Systemic tumor-specific gene delivery

Journal of Controlled Release

Volumn 172, Issue 3, 2013, Pages 730-736

  Kullberg, Max ^a   McCarthy, Ryan ^a   Anchordoquy, Thomas J ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Delivery system; Dendrimer; Gene therapy; Non viral; Systemic; Viral

Indexed keywords

CANCER GENE THERAPY; DELIVERY SYSTEMS; IMMUNE RESPONSE; NONVIRAL; RECEPTOR TARGETING; SYSTEMIC; SYSTEMIC ADMINISTRATION; VIRAL;

CELL DEATH; DENDRIMERS; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; STEM CELLS;

TUMORS;

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; CHOLESTEROL; DENDRIMER; DNA; INTERLEUKIN 12; LIGAND; LIPOPLEX; POLYETHYLENEIMINE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; TUMOR PROMOTER;

APOPTOSIS; BINDING AFFINITY; CANCER GENE THERAPY; CELL DIVISION; CONJUGATION; GENE EXPRESSION; GENE TARGETING; HERPES VIRUS; HUMAN; LENTIVIRINAE; MESENCHYMAL STEM CELL; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; STEM CELL; SURVIVAL TIME; TUMOR CELL; VACCINIA VIRUS; VIRAL GENE DELIVERY SYSTEM; VIRUS MUTATION;

DELIVERY SYSTEM; DENDRIMER; GENE THERAPY; NON-VIRAL; SYSTEMIC; VIRAL;

ANIMALS; DENDRIMERS; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HUMANS; LIPOSOMES; NEOPLASMS; POLYETHYLENEIMINE; RNA, SMALL INTERFERING; VIRUSES;

EID: 84887139708     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.08.300     Document Type: Review

References (71)

