Preparation of (-)-nutlin-3 using enantioselective organocatalysis at decagram scale

Journal of Organic Chemistry

Volumn 78, Issue 21, 2013, Pages 10605-10616

  Davis, Tyler A ^a,b   Vilgelm, Anna E ^a   Richmond, Ann ^a   Johnston, Jeffrey N ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CHEMOTHERAPEUTICS; CATALYST LOADINGS; CHROMATOGRAPHIC PURIFICATION; ENANTIOSELECTIVE ORGANOCATALYSIS; ENANTIOSELECTIVE SYNTHESIS; HIGH ENANTIOSELECTIVITY; HOFFMANN-LA ROCHE; REACTION TEMPERATURE;

CATALYSTS; CELL DEATH; CHROMATOGRAPHIC ANALYSIS; DISEASES; REACTION KINETICS; SELECTIVE CATALYTIC REDUCTION; SYNTHESIS (CHEMICAL);

ENANTIOSELECTIVITY;

AMIDINE; NITROALKANE; NITROMETHANE; NUTLIN 3; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASYMMETRIC SYNTHESIS; CANCER INHIBITION; CATALYSIS; CATALYST; CELL VIABILITY; CHIRALITY; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CULTURE MEDIUM; CYCLIZATION; DECAGRAM SCALE; DECARBOXYLATION; DIASTEREOISOMER; ELECTROPHILICITY; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MELANOMA CELL; NITRATION; NUCLEAR MAGNETIC RESONANCE; PRECIPITATION; REACTION TIME; SCALE UP; SOLUBILITY; STEREOCHEMISTRY; STOICHIOMETRY; TEMPERATURE; WESTERN BLOTTING;

AMIDINES; ANIMALS; CATALYSIS; HUMANS; IMIDAZOLES; IMIDAZOLINES; MICE; PIPERAZINES; STEREOISOMERISM; TEMPERATURE; TUMOR CELLS, CULTURED;

EID: 84887108064     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo401321a     Document Type: Article

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