Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity

European Journal of Pharmacology

Volumn 718, Issue 1-3, 2013, Pages 361-369

  Al Abd, Ahmed M ^a,b   Al Abbasi, Fahad A ^a   Asaad, Gihan F ^b   Abdel Naim, Ashraf B ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Cardiotoxicity; Didox; Doxorubicin; Liver cancer

Indexed keywords

3,4 DIHYDROXYBENZOHYDROXAMIC ACID; CASPASE 3; DOXORUBICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CARDIOMEGALY; CARDIOTOXICITY; CELL CYCLE S PHASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVITY; HEART PROTECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IC 50; LIVER CANCER; MALE; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SURVIVAL TIME;

CARDIOTOXICITY; DIDOX; DOXORUBICIN; LIVER CANCER;

ANIMALS; CARDIOTONIC AGENTS; CASPASE 3; CELL CYCLE; CELL LINE, TUMOR; DOXORUBICIN; DRUG SYNERGISM; HEART; HYDROXAMIC ACIDS; LIVER NEOPLASMS; MALE; MICE; POLY(ADP-RIBOSE) POLYMERASES; SURVIVAL RATE;

EID: 84887126305     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.08.009     Document Type: Article

References (44)

1. A.M. Al-Abd, K.Y. Hong, S.C. Song, and H.J. Kuh Pharmacokinetics of doxorubicin after intratumoral injection using a thermosensitive hydrogel in tumor-bearing mice Journal of Controlled Release 142 2010 101 107
2. A.M. Al-Abd, J.H. Lee, S.Y. Kim, N. Kun, and H.J. Kuh Novel application of multicellular layers culture for in situ evaluation of cytotoxicity and penetration of paclitaxel Cancer Science 99 2008 423 431 (Pubitemid 351228501)
3. A.M. Al-Abd, A.M. Mahmoud, G.A. El-Sherbiny, M.A. El-Moselhy, S.M. Nofal, H.A. El-Latif, W.I. El-Eraky, and H.A. El-Shemy Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro Cell Proliferation 44 2011 591 601
4. T. Arai, T. Joki, M. Akiyama, M. Agawa, Y. Mori, H. Yoshioka, and T. Abe Novel drug delivery system using thermoreversible gelation polymer for malignant glioma Journal of Neuro-Oncology 77 2006 9 15 (Pubitemid 43870556)
5. F. Arcamone, G. Cassinelli, G. Fantini, A. Grein, P. Orezzi, C. Pol, and C. Spalla Adriamycin, 14-hydroxydaunomycin, a new antitumor antibiotic from S. peucetius var. caesius Biotechnology and Bioengineering 11 1969 1101 1110
6. Asensio-Lopez, M.C., Sanchez-Mas, J., Pascual-Figal, D.A., Abenza, S., Perez-Martinez, M.T., Valdes, M., Lax, A., 2012. Involvement of ferritin heavy chain in the preventive effect of metformin against doxorubicin-induced cardiotoxicity. Free Radical Biology and Medicine
7. E.B. Behling, M.C. Sendao, H.D. Francescato, L.M. Antunes, R.S. Costa, and L. Bianchi Mde Comparative study of multiple dosage of quercetin against cisplatin-induced nephrotoxicity and oxidative stress in rat kidneys Pharmacological Reports 58 2006 526 532 (Pubitemid 44383278)
8. D.C. Bibby, J.E. Talmadge, M.K. Dalal, S.G. Kurz, K.M. Chytil, S.E. Barry, D.G. Shand, and M. Steiert Pharmacokinetics and biodistribution of RGD-targeted doxorubicin-loaded nanoparticles in tumor-bearing mice International Journal of Pharmaceutics 293 2005 281 290 (Pubitemid 40381100)
9. A. Cervantes, H.M. Pinedo, J. Lankelma, and G.J. Schuurhuis The role of oxygen-derived free radicals in the cytotoxicity of doxorubicin in multidrug resistant and sensitive human ovarian cancer cells Cancer Letters 41 1988 169 177
10. T.R. Chapman, and T.J. Kinsella Ribonucleotide reductase inhibitors: a new look at an old target for radiosensitization Frontiers in Oncology 1 2011 56
11. T.C. Chou, and P. Talalay Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors Advances in Enzyme Regulation 22 1984 27 55
