Loss expression of PHLPP1 correlates with lymph node metastasis and exhibits a poor prognosis in patients with gastric cancer

Journal of Surgical Oncology

Volumn 108, Issue 7, 2013, Pages 427-432

  Wang, Zhao ^a   Wang, Zhixiong ^a   Shu, Haihua ^a   Li, Guanghua ^a   Cui, Ji ^a   Wu, Hui ^a   Cai, Shirong ^a   He, Weiling ^a   He, Yulong ^a   Zhan, Wenhua ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

gastric cancer; overall survival (OS); PHLPP1; prognosis; relapse free survival (RFS)

Indexed keywords

PH DOMAIN LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CANCER TISSUE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GASTRECTOMY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENCE FREE SURVIVAL; STOMACH CANCER; STOMACH MUCOSA;

GASTRIC CANCER; OVERALL SURVIVAL (OS); PHLPP1; PROGNOSIS; RELAPSE-FREE SURVIVAL (RFS);

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; DISEASE-FREE SURVIVAL; FEMALE; GASTRECTOMY; GASTRIC MUCOSA; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 84887146757     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.23419     Document Type: Article

References (26)

1. Jemal A, Bray F, Center MM, et al.: Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
2. Amedei A, Benagiano M, della BC, et al.: Novel immunotherapeutic strategies of gastric cancer treatment. J Biomed Biotechnol 2011; 2011: 437348.
3. Wang S, Zheng G, Chen L, et al.: Effect of HER-2/neu over-expression on prognosis in gastric cancer: A meta-alysis. Asian Pac J Cancer Prev 2011; 12: 1417-1423.
4. Tang B, Peng ZH, Yu PW, et al.: Expression and significance of Cx43 and E-cadherin in gastric cancer and metastatic lymph nodes. Med Oncol 2011; 28: 502-508.
5. Wang S, Wu X, Chen Y, et al.: Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer. Clin Cancer Res 2012; 18: 2987-2996.
6. Wen Y, Wang Q, Zhou C, et al.: Decreased expression of RASSF6 is a novel independent prognostic marker of a worse outcome in gastric cancer patients after curative surgery. Ann Surg Oncol 2011; 18: 3858-3867.
7. Wang Z, Cai SR, He YL, et al.: High expression of PRL-3 can promote growth of gastric cancer and exhibits a poor prognostic impact on patients. Ann Surg Oncol 2009; 16: 208-219.
8. Kim DH:, Prognostic implications of cyclin B1, p34cdc2, p27(Kip1) and p53 expression in gastric cancer. Yonsei Med J 2007; 48: 694-700. (Pubitemid 47496734)
9. Nam KH, Lee BL, Park JH, et al.: Caveolin 1 expression correlates with poor prognosis and focal adhesion kinase expression in gastric cancer. Pathobiology 2013; 80: 87-94.
10. Gao T, Furnari F, Newton AC:, PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005; 18: 13-24. (Pubitemid 40444644)
11. Brognard J, Sierecki E, Gao T, et al. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 2007; 25: 917-931. (Pubitemid 46436532)
12. Liu J, Stevens PD, Li X, et al.: PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth. Mol Cell Biol 2011; 31: 4917-4927.
13. Shimizu K, Mackenzie SM, Storm DR:, SCOP/PHLPP and its functional role in the brain. Mol Biosyst 2010; 6: 38-43.
14. Gao T, Brognard J, Newton AC:, The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem 2008; 283: 6300-6311.
15. Qiao M, Wang Y, Xu X, et al.: Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Mol Cell 2010; 38: 512-523.
16. Brognard J, Newton AC:, PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab 2008; 19: 223-230. (Pubitemid 351993013)
17. Chen M, Pratt CP, Zeeman ME, et al.: Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression. Cancer Cell 2011; 20: 173-186.
18. Liu J, Weiss HL, Rychahou P, et al.: Loss of PHLPP expression in colon cancer: Role in proliferation and tumorigenesis. Oncogene 2009; 28: 994-1004.
19. Zhiqiang Z, Qinghui Y, Yongqiang Z, et al.: USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells. J Cancer Res Clin Oncol 2012. 138: 1231-1238.
20. O'Hayre M, Niederst M, Fecteau JF, et al.: Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL). Leukemia 2012; 26: 1689-1692.
21. Nitsche C, Edderkaoui M, Moore RM, et al.: The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology 2012; 142: 377-387.
22. Molina JR, Agarwal NK, Morales FC, et al.: PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene 2012; 31: 1264-1274.
23. Wang Z, Cai SR, He YL, et al.: Elevated PRL-3 expression was more frequently detected in the large primary gastric cancer and exhibits a poor prognostic impact on the patients. J Cancer Res Clin Oncol 2009; 135: 1041-1046.
24. O'Neill AK, Niederst MJ, Newton AC:, Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J 2012.
25. Suljagic M, Laurenti L, Tarnani M, et al.: Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells. Leukemia 2010; 24: 2063-2071.
26. Li X, Liu J, Gao T:, Beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. Mol Cell Biol 2009; 29: 6192-6205.