Induction of cyclooxygenase-2 expression by prostaglandin E2 stimulation of the prostanoid EP4 receptor via coupling to Gαi and transactivation of the epidermal growth factor receptor in HCA-7 human colon cancer cells

European Journal of Pharmacology

Volumn 718, Issue 1-3, 2013, Pages 408-417

  Yoshida, Kenji ^a   Fujino, Hiromichi ^a   Otake, Sho ^a   Seira, Naofumi ^a   Regan, John W ^b   Murayama, Toshihiko ^a  

^a CHIBA UNIVERSITY   (Japan)

^b Division of Plant Pathology and Microbiology   (United States)

Author keywords

Colon cancer; Cyclooxygenase 2; G i; Human prostanoid EP4 receptor; PGE2; Phosphatidylinositol 3 kinase; Prostaglandin E2

Indexed keywords

CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2;

ARTICLE; CANCER CELL; CARCINOGENESIS; CELL STIMULATION; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; UPREGULATION;

COLON CANCER; CYCLOOXYGENASE-2; G(ΑI); HUMAN PROSTANOID EP4 RECEPTOR; PGE(2); PHOSPHATIDYLINOSITOL 3-KINASE; PROSTAGLANDIN E(2);

CELL LINE, TUMOR; CELL MEMBRANE; COLONIC NEOPLASMS; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GTP-BINDING PROTEIN ALPHA SUBUNITS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; METALLOPROTEASES; PHOSPHATIDYLINOSITOL 3-KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; TRANSCRIPTIONAL ACTIVATION; TYROSINE;

EID: 84887090740     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.08.002     Document Type: Article

References (37)

