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Volumn 127, Issue 4, 2013, Pages 531-540

Growth hormone releasing hormone (GHRH) signaling modulates intermittent hypoxia-induced oxidative stress and cognitive deficits in mouse

Author keywords

8 hydroxydeoxyguanosine; cortex; hippocampus; intermittent hypoxia; malondialdehyde; Morris water maze

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; DNA; ERYTHROPOIETIN; GROWTH HORMONE RELEASING FACTOR; HORMONE ANTAGONIST; HYPOXIA INDUCIBLE FACTOR 1ALPHA; JI 34; MALONALDEHYDE; NEUROPROTECTIVE AGENT; SOMATOMEDIN C; UNCLASSIFIED DRUG;

EID: 84887116540     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12360     Document Type: Article
Times cited : (42)

References (53)
  • 1
    • 4644259153 scopus 로고    scopus 로고
    • Cellular oxygen sensing need in CNS function: Physiological and pathological implications
    • Acker T., and, Acker H., (2004) Cellular oxygen sensing need in CNS function: physiological and pathological implications. J. Exp. Biol. 207, 3171-3188.
    • (2004) J. Exp. Biol. , vol.207 , pp. 3171-3188
    • Acker, T.1    Acker, H.2
  • 2
    • 75149121182 scopus 로고    scopus 로고
    • Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: Implications for sleep apnea
    • Aviles-Reyes R. X., Angelo M. F., Villarreal A., Rios H., Lazarowski A., and, Ramos A. J., (2010) Intermittent hypoxia during sleep induces reactive gliosis and limited neuronal death in rats: implications for sleep apnea. J. Neurochem. 112, 854-869.
    • (2010) J. Neurochem. , vol.112 , pp. 854-869
    • Aviles-Reyes, R.X.1    Angelo, M.F.2    Villarreal, A.3    Rios, H.4    Lazarowski, A.5    Ramos, A.J.6
  • 3
    • 78650642919 scopus 로고    scopus 로고
    • Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice
    • Banks W. A., Morley J. E., Farr S. A., Price T. O., Ercal N., Vidaurre I., and, Schally A. V., (2010) Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice. Proc. Natl Acad. Sci. USA 107, 22272-22277.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 22272-22277
    • Banks, W.A.1    Morley, J.E.2    Farr, S.A.3    Price, T.O.4    Ercal, N.5    Vidaurre, I.6    Schally, A.V.7
  • 4
    • 58149479262 scopus 로고    scopus 로고
    • Antioxidant activity of growth hormone-releasing hormone antagonists in LNCaP human prostate cancer line
    • Barabutis N., and, Schally A. V., (2008) Antioxidant activity of growth hormone-releasing hormone antagonists in LNCaP human prostate cancer line. Proc. Natl Acad. Sci. USA 105, 20470-20475.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20470-20475
    • Barabutis, N.1    Schally, A.V.2
  • 5
    • 0036118890 scopus 로고    scopus 로고
    • Obstructive sleep apnea and the prefrontal cortex: Towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits
    • Beebe D. W., and, Gozal D., (2002) Obstructive sleep apnea and the prefrontal cortex: towards a comprehensive model linking nocturnal upper airway obstruction to daytime cognitive and behavioral deficits. J. Sleep Res. 11, 1-16.
    • (2002) J. Sleep Res. , vol.11 , pp. 1-16
    • Beebe, D.W.1    Gozal, D.2
  • 6
    • 63549129273 scopus 로고    scopus 로고
    • Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea
    • Belaidi E., Joyeux-Faure M., Ribuot C., Launois S. H., Levy P., and, Godin-Ribuot D., (2009) Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. J. Am. Coll. Cardiol. 53, 1309-1317.
