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Volumn 19, Issue 1, 2013, Pages 161-169

Lupus nephritis: Enigmas, conflicting models and an emerging concept

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE I; DOUBLE STRANDED DNA ANTIBODY; HISTONE ANTIBODY; IMMUNOGLOBULIN G; NUCLEOSOME ANTIBODY;

EID: 84887059952     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2013.00010     Document Type: Article
Times cited : (51)

References (100)
  • 1
    • 0000373624 scopus 로고
    • A DNA-reacting factor in serum of a patient with lupus erythematosus diffusus
    • Ceppellini R, Polli E, Celada F. (1957) A DNA-reacting factor in serum of a patient with lupus erythematosus diffusus. Proc. Soc. Exp. Biol. Med. 96:572-4.
    • (1957) Proc. Soc. Exp. Biol. