Differential processing of neuropeptide proprotein in human breast adenocarcinoma

Journal of Endocrinological Investigation

Volumn 36, Issue 9, 2013, Pages 745-752

  Zhang, J H ^b   Zhou, D ^c   You, J ^a   Tang, B S ^d   Li, P Y ^a   Tang, S S ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b GUANGZHOU MEDICAL UNIVERSITY   (China)

^c GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

GHRH; Human breast adenocarcinoma; Neuropeptide proprotein processing; Neuropeptide Y; Proprotein convertase

Indexed keywords

CARBOXYPEPTIDASE H; GROWTH HORMONE RELEASING FACTOR; NEUROPEPTIDE; NEUROPEPTIDE Y; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; PROTEIN PRECURSOR;

ADULT; ARTICLE; BREAST ADENOCARCINOMA; CANCER PATIENT; CANCER TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; PROTEIN DETERMINATION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE LEVEL; UPREGULATION;

ADENOCARCINOMA; ADULT; BREAST NEOPLASMS; CARBOXYPEPTIDASE H; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; PROPROTEIN CONVERTASES; PROTEIN PRECURSORS;

EID: 84887184280     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.3275/8935     Document Type: Article

References (30)

1. Posner SF, Vaslet CA, Jurofcik M, Lee A, Seidah NG, Nillni EA. Stepwise posttranslational processing of progrowth hormone-releasing hormone (proGHRH) polypeptide by furin and PC1. Endocrine 2004, 23: 199-213.
2. Ling N, Esch F, Böhlen P, Brazeau P, Wehrenberg WB, Guillemin R. Isolation, primary structure and synthesis of human hypothalamic somatocrinin: Growth hormone-releasing factor. Proc Natl Acad Sci 1984, 81: 4302-6.
3. Zhu X, Zhou A, Dey A, et al. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci 2002, 99: 10293-8.
4. Refaie S, Gagnon S, Gagnon H, et al. Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. J Biol Chem 2012, 287: 14703-17.
5. O'Hare MMT, Schwartz TW. Expression and precursor processing of neuropeptide Y in human pheochromocytoma and neuroblastoma tumors. Cancer Res 1989, 49: 7010-14.
6. Guillemot J, Thouënnon E, Guérin M, et al. Differential expression and processing of secretogranin II in relation to the status of pheochromocytoma: implications for the production of the tumoral marker EM66. J Mol Endocrinol 2012, 48: 115-27.
7. Stridsberg M, Eriksson B, Janson ET. Measurements of secretogranins II, III, V and proconvertases 1/3 and 2 in plasma from patients with neuroendocrine tumours. Regul Pept 2008, 148: 95-8.
8. Dhanvantari S, Arnaoutova I, Snell CR, et al. Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion. Biochemistry 2002, 41: 52-60.
9. Boudarine M, Yegorov O, Sterling-Dubrovsky A, Devi LA, Berman Y. Developmental changes in opioid peptides and their receptorsin Cpe(fat)/Cpe(fat) mice lacking peptide processing enzyme carboxypeptidase E. J Pharmacol Exp Ther 2002, 303: 1317-24.
10. Cawley NX, Yanik T, Woronowicz A, Chang W, Marini JC, Loh YP. Obese carboxypeptidase E knockout mice exhibit multiple defects in peptide hormone processing contributing to low bone mineral density. Am J Physiol Endocrinol Metab 2010, 299: E189-97.
11. Woronowicz A, Koshimizu H, Chang SY, et al. Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. Hippocampus 2008, 18: 1051-63.
12. Chu KY, Briggs MJ, Albrecht T, Drain PF, Johnson JD. Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells. Islets 2011, 3: 155-65.
13. Lee TK, Murthy SR, Cawley NX, et al. An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. J Clin Invest 2011, 121: 880-92.
14. Helwig M, Herwig A, Heldmaier G, Barrett P, Mercer JG, Klingenspor M. Photoperiod-dependent regulation of carboxypeptidase E affects selective processing of neuropeptides in the seasonal Siberian hamster (Phodopus sungorus). J Neuroendocrinol 2013, 25: 190-7.
15. Cawley NX, Wetsel WC, Murthy SR, Park JJ, Pacak K, Loh YP. New roles of carboxypeptidase E in endocrine and neural function and cancer. Endocr Rev 2012, 33: 216-53.
16. Seidah NG, Chretien M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res 1999, 848: 45-62.
17. Lim KC, Tyler CM, Lim ST, Giuliano R, Federoff HJ. Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. Biochem Biophys Res Commun 2007, 361: 599-604.
18. Iwai N, Martínez A, Miller MJ, Vos M, Mulshine JL, Treston AM. Autocrine growth loops dependent on peptidyl alpha-amidating enzyme as targets for novel tumor cell growth inhibitors. Lung Cancer 1999, 23: 209-22.
19. Ruscica M, Dozio E, Motta M, Magni P. Relevance of the neuropeptide Y system in the biology of cancer progression. Curr Top Med Chem 2007, 7: 1682-91.
20. Cyr NE, Stuart RC, Zhu X, Steiner DF, Nillni EA. Biosynthesis of proTRH-derived peptides in prohormone convertase 1 and 2 knockout mice. Peptides 2012, 35: 42-8.
21. Whalley NM, Pritchard LE, Smith DM, White A. Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells? J Endocrinol 2011, 211: 99-106.
22. Raverot G, Wierinckx A, Jouanneau E, et al. Clinical, hormonal and molecular characterization of pituitary ACTH adenomas without (silent corticotroph adenomas) and with Cushing's disease. Eur J Endocrinol 2010, 163: 35-43.
23. Mousa SA, Krajnik M, Sobanski P, et al. Dynorphin expression, processing and receptors in the alveolar macrophages, cancer cells and bronchial epithelium of lung cancer patients. Histol Histopathol 2010, 25: 755-64.
24. Blanchard A, Iwasiow B, Yarmill A, et al. Targeted production of proprotein convertase PC1 enhances mammary development and tumorigenesis in transgenic mice. Can J Physiol Pharmacol 2009, 87: 831-8.
25. Tang SS, Zhang JH, Liu HX, Li HZ. PC2/CPE - Mediated Pro-protein Processing in tumor cells and its differentiated cells or tissues. Mol Cell Endocrinol 2009, 303: 43-9.
26. Fortenberry Y, Hwang JR, Apletalina EV, Lindberg I. Functional characterization of ProSAAS: similarities and differences with 7B2. J Biol Chem 2002, 277: 5175-86.
27. Tang SS, Zhang JH, Liu HX, Zhou D, Qi R. Pro-protein convertase-2/ carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia. Neurosci Bull 2009, 25: 7-14.
28. Scopsi L, Gullo M, Rilke F, Martin S, Steiner DF. Proprotein convertases PC1/PC3 and PC2 in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation. J Clin Endocrinol Metab 1995, 80: 294-301.
29. Siegfried G, Basak A, Cromlish JA, et al. The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. J Clin Invest 2003, 111: 1723-32.
30. Tzimas GN, Chevet E, Jenna S, et al. Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases. BMC Cancer 2005, 5: 149.