3-O-methylthespesilactam, a new small-molecule anticancer pan-JAK inhibitor against A2058 human melanoma cells

Biochemical Pharmacology

Volumn 86, Issue 10, 2013, Pages 1411-1418

  Li, Min Yi ^a   Tian, Yan ^b   Shen, Li ^a   Buettner, Ralf ^b   Li, Hong Zhi ^b   Liu, Lucy ^b   Yuan, Yate Ching ^b   Xiao, Qiang ^c   Wu, Jun ^a   Jove, Richard ^b  

^a JINAN UNIVERSITY   (China)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c JIANGXI SCIENCE AND TECHNOLOGY NORMAL UNIVERSITY   (China)

Author keywords

3 O methylthespesilactam; Anticancer; Benzo cd indole; JAK inhibitor; Sesquiterpenoid alkaloid

Indexed keywords

3 O METHYLTHESPESILACTAM; ANTINEOPLASTIC AGENT; JANUS KINASE INHIBITOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MELANOMA CELL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; S PHASE CELL CYCLE CHECKPOINT; THESPESIA POPULNEA; X RAY DIFFRACTION;

3-O-METHYLTHESPESILACTAM; ANTICANCER; BENZO[CD]INDOLE; JAK INHIBITOR; SESQUITERPENOID-ALKALOID;

ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; JANUS KINASES; MAGNETIC RESONANCE SPECTROSCOPY; MALVACEAE; MELANOMA; PHOSPHORYLATION; S PHASE CELL CYCLE CHECKPOINTS; SESQUITERPENES; STAT3 TRANSCRIPTION FACTOR;

EID: 84887064512     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.065     Document Type: Article

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