisphénol A - Rapport d'expertise collective. Connaissances relatives aux usages du bisphénol A - Rapport d'étude. 2011.
6. Institut national de Santé publique Québec. Les phthalates: état des connaissances sur la toxicité et l'exposition de la population générale, 2004
7. Afssaps. Parabènes et médicaments: questions/ réponses, 2011.
8. S. Oishi Effects of propyl paraben on the male reproductive system Food Chem Toxicol 40 12 2002 1807 1813
9. EBFRIP (European Bromated Flame Retardant Industry Panel). Deca-BDE.
10. INERIS. PFOS, acide, sels et dérivés [Internet]. 2010 [consulté le 6 févr 2012]. Disponible sur: www.ineris.fr/ substances/fr/substance/getDocument/3029.
11. J.L. Carwile, H.T. Luu, L.S. Bassett, D.A. Driscoll, C. Yuan, and J.Y. Chang Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 117 9 2009 1368 1372
12. S.N. Loganathan, and K. Kannan Occurrence of bisphenol A in indoor dust from two locations in the eastern United States and implications for human exposures Arch Environ Contam Toxicol 61 1 2011 68 73
13. Danish Ministry of the Environment. Environmental protection agency. Migration of bisphenol A from cash register receipts and baby dummies.
14. W.A. Anderson, L. Castle, M.J. Scotter, R.C. Massey, and C. Springall A biomarker approach to measuring human dietary exposure to certain phthalate diesters Food Addit Contam 18 12 2001 1068 1074
15. C.G. Bornehag, and E. Nanberg Phthalate exposure and asthma in children Int J Androl 33 2 2010 333 345
16. C.-G. Bornehag, J. Sundell, C.J. Weschler, T. Sigsgaard, B. Lundgren, and M. Hasselgren The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case-control study Environ Health Perspect 112 14 2004 1393 1400
17. H.J. Koo, and B.M. Lee Estimated exposure to phthalates in cosmetics and risk assessment J Toxicol Environ Health Part A 67 23-24 2004 1901 1914
18. N.R. Janjua, G.K. Mortensen, A.-M. Andersson, B. Kongshoj, N.E. Skakkebaek, and H.C. Wulf Systemic uptake of diethyl phthalate, dibutyl phthalate, and butyl paraben following whole-body topical application and reproductive and thyroid hormone levels in humans Environ Sci Technol 41 15 2007 5564 5570
19. D. Fischer, K. Hooper, M. Athanasiadou, I. Athanassiadis, and A. Bergman Children show highest levels of polybrominated diphenyl ethers in a California family of four: a case study Environ Health Perspect 114 10 2006 1581 1584
20. H. Fromme, W. Körner, N. Shahin, A. Wanner, M. Albrecht, and S. Boehmer Human exposure to polybrominated diphenyl ethers (PBDE), as evidenced by data from a duplicate diet study, indoor air, house dust, and biomonitoring in Germany Environ Int 35 8 2009 1125 1135
