Lysophosphatidic acid induces rapid and sustained decreases in epidermal growth factor receptor binding via different signaling pathways in BEAS-2B airway epithelial cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 325, Issue 3, 2008, Pages 809-817

  Kassel, Karen M ^a   Dodmane, Puttappa R ^a   Schulte, Nancy A ^a   Toews, Myron L ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; BISINDOLYLMALEIMIDE I; CALCIUM ION; EPIDERMAL GROWTH FACTOR RECEPTOR; ILOMASTAT; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN; PHORBOL 12 ACETATE 13 MYRISTATE; PHOSPHOLIPID; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; UO 126;

ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; RESPIRATORY EPITHELIUM; TRANSACTIVATION;

CELL LINE; EPITHELIAL CELLS; HUMANS; LYSOPHOSPHOLIPIDS; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 44249098506     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.133736     Document Type: Article

References (40)

1. Ammit AJ and Panettieri RA Jr (2001) Invited review: the circle of life: cell cycle regulation in airway smooth muscle. J Appl Physiol 91:1431-1437.
2. An S, Bleu T, Hallmark OG, and Goetzl EJ (1998) Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid. J Biol Chem 273:7906-7910.
3. Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, and Inoue K (1999) Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J Biol Chem 274:27776-27785.
4. Boxall C, Holgate ST, and Davies DE (2006) The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma. Eur Respir J 27:208-229.
5. Cummings R, Zhao Y, Jacoby D, Spannhake EW, Ohba M, Garcia JG, Watkins T, He D, Saatian B, and Natarajan V (2004) Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells. J Biol Chem 279:41085-41094.
6. Dempsey E, Cool CD, and Littler CM (2007) Lung disease and PKCs. Pharmacol Res 55:545-559.
7. Ediger TL, Danforth BL, and Toews ML (2002) Lysophosphatidic acid upregulates the epidermal growth factor receptor in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 282:L91-L98.
8. Ediger TL, Schulte NA, Murphy TJ, and Toews ML (2003) Transcription factor activation and mitogenic synergism in airway smooth muscle cells. Eur Respir J 21:759-769.
9. Engelman JA and Cantley LC (2006) The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors. Clin Cancer Res 12:4372s-4376s.
10. Georas SN, Berdyshev E, Hubbard W, Gorshkova IA, Usatyuk PV, Saatian B, Myers AC, Williams MA, Xiao HQ, Liu M, et al. (2007) Lysophosphatidic acid is detectable in human bronchoalveolar lavage fluids at baseline and increased after segmental allergen challenge. Clin Exp Allergy 37:311-322.
11. Hecht JH, Weiner JA, Post SR, and Chun J (1996) Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J Cell Biol 135:1071-1083.
12. Hewson CA, Edbrooke MR, and Johnston SL (2004) PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. J Mol Biol 344:683-695.
13. Hubbard KB and Hepler JR (2006) Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Cell Signal 18:135-150.
14. Ingram JL and Bonner JC (2006) EGF and PDGF receptor tyrosine kinases as therapeutic targets for chronic lung diseases. Curr Mol Med 6:409-421.
15. Kang S, Luo R, Smicun Y, Fishman DA, and Meng Y (2006) Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation. FEBS Lett 580:443-449.
16. Kassel KM, Schulte NA, Parker SM, Lanik AD, and Toews ML (2007) Lysophosphatidic acid decreases epidermal growth factor receptor binding in airway epithelial cells. J Pharmacol Exp Ther 323:109-118.
17. Kassel K, Lanik A, Danforth BL, and Toews ML (2004) Opposite regulation of epidermal growth factor receptors by lysophosphatidic acid and isoproterenol. FASEB J 18:A236.
18. Kim J, Keys JR, and Eckhart AD (2006) Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq. Cell Signal 18:1695-1701.
19. Lazaar AL and Panettieri RA Jr (2003) Is airway remodeling clinically relevant in asthma? Am J Med 115:652-659.
