Determination of a highly selective mixed-affinity sigma receptor ligand, in rat plasma by ultra performance liquid chromatography mass spectrometry and its application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 891-892, Issue , 2012, Pages 1-6

  Jamalapuram, Seshulatha ^a   Vuppala, Pradeep K ^a   Mesangeau, Christophe ^b   McCurdy, Christopher R ^a,b   Avery, Bonnie A ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Method validation; Pharmacokinetics; Sigma receptor ligand; UPLC MS

Indexed keywords

ACQUITY; AMMONIUM FORMATE; ANALYTES; ANALYTICAL METHOD; ARIPIPRAZOLE; CALIBRATION CURVES; CONCENTRATION RANGES; INTERNAL STANDARDS; ISOCRATIC ELUTION; LIQUID-LIQUID EXTRACTION; LOWER LIMIT OF QUANTIFICATIONS; METHOD VALIDATIONS; MOBILE PHASE; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; POSITIVE ELECTROSPRAY IONIZATION; RAT PLASMA; RETENTION TIME; RUNTIMES; SIGMA RECEPTORS; SINGLE-STEP; ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; UPLC/MS; VALIDATED METHODS;

ACETONITRILE; AMMONIUM COMPOUNDS; BODY FLUIDS; ELECTROSPRAY IONIZATION; FORMIC ACID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

LIGANDS;

[3 [4 (4 CYCLOHEXYLPIPERAZIN 1 YL)BUTYL]BENZO[D]THIAZOLE 2(3H)THIONE]; ACETONITRILE; AMMONIUM FORMATE; ARIPIPRAZOLE; CHLOROFORM; FORMIC ACID; SIGMA RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD ANALYSIS; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTROSPRAY; ELUTION; FLOW RATE; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROCESS DEVELOPMENT; QUANTITATIVE ANALYSIS; RAT; TIME; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, LIQUID; COCAINE; LIGANDS; LIMIT OF DETECTION; PIPERAZINES; RATS; RECEPTORS, SIGMA; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFUR COMPOUNDS;

RATTUS;

EID: 84858624297     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.12.013     Document Type: Article

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