21. Chateau G, Chavroche J, Dupoiron B. composés perfluorés. Evaluation et gestion des risques liés au PFOS.
22. T. Unuvar, and A. Buyukgebiz Fetal and neonatal endocrine disruptors J Clin Res Pediatr Endocrinol 4 2 2012 51 60
23. W.-C. Chou, J.-L. Chen, C.-F. Lin, Y.-C. Chen, F.-C. Shih, and C.-Y. Chuang Biomonitoring of bisphenol A concentrations in maternal and umbilical cord blood in regard to birth outcomes and adipokine expression: a birth cohort study in Taiwan Environ Health 10 2011 94 10.1186/1476-069X-10-94 [Disponible sur Internet] http://www.ehjournal.net/content/10/1/94
24. Y.J. Lee, H.-Y. Ryu, H.-K. Kim, C.S. Min, J.H. Lee, and E. Kim Maternal and fetal exposure to bisphenol A in Korea Reprod Toxicol 25 4 2008 413 419
25. Y. Zhang, L. Lin, Y. Cao, B. Chen, L. Zheng, and R.-S. Ge Phthalate levels and low birth weight: a nested case-control study of Chinese newborns J Pediatr 155 4 2009 500 504
26. B.J. Apelberg, F.R. Witter, J.B. Herbstman, A.M. Calafat, R.U. Halden, and L.L. Needham Cord serum concentrations of perfluorooctane sulfonate (pfos) and perfluorooctanoate (pfoa) in relation to weight and size at birth Environ Health Perspect 115 11 2007 1670 1676
27. S.G. Selevan, C.A. Kimmel, and P. Mendola Identifying critical windows of exposure for children's health Environ Health Perspect 108 Suppl. 3 2000 451 455
28. D.J. Barker, and P.M. Clark Fetal undernutrition and disease in later life Rev Reprod 2 2 1997 105 112
29. D.J.P. Barker The developmental origins of adult disease J Am Coll Nutr 23 Suppl. 6 2004 588S 595S
30. J.J. Heindel, and F.S. vom Saal Role of nutrition and environmental endocrine disrupting chemicals during the perinatal period on the aetiology of obesity Mol Cell Endocrinol 304 1-2 2009 90 96
31. T.T. Schug, A. Erlebacher, S. Leibowitz, L. Ma, L.J. Muglia, and O.J. Rando Fetal programming and environmental exposures: implications for prenatal care and preterm birth Ann N Y Acad Sci 1276 2012 37 46
32. A.M. Soto, L.N. Vandenberg, M.V. Maffini, and C. Sonnenschein Does breast cancer start in the womb? Basic Clin Pharmacol Toxicol 102 2 2008 125
33. F.S. Vom Saal, S.C. Nagel, B.L. Coe, B.M. Angle, and J.A. Taylor The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity Mol Cell Endocrinol 354 1-2 2012 74 84
34. Inserm. Expertise collective: Reproduction et environnement ? 2011.
35. Fourth meeting of the Conference of the Parties to the Stockholm convention on persistent organic pollutants (POPs COP4), 2009.
36. Anses. Évaluation des risques du bisphénol A (BPA) pour la santé humaine, 2013.
37. o 2010-729 du 30 juin 2010 tendant à suspendre la commercialisation de biberons produits à base de bisphénol A. 2010-729 juin 30, 2010.
38. Directive 2011/8/UE de la Commission du 28 janvier 2011 modifiant la directive 2002/72/CE en ce qui concerne la restriction de l'utilisation du bisphénol A dans les biberons en plastique pour nourrissons.
39. Directive 2004/93/ce de la Commission du 21 septembre 2004 portant modification de la directive 76/768/CEE, relatives aux produits cosmétiques, du Conseil en vue de l'adaptation au progrès technique de ses annexes II et III.
40. o 2006-1361 du 9 novembre 2006 relatif à la limitation de l'emploi de certains phtalates dans les jouets et les articles de puériculture. 2006-1361 nov 9, 2006.
41. Directive 2007/47/ce du parlement Européen et du conseil du 5 septembre 2007 modifiant la directive 90/385/CEE du Conseil concernant le rapprochement des législations des États membres relatives aux dispositifs médicaux implantables actifs, la directive 93/42/CEE du Conseil relative aux dispositifs médicaux et la directive 98/8/CE concernant la mise sur le marché des produits biocides.
42. Directive 2007/19/ce de la Commission du 30 mars 2007 portant modification de la directive 2002/72/CE concernant les matériaux et objets en matière plastique destinés à entrer en contact avec les denrées alimentaires et de la directive 85/572/CEE du Conseil fixant la liste des simulants à utiliser pour vérifier la migration des constituants des matériaux et objets en matière plastique destinés à entrer en contact avec les denrées alimentaires.
43. Directive du conseil du 27 juillet 1976 concernant le rapprochement des législations des États membres relatives aux produits cosmétiques.
44. Proposition de loi visant à interdire l'utilisation des phtalates, des parabènes et des alkylphénols. Enregistrée à la Présidence de l'Assemblée nationale le 13 juillet 2010. 2738.
45. Directive 95/2/ce du Parlement Européen et du conseil du 20 février 1995 concernant les additifs alimentaires autres que les colorants et les édulcorants (JO n o L 61 du 18. 3. 1995, p. 1).