12. S. Dev Impact of natural products in modern drug development Indian Journal of Experimental Biology 48 2010 191 198
13. El-Bakly, W.M., Louka, M.L., El-Halawany, A.M., Schaalan, M.F., 2012. 6-gingerol ameliorated doxorubicin-induced cardiotoxicity: role of nuclear factor kappa B and protein glycation. Cancer Chemotherapy and Pharmacology
14. H.L. Elford, and B. van't Riet Inhibition of nucleoside diphosphate reductase by hydroxybenzohydroxamic acid derivatives Pharmacology and Therapeutics 29 1985 239 254 (Pubitemid 16168253)
15. H.L. Elford, G.L. Wampler, and B. van't Riet New ribonucleotide reductase inhibitors with antineoplastic activity Cancer Research 39 1979 844 851 (Pubitemid 9143275)
16. G.L. Ellman Tissue sulfhydryl groups Archives of Biochemistry and Biophysics 82 1959 70 77
17. H. Greenlee, J. Shaw, Y.K. Lau, A. Naini, and M. Maurer Lack of effect of coenzyme q10 on Doxorubicin cytotoxicity in breast cancer cell cultures Integrative Cancer Therapies 11 2012 243 250
18. J.C. Henry, M.M. Bonar, P.N. Kearns, H. Cui, M.M. Mutchler, M.V. Martin, A.R. Orsini, H.L. Elford, C.A. Bush, J.L. Zweier, and A.J. Cardounel Inhibition of ribonucleotide reductase reduces neointimal formation following balloon injury Journal of Pharmacology and Experimental Therapeutics 314 2005 70 76 (Pubitemid 41058242)
19. Z. Herceg, and Z.Q. Wang Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death Mutation Research 477 2001 97 110 (Pubitemid 32480193)
20. G.N. Hortobagyi Anthracyclines in the treatment of cancer. An overview Drugs 54 4 1997 1 7 (Pubitemid 27487789)
21. Z. Horvath, T. Hochtl, W. Bauer, M. Fritzer-Szekeres, H.L. Elford, T. Szekeres, and T. Tihan Synergistic cytotoxicity of the ribonucleotide reductase inhibitor didox (3,4-dihydroxy-benzohydroxamic acid) and the alkylating agent carmustine (BCNU) in 9L rat gliosarcoma cells and DAOY human medulloblastoma cells Cancer Chemotherapy and Pharmacology 54 2004 139 145 (Pubitemid 39044243)
22. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, and D. Forman Global cancer statistics CA: A Cancer Journal for Clinicians 61 2011 69 90
23. J. Kapuscinski, B. Ardelt, J. Piosik, M. Zdunek, and Z. Darzynkiewicz The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine Biochemical Pharmacology 63 2002 625 634 (Pubitemid 34457696)
24. K. Kataoka, T. Matsumoto, M. Yokoyama, T. Okano, Y. Sakurai, S. Fukushima, K. Okamoto, and G.S. Kwon Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-l-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance Journal of Controlled Release 64 2000 143 153 (Pubitemid 30035315)
25. D.K. Kaul, R. Kollander, H. Mahaseth, X.D. Liu, A. Solovey, J. Belcher, R.J. Kelm Jr., G.M. Vercellotti, and R.P. Hebbel Robust vascular protective effect of hydroxamic acid derivatives in a sickle mouse model of inflammation Microcirculation 13 2006 489 497 (Pubitemid 44322164)
26. D. Koracevic, G. Koracevic, V. Djordjevic, S. Andrejevic, and V. Cosic Method for the measurement of antioxidant activity in human fluids Journal of Clinical Pathology 54 2001 356 361 (Pubitemid 32458132)
27. S. Licata, A. Saponiero, A. Mordente, and G. Minotti Doxorubicin metabolism and toxicity in human myocardium: role of cytoplasmic deglycosidation and carbonyl reduction Chemical Research in Toxicology 13 2000 414 420 (Pubitemid 30327162)
28. J.H. Maeng, D.H. Lee, K.H. Jung, Y.H. Bae, I.S. Park, S. Jeong, Y.S. Jeon, C.K. Shim, W. Kim, J. Kim, J. Lee, Y.M. Lee, J.H. Kim, W.H. Kim, and S.S. Hong Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer Biomaterials 31 2010 4995 5006
