Fetal and neonatal endocrine disruptors

JCRPE Journal of Clinical Research in Pediatric Endocrinology

Volumn 4, Issue 2, 2012, Pages 51-60

  Ünüvar, Tolga ^a   Büyükgebiz, Atilla ^b  

^a Training and Research Hospital   (Turkey)

^b ISTANBUL BILIM UNIVERSITY   (Turkey)

Author keywords

Endocrine disruptors; Fetal; Neonatal

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CHLORPHENOTANE; DIETHYLSTILBESTROL; ENDOCRINE DISRUPTOR; MERCURY; ORGANOPHOSPHATE PESTICIDE; PERFLUORO COMPOUND; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID DIBUTYL ESTER; PHYTOESTROGEN; POLYBROMINATED DIOXIN; POLYBROMINATED DIPHENYL ETHER; POLYBROMINATED FURAN; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIOXIN; POLYCHLORINATED FURAN; POLYCHLORINATED NAPHTHALENE; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG; VINCLOZOLIN;

BREAST DEVELOPMENT; DELAYED PUBERTY; FETUS DEVELOPMENT; GROWTH RETARDATION; HUMAN; HYPOSPADIAS; IMMUNITY; LOW BIRTH WEIGHT; MECONIUM; MENTAL DEFICIENCY; NERVOUS SYSTEM DEVELOPMENT; OVARY POLYCYSTIC DISEASE; PLACENTA; PRECOCIOUS PUBERTY; REVIEW; TH2 CELL;

ENDOCRINE DISRUPTORS; FEMALE; FETAL DEVELOPMENT; FETUS; HUMANS; INFANT, NEWBORN; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; PREGNANCY; UROGENITAL SYSTEM;

EID: 84862904639     PISSN: 13085727     EISSN: 13085735     Source Type: Journal    
DOI: 10.4274/Jcrpe.569     Document Type: Review

References (75)