    • (2009) J. Am. Coll. Cardiol. , vol.53 , pp. 1309-1317
    • Belaidi, E.1    Joyeux-Faure, M.2    Ribuot, C.3    Launois, S.H.4    Levy, P.5    Godin-Ribuot, D.6
  • 7
    • 77958011136 scopus 로고    scopus 로고
    • Central serotonin neurons are required for arousal to CO2
    • Buchanan G. F., and, Richerson G. B., (2010) Central serotonin neurons are required for arousal to CO2. Proc. Natl Acad. Sci. USA 107, 16354-16359.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 16354-16359
    • Buchanan, G.F.1    Richerson, G.B.2
  • 8
    • 33645861076 scopus 로고    scopus 로고
    • Physiological consequences of prolonged periods of flow limitation in patients with sleep apnea hypopnea syndrome
    • Calero G., Farre R., Ballester E., Hernandez L., Daniel N., and, Montserrat Canal J. M., (2006) Physiological consequences of prolonged periods of flow limitation in patients with sleep apnea hypopnea syndrome. Respir. Med. 100, 813-817.
    • (2006) Respir. Med. , vol.100 , pp. 813-817
    • Calero, G.1    Farre, R.2    Ballester, E.3    Hernandez, L.4    Daniel, N.5    Montserrat Canal, J.M.6
  • 9
    • 84863189543 scopus 로고    scopus 로고
    • Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea
    • Dayyat E. A., Zhang S. X., Wang Y., Cheng Z. J., and, Gozal D., (2012) Exogenous erythropoietin administration attenuates intermittent hypoxia-induced cognitive deficits in a murine model of sleep apnea. BMC Neurosci. 13, 77.
    • (2012) BMC Neurosci. , vol.13 , pp. 77
    • Dayyat, E.A.1    Zhang, S.X.2    Wang, Y.3    Cheng, Z.J.4    Gozal, D.5
  • 11
    • 2342429486 scopus 로고    scopus 로고
    • Passage of VIP/PACAP/secretin family across the blood-brain barrier: Therapeutic effects
    • Dogrukol-Ak D., Tore F., and, Tuncel N., (2004) Passage of VIP/PACAP/secretin family across the blood-brain barrier: therapeutic effects. Curr. Pharm. Des. 10, 1325-1340.
    • (2004) Curr. Pharm. Des. , vol.10 , pp. 1325-1340
    • Dogrukol-Ak, D.1    Tore, F.2    Tuncel, N.3
  • 13
    • 0034717688 scopus 로고    scopus 로고
    • Acute treatments with GMP produce antidepressant-like effects in mice
    • Eckeli A. L., Dach F., and, Rodrigues A. L., (2000) Acute treatments with GMP produce antidepressant-like effects in mice. NeuroReport 11, 1839-1843.
    • (2000) NeuroReport , vol.11 , pp. 1839-1843
    • Eckeli, A.L.1    Dach, F.2    Rodrigues, A.L.3
  • 14
    • 20844431565 scopus 로고    scopus 로고
    • Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders
    • Freeman R. S., and, Barone M. C., (2005) Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders. Curr. Drug Targets CNS Neurol. Disord. 4, 85-92.
    • (2005) Curr. Drug Targets CNS Neurol. Disord. , vol.4 , pp. 85-92
    • Freeman, R.S.1    Barone, M.C.2
  • 15
    • 0033082436 scopus 로고    scopus 로고
    • Analysing hippocampal function in transgenic mice: An ethological perspective
    • Gerlai R., and, Clayton N. S., (1999) Analysing hippocampal function in transgenic mice: an ethological perspective. Trends Neurosci. 22, 47-51.
    • (1999) Trends Neurosci. , vol.22 , pp. 47-51
    • Gerlai, R.1    Clayton, N.S.2
  • 16
    • 0035313599 scopus 로고    scopus 로고
    • Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat
    • Gozal D., Daniel J. M., and, Dohanich G. P., (2001) Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. J. Neurosci. 21, 2442-2450.