20. Lechner JF and Laveck MA (1985) A serum-free method for culturing normal human epithelial cells at clonal density. J Tissue Cult Methods 9:43-48.
21. Lee CW, Rivera R, Gardell S, Dubin AE, and Chun J (2006) GPR92 as a new G12/13-and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J Biol Chem 281:23589-23597.
22. Liu W and Heckman C (1998) The sevenfold way of PKC regulation. Cell Signal 10:529-542.
23. Mendelsohn J and Baselga J (2006) Epidermal growth factor receptor targeting in cancer. Semin Oncol 33:369-385.
24. Munakata M (2006) Airway remodeling and airway smooth muscle in asthma. Allergol Int 55:235-243.
25. Nakanaga T, Nadel JA, Ueki IF, Koff JL, and Shao MX (2007) Regulation of interleukin-8 via an airway epithelial signaling cascade. Am J Physiol Lung Cell Mol Physiol 292:L1289-L1296.
26. Noguchi K, Ishii S, and Shimizu T (2003) Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family. J Biol Chem 278:25600-25606.
27. Ogawa H, Inoue S, Ogushi F, Ogura H, and Nakamura Y (2006) Toluene diisocyanate (TDI) induces production of inflammatory cytokines and chemokines by bronchial epithelial cells via the epidermal growth factor receptor and p38 mitogen-activated protein kinase pathways. Exp Lung Res 32:245-262.
28. Olivares-Reyes JA, Shah BH, Hernandez-Aranda J, Garcia-Caballero A, Farshori MP, Garcia-Sainz JA, and Catt KJ (2005) Agonist-induced interactions between angiotensin AT1 and epidermal growth factor receptors. Mol Pharmacol 68:356-364.
29. Pierce KL, Maudsley S, Daaka Y, Luttrell LM, and Lefkowitz RJ (2000) Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proc Natl Acad Sci U S A 97:1489-1494.
30. Rizzino A, Kazakoff P, Ruff E, Kuszynski C, and Nebelsick J (1988) Regulatory effects of cell density on the binding of transforming growth factor beta, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor. Cancer Res 48:4266-4271.
31. Saatian B, Zhao Y, He D, Georas SN, Watkins T, Spannhake EW, and Natarajan V (2006) Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells. Biochem J 393:657-668.
32. Shah BH, Baukal AJ, Shah FB, and Catt KJ (2005a) Mechanisms of extracellularly regulated kinases 1/2 activation in adrenal glomerulosa cells by lysophosphatidic acid and epidermal growth factor. Mol Endocrinol 19:2535-2548.
33. Shah BH, Olivares-Reyes JA, and Catt KJ (2005b) The protein kinase C inhibitor Go6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H- indolo(2,3-a)py rrolo(3,4-c)-carbazole] potentiates agonist-induced mitogen-activated protein kinase activation through tyrosine phosphorylation of the epidermal growth factor receptor. Mol Pharmacol 67:184-194.
34. Tager A, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, et al. (2008) The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med 14:45-54.
35. Toews ML, Ediger TL, Romberger DJ, and Rennard SI (2002) Lysophosphatidic acid in airway function and disease. Biochim Biophys Acta 1582:240-250.
36. Toews M, Moore BB, Saulnier-Blache JS, Thronson HL, Schulte NA, and Toews G (2004) Elevated concentrations of lysophosphatidic acid in airway lavage fluids from mouse models of pulmonary fibrosis. Am J Respir Crit Care Med 169:A300.
37. Wang L, Cummings R, Zhao Y, Kazlauskas A, Sham JK, Morris A, Georas S, Brindley DN, and Natarajan V (2003) Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells. J Biol Chem 278:39931-39940.
38. Wyatt TA, Slager RE, Devasure J, Auvermann BW, Mulhern ML, Von Essen SG, Mathisen T, Floreani AA, and Romberger DJ (2007) Feedlot dust stimulation of interleukin-6 and 8 requires protein kinase C-epsilon human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 293:L1163-L1170.
39. Zhang Z, Liu Z, and Meier KE (2006) Lysophosphatidic acid as a mediator for proinflammatory agonists in a human corneal epithelial cell line. Am J Physiol Cell Physiol 291:C1089-C1098.
40. Zhao Y, He D, Saatian B, Watkins T, Spannhake EW, Pyne NJ, and Natarajan V (2006) Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases. J Biol Chem 281:19501-19511.