1. T. Gjetting, N.S. Arildsen, C.L. Christensen, T.T. Poulsen, J.A. Roth, V.N. Handlos, and H.S. Poulsen In vitro and in vivo effects of polyethylene glycol (PEG)-modified lipid in DOTAP/cholesterol-mediated gene transfection Int. J. Nanomed. 5 2010 371 383
2. C. Tros de Ilarduya, Y. Sun, and N. Duzgunes Gene delivery by lipoplexes and polyplexes Eur. J. Pharm. Sci. 40 2010 159 170
3. L. Liu, S. Wang, B. Shan, M. Sang, S. Liu, and G. Wang Advances in viral-vector systemic cytokine gene therapy against cancer Vaccine 28 2010 3883 3887
4. L.S. Young, P.F. Searle, D. Onion, and V. Mautner Viral gene therapy strategies: from basic science to clinical application J. Pathol. 208 2006 299 318 (Pubitemid 43126122)
5. A.W. Tong Small RNAs and non-small cell lung cancer Curr. Mol. Med. 6 2006 339 349
6. D. Chen, A. Siddiq, L. Emdad, D. Rajasekaran, R. Gredler, X.N. Shen, P.K. Santhekadur, J. Srivastava, C.L. Robertson, I. Dmitriev, E.A. Kashentseva, D.T. Curiel, P.B. Fisher, and D. Sarkar Insulin-like growth factor-binding protein-7 (IGFBP7): a promising gene therapeutic for hepatocellular carcinoma (HCC) Mol. Ther. 21 4 2013 758 766
7. X. Zeng, Y. Lin, C. Yin, X. Zhang, B.F. Ning, Q. Zhang, J.P. Zhang, L. Qiu, X.R. Qin, Y.X. Chen, and W.F. Xie Recombinant adenovirus carrying the hepatocyte nuclear factor-1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice Hepatology 54 2011 2036 2047
8. X. Sun, H.W. Zhang, and Z.R. Zhang Growth inhibition of the pulmonary metastatic tumors by systemic delivery of the p27 kip1 gene using lyophilized lipid-polycation-DNA complexes J. Gene Med. 11 2009 535 544
9. L. Zhao, J. Wu, H. Zhou, A. Yuan, X. Zhang, F. Xu, and Y. Hu Local gene delivery for cancer therapy Curr. Gene Ther. 11 2011 423 432
10. J.Y. Shin, H.T. Lim, A. Minai-Tehrani, M.S. Noh, J.E. Kim, J.H. Kim, H.L. Jiang, R. Arote, D.Y. Kim, C. Chae, K.H. Lee, M.S. Kim, and M.H. Cho Aerosol delivery of beclin1 enhanced the anti-tumor effect of radiation in the lungs of K-rasLA1 mice J. Radiat. Res. 53 2012 506 515
11. Y. Liu, F. Lang, X. Xie, S. Prabhu, J. Xu, D. Sampath, K. Aldape, G. Fuller, and V.K. Puduvalli Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts Cell Death Dis. 2 2011 e121
12. J. Wojas-Turek, E. Pajtasz-Piasecka, J. Rossowska, E. Piasecki, and D. Dus Antitumor effect of murine dendritic and tumor cells transduced with IL-2 gene Folia Histochem. Cytobiol. 50 2012 414 419
13. H.Y. Zhang, J.H. Man, B. Liang, T. Zhou, C.H. Wang, T. Li, H.Y. Li, W.H. Li, B.F. Jin, P.J. Zhang, J. Zhao, X. Pan, K. He, W.L. Gong, X.M. Zhang, and A.L. Li Tumor-targeted delivery of biologically active TRAIL protein Cancer Gene Ther. 17 2010 334 343
14. S. Hallaj-Nezhadi, F. Lotfipour, and C. Dass Nanoparticle-mediated interleukin-12 cancer gene therapy J. Pharm. Pharm. Sci. 13 2010 472 485
15. E. Kanaoka, K. Takahashi, T. Yoshikawa, H. Jizomoto, Y. Nishihara, N. Uchida, R. Maekawa, and K. Hirano A significant enhancement of therapeutic effect against hepatic metastases of M5076 in mice by a liposomal interleukin-2 (mixture) J. Control. Release 82 2002 183 187 (Pubitemid 34880177)
16. S. Dow, R. Elmslie, I. Kurzman, G. MacEwen, F. Pericle, and D. Liggitt Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases Human Gene Ther. 16 2005 937 946 (Pubitemid 41153863)
17. M.L. Salem, W.E. Gillanders, A.N. Kadima, S. El-Naggar, M.P. Rubinstein, M. Demcheva, J.N. Vournakis, and D.J. Cole Review: novel nonviral delivery approaches for interleukin-12 protein and gene systems: curbing toxicity and enhancing adjuvant activity J. Interferon Cytokine Res. 26 2006 593 608 (Pubitemid 44689649)