    • (2001) J. Neurosci. , vol.21 , pp. 2442-2450
    • Gozal, D.1    Daniel, J.M.2    Dohanich, G.P.3
  • 17
    • 77955871507 scopus 로고    scopus 로고
    • Physical activity attenuates intermittent hypoxia-induced spatial learning deficits and oxidative stress
    • Gozal D., Nair D., and, Goldbart A. D., (2010) Physical activity attenuates intermittent hypoxia-induced spatial learning deficits and oxidative stress. Am. J. Respir. Crit. Care Med. 182, 104-112.
    • (2010) Am. J. Respir. Crit. Care Med. , vol.182 , pp. 104-112
    • Gozal, D.1    Nair, D.2    Goldbart, A.D.3
  • 18
    • 79961151706 scopus 로고    scopus 로고
    • A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories
    • Hallschmid M., Wilhelm I., Michel C., Perras B., and, Born J., (2011) A role for central nervous growth hormone-releasing hormone signaling in the consolidation of declarative memories. PLoS ONE 6, e23435.
    • (2011) PLoS ONE , vol.6
    • Hallschmid, M.1    Wilhelm, I.2    Michel, C.3    Perras, B.4    Born, J.5
  • 19
    • 0029069917 scopus 로고
    • Synthesis and biological evaluation of superactive agonists of growth hormone-releasing hormone
    • Izdebski J., Pinski J., Horvath J. E., Halmos G., Groot K., and, Schally A. V., (1995) Synthesis and biological evaluation of superactive agonists of growth hormone-releasing hormone. Proc. Natl Acad. Sci. USA 92, 4872-4876.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 4872-4876
    • Izdebski, J.1    Pinski, J.2    Horvath, J.E.3    Halmos, G.4    Groot, K.5    Schally, A.V.6
  • 20
    • 79955377362 scopus 로고    scopus 로고
    • Cognition and daytime functioning in sleep-related breathing disorders
    • Jackson M. L., Howard M. E., and, Barnes M., (2011) Cognition and daytime functioning in sleep-related breathing disorders. Prog. Brain Res. 190, 53-68.
    • (2011) Prog. Brain Res. , vol.190 , pp. 53-68
    • Jackson, M.L.1    Howard, M.E.2    Barnes, M.3
  • 21
    • 24644432471 scopus 로고    scopus 로고
    • Antagonists of growth hormone-releasing hormone cross the blood-brain barrier: A potential applicability to treatment of brain tumors
    • Jaeger L. B., Banks W. A., Varga J. L., and, Schally A. V., (2005) Antagonists of growth hormone-releasing hormone cross the blood-brain barrier: a potential applicability to treatment of brain tumors. Proc. Natl Acad. Sci. USA 102, 12495-12500.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 12495-12500
    • Jaeger, L.B.1    Banks, W.A.2    Varga, J.L.3    Schally, A.V.4
  • 22
    • 84863502131 scopus 로고    scopus 로고
    • Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia
    • Kaushal N., Ramesh V., and, Gozal D., (2012) Human apolipoprotein E4 targeted replacement in mice reveals increased susceptibility to sleep disruption and intermittent hypoxia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303, R19-R29.
    • (2012) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.303
    • Kaushal, N.1    Ramesh, V.2    Gozal, D.3
  • 23
    • 83455199632 scopus 로고    scopus 로고
    • Novel antagonists of growth hormone-releasing hormone inhibit growth and vascularization of human experimental ovarian cancers
    • Klukovits A., Schally A. V., Szalontay L., Vidaurre I., Papadia A., Zarandi M., Varga J. L., Block N. L., and, Halmos G., (2012) Novel antagonists of growth hormone-releasing hormone inhibit growth and vascularization of human experimental ovarian cancers. Cancer 118, 670-680.
