Hepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis

Digestive and Liver Disease

Volumn 45, Issue 12, 2013, Pages 1041-1048

  Niu, Yongdong ^a,b   Wu, Zheng ^a   Shen, Qiujin ^a   Song, Jin ^a   Luo, Qin ^a   You, Haiyan ^a   Shi, Ganggang ^b   Qin, Wenxin ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

ChIP; CYP3A4; Cytochrome P450 3A4; DMSO; GST; HBV; HBx; HCC; Hepatitis B virus X protein; Liver cancer; PCN; Pregnane X receptor; PXR; RIF; XREM

Indexed keywords

CYTOCHROME P450 3A4; GLUTATHIONE TRANSFERASE; HEPATITIS B VIRUS X PROTEIN; PREGNANE X RECEPTOR;

ARTICLE; CHROMATIN IMMUNOPRECIPITATION; HEPATITIS B VIRUS; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; VIRUS CARCINOGENESIS;

CHIP; CHROMATIN IMMUNOPRECIPITATION; CYP3A4; CYTOCHROME P450 3A4; DIMETHYL SULFOXIDE; DMSO; GLUTATHIONE S-TRANSFERASE; GST; HBV; HBX; HCC; HEPATITIS B VIRUS; HEPATITIS B VIRUS X PROTEIN; HEPATOCELLULAR CARCINOMA; LIVER CANCER; PCN; PREGNANE X RECEPTOR; PREGNENOLONE 16Α CARBONITRILE; PXR; RIF; RIFAMPICIN; XENOBIOTIC RESPONSIVE ENHANCER MODULE; XREM;

CARCINOGENESIS; CARCINOMA, HEPATOCELLULAR; CYTOCHROME P-450 CYP3A; ENZYME INDUCTION; HEPATITIS B, CHRONIC; HEPATOCYTES; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; RECEPTORS, STEROID; RNA, MESSENGER; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 84887136953     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2013.06.004     Document Type: Article

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