46. Directive 2002/95/ce du Parlement Européen et du conseil du 27 janvier 2003 relative à la limitation de l'utilisation de certaines substances dangereuses dans les équipements électriques et électroniques.
47. Directive 2003/11/ce du Parlement Européen et du conseil du 6 février 2003 portant vingt-quatrième modification de la directive 76/769/CEE du Conseil relative à la limitation de la mise sur le marché et de l'emploi de certaines substances et préparations dangereuses (penta- bromodiphényléther, octabromodiphé nyléther).
48. o 552/2009 de la Commission du 22 juin 2009 modifiant le règlement (CE) n o 1907/2006 du Parlement européen et du Conseil concernant l'enregistrement, l'évaluation et l'autorisation des substances chimiques, ainsi que les restrictions applicables à ces substances (REACH), en ce qui concerne l'annexe XVII.
49. Rapport de la conférence des parties à la convention de Stockholm sur les polluants organiques persistants sur les travaux de sa quatrième réunion. mai 4, 2009.
50. Strobe Statement. Stobe Checklist [Internet]. Disponible sur: http://www.strobe-statement.org/index.php?id = available-checklists.
51. L. Fairley, and A.H. Leyland Social class inequalities in perinatal outcomes: Scotland 1980-2000 J Epidemiol Commun Health 60 2006 31 36
52. A. Macfarlane, M. Gissler, F. Bolumar, and S. Rasmussen The availability of perinatal health indicators in Europe Eur J Obstet Gynecol Reprod Biol 111 Suppl. 1 2003 S15 S32
53. J. Zeitlin, K. Wildman, G. Breart, S. Alexander, H. Barros, and B. Blondel Peristat: indicators for monitoring and evaluating perinatal health in Europe Eur J Public Health 13 Suppl. 3 2003 29 37
54. R.L. Goldenberg, J.F. Culhane, J.D. Iams, and R. Romero Epidemiology and causes of preterm birth Lancet 371 9606 2008 75 84
55. P.E. Clayton, S. Cianfarani, P. Czernichow, G. Johannsson, R. Rapaport, and A. Rogol Management of the child born small for gestational age through to adulthood: a consensus statement of the international societies of pediatric endocrinology and the growth hormone research society JCEM 92 3 2007 804 810
56. C. Philippat, M. Mortamais, C. Chevrier, C. Petit, A.M. Calafat, and X. Ye Exposure to phthalates and phenols during pregnancy and offspring size at birth Environ Health Perspect 120 3 2012 464 470
57. M. Miao, W. Yuan, G. Zhu, X. He, and D.-K. Li In utero exposure to bisphenol-A and its effect on birth weight of offspring Reprod Toxicol 32 1 2011 64 68
58. D. Cantonwine, J.D. Meeker, H. Hu, B.N. Sánchez, H. Lamadrid-Figueroa, and A. Mercado-García Bisphenol a exposure in Mexico City and risk of prematurity: a pilot nested case control study Environ Health 9 2010 62
59. M.S. Wolff, S.M. Engel, G.S. Berkowitz, X. Ye, M.J. Silva, and C. Zhu Prenatal phenol and phthalate exposures and birth outcomes Environ Health Perspect 116 8 2008 1092 1097
60. V. Padmanabhan, K. Siefert, S. Ransom, T. Johnson, J. Pinkerton, and L. Anderson Maternal bisphenol-A levels at delivery: a looming problem? J Perinatol 28 4 2008 258 263
61. Y. Suzuki, M. Niwa, J. Yoshinaga, Y. Mizumoto, S. Serizawa, and H. Shiraishi Prenatal exposure to phthalate esters and PAHs and birth outcomes Environ Int 36 7 2010 699 704
62. R.M. Whyatt, J.J. Adibi, A.M. Calafat, D.E. Camann, V. Rauh, and H.K. Bhat Prenatal di(2-ethylhexyl)phthalate exposure and length of gestation among an inner-city cohort Pediatrics 124 6 2009 e1213 e1220
63. J.D. Meeker, H. Hu, D.E. Cantonwine, H. Lamadrid-Figueroa, A.M. Calafat, and A.S. Ettinger Urinary phthalate metabolites in relation to preterm birth in Mexico city Environ Health Perspect 117 10 2009 1587 1592
64. J.J. Adibi, R. Hauser, P.L. Williams, R.M. Whyatt, A.M. Calafat, and H. Nelson Maternal urinary metabolites of di-(2-ethylhexyl) phthalate in relation to the timing of labor in a us multicenter pregnancy cohort study Am J Epidemiol 169 8 2009 1015 1024