18. M.F. Gnant, A.C. Berger, J. Huang, M. Puhlmann, P.C. Wu, M.J. Merino, D.L. Bartlett, H.R. Alexander Jr., and S.K. Libutti Sensitization of tumor necrosis factor alpha-resistant human melanoma by tumor-specific in vivo transfer of the gene encoding endothelial monocyte-activating polypeptide II using recombinant vaccinia virus Cancer Res. 59 1999 4668 4674 (Pubitemid 29428974)
19. H. Wajant CD95L/FasL and TRAIL in tumour surveillance and cancer therapy Cancer Treat. Res. 130 2006 141 165
20. R. Yerbes, C. Palacios, and A. Lopez-Rivas The therapeutic potential of TRAIL receptor signalling in cancer cells Clin. Transl. Oncol. 13 2011 839 847
21. X. Volkmann, U. Fischer, M.J. Bahr, M. Ott, F. Lehner, M. Macfarlane, G.M. Cohen, M.P. Manns, K. Schulze-Osthoff, and H. Bantel Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver Hepatology 46 2007 1498 1508 (Pubitemid 350155532)
22. D. Kolodkin-Gal, Y. Edden, Z. Hartshtark, L. Ilan, A. Khalaileh, A.J. Pikarsky, E. Pikarsky, S.D. Rabkin, A. Panet, and G. Zamir Herpes simplex virus delivery to orthotopic rectal carcinoma results in an efficient and selective antitumor effect Gene Ther. 16 2009 905 915
23. P. Rath, H. Shi, J.A. Maruniak, N.S. Litofsky, B.L. Maria, and M.D. Kirk Stem cells as vectors to deliver HSV/tk gene therapy for malignant gliomas Curr. Stem Cell Res. Ther. 4 2009 44 49
24. Y. Duan, S. Zhang, B. Wang, B. Yang, and D. Zhi The biological routes of gene delivery mediated by lipid-based non-viral vectors Expert Opin. Drug Deliv. 6 2009 1351 1361
25. T. Wang, J.R. Upponi, and V.P. Torchilin Design of multifunctional non-viral gene vectors to overcome physiological barriers: dilemmas and strategies Int. J. Pharm. 427 2012 3 20
26. L. Xu, and T. Anchordoquy Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics J. Pharm. Sci. 100 2011 38 52
27. A.D. Tagalakis, S.M. Grosse, Q.H. Meng, M.F. Mustapa, A. Kwok, S.E. Salehi, A.B. Tabor, H.C. Hailes, and S.L. Hart Integrin-targeted nanocomplexes for tumour specific delivery and therapy by systemic administration Biomaterials 32 2011 1370 1376
28. Y. Zhang, E.L. Bradshaw-Pierce, A. Delille, D.L. Gustafson, and T.J. Anchordoquy In vivo comparative study of lipid/DNA complexes with different in vitro serum stability: effects on biodistribution and tumor accumulation J. Pharm. Sci. 97 2008 237 250
29. M.F. Mustapa, S.M. Grosse, L. Kudsiova, M. Elbs, E.A. Raiber, J.B. Wong, A.P. Brain, H.E. Armer, A. Warley, M. Keppler, T. Ng, M.J. Lawrence, S.L. Hart, H.C. Hailes, and A.B. Tabor Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell Bioconjug. Chem. 20 2009 518 532
30. S.M. Grosse, A.D. Tagalakis, M.F. Mustapa, M. Elbs, Q.H. Meng, A. Mohammadi, A.B. Tabor, H.C. Hailes, and S.L. Hart Tumor-specific gene transfer with receptor-mediated nanocomplexes modified by polyethylene glycol shielding and endosomally cleavable lipid and peptide linkers FASEB J. 24 2010 2301 2313
31. Y. Wang, H.H. Su, Y. Yang, Y. Hu, L. Zhang, P. Blancafort, and L. Huang Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy Mol. Ther. 21 2013 358 367
32. S. Ikegami, K. Yamakami, T. Ono, M. Sato, S. Suzuki, I. Yoshimura, T. Asano, M. Hayakawa, and T. Tadakuma Targeting gene therapy for prostate cancer cells by liposomes complexed with anti-prostate-specific membrane antigen monoclonal antibody Hum. Gene Ther. 17 2006 997 1005 (Pubitemid 46076741)
33. Z. Li, Q. Ding, Y. Li, S.A. Miller, J.L. Abbruzzese, and M.C. Hung Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant Cancer Lett. 236 2006 58 63
34. J. Heyes, L. Palmer, K. Chan, C. Giesbrecht, L. Jeffs, and I. MacLachlan Lipid encapsulation enables the effective systemic delivery of polyplex plasmid DNA Mol. Ther. 15 2007 713 720 (Pubitemid 46431991)