    • (2012) Cancer , vol.118 , pp. 670-680
    • Klukovits, A.1    Schally, A.V.2    Szalontay, L.3    Vidaurre, I.4    Papadia, A.5    Zarandi, M.6    Varga, J.L.7    Block, N.L.8    Halmos, G.9
  • 24
    • 80054035935 scopus 로고    scopus 로고
    • Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats
    • Li R. C., Guo S. Z., Raccurt M., Moudilou E., Morel G., Brittian K. R., and, Gozal D., (2011) Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats. Neuroscience 196, 237-250.
    • (2011) Neuroscience , vol.196 , pp. 237-250
    • Li, R.C.1    Guo, S.Z.2    Raccurt, M.3    Moudilou, E.4    Morel, G.5    Brittian, K.R.6    Gozal, D.7
  • 25
    • 77949770733 scopus 로고    scopus 로고
    • Localized suppression of cortical growth hormone-releasing hormone receptors state-specifically attenuates electroencephalographic delta waves
    • Liao F., Taishi P., Churchill L., Urza M. J., and, Krueger J. M., (2010) Localized suppression of cortical growth hormone-releasing hormone receptors state-specifically attenuates electroencephalographic delta waves. J. Neurosci. 30, 4151-4159.
    • (2010) J. Neurosci. , vol.30 , pp. 4151-4159
    • Liao, F.1    Taishi, P.2    Churchill, L.3    Urza, M.J.4    Krueger, J.M.5
  • 26
    • 77955443500 scopus 로고    scopus 로고
    • Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets
    • Ludwig B., Ziegler C. G., Schally A. V., et al,. (2010) Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets. Proc. Natl Acad. Sci. USA 107, 12623-12628.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 12623-12628
    • Ludwig, B.1    Ziegler, C.G.2    Schally, A.V.3
  • 27
    • 84859475829 scopus 로고    scopus 로고
    • Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist
    • Ludwig B., Rotem A., Schmid J., et al,. (2012) Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc. Natl Acad. Sci. USA 109, 5022-5027.
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 5022-5027
    • Ludwig, B.1    Rotem, A.2    Schmid, J.3
  • 29
    • 0021173996 scopus 로고
    • Developments of a water-maze procedure for studying spatial learning in the rat
    • Morris R., (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11, 47-60.
    • (1984) J. Neurosci. Methods , vol.11 , pp. 47-60
    • Morris, R.1
  • 30
    • 17644439585 scopus 로고    scopus 로고
    • Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland
    • Muccioli G., Ghe C., Ghigo M. C., et al,. (1998) Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland. J. Endocrinol. 157, 99-106.
    • (1998) J. Endocrinol. , vol.157 , pp. 99-106
    • Muccioli, G.1    Ghe, C.2    Ghigo, M.C.3
  • 31
    • 84871396247 scopus 로고    scopus 로고
    • Inhibitory effects of antagonists of growth hormone-releasing hormone on growth and invasiveness of PC3 human prostate cancer
    • Munoz-Moreno L., Arenas M. I., Schally A. V., et al,. (2013) Inhibitory effects of antagonists of growth hormone-releasing hormone on growth and invasiveness of PC3 human prostate cancer. Int. J. Cancer 132, 755-765.
    • (2013) Int. J. Cancer , vol.132 , pp. 755-765
    • Munoz-Moreno, L.1    Arenas, M.I.2    Schally, A.V.3
  • 32
    • 79956347138 scopus 로고    scopus 로고
    • Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea
    • Nair D., Dayyat E. A., Zhang S. X., Wang Y., and, Gozal D., (2011a) Intermittent hypoxia-induced cognitive deficits are mediated by NADPH oxidase activity in a murine model of sleep apnea. PLoS ONE 6, e19847.
    • (2011) PLoS ONE , vol.6
    • Nair, D.1    Dayyat, E.A.2    Zhang, S.X.3    Wang, Y.4    Gozal, D.5
  • 33
    • 82555168382 scopus 로고    scopus 로고
    • Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouse
    • Nair D., Zhang S. X., Ramesh V., Hakim F., Kaushal N., Wang Y., and, Gozal D., (2011b) Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouse. Am. J. Respir. Crit. Care Med. 184, 1305-1312.