29. S.L. Marklund Product of extracellular-superoxide dismutase catalysis FEBS Letters 184 1985 237 239 (Pubitemid 15011420)
30. A.M. Osman, S.E. Al-Harthi, O.M. Alarabi, M.F. Elshal, W.S. Ramadan, M.N. Alaama, H.M. Al-Kreathy, Z.A. Damanhouri, and O.H. Osman Chemosensetizing and cardioprotective effects of resveratrol in doxorubicin- treated animals Cancer Cell International 13 2013 52
31. N. Raje, S. Kumar, T. Hideshima, K. Ishitsuka, H. Yasui, S. Chhetri, S. Vallet, E. Vonescu, N. Shiraishi, T. Kiziltepe, H.L. Elford, N.C. Munshi, and K.C. Anderson Didox, a ribonucleotide reductase inhibitor, induces apoptosis and inhibits DNA repair in multiple myeloma cells British Journal of Haematology 135 2006 52 61 (Pubitemid 44337662)
32. S.A. Sakr, S.M. El-Shenawy, and A.M. Al-Shabka Aqueous fenugreek seed extract ameliorates adriamycin-induced cytotoxicity and testicular alterations in albino rats Reproduction Science 19 2012 70 80
33. P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J.T. Warren, H. Bokesch, S. Kenney, and M.R. Boyd New colorimetric cytotoxicity assay for anticancer-drug screening Journal of the National Cancer Institute 82 1990 1107 1112 (Pubitemid 20213250)
34. P.J. Snodgrass, W.E. Wacker, E.C. Eppinger, and B.L. Vallee Metalloenzymes and myocardial infarction. III. Lactic dehydrogenase activity of serum-a determinate diagnostic measure New England Journal of Medicine 261 1959 1259 1266
35. L. Songgang, L. Jiyu, Gongwei, L. Yingbin, Q. Yiyu, and Q Zhiwei Somatostatin enhances the chemosensitivity of GBC-SD cell line to doxorubicin through arresting the cell cycle to S phase rather than through the P53/Bax-depended apoptosis way in vitro Hepatogastroenterology 56 2009 1253 1260
36. T. Szekeres, M. Fritzer-Szekeres, and H.L. Elford The enzyme ribonucleotide reductase: target for antitumor and anti-HIV therapy Critical Reviews in Clinical Laboratory Sciences 34 1997 503 528 (Pubitemid 28043734)
37. W.G. Thompson, R.G. Mahr, W.S. Yohannan, and M.R. Pincus Use of creatine kinase MB isoenzyme for diagnosing myocardial infarction when total creatine kinase activity is high Clinical Chemistry 34 1988 2208 2210 (Pubitemid 19001236)
38. T. Topal, Y. Oztas, A. Korkmaz, S. Sadir, S. Oter, O. Coskun, and H. Bilgic Melatonin ameliorates bladder damage induced by cyclophosphamide in rats Journal of Pineal Research 38 2005 272 277 (Pubitemid 41475439)
39. J. Turchan, C.B. Pocernich, C. Gairola, A. Chauhan, G. Schifitto, D.A. Butterfield, S. Buch, O. Narayan, A. Sinai, J. Geiger, J.R. Berger, H. Elford, and A. Nath Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants Neurology 60 2003 307 314 (Pubitemid 36152028)
40. J. Vilaseca, J. Guardia, R. Bacardi, and J. Monne Doxorubicin for liver cancer Lancet 1 1978 1367 (Pubitemid 8367149)
41. D.D. Von Hoff, M.W. Layard, P. Basa, H.L. Davis Jr., A.L. Von Hoff, M. Rozencweig, and F.M. Muggia Risk factors for doxorubicin-induced congestive heart failure Annals of Internal Medicine 91 1979 710 717 (Pubitemid 10218041)
42. N. Wakisaka, T. Yoshizaki, N. Raab-Traub, and J.S. Pagano Ribonucleotide reductase inhibitors enhance cidofovir-induced apoptosis in EBV-positive nasopharyngeal carcinoma xenografts International Journal of Cancer 116 2005 640 645 (Pubitemid 41099202)
43. M.F. Xu, P.L. Tang, Z.M. Qian, and M. Ashraf Effects by doxorubicin on the myocardium are mediated by oxygen free radicals Life Sciences 68 2001 889 901 (Pubitemid 32168065)
44. R. Zhou, M. Fukui, H.J. Choi, and B.T. Zhu Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection British Journal of Pharmacology 158 2009 462 474