65. Po-Chin Huang, Pao-Lin Kuo, Yen-Yin Chou, Shio-Jean Lin, and Lee. Ching-Chang Association between prenatal exposure to phthalates and the health of newborns Environ Int 35 2009 14 20
66. W.G. Foster, S. Gregorovich, K.M. Morrison, S.A. Atkinson, C. Kubwabo, and B. Stewart Human maternal and umbilical cord blood concentrations of polybrominated diphenyl ethers Chemosphere 84 10 2011 1301 1309
67. K.G. Harley, J. Chevrier, R. Aguilar Schall, A. Sjödin, A. Bradman, and B. Eskenazi Association of prenatal exposure to polybrominated diphenyl ethers and infant birth weight Am J Epidemiol 174 8 2011 885 892
68. K. Wu, X. Xu, J. Liu, Y. Guo, Y. Li, and X. Huo Polybrominated diphenyl ethers in umbilical cord blood and relevant factors in neonates from Guiyu China Environ Sci Technol 44 2 2010 813 819
69. H.-R. Chao, S.-L. Wang, W.-J. Lee, Y.-F. Wang, and O. Päpke Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects Environ Int 33 2007 239 245
70. T.-W. Wen, M.-H. Chen, G.-W. Lien, Y.-J. Lin, W.-S. Hsieh, and C.-Y. Chen The association between perfluoroalkyl chemical levels in umbilical cord blood and birth outcomes Epidemiology 22 2011 S240
71. M. Hamm, N. Cherry, E. Chan, J. Martin, and I. Burstyn Maternal exposure to perfluorinated acids and fetal growth J Expo Sci Environ Epidemiol 20 2010 589 597
72. C.R. Stein, D.A. Savitz, and M. Dougan Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome Am J Epidemiol 170 7 2009 837 846
73. L.A. Nolan, J.M. Nolan, F.S. Shofer, N.V. Rodway, and E.A. Emmett The relationship between birth weight gestational age and perfluorooctanoic acid (pfoa)-contaminated public drinking water Reprod Toxicol 27 3-4 2009 231 238
74. N. Washino, Y. Saijo, S. Sasaki, S. Kato, S. Ban, and K. Konishi Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth Environ Health Perspect 117 4 2009 660 667
75. R. Monroy, K. Morrison, K. Teo, S. Atkinson, C. Kubwabo, B. Stewart, and W. Foster Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples Environ Res 108 2008 56 62
76. C. Fei, J.K. McLaughlin, R.E. Tarone, and J. Olsen Perfluorinated chemicals and fetal growth: a study within the danish national birth cohort Environ Health Perspect 115 11 2007 1677 1682
77. K.P. Stillerman, D.R. Mattison, L.C. Giudice, and T.J. Woodruff Environmental exposures and adverse pregnancy outcomes: a review of the science Reprod Sci 15 7 2008 631 650
78. G. Windham, and L. Fenster Environmental contaminants and pregnancy outcomes Fertil Steril 89 2 Suppl. 2008 e111 e116 [discussion e117]
79. D.T. Wigle, T.E. Arbuckle, M.C. Turner, A. Bérubé, Q. Yang, and S. Liu Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants J Toxicol Environ Health B Crit Rev 11 5-6 2008 373 517
80. L.N. Vandenberg, I. Chahoud, J.J. Heindel, V. Padmanabhan, F.J.R. Paumgartten, and G. Schoenfelder Urinary circulating tissue biomonitoring studies indicate widespread exposure to bisphenol A Environ Health Perspect 118 8 2010 1055 1070
81. N. Kuroda, Y. Kinoshita, Y. Sun, M. Wada, N. Kishikawa, and K. Nakashima Measurement of bisphenol A levels in human blood serum and ascitic fluid by HPLC using a fluorescent labelling reagent J Pharm Biomed Anal 30 6 2003 1743 1749
82. M. Liu, Y. Hashi, F. Pan, J. Yao, G. Song, and J.-M. Lin Automated on-line liquid chromatography-photodiode array-mass spectrometry method with dilution line for the determination of bisphenol A and 4-octylphenol in serum J Chromatogr A 1133 1-2 2006 142 148
83. Y. Sun, M. Irie, N. Kishikawa, M. Wada, N. Kuroda, and K. Nakashima Determination of bisphenol A in human breast milk by HPLC with column-switching and fluorescence detection Biomed. Chromatogr 18 8 2004 501 507
84. Buckenmeier N, Dereumeaux C, Rouy P, Vigneron M. Projet d'évaluation des risques sanitaires: lespolyBromo Diphenyl Ethers.
