Lipid resuscitation of bupivacaine toxicity: Long-chain triglyceride emulsion provides benefits over long-and medium-chain triglyceride emulsion

Anesthesiology

Volumn 115, Issue 6, 2011, Pages 1219-1228

  Li, Zhengqian ^a   Xia, Yun ^c   Dong, Xiaoxi ^a,b   Chen, Hongfei ^a   Xia, Fangfang ^a   Wang, Xianqin ^a   Dong, Huimin ^a   Jin, Zhousheng ^a   Ding, Xili ^a   Papadimos, Thomas J ^c   Xu, Xuzhong ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THE THIRD AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BUPIVACAINE; INTRALIPID; LIPOVENOES;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; ASYSTOLE; BIOENERGY; CARDIOTOXICITY; CONTINUOUS INFUSION; CONTROLLED STUDY; HEART ARREST; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RAT; RESUSCITATION; RETURN OF SPONTANEOUS CIRCULATION; SURVIVAL; TRIACYLGLYCEROL BLOOD LEVEL;

ANALYSIS OF VARIANCE; ANESTHETICS, LOCAL; ANIMALS; BRONCHODILATOR AGENTS; BUPIVACAINE; DISEASE MODELS, ANIMAL; EMULSIONS; EPINEPHRINE; FAT EMULSIONS, INTRAVENOUS; HEART ARREST; LIPIDS; MALE; PHOSPHOLIPIDS; RATS; RATS, SPRAGUE-DAWLEY; RESUSCITATION; SOYBEAN OIL; TRIGLYCERIDES;

EID: 81855221701     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318238be73     Document Type: Article

References (34)

