Caffeine use in neonates: Indications, pharmacokinetics, clinical effects, outcomes

NeoReviews

Volumn 14, Issue 11, 2013, Pages

  Dobson, Nicole R ^a   Hunt, Carl E ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84887078379     PISSN: 15269906     EISSN: 15269906     Source Type: Journal    
DOI: 10.1542/neo.14-11-e540     Document Type: Article

References (55)

1. Aranda JV, Beharry K, Valencia GB, Natarajan G, Davis J. Caffeine impact on neonatal morbidities. J Matern Fetal Neonatal Med. 2010;23(Suppl 3):20-23
2. Natarajan G, Lulic-Botica M, Aranda JV. Pharmacologic Reviews: Clinical pharmacology of caffeine in the newborn. Neoreviews. 2007;8(5):e214-e221
3. Dobson NR, Patel R, Smith PB, et al. Trends in caffeine use and association between clinical outcomes and timing of therapy in VLBW infants. J Pediatr. In press
4. Bhatt-Mehta V, Schumacher RE. Treatment of apnea of prematurity. Paediatr Drugs. 2003;5(3):195-210
5. Fredholm BB, Bättig K, Holmén J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51(1):83-133
6. Mayer CA, Haxhiu MA, Martin RJ, Wilson CG. Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats. J Appl Physiol. 2006;100(1): 91-97
7. Wilson CG, Martin RJ, Jaber M, et al. Adenosine A2A receptors interact with GABAergic pathways to modulate respiration in neonatal piglets. Respir Physiol Neurobiol. 2004;141(2):201-211
8. Bairam A, Carroll JL. Neurotransmitters in carotid body development. Respir Physiol Neurobiol. 2005;149(1-3):217-232
9. Kumral A, Tuzun F, Yesilirmak DC, Duman N, Ozkan H. Genetic basis of apnoea of prematurity and caffeine treatment response: role of adenosine receptor polymorphisms: genetic basis of apnoea of prematurity. Acta Paediatr. 2012;101(7): e299-e303
10. Kot M, Daniel WA. The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNAexpressed P450s including CYP2C isoforms. Biochem Pharmacol. 2008;76(4):543-551
11. Leon AE, Michienzi K, Ma CX, Hutchison AA. Serum caffeine concentrations in preterm neonates. Am J Perinatol. 2007;24(1): 39-47
12. Charles BG, Townsend SR, Steer PA, Flenady VJ, Gray PH, Shearman A. Caffeine citrate treatment for extremely premature infants with apnea: population pharmacokinetics, absolute bioavailability, and implications for therapeutic drug monitoring. Ther Drug Monit. 2008;30(6):709-716
13. Steer PA, Flenady VJ, Shearman A, Lee TC, Tudehope DI, Charles BG. Periextubation caffeine in preterm neonates: a randomized dose response trial. J Paediatr Child Health. 2003;39(7):511-515
14. Gray PH, Flenady VJ, Charles BG, Steer PA; Caffeine Collaborative Study Group. Caffeine citrate for very preterm infants: effects on development, temperament and behaviour. J Paediatr Child Health. 2011;47(4):167-172
15. Steer P, Flenady V, Shearman A, et al; Caffeine Collaborative Study Group Steering Group. High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2004;89(6):F499-F503
16. Skouroliakou M, Bacopoulou F, Markantonis SL. Caffeine versus theophylline for apnea of prematurity: a randomised controlled trial. J Paediatr Child Health. 2009;45(10):587-592
17. Natarajan G, Botica ML, Thomas R, Aranda JV. Therapeutic drug monitoring for caffeine in preterm neonates: an unnecessary exercise? Pediatrics. 2007;119(5): 936-940
