Antagonists of growth hormone-releasing hormone cross the blood-brain barrier: A potential applicability to treatment of brain tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 35, 2005, Pages 12495-12500

  Jaeger, Laura B ^a,b   Banks, William A ^a,b   Varga, Jozsef L ^c,d   Schally, Andrew V ^c,d  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer therapy; P glycoprotein

Indexed keywords

CYCLOSPORIN A; GLYCOPROTEIN P; GROWTH FACTOR; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; GROWTH HORMONE RELEASING HORMONE ANTAGONIST; HORMONE ANTAGONIST; JV 1 142; JV 1 142 I 131; JV 1 36; JV 1 42; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TUMOR; CANCER INHIBITION; CANCER SURVIVAL; CANCER TRANSPLANTATION; CARCINOGENICITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BINDING SITE; DRUG HALF LIFE; DRUG TRANSPORT; ENDOTHELIUM CELL; GLIOBLASTOMA; GROWTH HORMONE RELEASE; HORMONE SYNTHESIS; HYPOPHYSIS; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; TIGHT JUNCTION; TUMOR MODEL;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; GLIOBLASTOMA; GONADOTROPIN-RELEASING HORMONE; HUMANS; IODINE RADIOISOTOPES; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; TRANSPLANTATION, HETEROLOGOUS;

MUS MUSCULUS;

EID: 24644432471     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0504163102     Document Type: Article

References (38)

1. Schally, A. V., Comaru-Schally, A. M., Nagy, A., Kovacs, M., Szepeshazi, K., Plonowski, A., Varga, J. L. & Halamos, G. (2001) Front. Neuroendocrinol. 22, 248-291.
2. Schally, A. V. & Varga, J. L. (1999) Trends Endocrinol. Metab. 10, 383-393.
3. Plonowski, A., Schally, A. V., Busto, R., Krupa, M., Varga, J. L. & Halmos, G. (2002) Peptides 23, 1127-1133.
4. Halmos, G., Schally, A. V., Czompoly, T., Krupa, M., Varga, J. L. & Rekasi, Z. (2002) J. Clin. Endocrinol. Metab. 87, 4707-4714.
5. Halmos, G., Schally, A. V., Varga, J. L., Plonowski, A., Rekasi, Z. & Czompoly, T. (2000) Proc. Natl. Acad. Sci. USA 97, 10555-10560.
6. Rekasi, Z., Czompoly, T., Schally, A. V. & Halmos, G. (2000) Proc. Natl. Acad. Sci. USA 97, 10561-10566.
7. Braczkowski, R., Schally, A. V., Plonowski, A., Varga, J. L., Groot, K., Krupa, M. & Armatis, P. (2002) Cancer 95, 1735-1745.
8. Kiaris, H., Schally, A. V. & Varga, J. L. (2000) Neoplasia 2, 242-250.
9. Kiaris, H., Schally, A. V., Varga, J. L., Groot, K. & Armatis, P. (1999) Proc. Natl. Acad. Sci. USA 96, 14894-14898.
10. Chatzistamou, I., Schally, A. V., Varga, J. L., Groot, K., Armatis, P. & Halmos, G. (2001) J. Clin. Endocrinol. Metab. 86, 2144-2152.
11. Kahan, Z., Varga, J. L., Schally, A. V., Rekasi, Z. & Armatis, P. (2000) Breast Cancer Res. Treat. 60, 71-79.
12. Szepeshazi, K., Schally, A. V., Groot, K., Armatis, P., Halmos, G., Hebert, F., Szende, B., Varga, J. L. & Zarandi, M. (1999) Br. J. Cancer 82, 1724-1731.
13. Szepeshazi, K., Schally, A. V., Groot, K., Armatis, P., Hebert, F. & Halmos, G. (1999) Eur. J. Cancer 36, 128-136.
14. Letsch, M., Schally, A. V., Busto, R., Bajo, A. M. & Varga, J. L. (2003) Proc. Natl. Acad. Sci. USA 100, 1250-1255.
15. Jungwirth, A., Schally, A. V., Pinski, J., Groot, K., Armatis, P. & Halmos, G. (1997) Proc. Natl. Acad. Sci. USA 94, 5810-5813.
16. Busto, R., Schally, A. V., Varga, J. L., Garcia-Fernandez, M. O., Groot, K., Armatis, P. & Szepeshazi, K. (2002) Proc. Natl. Acad. Sci. USA 99, 11866-11871.
17. Behin, A., Hoang-Xuan, K., Carpentier, A. F. & Delattre, J. Y. (2003) Lancet 361, 323-331.
18. Boado, R. J., Li, J. Y. & Pardridge, W. M. (2004) Pediatr. Res. 55, 557-560.
19. Tohyama, K., Kusuhara, H. & Sugiyama, Y. (2004) Endocrinology 145, 4384-4391.
20. Isakovic, A. J., Abbott, N. J. & Redzic, Z. B. (2004) J. Neurochem. 90, 272-286.
21. Banks, W. A., Kastin, A. J., Huang, W., Jaspan, J. B. & Maness, L. M. (1996) Peptides 17, 305-311.
22. Banks, W. A. (2005) Curr. Pharmacol. Des. 11, 973-984.
23. Blasberg, R. G., Fenstermacher, J. D. & Patlak, C. S. (1983) J. Cereb. Blood Flow Metab. 3, 8-32.
24. Patlak, C. S., Blasberg, R. G. & Fenstermacher, J. D. (1983) J. Cereb. Blood Flow Metab. 3, 1-7.
25. Banks, W. A., Kastin, A. J., Fischman, A. J., Coy, D. H. & Strauss, S. L. (1986) Am. J. Physiol. 251, E477-E482.
26. Triguero, D., Buciak, J. & Pardridge, W. M. (1990) J. Neurochem. 54, 1882-1888.
27. Guitierrez, E. G., Banks, W. A. & Kastin, A. J. (1993) J. Neuroimmunol. 47, 169-176.
28. Thomas, H. & Coley, H. M. (2003) Cancer Control 10, 159-165.
29. Banks, W. A. & Kastin, A. J. (1994) Peptides 15, 23-29.
30. Lam, F. C., Liu, R., Lu, P., Shapiro, A. B., Renior, J. M., Sharom, F. J. & Reiner, P. B. (2001) J. Neurochem. 76, 1121-1128.
31. Banks, W. A., Farr, S. A., La Scola, M. E. & Morley, J. E. (2001) J. Pharmacol. Exp. Ther. 299, 536-541.
32. Yates, C. R., Chang, C., Kearbey, J. D., Yasuda, K., Schuetz, E. G., Miller, D. D., Dalton, J. T. & Swaan, P. W. (2003) Pharmacol. Res. 20, 1794-1803.
33. Troost, J., Lindenmaier, H., Haefeli, W. E. & Weiss, J. (2004) Mol. Pharmacol. 66, 1332-1339.
34. Begley, D. J. (2004) Curr. Pharmcol. Des. 10, 1295-1312.
35. Chikale, E. G., Burton, P. S. & Borchardt, R. T. (1995) J. Pharmacol. Exp. Ther. 273, 298-303.
36. Fellay, J., Marzolini, C., Meaden, E. R., Black, D. J., Buclin, T., Chave, J. P., Decosterd, L. A., Furrer, H., Opravil, M., Pantaleo, G., et al. (2002) Lancet 359, 30-36.
37. Löscher, W. & Potschka, H. (2002) J. Pharmacol. Exp. Ther. 30, 7-14.
38. Taylor, E. M. (2002) Clin. Pharmacokinet. 41, 81-92.