1. Weinberg GL, VadeBoncouer T, Ramaraju GA, Garcia-Amaro MF, Cwik MJ: Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. ANESTHESIOLOGY 1998; 88:1071-5
2. Neal JM, Bernards CM, Butterworth JF 4th, Di Gregorio G, Drasner K, Hejtmanek MR, Mulroy MF, Rosenquist RW, Weinberg GL: ASRA practice advisory on local anesthetic systemic toxicity. Reg Anesth Pain Med 2010; 35:152-61
3. Rothschild L, Bern S, Oswald S, Weinberg G: Intravenous lipid emulsion in clinical toxicology. Scand J Trauma Resusc Emerg Med 2010; 18:51
4. Rosenblatt MA, Abel M, Fischer GW, Itzkovich CJ, Eisenkraft JB: Successful use of a 20% lipid emulsion to resuscitate a patient after a presumed bupivacaine-related cardiac arrest. ANESTHESIOLOGY 2006; 105:217-8
5. Harvey M, Cave G, Prince G, Lahner D: Epinephrine injection in lipid-based resuscitation from bupivacaine-induced cardiac arrest: Transient circulatory return in rabbits. Anesth Analg 2010; 111:791-6
6. Weinberg GL, Di Gregorio G, Ripper R, Kelly K, Massad M, Edelman L, Schwartz D, Shah N, Zheng S, Feinstein DL: Resuscitation with lipid versus epinephrine in a rat model of bupivacaine overdose. ANESTHESIOLOGY 2008; 108:907-13
7. Weinberg GL, Ripper R, Murphy P, Edelman LB, Hoffman W, Strichartz G, Feinstein DL: Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med 2006; 31:296-303
8. Cave G, Harvey M, Prince G, Lahner D, Desmet J: Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid. Anaesthesia 2010; 65:792-8
9. Di Gregorio G, Schwartz D, Ripper R, Kelly K, Feinstein DL, Minshall RD, Massad M, Ori C, Weinberg GL: Lipid emulsion is superior to vasopressin in a rodent model of resuscitation from toxin-induced cardiac arrest. Crit Care Med 2009; 37: 993-9
10. Warren JA, Thoma RB, Georgescu A, Shah SJ: Intravenous lipid infusion in the successful resuscitation of local anesthetic-induced cardiovascular collapse after supraclavicular brachial plexus block. Anesth Analg 2008; 106:1578-80
11. Ludot H, Tharin JY, Belouadah M, Mazoit JX, Malinovsky JM: Successful resuscitation after ropivacaine and lidocaine-induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg 2008; 106:1572-4
12. Charbonneau H, Marcou TA, Mazoit JX, Zetlaoui PJ, Benhamou D: Early use of lipid emulsion to treat incipient mepivacaine intoxication. Reg Anesth Pain Med 2009; 34: 277-8
13. Weinberg GL, Palmer JW, VadeBoncouer TR, Zuechner MB, Edelman G, Hoppel CL: Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria. ANESTHESIOLOGY 2000; 92: 523-8
14. Johnson RC, Young SK, Cotter R, Lin L, Rowe WB: Mediumchain-triglyceride lipid emulsion: Metabolism and tissue distribution. Am J Clin Nutr 1990; 52:502-8
15. Mazoit JX, Le Guen R, Beloeil H, Benhamou D: Binding of longlasting local anesthetics to lipid emulsions. ANESTHESIOLOGY 2009; 110:380-6
16. Dennison AR, Ball M, Crowe PJ, White K, Hands L, Watkins RM, Kettlewell M: The metabolic consequences of infusing emulsions containing medium chain triglycerides for parenteral nutrition: A comparative study with conventional lipid. Ann R Coll Surg Engl 1986; 68:119-21
17. Cotter R, Johnson RC, Young SK, Lin LI, Rowe WB: Competitive effects of long-chain-triglyceride emulsion on the metabolism of medium-chain-triglyceride emulsions. Am J Clin Nutr 1989; 50:794-800
18. Candela D, Louart G, Bousquet PJ, Muller L, Nguyen M, Boyer JC, Peray PA, Goret L, Ripart J, Lefrant JY, de La Coussaye JE: Reversal of bupivacaine-induced cardiac electrophysiologic changes by two lipid emulsions in anesthetized and mechanically ventilated piglets. Anesth Analg 2010; 110:1473-9
19. Hiller DB, Gregorio GD, Ripper R, Kelly K, Massad M, Edelman L, Edelman G, Feinstein DL, Weinberg GL: Epinephrine impairs lipid resuscitation from bupivacaine overdose: A threshold effect. ANESTHESIOLOGY 2009; 111:498-505
20. Weinberg GL: Reply to Drs. Goor, Groban and Butterworth-Lipid rescue: Caveats and recommendations for the "silverbullet" (letter). Reg Anesth Pain Med 2004; 29:74-5
21. Weinberg G, Hertz P, Newman J: Lipid, not propofol, treats bupivacaine overdose. Anesth Analg 2004; 99:1875-6
22. Smith HM, Jacob AK, Segura LG, Dilger JA, Torsher LC: Simulation education in anesthesia training: A case report of successful resuscitation of bupivacaine-induced cardiac arrest linked to recent simulation training. Anesth Analg 2008; 106:1581-4
23. Chen Y, Xia Y, Liu L, Shi T, Shi K, Wang Q, Chen L, Papadimos TJ, Xu X: Lipid emulsion reverses bupivacaineinduced asystole in isolated rat hearts: Concentration-response and time-response relationships. ANESTHESIOLOGY 2010; 113:1320-5
24. Song Z, Deaciuc I, Song M, Lee DY, Liu Y, Ji X, McClain C: Silymarin protects against acute ethanol-induced hepatotoxicity in mice. Alcohol Clin Exp Res 2006; 30:407-13
25. Stehr SN, Ziegeler JC, Pexa A, Oertel R, Deussen A, Koch T, Hübler M: The effects of lipid infusion on myocardial function and bioenergetics in l-bupivacaine toxicity in the isolated rat heart. Anesth Analg 2007; 104:186-92
26. Ali B, Zafari AM: Narrative review: Cardiopulmonary resuscitation and emergency cardiovascular care: review of the current guidelines. Ann Intern Med 2007; 147:171-9
27. Liu L, Xia Y, Chen Y, Wang Q, Shi T, Wang F, Small RH, Xu X: The comparative effects of lipid, epinephrine, and their combination in the reversal of bupivacaine-induced asystole in the isolated rat heart. Anesth Analg 2011 [Epub ahead of print]
28. Sailer D, Müller M: Medium chain triglycerides in parenteral nutrition. JPEN J Parenter Enteral Nutr 1981; 5:115-9
29. Calder PC, Deckelbaum RJ: 'New' metabolic pathways and roles for lipids and lipid emulsions. Curr Opin Clin Nutr Metab Care 1998; 1:139-41
30. Qi K, Seo T, Jiang Z, Carpentier YA, Deckelbaum RJ: Triglycerides in fish oil affect the blood clearance of lipid emulsions containing long-and medium-chain triglycerides in mice. J Nutr 2006; 136:2766-72
31. Jang JH, Kim CK, Choi HG, Sung JH: Preparation and evaluation of 2-(allylthio)pyrazine-loaded lipid emulsion with enhanced stability and liver targeting. Drug Dev Ind Pharm 2009; 35:363-8
32. Collins-Nakai RL, Noseworthy D, Lopaschuk GD: Epinephrine increases ATP production in hearts by preferentially increasing glucose metabolism. Am J Physiol 1994; 267: H1862-71
33. Mitchell ME: Carnitine metabolism in human subjects. I. Normal metabolism. Am J Clin Nutr 1978; 31:293-306
34. Koletzko B, Goulet O, Hunt J, Krohn K, Shamir R: 1. Guidelines on Paediatric Parenteral Nutrition of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and the European Society for Clinical Nutrition and Metabolism (ESPEN), Supported by the European Society of Paediatric Research (ESPR). J Pediatr Gastroenterol Nutr 2005; 41 Suppl 2:S1-87