Does caffeine impair cerebral oxygenation and blood flow velocity in preterm infants?

Acta Paediatrica, International Journal of Paediatrics

Volumn 99, Issue 9, 2010, Pages 1319-1323

  Tracy, M B ^a,c   Klimek, J ^a,c   Hinder, M ^a   Ponnampalam, G ^a   Tracy, S K ^b,c  

^a NEPEAN HOSPITAL   (Australia)

^b ROYAL HOSPITAL FOR WOMEN   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Caffeine; Cerebral Tissue Oxygenation Index; Doppler blood; Flow velocity; NIRS

Indexed keywords

CAFFEINE;

ANTERIOR CEREBRAL ARTERY; ARTICLE; BIRTH WEIGHT; BLOOD FLOW VELOCITY; BRAIN; BRAIN BLOOD FLOW; CLINICAL ARTICLE; ECHOGRAPHY; GESTATIONAL AGE; HEART OUTPUT; HUMAN; INFANT; INTRACARDIAC ECHOCARDIOGRAPHY; NEAR INFRARED SPECTROSCOPY; PREMATURITY; PRIORITY JOURNAL; TISSUE OXYGENATION; VASCULAR RESISTANCE;

BLOOD FLOW VELOCITY; BRAIN; CAFFEINE; CEREBROVASCULAR CIRCULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; OXYGEN CONSUMPTION; REGIONAL BLOOD FLOW;

EID: 77955898862     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2010.01828.x     Document Type: Article

References (30)

