Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL)

Leukemia

Volumn 26, Issue 7, 2012, Pages 1689-1692

  O'Hayre, M ^a,b   Niederst, M ^b   Fecteau, J F ^c   Nguyen, V M ^b   Kipps, T J ^c   Messmer, D ^c   Newton, A C ^b   Handel, T M ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CHEMOKINE RECEPTOR CXCR4; MITOGEN ACTIVATED PROTEIN KINASE 3; PHLPP1 ENZYME; PHOSPHATASE; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG;

APOPTOSIS; CELL SURVIVAL; CHRONIC LYMPHATIC LEUKEMIA; DNA SEQUENCE; ENZYME ACTIVATION; EXON; HUMAN; IN VIVO STUDY; LETTER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM; VIRAL GENE DELIVERY SYSTEM; WESTERN BLOTTING;

B-LYMPHOCYTES; BLOTTING, WESTERN; CASE-CONTROL STUDIES; DNA METHYLATION; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NUCLEAR PROTEINS; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA STABILITY; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 84863783409     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.6     Document Type: Letter

References (14)

1. Gao T, Brognard J, Newton AC. The phosphatase PHLPP controls the cellular levels of protein kinase C. J Biol Chem 2008; 283: 6300-6311.
2. Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005; 18: 13-24.
3. Shimizu K, Okada M, Nagai K, Fukada Y. Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway. J Biol Chem 2003; 278: 14920-14925.
4. Liu J, Weiss HL, Rychahou P, Jackson LN, Evers BM, Gao T. Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. Oncogene 2009; 28: 994-1004.
5. Hussain S, Foreman O, Perkins SL, Witzig TE, Miles RR, van Deursen J et al. The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling. Leukemia 2010; 24: 1641-1655.
6. Qiao M, Iglehart JD, Pardee AB. Metastatic potential of 21 T human breast cancer cells depends on Akt/protein kinase B activation. Cancer Res 2007; 67: 5293-5299.
7. Chen M, Pratt CP, Zeeman ME, Schultz N, Taylor BS, O'Neill A et al. Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTENmutant prostate cancer progression. Cancer Cell 2011; 20: 173-186.
8. Burger JA, Tsukada N, Burger M, Zvaifler NJ, Dell'Aquila M, Kipps TJ. Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1. Blood 2000; 96: 2655-2663.
9. Messmer D, Fecteau JF, O'Hayre M, Bharati IS, Handel TM, Kipps TJ. Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. Blood 2011; 117: 882-889.
10. Suljagic M, Laurenti L, Tarnani M, Alam M, Malek SN, Efremov DG. Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells. Leukemia 2010; 24: 2063-2071.
11. Woodgett JR, Hunter T. Immunological evidence for two physiological forms of protein kinase C. Mol Cell Biol 1987; 7: 85-96.
12. McCabe MT, Brandes JC, Vertino PM. Cancer DNA methylation: molecular mechanisms and clinical implications. Clin Cancer Res 2009; 15: 3927-3937.
13. Taberlay PC, Jones PA. DNA methylation and cancer. Prog Drug Res 2011; 67: 1-23.
14. Detich N, Bovenzi V, Szyf M. Valproate induces replication-independent active DNA demethylation. J Biol Chem 2003; 278: 27586-27592.