85. Arctic monitoring and assessment programme (AMAP). Assessment-Reports 2009: Human Health in the Arctic.
86. Fiche INRS BPA [Internet]. [consulté le 31 janv 2012]. Disponible sur: http://www.inrs.fr/accueil/produits/mediatheque/doc/publications.html? refINRS = FT%20279
87. R. Hauser, and A.M. Calafat Phthalates and human health Occup Environ Med 62 11 2005 806 818
88. R. Hauser, J.D. Meeker, S. Park, M.J. Silva, and A.M. Calafat Temporal variability of urinary phthalate metabolite levels in men of reproductive age Environ Health Perspect. 112 2004 1734 1740
89. S.L. Teitelbaum, J.A. Britton, A.M. Calafat, X. Ye, M.J. Silva, and J.A. Reidy Temporal variability in urinary concentrations of phthalate metabolites, phytœstrogens and phenols among minority children in the United States Environ Res 106 2 2008 257 269
90. E. Diamanti-Kandarakis, J.-P. Bourguignon, L.C. Giudice, R. Hauser, G.S. Prins, and A.M. Soto Endocrine-disrupting chemicals: an endocrine society scientific statement Endocr Rev 30 4 2009 293 342
91. L.N. Vandenberg, M.V. Maffini, C. Sonnenschein, B.S. Rubin, and A.M. Soto Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption Endocr Rev 30 1 2009 75 95
92. L.N. Vandenberg, T. Colborn, T.B. Hayes, J.J. Heindel, D.R. Jacobs Jr., and D.-H. Lee Regulatory decisions on endocrine disrupting chemicals should be based on the principles of endocrinology Reprod Toxicol 38 2013 1 15
93. L.N. Vandenberg, T. Colborn, T.B. Hayes, J.J. Heindel, D.R. Jacobs, D.R. Jacobs Jr., and D.-H. Lee Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses Endocr Rev 33 3 2012 378 455
94. L.S. Birnbaum Environmental Chemicals: Evaluating low-dose effects Environ Health Perspect 120 4 2012 a143 a144
95. A. Kortenkamp Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology Int J Androl 31 2 2008 233 240
96. A. Kortenkamp Ten years of mixing cocktails: a review of combination effects of endocrine-disrupting chemicals Environ Health Perspect 115 S-1 2007 98 105
97. R.R. Newbold, E. Padilla-Banks, and W.N. Jefferson Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations Endocrinology 147 6 Suppl. 2006 S11 S17
98. M.K. Skinner Endocrine disruptors epigenetic transgenerational disease etiology Pediatr Res 61 5 Part 2 2007 48R 50R
99. N. Kalfa, F. Paris, M.-O. Soyer-Gobillard, J.-P. Daures, and C. Sultan Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study Fertil Steril 95 8 2011 2574 2577
100. D. Crews, and J.A. McLachlan Epigenetics, Evolution, endocrine disruption health, and disease Endocrinology 147 6 2006 s4 s10
101. L.F. Doherty, J.G. Bromer, Y. Zhou, T.S. Aldad, and H.S. Taylor In utero exposure to diethylstilbestrol (des) or bisphenol-a (bpa) increases ezh2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer Horm Cancer 1 3 2010 146 155
102. J.C. Robins, C.J. Marsit, J.F. Padbury, and S.S. Sharma Endocrine disruptors, environmental oxygen epigenetics and pregnancy Front Biosci (Elite Ed) 3 2011 690 700
103. N.E. Skakkebaek, J. Toppari, O. Söder, C.M. Gordon, S. Divall, and M. Draznin The exposure of fetuses and children to endocrine disrupting chemicals: a european society for paediatric endocrinology (espe) and pediatric endocrine society (pes) call to action statement JCEM 96 10 2011 3056 3058
