Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness

Biochemical Pharmacology

Volumn 86, Issue 10, 2013, Pages 1419-1429

  Hirano, Tamaki ^a   Satow, Reiko ^a   Kato, Asami ^a   Tamura, Mana ^a   Murayama, Yumi ^a   Saya, Hideyuki ^b   Kojima, Hirotatsu ^c   Nagano, Tetsuo ^c   Okabe, Takayoshi ^c   Fukami, Kiyoko ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Colorectal cancer; Compound; E cadherin; Melanoma; Methotrexate; Small molecule screen

Indexed keywords

METHOTREXATE; UVOMORULIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; COLORECTAL CANCER; HUMAN; HUMAN CELL; MELANOMA CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL;

COLORECTAL CANCER; COMPOUND; E-CADHERIN; EMT; EPITHELIAL-MESENCHYMAL TRANSITION; FBS; FETAL BOVINE SERUM; MELANOMA; METHOTREXATE; MTX; SMALL MOLECULE SCREEN;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; CADHERINS; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; COLORECTAL NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MELANOMA; METHOTREXATE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-AKT; SMALL MOLECULE LIBRARIES;

EID: 84887064292     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.09.001     Document Type: Article

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