    • (2011) Am. J. Respir. Crit. Care Med. , vol.184 , pp. 1305-1312
    • Nair, D.1    Zhang, S.X.2    Ramesh, V.3    Hakim, F.4    Kaushal, N.5    Wang, Y.6    Gozal, D.7
  • 36
    • 29844452893 scopus 로고    scopus 로고
    • Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse
    • Polotsky V. Y., Rubin A. E., Balbir A., Dean T., Smith P. L., Schwartz A. R., and, O'Donnell C. P., (2006) Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse. Sleep Med. 7, 7-16.
    • (2006) Sleep Med. , vol.7 , pp. 7-16
    • Polotsky, V.Y.1    Rubin, A.E.2    Balbir, A.3    Dean, T.4    Smith, P.L.5    Schwartz, A.R.6    O'Donnell, C.P.7
  • 37
    • 0038132134 scopus 로고    scopus 로고
    • Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat
    • Row B. W., Liu R., Xu W., Kheirandish L., and, Gozal D., (2003) Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. Am. J. Respir. Crit. Care Med. 167, 1548-1553.
    • (2003) Am. J. Respir. Crit. Care Med. , vol.167 , pp. 1548-1553
    • Row, B.W.1    Liu, R.2    Xu, W.3    Kheirandish, L.4    Gozal, D.5
  • 38
    • 33846423862 scopus 로고    scopus 로고
    • Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep
    • Row B. W., Kheirandish L., Cheng Y., Rowell P. P., and, Gozal D., (2007) Impaired spatial working memory and altered choline acetyltransferase (CHAT) immunoreactivity and nicotinic receptor binding in rats exposed to intermittent hypoxia during sleep. Behav. Brain Res. 177, 308-314.
    • (2007) Behav. Brain Res. , vol.177 , pp. 308-314
    • Row, B.W.1    Kheirandish, L.2    Cheng, Y.3    Rowell, P.P.4    Gozal, D.5
  • 39
    • 35348944377 scopus 로고    scopus 로고
    • Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage
    • Shan X., Chi L., Ke Y., Luo C., Qian S., Gozal D., and, Liu R., (2007) Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damage. Neurobiol. Dis. 28, 206-215.
    • (2007) Neurobiol. Dis. , vol.28 , pp. 206-215
    • Shan, X.1    Chi, L.2    Ke, Y.3    Luo, C.4    Qian, S.5    Gozal, D.6    Liu, R.7
  • 40
    • 34547634696 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone: Cerebral cortical sleep-related EEG actions and expression
    • Szentirmai E., Yasuda T., Taishi P., et al,. (2007) Growth hormone-releasing hormone: cerebral cortical sleep-related EEG actions and expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293, R922-R930.
    • (2007) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.293
    • Szentirmai, E.1    Yasuda, T.2    Taishi, P.3
  • 42
    • 80053472333 scopus 로고    scopus 로고
    • Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats
    • Tarasiuk A., Berdugo-Boura N., Troib A., and, Segev Y., (2011) Role of growth hormone-releasing hormone in sleep and growth impairments induced by upper airway obstruction in rats. Eur. Respir. J. 38, 870-877.
    • (2011) Eur. Respir. J. , vol.38 , pp. 870-877
    • Tarasiuk, A.1    Berdugo-Boura, N.2    Troib, A.3    Segev, Y.4
  • 43
    • 84862277218 scopus 로고    scopus 로고
    • Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning
    • Telegdy G., and, Schally A. V., (2012a) Involvement of neurotransmitters in the action of growth hormone-releasing hormone antagonist on passive avoidance learning. Behav. Brain Res. 233, 326-330.
