Prenatal exposure to phthalate esters and PAHs and birth outcomes

Environment International

Volumn 36, Issue 7, 2010, Pages 699-704

  Suzuki, Yayoi ^a   Niwa, Mayu ^a   Yoshinaga, Jun ^a   Mizumoto, Yoshifumi ^b   Serizawa, Shigeko ^c   Shiraishi, Hiroaki ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b Department of Obstetrics and Gynecology   (Japan)

^c NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

Author keywords

Birth size; Gestational age; Phthalate esters; Polycyclic aromatic hydrocarbons; Prenatal exposure; Urinary metabolites

Indexed keywords

AROMATIC HYDROCARBONS; BIOMOLECULES; METABOLITES; POLYCYCLIC AROMATIC HYDROCARBONS; REGRESSION ANALYSIS;

BIRTH SIZE; GESTATIONAL AGE; PHTHALATE ESTER; PRENATAL EXPOSURE; URINARY METABOLITES;

ESTERS;

1 HYDROXYPYRENE; CREATININE; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BENZYL BUTYL ESTER; PHTHALIC ACID ESTER; POLYCYCLIC AROMATIC HYDROCARBON; 1-HYDROXYPYRENE; PHTHALIC ACID DERIVATIVE; POLLUTANT; PYRENE DERIVATIVE;

METABOLITE; PAH; PHTHALATE; POLLUTION EXPOSURE; PREGNANCY; URINE;

ADULT; ARTICLE; BIRTH WEIGHT; BODY HEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; HEAD CIRCUMFERENCE; HUMAN; JAPANESE; NEWBORN; NORMAL HUMAN; PREGNANCY; PREGNANCY OUTCOME; PRENATAL EXPOSURE; PRIORITY JOURNAL; URINALYSIS; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; MALE; METABOLISM; POLLUTANT; REGRESSION ANALYSIS; STATISTICS AND NUMERICAL DATA; TOXICITY; URINE;

JAPAN;

ADULT; BIRTH WEIGHT; BODY HEIGHT; ENVIRONMENTAL POLLUTANTS; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; MALE; MATERNAL EXPOSURE; PHTHALIC ACIDS; POLYCYCLIC HYDROCARBONS, AROMATIC; PREGNANCY; PYRENES; REGRESSION ANALYSIS;

EID: 77954537533     PISSN: 01604120     EISSN: 18736750     Source Type: Journal    
DOI: 10.1016/j.envint.2010.05.003     Document Type: Article

References (31)

