Decreased mRNA and protein expression of BDNF, NGF, and their receptors in the hippocampus from suicide: An analysis in human postmortem brain

Clinical Medicine Insights: Pathology

Volumn , Issue 6, 2013, Pages 1-11

  Banerjee, Ritabrata ^a   Ghosh, Anup K ^b   Ghosh, Balaram ^c   Bhattacharyya, Somnath ^d   Mondal, Amal C ^a  

^a UNIVERSITY OF CALCUTTA   (India)

^b JADAVPUR UNIVERSITY   (India)

^c MEDICAL COLLEGE AND HOSPITAL   (India)

^d BIDHAN CHANDRA KRISHI VISWAVIDYALAYA   (India)

Author keywords

Brain derived neurotrophic factor; ELISA; Hippocampus; Nerve growth factor; Postmortem brain; RT PCR; Suicide; TrkaA; TrkB

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR; MESSENGER RNA; NERVE GROWTH FACTOR RECEPTOR;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC EVALUATION AFTER DEATH; DISEASE ASSOCIATION; DSM-IV; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NERVE CELL PLASTICITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SUICIDAL BEHAVIOR; SUICIDE;

EID: 84887164319     PISSN: 11795557     EISSN: None     Source Type: Journal    
DOI: 10.4137/CPath.S12530     Document Type: Article

References (48)

