Caffeine citrate for the treatment of apnea of prematurity: A double- blind, placebo-controlled study

Pharmacotherapy

Volumn 20, Issue 6 I, 2000, Pages 644-652

  Erenberg, Allen ^a   Leff, Richard D ^a   Haack, Dennis G ^a   Mosdell, Kristen W ^a   Hicks, Gregory M ^a   Wynne, Beverley A ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE CITRATE; PLACEBO;

APNEA; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEWBORN; PREMATURITY; RANDOMIZED CONTROLLED TRIAL;

EID: 0034045190     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.20.7.644.35167     Document Type: Article

References (32)

1. Aranda JV, Turmen T. Methylxanthines in apnea of prematurity [review]. Clin Perinatol 1979;6:87-108.
2. Parmelee AH, Stern E, Harris MA. Maturation of respiration in premature and young infants. Neuropädiatrie 1972;3:294-304.
3. Rigatto H, Brady JP, de la Torre Verduzco R. Chemoreceptor reflexes in preterm infants. II. The effect of gestational and postnatal age on the ventilatory response to inhaled carbon dioxide. Pediatrics 1975;55:614-20.
4. Muller N, Volgyesi G, Bryan MH, Bryan AC. The consequences of diaphragmatic muscle fatigue in the newborn infant. J Pediatr 1979;95:793-7.
5. Scanlon JEM, Chin KC, Morgan MEI, Durbin GM, Hale KA, Brown SS. Caffeine or theophylline for neonatal apnoea? Arch Dis Child 1992;67:425-8.
6. Lee D, Caces R, Kwiatkowski K, Cates D, Rigatto H. A developmental study on types and frequency distribution of short apneas (3 to 15 seconds) in term and preterm infants. Pediatr Res 1987;22:344-9.
7. Kattwinkel J, Nearman HS, Fanaroff AA, Katona PG, Klaus MH. Apnea of prematurity: comparative therapeutic effects of cutaneous stimulation and nasal continuous positive airway pressure. J Pediatr 1975;86:588-92.
8. Upton CJ, Milner AD, Stokes GM. Apnea, bradycardia and oxygen saturation in preterm infants. Arch Dis Child 1991;66:381-5.
9. Perrin C, Debruyne D, Lacotte J, Laloum D, Bonte J-B, Moulin M. Treatment of caffeine intoxication by exchange transfusion in a newborn. Acta Paediatr Scand 1987;76:679-81.
10. van den Anker JN, Jongejan HTM, Sauer PJJ. Severe caffeine intoxication in a preterm neonate [letter]. Eur J Pediatr 1992;151:466-7.
11. COSTART. Coding symbols for thesaurus of adverse reaction terms, 5th ed. Rockville, MD: U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drugs and Biologies, 1995.
12. De Carolis MP, Romagnoli C, Muzii U, et al. Pharmacokinetic aspects of caffeine in premature infants. Dev Pharmacol Ther 1991;16:117-22.
13. Anwar M, Mondestin H, Mojica N, et al. Effect of caffeine on pneumogram and apnoea of infancy. Arch Dis Child 1986;61:891-5.
14. Brouard C, Moriette G, Murat I, et al. Comparative efficacy of theophylline and caffeine in the treatment of idiopathic apnea in premature infants. Am J Dis Child 1985;139:698-700.
15. Fuglsang G, Nielsen K, Nielson LK, Sennels F, Jakobsen P, Thelle T. The effect of caffeine compared with theophylline in the treatment of idiopathic apnea in premature infants. Acta Paediatr Scand 1989;78:786-8.
16. Murat I, Moriette G, Blin MC, et al. The efficacy of caffeine in the treatment of recurrent idiopathic apnea in premature infants. J Pediatr 1981;99:984-9.
17. Beal SL, Sheiner LB. NONMEM users' guide - part 1. San Francisco: NONMEM Project Group, 1989.
18. Romagnoli C, De Carolis MP, Muzii U, et al. Effectiveness and side effects of two different doses of caffeine in preventing apnea in premature infants. Ther Drug Monit 1992;14:14-19.
19. Bairam A, Boutroy M-J. Badonnel Y, Vert P. Theophylline versus caffeine: comparative effects in treatment of idiopathic apnea in the preterm infant. J Pediatr 1987;110:636-9.
20. Larsen PB, Brendstrup L, Skov L, Flachs H. Aminophylline versus caffeine citrate for apnea and bradycardia prophylaxis in premature infants. Acta Paediatr 1995;84:360-4.
21. Harrison H Jr. Apnea of prematurity: theophylline v. caffeine. Alaska Med 1992;34:173-6.
22. Martin RJ, Miller MJ, Carlo WA. Pathogenesis of apnea of preterm infants. J Pediatr 1986;109:733-41.
23. Schmidt B, Gillie P, Caco C, Roberts J, Roberts R. Do sick newborn infants benefit from participation in a randomizing clinical trial? J Pediatr 1999;134:151-5.
24. Albert SM, Sano M, Marder K, et al. Participation in clinical trials and long-term outcomes in Alzheimer's disease. Neurology 1997;49:38-43.
25. Gorodischer R, Karplus M. Pharmacokinetic aspects of caffeine in premature infants with apnoea. Eur J Clin Pharmacol 1982;22:47-52.
26. Earl RA, Erenberg A, Hicks GM, Leff RD. Evaluation of routine methods for the measurement of caffeine in human plasma. J Pediatr Pharm Pract 2000;5(1):35-8.
27. Stoll BJ. Epidemiology of necrotizing enterocolitis [review]. Clin Perinatol 1994;21:205-18.
28. Kliegman RM, Fanaroff AA. Neonatal necrotizing enterocolitis: a nine-year experience. 1. Epidemiology and uncommon observations. Am J Dis Child 1981;135:603-7.
29. Yu VYH, Joseph R, Bajuk B, Orgill A, Astbury J. Perinatal risk factors for necrotizing enterocolitis. Arch Dis Child 1984;59:430-4.
30. Uauy RD, Fanaroff AA, Korones SB, Phillips EA, Philips JB, Wright LL. Necrotizing enterocolitis in very low birth weight infants: biodemographic and clinical correlates. J Pediatr 1991;119:630-8.
31. Robinson MJ, Clayden GS, Smith MF. Xanthines and necrotising enterocolitis [letter]. Arch Dis Child 1980;55:494-5.
32. Williams AJ. Xanthines and necrotising enterocolitis [letter]. Arch Dis Child 1980;55:973-4.