Indole diterpene alkaloids as novel inhibitors of the Wnt/β-catenin pathway in breast cancer cells

European Journal of Medicinal Chemistry

Volumn 70, Issue , 2013, Pages 594-606

  Sallam, Asmaa A ^a   Ayoub, Nehad M ^a,b   Foudah, Ahmed I ^a   Gissendanner, Chris R ^a   Meyer, Sharon A ^a   El Sayed, Khalid A ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

^b JORDAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Jordan)

Author keywords

Antimigratory; Antiproliferative; BK channel inhibition; Breast cancer; Caenorhabditis elegans; Invasion; Penitrems; Wnt catenin pathway

Indexed keywords

15 HYDROPEROXYPENITREM A; 25 O BENZYLPENITREM A; 25 O METHYLPENITREM A; ALKALOID DERIVATIVE; BETA CATENIN; BROMINE DERIVATIVE; DITERPENE; EMINDOLE SB; ETHER DERIVATIVE; INDOLE DERIVATIVE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; N 1 25 O DI (3 METHOXY)BENZYLPENITREM A; N 1 25 O DIMETHYLPENITREM A; N 1 METHYLPENITREM A; PASPALINE; PENITREM A; PENITREM A 25 O BENZOATE; PENITREM B; PENITREM D; PENITREM E; PENITREM F; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CARCINOMA; CAENORHABDITIS ELEGANS; CANCER CELL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL INVASION; CONTROLLED STUDY; CYTOTOXICITY TEST; HUMAN; HUMAN CELL; IC 50; LD 50; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; TREMOR; WNT SIGNALING PATHWAY;

ANTIMIGRATORY; ANTIPROLIFERATIVE; BK CHANNEL INHIBITION; BREAST CANCER; CAENORHABDITIS ELEGANS; INVASION; PENITREMS; WNT/Β-CATENIN PATHWAY;

ANIMALS; ANTINEOPLASTIC AGENTS; BETA CATENIN; BREAST NEOPLASMS; CAENORHABDITIS ELEGANS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDOLE ALKALOIDS; MALE; MCF-7 CELLS; MICE; MOLECULAR STRUCTURE; MYCOTOXINS; STRUCTURE-ACTIVITY RELATIONSHIP; WNT PROTEINS;

EID: 84887071706     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.09.045     Document Type: Article

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