1. 2 in mouse skin Carcinogenesis 28 2007 2063 2068 (Pubitemid 47543363)
2. J.R. Brown, and R.N. DuBois COX-2: a molecular target for colorectal cancer prevention Journal of Clinical Oncology 23 2005 2840 2855 (Pubitemid 46179475)
3. J.P. Camiña, J.F. Campos, J.E. Caminos, C. Dieguez, and F.F. Casanueva Obestatin-mediated proliferation of human retinal pigment epithelial cells: regulatory mechanisms Journal of Cellular Physiology 211 2007 1 9 (Pubitemid 46363890)
4. M.D. Castellone, H. Teramoto, and J.S. Gutkind Cyclooxygenase-2 and colorectal cancer chemoprevention: the β-catenin connection Cancer Research 66 2006 11085 11088 (Pubitemid 46009929)
5. 2 promotes colon cancer cell growth through Gs-axin-β-catenin signaling axis Science 310 2005 1504 1510 (Pubitemid 41746348)
6. R.J. Coffey, C.J. Hawkey, L. Damstrup, R. Graves-Deal, V.C. Daniel, P.J. Dempsey, R. Chinery, S.C. Kirkland, R.N. DuBois, T.L. Jetton, and J.D. Morrow Epidermal growth factor receptor activation induced nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells Proceedings of the National Academy of Sciences of the United States of America 94 1997 657 662 (Pubitemid 27053689)
7. G. Cohen, R. Mustafi, A. Chumsangsri, N. Little, J. Nathanson, S. Cerda, S. Jagadeeswaran, U. Dougherty, L. Joseph, J. Hart, L. Yerian, M. Tretiakova, W. Yuan, P. Obara, S. Khare, F.A. Sinicrope, A. Fichera, G.R. Boss, R. Carroll, and M. Bissonnette Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci Cancer Research 66 2006 5656 5664 (Pubitemid 43927118)
8. A.J. Dannenberg, S.M. Lippman, J.R. Mann, K. Subbaramaiah, and R.N. DuBois Cyclooxygenase-2 and epidermal growth factor receptor: pharmacologic targets for chemoprevention Journal of Clinical Oncology 23 2005 254 266 (Pubitemid 46206877)
9. S. Desai, H. April, C. Nwaneshiudu, and B. Ashby Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration Molecular Pharmacology 58 2000 1279 1286
10. 2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion Journal of Biological Chemistry 277 2002 50828 50833 (Pubitemid 36042248)
11. 2 mediated by EP4 receptor in colorectal cancer BMC Cancer 9 2009 207
12. A.L. Eisinger, S.M. Prescott, D.A. Jones, and D.M. Stafforini The role of cyclooxygenase-2 and prostaglandin in colon cancer Prostaglandins & Other Lipid Mediators 82 2007 147 154 (Pubitemid 44880176)
13. H. Fujino, and J.W. Regan Prostanoid receptors and phosphatidylinositol 3-kinase: a pathway to cancer? Trends in Pharmacological Sciences 24 2003 335 340 (Pubitemid 37315524)
14. H. Fujino, and J.W. Regan EP4 prostanoid receptor coupling to a pertussis toxin-sensitive inhibitory G protein Molecular Pharmacology 69 2006 5 10
15. 2 Molecular Pharmacology 68 2005 251 259 (Pubitemid 41002965)
16. B prostanoid receptor Journal of Biological Chemistry 277 2002 48786 48795 (Pubitemid 35470845)
17. 2 regulates cellular migration via induction of vascular endothelial growth factor receptor-1 in HCA-7 human colon cancer cells Biochemical Pharmacology 81 2011 379 387
18. 2 Journal of Biological Chemistry 277 2002 2614 2619 (Pubitemid 34953286)
19. 2 induced functional expression of early growth response factor-1 by EP4, but not EP2, prostanoid receptors via the phosphatidylinositol 3-kinase and extracellular signal-regulated kinases Journal of Biological Chemistry 278 2003 12151 12156 (Pubitemid 36800194)
20. 2-adrenergic receptors Journal of Biological Chemistry 283 2008 29028 29036
21. L. Guo, C.J. Kozlosky, L.H. Ericsson, T.O. Daniel, D.P. Cerretti, and R.S. Johnson Studies of ligand-induced site-specific phosphorylation of epidermal growth factor receptor Journal of the American Society for Mass Spectrometry 14 2003 1022 1031 (Pubitemid 37040763)
22. R.C. Harris, E. Chung, and R.J. Coffey EGF receptor ligands Experimental Cell Research 284 2003 2 13 (Pubitemid 36331964)
23. M.A. Hull, S.C.W. Ko, and G. Hawcroft Prostaglandin EP receptors: targets for treatment and prevention of colorectal cancer? Molecular Cancer Research 3 2004 1031 1039 (Pubitemid 39199598)
24. Y.J. Kang, U.R. Mbonye, C.J. DeLong, M. Wada, and W.L. Smith Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation Progress in Lipid Research 46 2007 108 125 (Pubitemid 46661865)
25. K.M. Kassel, P.R. Dodmane, N.A. Schulte, and M.L. Toews Lysophosphatidic acid induces rapid and sustained decreases in epidermal growth factor receptor binding via different signaling pathways in BEAS-2B airway epithelial cells Journal of Pharmacology and Experimental Therapeutics 325 2008 809 817 (Pubitemid 351724321)
26. T.J. Myers, L.H. Brennaman, M. Stevenson, S. Higashiyama, W.E. Russell, D.C. Lee, and S.W. Sunnarborg Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-α shedding Molecular Biology of the Cell 20 2009 5236 5249
27. 2 synthase gene. Essential role of the transcription factor Egr-1 Journal of Biological Chemistry 277 2002 28601 28608 (Pubitemid 41079288)
28. 2-terminal kinase activation Endocrinology 147 2006 4505 4516 (Pubitemid 44268402)
29. H. Ohtsu, P.J. Dempsey, and S. Eguchi ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors American Journal of Physiology - Cell Physiology 291 2006 C1 C10
30. R.B. Penn, R.M. Pascual, Y.-M. Kim, S.J. Mundell, V.P. Krymskaya, R.A. Panettieri Jr., and J.L. Benovic Arrestin specificity for G protein-coupled receptors in human airway smooth muscle Journal of Biological Chemistry 276 2001 32648 32656
31. J.W. Regan EP2 and EP4 prostanoid receptor signaling Life Sciences 74 2003 143 153
32. W.L. Smith, D.L. DeWitt, and R.M. Garavito Cyclooxygenases: Structural, cellular, and molecular biology Annual Review of Biochemistry 69 2000 145 182
33. S. Song, S. Guha, K. Liu, N.S. Buttar, and R.S. Bresalier COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signaling pathways in Barrett's oesophagus and oesophageal adenocarcinoma Gut 56 2007 1512 1521 (Pubitemid 350033188)
34. S. Srivastava, M. Verma, and D.E. Henson Biomarkers for early detection of colon cancer Clinical Cancer Research 7 2001 1118 1126 (Pubitemid 32708660)
35. Q. Tang, W. Chen, M.S. Gonzales, J. Finch, H. Inoue, and G.T. Bowden Role of cyclic AMP responsive element in the UVB induction of cyclooxygenase-2 transcription in human keratinocyte Oncogene 20 2001 5161 5172
36. M. Tamura, S. Sebastian, B. Gurates, S. Yang, Z. Fang, and S.E. Bulun Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells Journal of Clinical Endocrinology and Metabolism 87 2002 3504 3507 (Pubitemid 34816409)
37. D.F. Woodward, R.L. Jones, and S. Narumiya International union of basic and clinical pharmacology. LXXXIII: classification of prostanoid receptors, updating 15 years of progress Pharmacological Reviews 63 2011 471 538