1. Westrin A. Stress system alterations and mood disorders in suicidal patients. A review. Biomed Pharmacother. 2000;54(3):142-5.
2. Banerjee R, Ghosh AK, Ghosh B, Bhattacharya S, Mondal AC. Reduced expression profile of neurotrophins and their cognitive receptors in the hippocampal region of postmortem suicidal brain. Nerve. 2012;1(1):13-7.
3. McAllister AK. Neurotrophins and neuronal differentiation in the central nervous system. Cell Mol Life Sci. 2001;58(8):1054-60.
4. Thoenen H. Neurotrophins and activity-dependent plasticity. Prog Brain Res. 2000;128:183-91.
5. Huang EJ, Reichardt LF. Neurotrophins: Roles in neuronal development and function. Annu Rev Neurosci. 2001;24:677-736.
6. Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. Genes Dev. 2000;14(23):2919-37.
7. Tyler WJ, Alonso M, Bramham CR, Pozzo-Miller LD. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampaldependent learning. Learn Mem. 2002;9(5):224-37.
8. Yamada K, Mizuno M, Nabeshima T. Role for brain-derived neurotrophic factor in learning and memory. Life Sci. 2002;70(7):735-44.
9. Bolaños CA, Nestler EJ. Neurotrophic mechanisms in drug addiction. Neuromolecular Med. 2004;5(1):69-83.
10. Berton O, McClung CA, Dileone RJ, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science. 2006;311(5762):864-8.
11. Tsankova NM, Berton O, Renthal W, Kumar A, Neve RL, Nestler EJ. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci. 2006;9(4):519-25.
12. Post RM. Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications. J Psychiatr Res. 2007;41(12):979-90.
13. Fiore M, Chaldakov GN, Aloe L. Nerve growth factor as a signaling molecule for nerve cells and also for the neuroendocrine-immune systems. Rev Neurosci. 2009;20(2):133-45.
14. Purves D, Augustine G, Fitzpatrick D, et al. Neuroscience, 5th ed. Sunderland, MA: Sinauer; 2004:72-173,600-6.
15. Smith MA, Makino S, Kvetnansky R, Post RM. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. J Neurosci. 1995;15(3 Pt 1): 1768-77.
16. Ueyama T, Kawai Y, Nemoto K, Sekimoto M, Toné S, Senba E. Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain. Neurosci Res. 1997;28(2):103-10.
17. Vaidya VA, Terwilliger RM, Duman RS. Role of 5-HT2A receptors in the stress-induced down-regulation of brain-derived neurotrophic factor expression in rat hippocampus. Neurosci Lett. 1999;262(1):1-4.
18. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry. 2003;60(8):804-15.
19. Dwivedi Y, Rizavi HS, Zhang H, et al. Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide. Biol Psychiatry. 2009;65(4):319-28.
20. Dwivedi Y, Pandey GN. What can post-mortem studies tell us about the pathoetiology of suicide? Future Neurol. 2010;5(5):701-20.
21. von Richthofen S, Lang UE, Hellweg R. Effects of different kinds of acute stress on nerve growth factor content in rat brain. Brain Res. 2003;987(2):207-13.
22. Ueyama T, Kawai Y, Nemoto K, Sekimoto M, Toné S, Senba E. Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain. Neurosci Res. 1997;28(2):103-10.
23. Chen B, Dowlatshahi D, MacQueen GM, Wang JF, Young LT. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry. 2001;50(4):260-5.
24. Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci. 1995;15(11):7539-47.
25. Duman RS, Vaidya VA. Molecular and cellular actions of chronic electroconvulsive seizures. J ECT. 1998;14(3):181-93.
26. McGeary JE, Gurel V, Knopik VS, Spaulding J, McMichael J. Effects of nerve growth factor (NGF), fluoxetine, and amitriptyline on gene expression profiles in rat brain. Neuropeptides. 2011;45(5):317-22.
27. Capsoni S, Covaceuszach S, Marinelli S, et al. Taking pain out of NGF: a "painless" NGF mutant, linked to hereditary sensory autonomic neuropathy type V, with full neurotrophic activity. PLoS One. 2011;6(2):e17321.
28. Hassanzadeh P, Rahimpour S. The cannabinergic system is implicated in the upregulation of central NGF protein by psychotropic drugs. Psychopharmacology (Berl). 2011;215(1):129-41.
29. Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Nuerobiol. 2000;10:381-91.
30. Reichardt LF. Neurotrophin-regulated signalling pathways. Phil Trans R Soc B, Biol Sci. 2006;361(1473):1545-64.
31. Kang H, Welcher AA, Shelton D, Schuman EM. Neurotrophins and time: different roles for TrkB signaling in hippocampal long-term potentiation. Neuron. 1997;19(3):653-64.
32. Conner KR, Conwell Y, Duberstein PR. The validity of proxy-based data in suicide research: a study of patients 50 years of age and older who attempted suicide. II. Life events, social support and suicidal behavior. Acta Psychiatr Scand. 2001;104(6):452-7.
33. Kelly TM, Mann JJ. Validity of DSM-III-R diagnosis by psychological autopsy: a comparison with clinician ante-mortem diagnosis. Acta Psychiatr Scand. 1996;94(5):337-43.
34. Salzman S, Endicott J, Clayton P, Winokur G. Diagnostic Evaluation After Death (DEAD). Rockville, MD, National Institute of Mental Health, Neuroscience Research Branch. 1983.
35. Deep-Soboslay A, Akil M, Martin CE, et al. Reliability of psychiatric diagnosis in postmortem research. Biol Psychiatry. 2005;57(1):96-101.
36. First MB, Spitzer RL, Miriam G, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P) New York: Biometrics Research, New York State Psychiatric Institute, Nov 2002.
37. Dwivedi Y. Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatr Dis Treat. 2009;5:433-49.
38. Dwivedi Y. Brain-derived neurotrophic factor and suicide pathogenesis. Ann Med. 2010;42(2):87-96.
39. Zetterström TS, Pei Q, Madhav TR, Coppell AL, Lewis L, Grahame-Smith DG. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain. Neuropharmacology. 1999;38(7):1063-73.
40. Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci. 2004;27(10):589-94.
41. Kim YK, Lee HP, Won SD, et al. Low plasma BDNF is associated with suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31(1):78-85.
42. Barbacid M. The Trk family of neurotrophin receptors. J Neurobiol. 1994;25(11):1386-403.
43. Dechant G, Rodríguez-Tébar A, Barde YA. Neurotrophin receptors. Prog Neurobiol. 1994;42(2):347-52.
44. Middlemas DS, Lindberg RA, Hunter T. trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol Cell Biol. 1991;11:143-53.
45. Hellweg R, Humpel C, Löwe A, Hörtnagl H. Moderate lesion of the rat cholinergic septohippocampal pathway increases hippocampal nerve growth factor synthesis: evidence for long-term compensatory changes? Brain Res Mol Brain Res. 1997;45(1):177-81.
46. Knipper M, de Penha Berzaghi M, Blöchl A, Breer H, Thoenen H, Lindholm D. Positive feedback between acetylcholine and the neurotrophins nerve growth factor and brain-derived neurotrophic factor in the rat hippocampus. Eur J Neurosci. 1994;6(4):668-71.
47. Scully JL, Otten U. Neurotrophin expression modulated by glucocorticoids and oestrogen in immortalized hippocampal neurons. Brain Res Mol Brain Res. 1995;31(1-2):158-64.
48. Hellweg R, von Richthofen S, Anders D, et al. The time course of nerve growth factor content in different neuropsychiatric diseases-a unifying hypothesis. J Neural Transm. 1998;105(8-9):871-903.