1. Wang MH, Baskin LS. Endocrine disruptors, genital development, and hypospadias. J Androl 2008;29:499-505.
2. Lee MM. Endocrine Disrupters. A Current Review of Pediatric Endocrinology 2007;109-118.
3. Phillips KP, Foster WG. Key developments in endocrine disrupter research and human health. J Toxicol Environ Health B Crit Rev 2008;11:322-344.
4. Suk WA, Murray K, Avakian MD. Environmental hazards to children's health in the modern world. Mutat Res 2003;544:235-242.
5. Abaci A, Demir K, Bober E, Buyukgebiz A. Endocrine disrupters-with special emphasis on sexual development. Pediatr Endocrinol Rev 2009;6:464-475.
6. Foster WG, Agzarian J. Toward less confusing terminology in endocrine disruptor research. J Toxicol Environ Health B Crit Rev 2008;11:152-161.
7. Whaley DA, Keyes D, Khorrami B. Incorporation of endocrine disruption into chemical hazard scoring for pollution prevention and current list of endocrine disrupting chemicals. Drug Chem Toxicol 2001;24:359-420.
8. Crinnion WJ. Maternal levels of xenobiotics that affect fetal development and childhood health. Altern Med Rev 2009;14:212-222.
9. Bruckner JV. Differences in sensitivity of children and adults to chemical toxicity: the NAS panel report. Regul Toxicol Pharmacol 2000;31:280-285.
10. Barker DJ. The developmental origins of adult disease. Eur J Epidemiol 2003;18:733-736.
11. Su PH, Chen JY, Chen JW, Wang SL. Growth and thyroid function in children with in utero exposure to dioxin: a 5-year follow-up study. Pediatr Res 2010;67:205-210.
12. Leonardi-Bee J, Smyth A, Britton J, Coleman T. Environmental tobacco smoke and fetal health: systematic review and metaanalysis. Arch Dis Child Fetal Neonatal Ed 2008;93:351-361.
13. Choi H, Jedrychowski W, Spengler J, Camann DE, Whyatt RM, Rauh V, et al. International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth. Environ Health Perspect 2006;114:1744-1750.
14. Choi H, Rauh V, Garfinkel R, Tu Y, Perera FP. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of intrauterine growth restriction. Environ Health Perspect 2008;116:658-665.
15. Perera FP, Rauh V, Tsai WY, Kinney P, Camann D, Barr D, Bernert T, Garfinkel R, Tu YH, Diaz D, Dietrich J, Whyatt RM. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environ Health Perspect 2003;111:201-205.
16. Sherman JD. Chlorpyrifos (Dursban)-associated birth defects: report of four cases. Arch Environ Health 1996;51:5-8.
17. Dietert RR, Zelikoff JT. Early-life environment, developmental immunotoxicology, and the risk of pediatric allergic disease including asthma. Birth Defects Res B Dev Reprod Toxicol 2008;83:547-560.
18. Gogal RM, Jr., Holladay SD. Perinatal TCDD exposure and the adult onset of autoimmune disease. J Immunotoxicol 2008;5:413-418.
19. Hertz-Picciotto I, Park HY, Dostal M, Kocan A, Trnovec T, Sram R. Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development. Basic Clin Pharmacol Toxicol 2008;102:146-154.
20. Dallaire F, Dewailly E, Vézina C, Muckle G, Weber JP, Bruneau S, Ayotte P. Effect of prenatal exposure to polychlorinated biphenyls on incidence of acute respiratory infections in preschool Inuit children. Environ Health Perspect 2006;114:1301-1305.
21. Weisglas-Kuperus N, Patandin S, Berbers GA, Sas TC, Mulder PG, Sauer PJ, Hooijkaas H. Immunologic effects of background exposure to polychlorinated biphenyls and dioxins in Dutch preschool children. Environ Health Perspect 2000;108:1203-1207.
22. Davidson PW, Strain JJ, Myers GJ, Thurston SW, Bonham MP, Shamlaye CF, Stokes-Riner A, Wallace JM, Robson PJ, Duffy EM, Georger LA, Sloane-Reeves J, Cernichiari E, Canfield RL, Cox C, Huang LS, Janciuras J, Clarkson TW. Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy. Neurotoxicology 2008;29:767-775.
23. Jett DA, Kuhlmann AC, Farmer SJ, Guilarte TR. Age-dependent effects of developmental lead exposure on performance in the Morris water maze. Pharmacol Biochem Behav 1997;57:271-279.
24. Gomaa A, Hu H, Bellinger D, Schwartz J, Tsaih SW, Gonzalez-Cossio T, Schnaas L, Peterson K, Aro A, Hernandez-Avila M. Maternal bone lead as an independent risk factor for fetal neurotoxicity: a prospective study. Pediatrics 2002;110:110-118.
25. Jacobson SW, Fein GG, Jacobson JL, Schwartz PM, Dowler JK. The effect of intrauterine PCB exposure on visual recognition memory. Child Dev 1985;56:853-860.
26. Chen YC, Yu ML, Rogan WJ, Gladen BC, Hsu CC. A 6-year follow-up of behavior and activity disorders in the Taiwan Yucheng children. Am J Public Health 1994;84:415-421.
27. Young JG, Eskenazi B, Gladstone EA, Bradman A, Pedersen L, Johnson C, Barr DB, Furlong CE, Holland NT. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology 2005;26:199-209.
