Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: Discovery of opioid agonists structurally different from other opioid ligands

Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2002, Pages 1949-1956

  Takayama, Hiromitsu ^a   Ishikawa, Hayato ^a   Kurihara, Mika ^a   Kitajima, Mariko ^a   Aimi, Norio ^a   Ponglux, Dhavadee ^b   Koyama, Fumi ^a   Matsumoto, Kenjiro ^a   Moriyama, Tomoyuki ^a   Yamamoto, Leonard T ^a   Watanabe, Kazuo ^a   Murayama, Toshihiko ^a   Horie, Syunji ^a  

^a CHIBA UNIVERSITY   (Japan)

^b CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYMITRAGYNINE; DELTA OPIATE RECEPTOR; HERBACEOUS AGENT; INDOLE ALKALOID; KAPPA OPIATE RECEPTOR; LEAD; LIGAND; MITRAGYNINE; MORPHINE; MU OPIATE RECEPTOR; OPIATE AGONIST; OPIATE RECEPTOR; PSEUDOINDOXYLMITRAGYNINE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; HERB; ILEUM; NONHUMAN; OXIDATION; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; TAIL FLICK TEST;

ANALGESICS; ANIMALS; BRAIN; ELECTRIC STIMULATION; GUINEA PIGS; ILEUM; INDOLE ALKALOIDS; LIGANDS; MICE; MODELS, MOLECULAR; MORPHINE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RADIOLIGAND ASSAY; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SECOLOGANIN TRYPTAMINE ALKALOIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037171809     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010576e     Document Type: Article

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