    • (2012) Behav. Brain Res. , vol.233 , pp. 326-330
    • Telegdy, G.1    Schally, A.V.2
  • 44
    • 84861754176 scopus 로고    scopus 로고
    • Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice
    • Telegdy G., and, Schally A. V., (2012b) Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice. Behav. Brain Res. 233, 232-236.
    • (2012) Behav. Brain Res. , vol.233 , pp. 232-236
    • Telegdy, G.1    Schally, A.V.2
  • 45
    • 79959558904 scopus 로고    scopus 로고
    • Effects of the growth hormone-releasing hormone (GH-RH) antagonist on brain functions in mice
    • Telegdy G., Tanaka M., and, Schally A. V., (2011) Effects of the growth hormone-releasing hormone (GH-RH) antagonist on brain functions in mice. Behav. Brain Res. 224, 155-158.
    • (2011) Behav. Brain Res. , vol.224 , pp. 155-158
    • Telegdy, G.1    Tanaka, M.2    Schally, A.V.3
  • 46
    • 0034133296 scopus 로고    scopus 로고
    • Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory
    • Thornton P. L., Ingram R. L., and, Sonntag W. E., (2000) Chronic [D-Ala2]-growth hormone-releasing hormone administration attenuates age-related deficits in spatial memory. J. Gerontol. A Biol. Sci. Med. Sci. 55, B106-B112.
    • (2000) J. Gerontol. A Biol. Sci. Med. Sci. , vol.55
    • Thornton, P.L.1    Ingram, R.L.2    Sonntag, W.E.3
  • 48
    • 84865628716 scopus 로고    scopus 로고
    • Inhibition of GHRH aggravated acetaminophen-induced acute mice liver injury through GH/IGF-I axis
    • Wang T., Hai J., Chen X., Peng H., Zhang H., Li L., and, Zhang Q., (2012) Inhibition of GHRH aggravated acetaminophen-induced acute mice liver injury through GH/IGF-I axis. Endocr. J. 59, 579-587.
    • (2012) Endocr. J. , vol.59 , pp. 579-587
    • Wang, T.1    Hai, J.2    Chen, X.3    Peng, H.4    Zhang, H.5    Li, L.6    Zhang, Q.7
  • 50
    • 2942668297 scopus 로고    scopus 로고
    • Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea
    • Xu W., Chi L., Row B. W., et al,. (2004) Increased oxidative stress is associated with chronic intermittent hypoxia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea. Neuroscience 126, 313-323.
    • (2004) Neuroscience , vol.126 , pp. 313-323
    • Xu, W.1    Chi, L.2    Row, B.W.3
  • 51
    • 54049088213 scopus 로고    scopus 로고
    • Induction of HIF-1alpha expression by intermittent hypoxia: Involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR
    • Yuan G., Nanduri J., Khan S., Semenza G. L., and, Prabhakar N. R., (2008) Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR. J. Cell. Physiol. 217, 674-685.
    • (2008) J. Cell. Physiol. , vol.217 , pp. 674-685
    • Yuan, G.1    Nanduri, J.2    Khan, S.3    Semenza, G.L.4    Prabhakar, N.R.5
  • 52
    • 79960697192 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia
    • Yuan G., Khan S. A., Luo W., Nanduri J., Semenza G. L., and, Prabhakar N. R., (2011) Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J. Cell. Physiol. 226, 2925-2933.
    • (2011) J. Cell. Physiol. , vol.226 , pp. 2925-2933
    • Yuan, G.1    Khan, S.A.2    Luo, W.3    Nanduri, J.4    Semenza, G.L.5    Prabhakar, N.R.6
  • 53
    • 19344375685 scopus 로고    scopus 로고
    • Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test
    • Zomkowski A. D., Santos A. R., and, Rodrigues A. L., (2005) Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test. Neurosci. Lett. 381, 279-283.
    • (2005) Neurosci. Lett. , vol.381 , pp. 279-283
    • Zomkowski, A.D.1    Santos, A.R.2    Rodrigues, A.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.