28. Jurewicz J, Hanke W. Prenatal and childhood exposure to pesticides and neurobehavioral development: review of epidemiological studies. Int J Occup Med Environ Health 2008;21:121-132.
29. Norgil DI, Main KM, Toppari J, Skakkebaek NE. Impact of exposure to endocrine disrupters in utero and in childhood on adult reproduction. Best Pract Res Clin Endocrinol Metab 2002;16:289-309.
30. Toppari J, Kaleva M, Virtanen HE. Trends in the incidence of cryptorchidism and hypospadias, and methodological limitations of registry-based data. Hum Reprod Update 2001;7:282-286.
31. Longnecker MP, Klebanoff MA, Brock JW, Zhou H, Gray KA, Needham LL, Wilcox AJ. Maternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring. Am J Epidemiol 2002;155:313-322.
32. Bhatia R, Shiau R, Petreas M, Weintraub JM, Farhang L, Eskenazi B. Organochlorine pesticides and male genital anomalies in the child health and development studies. Environ Health Perspect 2005;113:220-224.
33. Pierik FH, Burdorf A, Deddens JA, Juttmann RE, Weber RF. Maternal and paternal risk factors for cryptorchidism and hypospadias: a case-control study in newborn boys. Environ Health Perspect 2004;112:1570-1576.
34. Kakeyama M, Sone H, Miyabara Y, Tohyama C. Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters activitydependent expression of BDNF mRNA in the neocortex and male rat sexual behavior in adulthood. Neurotoxicology 2003;24:207-217.
35. Ikeda M, Mitsui T, Setani K, Tamura M, Kakeyama M, Sone H, Tohyama C, Tomita T. In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation. Toxicol Appl Pharmacol 2005;205:98-105.
36. Cao Y, Winneke G, Wilhelm M, Wittsiepe J, Lemm F, Fürst P, Ranft U, Imöhl M, Kraft M, Oesch-Bartlomowicz B, Krämer U. Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: results from the Duisburg cohort study. Int J Hyg Environ Health 2008;211:30-39.
37. Hsu PC, Lai TJ, Guo NW, Lambert GH, Leon Guo Y. Serum hormones in boys prenatally exposed to polychlorinated biphenyls and dibenzofurans. J Toxicol Environ Health A 2005;68:1447-1456.
38. Gonc N. Endokrin Bozucular. Katki{dotless} Pediatri Dergisi 2008;30:511-518.
39. Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, Zoeller RT, Gore AC. Endocrinedisrupting chemicals: an Endocrine Society scientific statement. Endocr Rev 2009;30:293-342.
40. Brown NM, Manzolillo PA, Zhang JX, Wang J, Lamartiniere CA. Prenatal TCDD and predisposition to
41. Fenton SE. Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequences. Endocrinology 2006;147:18-24.
42. Kakeyama M, Sone H, Tohyama C. Perinatal exposure of female rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces central precocious puberty in the offspring. J Endocrinol 2008;197:351-358.
43. vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA, Eriksen M, Farabollini F, Guillette LJ Jr, Hauser R, Heindel JJ, Ho SM, Hunt PA, Iguchi T, Jobling S, Kanno J, Keri RA, Knudsen KE, Laufer H, LeBlanc GA, Marcus M, McLachlan JA, Myers JP, Nadal A, Newbold RR, Olea N, Prins GS, Richter CA, Rubin BS, Sonnenschein C, Soto AM, Talsness CE, Vandenbergh JG, Vandenberg LN, Walser-Kuntz DR, Watson CS, Welshons WV, Wetherill Y, Zoeller RT. Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol 2007;24:131-138.
44. Vandenberg LN, Hauser R, Marcus M, Olea N, Welshons WV. Human exposure to bisphenol A (BPA). Reprod Toxicol 2007;24:139-177.
45. Calafat AM, Weuve J, Ye X, Jia LT, Hu H, Ringer S, Huttner K, Hauser R. Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants. Environ Health Perspect 2009;117:639-644.
46. Stahlhut RW, Welshons WV, Swan SH. Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both. Environ Health Perspect 2009;117:784-789.
47. Vandenberg LN, Maffini MV, Wadia PR, Sonnenschein C, Rubin BS, Soto AM. Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland. Endocrinology 2007;148:116-127.
48. Vandenberg LN, Maffini MV, Schaeberle CM, Ucci AA, Sonnenschein C, Rubin BS, Soto AM. Perinatal exposure to the xenoestrogen bisphenol-A induces mammary intraductal hyperplasias in adult CD-1 mice. Reprod Toxicol 2008;26:210-219.
49. Jenkins S, Raghuraman N, Eltoum I, Carpenter M, Russo J, Lamartiniere CA. Oral exposure to bisphenol a increases dimethylbenzanthracene-induced mammary cancer in rats. Environ Health Perspect 2009;117:910-915.
50. Yang CY, Yu ML, Guo HR, Lai TJ, Hsu CC, Lambert G, Guo YL. The endocrine and reproductive function of the female Yucheng adolescents prenatally exposed to PCBs/PCDFs. Chemosphere 2005;61:355-360.
51. Zhang Y, Lin L, Cao Y, Chen B, Zheng L, Ge RS. Phthalate levels and low birth weight: a nested case-control study of Chinese newborns. J Pediatr 2009;155:500-544.
