Anion-induced water flux as drug release mechanism through cationic Eudragit RS 30D film coatings

AAPS Journal

Volumn 7, Issue 3, 2005, Pages

  Wagner, Karl G ^a   Gruetzmann, Ronny ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Eudragit; Ion exchange; Plasticizer leaching; Water uptake

Indexed keywords

ACETIC ACID; CHLORIDE ION; EUDRAGIT; SODIUM NITRATE; SODIUM SULFATE; SUCCINIC ACID; THEOPHYLLINE; WATER; ACRYLIC ACID RESIN; ANION; EUDRAGIT RS; POLYMER;

ANION EXCHANGE; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; FILM COATING; ION PAIR CHROMATOGRAPHY; LEACHING; WATER CONTENT; WATER TRANSPORT; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; ENTERIC COATED TABLET; METABOLISM;

ACRYLIC RESINS; ANIONS; DELAYED-ACTION PREPARATIONS; POLYMERS; TABLETS, ENTERIC-COATED; WATER;

EID: 33646640825     PISSN: 15221059     EISSN: 15221059     Source Type: Journal    
DOI: 10.1208/aapsj070367     Document Type: Article

References (16)

1. Sutter B, Lippold BH, Lippold BC. Polymerfilme als Diffusionsbarrieren für perorale Retardarzneiformen unter besonderer Berücksichtigung wässriger Dispersionen. Acta Pharm Technol. 1988;34:179-188.
2. Lippold BH, Sutter B, Lippold BC. Parameters controlling drug release from pellets coated with aqueous ethyl cellulose dispersions. Int J Pharm. 1989;54:15-25.
3. Bindschaedler C, Gurny R, Doelker E. Osmotic water transport through cellulose acetate membranes produced from a latex system. J Pharm Sci. 1987;76:455-460.
4. Lippold BC, Lippold BH, Lichey JF. Drug transport through lipophilic membranes. 3rd Comm.: Relationship between diffusion rates of drugs through membranes and their properties. Pharm Ind. 1981;47:1195-1201.
5. Bodmeier R, Guo X, Sarabia RE, Skultety PF. The influence of buffer species and strength on Diltiazem HCl release from beads coated with the aqueous cationic polymer dispersions, Eudragit RS, RL 3OD. Pharm Res. 1996;13:52-56.
6. Narisawa S, Minako M, Hirakawa Y, Kobayashi M, Yoshino H. An organic acid-induced sigmoidal release system for oral controlled-release preparations. 2. Permeability enhancement of Eudragit RS coating led by physicochemical interactions with organic acid. J Pharm Sci. 1996;85:184-188.
7. Beckert TE, Lynenskjold E, Petereit HU. Anionic influence on the permeability of Eudragit RS. Proc Int Symp Controlled Release Bioact Mater. 1997;24:1031.
8. Knop K. Influence of buffer solution composition on drug release from pellets coated with neutral and quarternary acrylic polymers and on swelling of free polymer films. Eur J Pharm Sci. 1996;4:293-300.
9. Wagner KG, McGinity JW. Influence of chloride ion exchange on the permeability and drug release of Eudragit RS 30 D films. J Control Release. 2002;82:385-397.
10. Gruetzmann R, Wagner KG. Quantification of the leaching of triethyl citrate/polysorbate 80 mixtures from Eudragit RS films by differential scanning calorimetry. Eur J Pharm Biopharm. 2005;60:159-162.
11. Falkenhagen H, Kelbg G, Schmutzer E. Elektrische Leitfahigkeiten wässriger Lösungen. In: Hellwege KH, Hellwege AM, Schafer K, Lax E, eds. Landolt-Börnstein Zahlenwerte und Funktionen aus Physik, Chemie, Astronomie, Geophysik und Technik 2, Band - Eigenschaften der Materie in ihren Aggregatzuständen vol. 7. Teil Elektrische Eigenschaften II(Elektrochemische Systems). Berlin: Springer Verlag; 1960:260-267.
12. Dorfner K. Ion Exchangers. New York: de Gruyter; 1991:70, 341.
13. Lippold BH, Sutter B, Lippold BC. Parameters controlling drug release from pellets coated with aqueous ethyl cellulose dispersion. Int J Pharm. 1989;54-15-25.
14. Lippold BC, Gunder W, Lippold BH. Drug release from diffusion pellets coated with the aqueous ethyl cellulose dispersion aquacoat ® ECD-30 and 20% dibutyl sebactate as plasticizer: partition mechanism and pore diffusion. Eur J Pharm Biopharm. 1999;47:27-32.
15. Amighi K, Moës A. Influence of plasticizer concentration and storage conditions on the drug release rate from Eudragit RS30D filmcoated sustained-release theophylline pellets. Eur J Pharm Biopharm. 1996;42:29-35.
16. Lieb S, Szeimies RM, Lee G. Self adhesive thin films fort he topical delivery of 5-aminolevulinic acid. Eur J Pharm Biopharm. 2002;53:99-106.