18. Schmidt B, Anderson PJ, Doyle LW, et al; Caffeine for Apnea of Prematurity (CAP) Trial Investigators. Survival without disability to age 5 years after neonatal caffeine therapy for apnea of prematurity. JAMA. 2012;307(3):275-282
19. Schmidt B, Roberts RS, Davis P, et al; Caffeine for Apnea of Prematurity Trial Group. Caffeine therapy for apnea of prematurity. N Engl J Med. 2006;354(20): 2112-2121
20. Schmidt B, Roberts RS, Davis P, et al; Caffeine for Apnea of Prematurity Trial Group. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med. 2007;357(19):1893-1902
21. Henderson-Smart DJ, De Paoli AG. Methylxanthine treatment for apnoea in preterm infants. Cochrane Database Syst Rev. 2010;(12):CD000140
22. Erenberg A, Leff RD, Haack DG, Mosdell KW, Hicks GM, Wynne BA. Caffeine citrate for the treatment of apnea of prematurity: a double-blind, placebocontrolled study. Pharmacotherapy. 2000; 20(6):644-652
23. Davis PG, Schmidt B, Roberts RS, et al; Caffeine for Apnea of Prematurity Trial Group. Caffeine for Apnea of Prematurity trial: benefits may vary in subgroups. J Pediatr. 2010;156(3):382-387
24. Henderson-Smart DJ, De Paoli AG. Prophylactic methylxanthine for prevention of apnoea in preterm infants. Cochrane Database Syst Rev. 2010;(12):CD000432
25. Murphy JJ, Swanson T, Ansermino M, Milner R. The frequency of apneas in premature infants after inguinal hernia repair: do they need overnight monitoring in the intensive care unit? J Pediatr Surg. 2008;43 (5):865-868
26. Henderson-Smart DJ, Steer P. Prophylactic caffeine to prevent postoperative apnea following general anesthesia in preterm infants. Cochrane Database Syst Rev. 2001; (4):CD000048
27. Kronenburg A, Han KS, Gooskens R, Esposito G, Cochrane D, Woerdeman P. Imaging the course of a hypoplastic cerebellum in a spina bifida newborn [published online ahead of print May 19, 2013]. Childs Nerv Syst.
28. Cesar K, Iolster T, White D, Latifi S. Caffeine as treatment for bronchiolitisrelated apnoea. J Paediatr Child Health. 2012;48(7):619
29. Anwar M, Mondestin H, Mojica N, et al. Effect of caffeine on pneumogram and apnoea of infancy. Arch Dis Child. 1986;61 (9):891-895
30. Henderson-Smart DJ, Davis PG. Prophylactic methylxanthines for endotracheal extubation in preterm infants. Cochrane Database Syst Rev. 2010;(12):CD000139
31. Kassim Z, Greenough A, Rafferty GF. Effect of caffeine on respiratory muscle strength and lung function in prematurely born, ventilated infants. Eur J Pediatr. 2009;168(12):1491-1495
32. Yoder B, Thomson M, Coalson J. Lung function in immature baboons with respiratory distress syndrome receiving early caffeine therapy: a pilot study. Acta Paediatr. 2005;94(1):92-98
33. Patel RM, Leong T, Carlton DP, Vyas-Read S. Early caffeine therapy and clinical outcomes in extremely preterm infants. J Perinatol. 2013;33(2):134-140
34. Di Fiore JM, Bloom JN, Orge F, et al. A higher incidence of intermittent hypoxemic episodes is associated with severe retinopathy of prematurity. J Pediatr. 2010; 157(1):69-73
35. Hunt CE, Corwin MJ, Baird T, et al; Collaborative Home Infant Monitoring Evaluation study group. Cardiorespiratory events detected by home memory monitoring and one-year neurodevelopmental outcome. J Pediatr. 2004;145(4):465-471
36. Pillekamp F, Hermann C, Keller T, von Gontard A, Kribs A, Roth B. Factors influencing apnea and bradycardia of prematurity-implications for neurodevelopment. Neonatology. 2007;91(3):155-161