52. Newbold R. Cellular and molecular effects of developmental exposure to diethylstilbestrol: implications for other environmental estrogens. Environ Health Perspect 1995;103:83-87.
53. Boas M, Main KM, Feldt-Rasmussen U. Environmental chemicals and thyroid function: an update. Curr Opin Endocrinol Diabetes Obes 2009;16:385-391.
54. Chevrier J, Eskenazi B, Bradman A, Fenster L, Barr DB. Associations between prenatal exposure to polychlorinated biphenyls and neonatal thyroid-stimulating hormone levels in a Mexican-American population, Salinas Valley, California. Environ Health Perspect 2007;115:1490-1496.
55. Meerts IA, Assink Y, Cenijn PH, Van Den Berg JH, Weijers BM, Bergman A, Koeman JH, Brouwer A. Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. Toxicol Sci 2002;68:361-371.
56. Crofton KM, Kodavanti PR, Yellin EC, Casey AC, Kehn LS. PCBs, thyroid hormones, and ototoxicity in rats: crossfostering experiments demonstrate the impact of postnatal lactation exposure. Toxicol Sci 2000;57:131-140.
57. Darnerud PO, Morse D, Klasson-Wehler E, Brouwer A. Binding of a 3,3', 4,4'-tetrachlorobiphenyl (CB-77) metabolite to fetal transthyretin and effects on fetal thyroid hormone levels in mice. Toxicology 1996;106:105-114.
58. Langer P, Tajtáková M, Kocan A, Petrík J, Koska J, Ksinantová L, Rádiková Z, Ukropec J, Imrich R, Hucková M, Chovancová J, Drobná B, Jursa S, Vlcek M, Bergman A, Athanasiadou M, Hovander L, Shishiba Y, Trnovec T, Seböková E, Klimes I. Thyroid ultrasound volume, structure and function after long-term high exposure of large population to polychlorinated biphenyls, pesticides and dioxin. Chemosphere 2007;69:118-127.
59. Schell LM, Gallo MV, Ravenscroft J, DeCaprio AP. Persistent organic pollutants and anti-thyroid peroxidase levels in Akwesasne Mohawk young adults. Environ Res 2009;109:86-92.
60. Koopman-Esseboom C, Morse DC, Weisglas-Kuperus N, Lutkeschipholt IJ, Van der Paauw CG, Tuinstra LG, Brouwer A, Sauer PJ. Effects of dioxins and polychlorinated biphenyls on thyroid hormone status of pregnant women and their infants. Pediatr Res 1994;36:468-473.
61. Nishimura N, Yonemoto J, Miyabara Y, Sato M, Tohyama C. Rat thyroid hyperplasia induced by gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Endocrinology 2003;144:2075-2083.
62. Zhou T, Taylor MM, DeVito MJ, Crofton KM. Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption. Toxicol Sci 2002;66:105-116.
63. Kuriyama SN, Wanner A, Fidalgo-Neto AA, Talsness CE, Koerner W, Chahoud I. Developmental exposure to low-dose PBDE-99: tissue distribution and thyroid hormone levels. Toxicology 2007;242:80-90.
64. Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Barbee BD, Richards JH, Butenhoff JL, Stevenson LA, Lau C. Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations. Toxicol Sci 2003;74:369-781.
65. Lau C, Thibodeaux JR, Hanson RG, Rogers JM, Grey BE, Stanton ME, Butenhoff JL, Stevenson LA. Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. II: postnatal evaluation. Toxicol Sci 2003;74:382-392.
66. Chang SC, Thibodeaux JR, Eastvold ML, Ehresman DJ, Bjork JA, Froehlich JW, Lau C, Singh RJ, Wallace KB, Butenhoff JL. Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS). Toxicology 2008;243:330-339.
67. O'Connor JC, Frame SR, Ladics GS. Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens. Toxicol Sci 2002;69:92-108.
68. Howarth JA, Price SC, Dobrota M, Kentish PA, Hinton RH. Effects on male rats of di-(2-ethylhexyl) phthalate and di-nhexylphthalate administered alone or in combination. Toxicol Lett 2001;12:35-43.
69. Huang PC, Kuo PL, Guo YL, Liao PC, Lee CC. Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Hum Reprod 2007;22:2715-2722.
70. Zoeller RT, Bansal R, Parris C. Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain. Endocrinology 2005;146:607-612.
71. Xu X, Liu Y, Sadamatsu M, Tsutsumi S, Akaike M, Ushijima H, Kato N. Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Neurosci Res 2007;58:149-155.
72. Smink A, Ribas-Fito N, Garcia R, Torrent M, Mendez MA, Grimalt JO, et al. Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years. Acta Paediatr 2008;97:1465-1469.
73. Bay K, Asklund C, Skakkebaek NE, Andersson AM. Testicular dysgenesis syndrome: possible role of endocrine disrupters. Best Pract Res Clin Endocrinol Metab 2006;20:77-90.
74. Cao Y, Calafat AM, Doerge DR, Umbach DM, Bernbaum JC, Twaddle NC, Ye X, Rogan WJ. Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula. J Expo Sci Environ Epidemiol 2009;19:223-234.
75. Divi RL, Chang HC, Doerge DR. Anti-thyroid isoflavones from soybean: isolation, characterization, and mechanisms of action. Biochem Pharmacol 1997;54:1087-1096.