1. Adibi J.J., Hauser R., Williams P.L., Whyatt R.M., Calafat A.M., Nelson H., et al. Maternal urinary metabolites of Di-(2-Ethylhexyl) phthalate in relation to the timing of labor in a US multicenter pregnancy cohort study. Am J Epidemiol 2009, 169:1015-1024.
2. Plastics Data Book 1999, Asahikasei amidas and editorial offices of "Plastics", Kogyo chosakai Publishing, in Japanese.
3. Centers for Disease Control and Prevention (CDC), United States. Fourth National Report on Human Exposure to Environmental Chemicals. (December 2009 ). http://www.cdc.gov/exposurereport/.
4. Chetiyanukornkul T., Toriba A., Kizu R., Makino T., Nakazawa H., Hayakaw K. Determination of 1-hydroxypyrene in human urine by high-performance liquid chromatography with fluorescence detection using a deuterated internal standard. J Chromatogr A 2002, 961:107-112.
5. David R.M. Exposure to phthalates. Environ Health Perspect 2000, 108:A440.
6. Davison J.M., Dunlop W., Ezimokhai M. 24-hour creatinine clearance during the third trimester of normal pregnancy. Br J Obstet Gynaecol 1980, 87:106-109.
7. Dejmek J., Solansky I., Benes I., Lenicek J., Sram R.J. The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome. Environ Health Perspect 2000, 108:1159-1164.
8. Hauser R., Meeker J.D., Park S., Silva M.J., Calafat A.M. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ Health Perspect 2004, 112:1734-1740.
9. Högberg J., Hanberg A., Berglund M., Skerfving S., Remberger M., Calafat A.M., et al. Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations. Environ Health Perspect 2008, 116:334-339.
10. Hoppin J.A., Brock J.W., Davis B.J., Baird D.D. Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ Health Perspect 2002, 110:515-518.
11. International programme on chemical safety (IPCS). 2006. Principles for evaluating health risks in children associated with exposure to chemicals (Environmental health criteria; 237).
12. Jacob J., Seidel A. Biomonitoring of polycyclic aromatic hydrocarbons in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2002, 778:31-47.
13. Japanese Ministry of Health, Labor and Welfare. 2010. Population survey report [in Japanese]. Available: [accessed 13 Mar 2010]. http://www.e-stat.go.jp/SG1/estat/eStatTopPortal.do.
14. Koch H.M., Drexler H., Angerer J. An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population. Int J Hyg Environ Health 2003, 206:77-83.
15. Latini G., De Felice C., Presta G., Del Vecchio A., Paris I., Ruggieri F., et al. In utero exposure to di-(2-ethylhexyl) phthalate and duration of human pregnancy. Environ Health Perspect 2003, 111:1783-1785.
16. Lau C., Rogers J.M. Embryonic and fetal programming of physiological disorders in adulthood. Birth Defects Res C Embryo Today 2004, 72:300-312.
17. Li Z., Sandau C.D., Romanoff L.C., Caudill S.P., Sjodin A., Needham L.L., et al. Concentration and profile of 22 urinary polycyclic aromatic hydrocarbon metabolites in the US population. Environ Res 2008, 107:320-331.
18. Lyche Jan L., Gutleb Arno C., Bergman Ake, et al. Reproductive and developmental toxicity of phthalates. J Toxicol Environ Health B 2009, 12:225-249.
19. Meeker J.D., Hu H., Cantonwine D.E., Lamadrid-Figueroa H., Calafat A.M., Ettinger A.S., et al. Urinary phthalate metabolites in relation to preterm birth in Mexico city. Environ Health Perspect 2009, 117:1587-1592.
20. Niwa M, Suzuki Y, Yoshinaga J, Watanabe C, Mizumoto Y. unpublished. Biological monitoring of prenatal PAHs exposure by metabolite analysis of maternal urine during pregnancy.
21. Perera F.P., Rauh V., Tsai W.Y., Kinney P., Camann D., Barr D., et al. Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population. Environ Health Perspect 2003, 111:201-205.
22. Phillips D.H. Polycyclic aromatic hydrocarbons in the diet. Mutat Res 1999, 443:139-147.
23. Shenkin S.D., Starr J.M., Deary I.J. Birth weight and cognitive ability in childhood: a systematic review. Phychological Bulletin 2004, 130:989-1013.
24. Suzuki K., Yoshinaga J. Inhalation and dietary exposure to polycyclic aromatic hydrocarbons and urinary 1-hydroxypyrene in non-smoking university students. Int Arch Occup Environ Health 2007, 81:115-121.
25. Suzuki Y., Niwa M., Yoshinaga J., Watanabe C., Mizumoto Y., Serizawa S., et al. Exposure assessment of phthalate esters in Japanese pregnant women by using urinary metabolite analysis. Environ Health Prev Med 2009, 14:180-187.
26. Teitelbaum S.L., Britton J.A., Calafat A.M., Ye X., Silva M.J., Reidy J.A., et al. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res 2008, 106:257-269.
27. Tyl R.W., Price C.J., Marr M.C., Kimmel C.A. Developmental toxicity evaluation of dietary di(2-ethylhexyl)phthalate in Fischer 344 rats and CD-1 mice. Fundam Appl Toxicol 1988, 10:395-412.
28. Van Rooij J.G., Veeger M.M., Bodelier-Bade M.M., Scheepers P.T., Jongeneelen F.J. Smoking and dietary intake of polycyclic aromatic hydrocarbons as sources of interindividual variability in the baseline excretion of 1-hydroxypyrene in urine. Int Arch Occup Environ Health 1994, 66:55-65.
29. Wine R.N., Li L.H., Barnes L.H., Gulati D.K., Chapin R.E. Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats. Environ Health Perspect 1997, 105:102-107.
30. Wolff M.S., Engel S.M., Berkowitz G.S., Ye X., Silva M.J., Zhu C., et al. Prenatal phenol and phthalate exposures and birth outcomes. Environ Health Perspect 2008, 116:1092-1097.
31. Zhang Y., Lin L., Cao Y., Chen B., Zheng L., Ge R.S. Phthalate levels and low birth weight: a nested case-control study of Chinese newborns. J Pediatr 2009, 155:500-504.