104. P.J. Lioy, and S.M. Rappaport Exposure science and the exposome: an opportunity for coherence in the environmental health sciences Environ Health Perspect 119 11 2011 a466 a467
105. M. Van Tongeren, and J.W. Cherrie An integrated approach to the exposome Environ Health Perspect 120 3 2012 a103 a104
106. J.D. Meeker Exposure to environmental endocrine disruptors and child development Arch Pediatr Adolesc Med 166 10 2012 952 958
107. M.S. Golub, K.L. Wu, F.L. Kaufman, L.-H. Li, F. Moran-Messen, and L. Zeise Bisphenol A: developmental toxicity from early prenatal exposure Birth Defects Res B Dev Reprod Toxicol 89 6 2010 441 466
108. EFSA Scientific Committe, Scientif Panel. Opinion of the Scientific Committee/Scientific Panel [Internet]. 2011. Disponible sur: http://www.efsa.europa.eu/en/efsajournal/pub/2156.htm.
109. K.W. Whitworth, L.S. Haug, D.D. Baird, G. Becher, J.A. Hoppin, and R. Skjaerven Perfluorinated compounds in relation to birth weight in the Norwegian mother and child cohort study Am J Epidemiol 175 12 2012 1209 1216
110. S.S. White, S.E. Fenton, and E.P. Hines Endocrine disrupting properties of perfluorooctanoic acid J Steroid Biochem Mol Biol 127 1-2 2011 16 26
111. K. Steenland, T. Fletcher, and D.A. Savitz Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA) Environ Health Perspect 118 8 2010 1100 1108
112. G.W. Olsen, J.L. Butenhoff, and L.R. Zobel Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives Reprod Toxicol 27 3-4 2009 212 230
113. A. Mazdai, N.G. Dodder, M.P. Abernathy, R.A. Hites, and R.M. Bigsby Polybrominated diphenyl ethers in maternal and fetal blood samples Environ Health Perspect 111 9 2003 1249 1252
114. M.K. So, N. Yamashita, S. Taniyasu, Q. Jiang, J.P. Giesy, and K. Chen Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan China Environ Sci Technol 40 9 2006 2924 2929
115. K. Inoue, F. Okada, R. Ito, S. Kato, S. Sasaki, and S. Nakajima Perfluorooctane sulfonate (pfos) and related perfluorinated compounds in human maternal and cord blood samples: assessment of pfos exposure in a susceptible population during pregnancy Environ Health Perspect 112 11 2004 1204 1207
116. G. Latini, C. De Felice, G. Presta, A. Del Vecchio, I. Paris, and F. Ruggieri In utero exposure to di-(2-ethylhexyl)phthalate and duration of human pregnancy Environ. Health Perspect 111 14 2003 1783 1785
117. A. Burdorf, T. Brand, V.W. Jaddoe, A. Hofman, J.P. Mackenbach, and E.A.P. Steegers The effects of work-related maternal risk factors on time to pregnancy, preterm birth and birth weight: the Generation R Study Occup Environ Med 68 3 2011 197 204
118. C.A. Snijder, N. Roeleveld, E. te Velde, E.A.P. Steegers, H. Raat, and A. Hofman Occupational exposure to chemicals and fetal growth: the Generation R Study Hum Reprod 27 3 2012 910 920
119. D.A. Savitz, C.R. Stein, S.M. Bartell, B. Elston, J. Gong, and H.-M. Shin Perfluorooctanoic acid exposure and pregnancy outcome in a highly exposed community Epidemiology 23 3 2012 386 392
120. K. Wu, X. Xu, L. Peng, J. Liu, Y. Guo, and X. Huo Association between maternal exposure to perfluorooctanoic acid (PFOA) from electronic waste recycling and neonatal health outcomes Environ Int 48 2012 1 8