35. D. Li, Y. Ping, F. Xu, H. Yu, H. Pan, H. Huang, Q. Wang, G. Tang, and J. Li Construction of a star-shaped copolymer as a vector for FGF receptor-mediated gene delivery in vitro and in vivo Biomacromolecules 11 2010 2221 2229
36. S. Patnaik, and K.C. Gupta Novel polyethylenimine-derived nanoparticles for in vivo gene delivery Expert Opin. Drug Deliv. 10 2013 215 228
37. R. Kircheis, L. Wightman, A. Schreiber, B. Robitza, V. Rossler, M. Kursa, and E. Wagner Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application Gene Ther. 8 2001 28 40 (Pubitemid 32162413)
38. M. Ogris, G. Walker, T. Blessing, R. Kircheis, M. Wolschek, and E. Wagner Tumor-targeted gene therapy: strategies for the preparation of ligand-polyethylene glycol-polyethylenimine/DNA complexes J. Control. Release 91 2003 173 181 (Pubitemid 37288888)
39. M. Kursa, G.F. Walker, V. Roessler, M. Ogris, W. Roedl, R. Kircheis, and E. Wagner Novel shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic tumor-targeted gene transfer Bioconjug. Chem. 14 2003 222 231 (Pubitemid 36169036)
40. M.F. Wolschek, C. Thallinger, M. Kursa, V. Rossler, M. Allen, C. Lichtenberger, R. Kircheis, T. Lucas, M. Willheim, W. Reinisch, A. Gangl, E. Wagner, and B. Jansen Specific systemic nonviral gene delivery to human hepatocellular carcinoma xenografts in SCID mice Hepatology 36 2002 1106 1114 (Pubitemid 35253426)
41. C. Dufes, I.F. Uchegbu, and A.G. Schatzlein Dendrimers in gene delivery Adv. Drug Deliv. Rev. 57 2005 2177 2202 (Pubitemid 41759392)
42. E.J. Chisholm, G. Vassaux, P. Martin-Duque, R. Chevre, O. Lambert, B. Pitard, A. Merron, M. Weeks, J. Burnet, I. Peerlinck, M.S. Dai, G. Alusi, S.J. Mather, K. Bolton, I.F. Uchegbu, A.G. Schatzlein, and P. Baril Cancer-specific transgene expression mediated by systemic injection of nanoparticles Cancer Res. 69 2009 2655 2662
43. V. Russ, M. Gunther, A. Halama, M. Ogris, and E. Wagner Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery J. Control. Release 132 2008 131 140
44. C. Dufes, W.N. Keith, A. Bilsland, I. Proutski, I.F. Uchegbu, and A.G. Schatzlein Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors Cancer Res. 65 2005 8079 8084 (Pubitemid 41330568)
45. S. Koppu, Y.J. Oh, R. Edrada-Ebel, D.R. Blatchford, L. Tetley, R.J. Tate, and C. Dufes Tumor regression after systemic administration of a novel tumor-targeted gene delivery system carrying a therapeutic plasmid DNA J. Control. Release 143 2010 215 221
46. G. Navarro, G. Maiwald, R. Haase, A.L. Rogach, E. Wagner, C.T. de Ilarduya, and M. Ogris Low generation PAMAM dendrimer and CpG free plasmids allow targeted and extended transgene expression in tumors after systemic delivery J. Control. Release 146 2010 99 105
47. M. Cihova, V. Altanerova, and C. Altaner Stem cell based cancer gene therapy Mol. Pharm. 8 2011 1480 1487
48. R. Uchibori, T. Tsukahara, H. Mizuguchi, Y. Saga, M. Urabe, H. Mizukami, A. Kume, and K. Ozawa NF-kappaB activity regulates mesenchymal stem cell accumulation at tumor sites Cancer Res. 73 2013 364 372
49. R. Uchibori, T. Okada, T. Ito, M. Urabe, H. Mizukami, A. Kume, and K. Ozawa Retroviral vector-producing mesenchymal stem cells for targeted suicide cancer gene therapy J. Gene Med. 11 2009 373 381
50. M. Studeny, F.C. Marini, R.E. Champlin, C. Zompetta, I.J. Fidler, and M. Andreeff Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors Cancer Res. 62 2002 3603 3608 (Pubitemid 34728832)
51. M. Studeny, F.C. Marini, J.L. Dembinski, C. Zompetta, M. Cabreira-Hansen, B.N. Bekele, R.E. Champlin, and M. Andreeff Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents J. Natl. Cancer Inst. 96 2004 1593 1603 (Pubitemid 39534883)
52. D. Wolf, H. Rumpold, R. Koeck, and E. Gunsilius Re: Mesenchymal stem cells: potential precursors for tumor stroma and targeted-delivery vehicles for anticancer agents J. Natl. Cancer Inst. 97 2005 540 541 (author reply 541-542)