37. Rhein LM, Dobson NR, Darnall RA, et al. Effects of caffeine on intermittent hypoxia in infants born preterm. JAMA Pediatr. In press
38. Soloveychik V, Bin-Nun A, Ionchev A, Sriram S, Meadow W. Acute hemodynamic effects of caffeine administration in premature infants. J Perinatol. 2009;29(3):205-208
39. Desfrere L, Olivier P, Schwendimann L, Verney C, Gressens P. Transient inhibition of astrocytogenesis in developing mouse brain following postnatal caffeine exposure. Pediatr Res. 2007;62(5):604-609
40. Gaytan SP, Pasaro R. Neonatal caffeine treatment up-regulates adenosine receptors in brainstem and hypothalamic cardiorespiratory related nuclei of rat pups. Exp Neurol. 2012;237(2):247-259
41. Turner CP, Seli M, Ment L, et al. A1 adenosine receptors mediate hypoxia-induced ventriculomegaly. Proc Natl Acad Sci U S A. 2003;100(20):11718-11722
42. Back SA, Craig A, Luo NL, et al. Protective effects of caffeine on chronic hypoxiainduced perinatal white matter injury. Ann Neurol. 2006;60(6):696-705
43. Connolly S, Kingsbury TJ. Caffeine modulates CREB-dependent gene expression in developing cortical neurons. Biochem Biophys Res Commun. 2010;397(2):152-156
44. Chardon K, Bach V, Telliez F, et al. Effect of caffeine on peripheral chemoreceptor activity in premature neonates: interaction with sleep stages. J Appl Physiol. 2004;96(6):2161-2166
45. Hayes MJ, Akilesh MR, Fukumizu M, et al. Apneic preterms and methylxanthines: arousal deficits, sleep fragmentation and suppressed spontaneous movements. J Perinatol. 2007;27(12):782-789
46. Supcun S, Kutz P, PielemeierW, Roll C. Caffeine increases cerebral cortical activity in preterm infants. J Pediatr. 2010;156(3): 490-491
47. Hoecker C, Nelle M, Poeschl J, Beedgen B, Linderkamp O. Caffeine impairs cerebral and intestinal blood flow velocity in preterm infants. Pediatrics. 2002;109(5):784-787
48. Tracy MB, Klimek J, Hinder M, Ponnampalam G, Tracy SK. Does caffeine impair cerebral oxygenation and blood flow velocity in preterm infants? Acta Paediatr. 2010;99(9):1319-1323
49. Dani C, Bertini G, Reali MF, et al. Brain hemodynamic changes in preterm infants after maintenance dose caffeine and aminophylline treatment. Biol Neonate. 2000;78(1):27-32
50. Doyle LW, Cheong J, Hunt RW, et al. Caffeine and brain development in very preterm infants. Ann Neurol. 2010;68(5): 734-742
51. Soraisham AS, Elliott D, Amin H. Effect of single loading dose of intravenous caffeine infusion on superior mesenteric artery blood flow velocities in preterm infants. J Paediatr Child Health. 2008;44 (3):119-121
52. Chavez-Valdez R, Wills-KarpM, Ahlawat R, Cristofalo EA, Nathan A, Gauda EB. Caffeine modulates TNF-alpha production by cord blood monocytes: the role of adenosine receptors. Pediatr Res. 2009;65 (2):203-208
53. Chavez Valdez R, Ahlawat R, Wills-KarpM, et al. Correlation between serum caffeine levels and changes in cytokine profile in a cohort of preterm infants. J Pediatr. 2011;158(1):57-64, 64. e1
54. Ergenekon E, Dalgiç N, Aksoy E, Koç E, Atalay Y. Caffeine intoxication in a premature neonate. Paediatr Anaesth. 2001;11 (6):737-739
55. Dukhovny D, Lorch SA, Schmidt B, et al; Caffeine for Apnea of Prematurity Trial Group. Economic evaluation of caffeine for apnea of prematurity. Pediatrics. 2011;127(1). Available at: www.pediatrics. org/cgi/content/full/127/1/e146