MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: A novel dual-acting μ- and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice

Neuropharmacology

Volumn 55, Issue 2, 2008, Pages 154-165

  Matsumoto, Kenjiro ^a   Takayama, Hiromitsu ^b   Narita, Minoru ^c   Nakamura, Atsushi ^c   Suzuki, Masami ^c   Suzuki, Tsutomu ^c   Murayama, Toshihiko ^b   Wongseripipatana, Sumphan ^d   Misawa, Kaori ^b   Kitajima, Mariko ^b   Tashima, Kimihito ^a   Horie, Syunji ^a  

^a JOSAI INTERNATIONAL UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c HOSHI UNIVERSITY   (Japan)

^d CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

Antinociception; Gastrointestinal transit; Kappa opioid receptor; Morphine; Mu opioid receptor; Rewarding effect

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; 5' GUANIDYL 17 (CYCLOPRORYLMETHYL) 6,7 DEHYDRO 4,5ALPHA EPOXY 3,14 DIHYDROXY 6,7 2',3' INDOLOMORPHINAN DIHYDROCHLORIDE; 7 HYDROXYMITRAGYNINE; BETA FUNALTREXAMINE; CYPRODIME; KAPPA OPIATE RECEPTOR AGONIST; METHYL 2 [3 ETHYL 7A,12A (EPOXYETHANOXY) 9 FLUORO 1,2,3,4,6,7,12,12B OCTAHYDRO 8 METHOXYINDOLO[2,3 A]QUINOLIZIN 2 YL] 3 METHOXYACRYLATE; MGM 9; MITRAGYNINE; MORPHINE; MU OPIATE RECEPTOR AGONIST; N METHYL N [7 (1 PYRROLIDINYL) 1 OXASPIRO[4.5]DEC 8 YL]BENZENEACETAMIDE; NALOXONE; NALTRINDOLE; NORBINALTORPHIMINE; OPIATE;

ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SAFETY; GUINEA PIG; HOT PLATE TEST; ILEUM; IN VITRO SELECTION; INTESTINE TRANSIT TIME; LOCOMOTION; MALE; MEDICINAL PLANT; MITRAGYNA; MOUSE; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RECEPTOR AFFINITY; REPEATED DRUG DOSE; REWARD; TAIL FLICK TEST; VAS DEFERENS; WRITHING TEST;

ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG TOLERANCE; GASTROINTESTINAL TRANSIT; GUINEA PIGS; MALE; MICE; MORPHINE; MORPHINE DERIVATIVES; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PROTEIN BINDING; REACTION TIME; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; REWARD; SECOLOGANIN TRYPTAMINE ALKALOIDS; TIME FACTORS;

EID: 47149104659     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.05.003     Document Type: Article

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