1. O'Donnell CP, Stone RJ, Morley CJ. Unlicensed and off-label drug use in an Australian neonatal intensive care unit. Pediatrics 2002 110 : e52.
2. Fredholm BB. Astra Award Lecture. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol 1995 76 : 93 101.
3. Smits P, Lenders JW, Thien T. Caffeine and theophylline attenuate adenosine-induced vasodilation in humans. Clin Pharmacol Ther 1990 48 : 410 8.
4. Lunt MJ, Ragab S, Birch AA, Schley D, Jenkinson DF. Comparison of caffeine-induced changes in cerebral blood flow and middle cerebral artery blood velocity shows that caffeine reduces middle cerebral artery diameter. Physiol Meas 2004 25 : 467 74.
5. Cameron OG, Modell JG, Hariharan M. Caffeine and human cerebral blood flow: a positron emission tomography study. Life Sci 1990 47 : 1141 6.
6. Rosenkrantz TS, Oh W. Aminophylline reduces cerebral blood flow velocity in low-birth-weight infants. Am J Dis Child 1984 138 : 489 91.
7. Pryds O, Schneider S. Aminophylline reduces cerebral blood flow in stable, preterm infants without affecting the visual evoked potential. Eur J Pediatr 1991 150 : 366 9.
8. Hoecker C, Nelle M, Poeschl J, Beedgen B, Linderkamp O. Caffeine impairs cerebral and intestinal blood flow velocity in preterm infants. Pediatrics 2002 109 : 784 7.
9. Hoecker C, Nelle M, Beedgen B, Rengelshausen J, Linderkamp O. Effects of a divided high loading dose of caffeine on circulatory variables in preterm infants. Arch Dis Child Fetal Neonatal Ed 2006 91 : F61 4.
10. Saliba E, Autret E, Gold F, Bloc D, Pourcelot L, Laugier J. Effect of caffeine on cerebral blood flow velocity in preterm infants. Biol Neonate 1989 56 : 198 203. (Pubitemid 19247329)
11. Van Bel F, Van de BM, Stijnen T, Baan J, Ruys JH. Does caffeine affect cerebral blood flow in the preterm infant? Acta Paediatr Scand 1989 78 : 205 9.
12. Black AM, Pandya S, Clark D, Armstrong EA, Yager JY. Effect of caffeine and morphine on the developing pre-mature brain. Brain Res 2008 1219 : 136 42.
13. Kang SH, Lee YA, Won SJ, Rhee KH, Gwag BJ. Caffeine-induced neuronal death in neonatal rat brain and cortical cell cultures. Neuroreport 2002 13 : 1945 50.
14. Millar D, Schmidt B. Controversies surrounding xanthine therapy. Semin Neonatol 2004 9 : 239 44.
15. Davis PG, Doyle LW, Rickards AL, Kelly EA, Ford GW, Davis NM, et al. Methylxanthines and sensorineural outcome at 14 years in children <1501 g birthweight. J Paediatr Child Health 2000 36 : 47 50.
16. Bauer J, Maier K, Linderkamp O, Hentschel R. Effect of caffeine on oxygen consumption and metabolic rate in very low birth weight infants with idiopathic apnea. Pediatrics 2001 107 : 660 3.
17. Walther FJ, Erickson R, Sims ME. Cardiovascular effects of caffeine therapy in preterm infants. Am J Dis Child 1990 144 : 1164 6.
18. Soloveychik V, Bin-Nun A, Ionchev A, Sriram S, Meadow W. Acute hemodynamic effects of caffeine administration in premature infants. J Perinatol 2009 29 : 205 8.
19. Fesslova V, Caccamo ML, Salice P, Marimi A. Assessment of cardiovascular effects to theophylline in premature newborns by means of serial echocardiography. Acta Paediatr Scand 1984 73 : 404 5.
20. Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, et al. Caffeine therapy for apnea of prematurity. N Engl J Med 2006 354 : 2112 21.
21. Schmidt B, Roberts RS, Davis P, Doyle LW, Barrington KJ, Ohlsson A, et al. Long-term effects of caffeine therapy for apnea of prematurity. N Engl J Med 2007 357 : 1893 902.
22. Suzuki S, Takasaki S, Ozaki T, Kobayashi Y. Tissue oxygenation monitor using NIR spatially resolved spectroscopy. Proc Soc Photo Opt Instrum Eng 1999 3597 : 582 92.
23. Matcher SJ, Kirkpatrick PJ, Nahid K, Cope M, Delpy DT. Absolute quantification methods in tissue near-infrared spectroscopy. Proc Soc Photo Opt Instrum Eng 1995 2389 : 486 95.
24. Lemmers PM, Toet M, van Schelven LJ, van BF. Cerebral oxygenation and cerebral oxygen extraction in the preterm infant: the impact of respiratory distress syndrome. Exp Brain Res 2006 173 : 458 67.
25. Evans N, Kluckow M. Early determinants of right and left ventricular output in ventilated preterm infants. Arch Dis Child Fetal Neonatal Ed 1996 74 : F88 94.
26. Lundstrom KE, Larsen PB, Brendstrup L, Skov L, Greisen G. Cerebral blood flow and left ventricular output in spontaneously breathing, newborn preterm infants treated with caffeine or aminophylline. Acta Paediatr 1995 84 : 6 9.
27. Steer P, Flenady V, Shearman A, Charles B, Gray PH, Henderson-Smart D, et al. High dose caffeine citrate for extubation of preterm infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 2004 89 : F499 503.
28. Pryds O, Greisen G, Skov LL, Friis-Hansen B. Carbon dioxide-related changes in cerebral blood volume and cerebral blood flow in mechanically ventilated preterm neonates: comparison of near infrared spectrophotometry and 133Xenon clearance. Pediatr Res 1990 27 : 445 9.
29. Dullenkopf A, Kolarova A, Schulz G, Frey B, Baenziger O, Weiss M. Reproducibility of cerebral oxygenation measurement in neonates and infants in the clinical setting using the NIRO 300 oximeter. Pediatr Crit Care Med 2005 6 : 344 7.
30. Weiss M, Dullenkopf A, Kolarova A, Schulz G, Frey B, Baenziger O. Near-infrared spectroscopic cerebral oxygenation reading in neonates and infants is associated with central venous oxygen saturation. Paediatr Anaesth 2005 15 : 102 9.