53. H. Xin, M. Kanehira, H. Mizuguchi, T. Hayakawa, T. Kikuchi, T. Nukiwa, and Y. Saijo Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells Stem Cells 25 2007 1618 1626 (Pubitemid 47121838)
54. X. Duan, H. Guan, Y. Cao, and E.S. Kleinerman Murine bone marrow-derived mesenchymal stem cells as vehicles for interleukin-12 gene delivery into Ewing sarcoma tumors Cancer 115 2009 13 22
55. J. Xiang, J. Tang, C. Song, Z. Yang, D.G. Hirst, Q.J. Zheng, and G. Li Mesenchymal stem cells as a gene therapy carrier for treatment of fibrosarcoma Cytotherapy 11 2009 516 526
56. D. Kirn, I. Niculescu-Duvaz, G. Hallden, and C.J. Springer The emerging fields of suicide gene therapy and virotherapy Trends Mol. Med. 8 2002 S68 S73
57. K. Morizono, Y. Xie, G.E. Ringpis, M. Johnson, H. Nassanian, B. Lee, L. Wu, and I.S. Chen Lentiviral vector retargeting to P-glycoprotein on metastatic melanoma through intravenous injection Nat. Med. 11 2005 346 352 (Pubitemid 40460565)
58. M. Puhlmann, C.K. Brown, M. Gnant, J. Huang, S.K. Libutti, H.R. Alexander, and D.L. Bartlett Vaccinia as a vector for tumor-directed gene therapy: biodistribution of a thymidine kinase-deleted mutant Cancer Gene Ther. 7 2000 66 73 (Pubitemid 30080989)
59. M.F. Gnant, L.A. Noll, K.R. Irvine, M. Puhlmann, R.E. Terrill, H.R. Alexander Jr., and D.L. Bartlett Tumor-specific gene delivery using recombinant vaccinia virus in a rabbit model of liver metastases J. Natl. Cancer Inst. 91 1999 1744 1750 (Pubitemid 29518770)
60. M.F. Gnant, M. Puhlmann, D.L. Bartlett, and H.R. Alexander Jr. Regional versus systemic delivery of recombinant vaccinia virus as suicide gene therapy for murine liver metastases Ann. Surg. 230 1999 352 360 (discussion 360-351)
61. J. Veerapong, K.A. Bickenbach, M.Y. Shao, K.D. Smith, M.C. Posner, B. Roizman, and R.R. Weichselbaum Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity Cancer Res. 67 2007 8301 8306 (Pubitemid 47395168)
62. X. Han, N. Kasahara, and Y.W. Kan Ligand-directed retroviral targeting of human breast cancer cells Proc. Natl. Acad. Sci. U. S. A. 92 1995 9747 9751
63. A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811 (Pubitemid 28099681)
64. P. Resnier, T. Montier, V. Mathieu, J.P. Benoit, and C. Passirani A review of the current status of siRNA nanomedicines in the treatment of cancer Biomaterials 34 2013 6429 6443
65. R.S. Bora, D. Gupta, T.K. Mukkur, and K.S. Saini RNA interference therapeutics for cancer: challenges and opportunities (review) Mol. Med. Rep. 6 2012 9 15
66. J. Gao, Y. Yu, Y. Zhang, J. Song, H. Chen, W. Li, W. Qian, L. Deng, G. Kou, J. Chen, and Y. Guo EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma Biomaterials 33 2012 270 282
67. L.C. Gomes-da-Silva, A.O. Santos, L.M. Bimbo, V. Moura, J.S. Ramalho, M.C. Pedroso de Lima, S. Simoes, and J.N. Moreira Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment Int. J. Pharm. 434 2012 9 19
68. B. Xiang, D.W. Dong, N.Q. Shi, W. Gao, Z.Z. Yang, Y. Cui, D.Y. Cao, and X.R. Qi PSA-responsive and PSMA-mediated multifunctional liposomes for targeted therapy of prostate cancer Biomaterials 34 2013 6976 6991
69. Y. Shu, F. Haque, D. Shu, W. Li, Z. Zhu, M. Kotb, Y. Lyubchenko, and P. Guo Fabrication of 14 different RNA nanoparticles for specific tumor targeting without accumulation in normal organs RNA 19 2013 767 777
70. C. Lonez, M. Vandenbranden, and J.M. Ruysschaert Cationic lipids activate intracellular signaling pathways Adv. Drug Deliv. Rev. 64 2012 1749 1758
71. M. Lamkanfi, and V.M. Dixit Modulation of inflammasome pathways by bacterial and viral pathogens J. Immunol. 187 2011 597 602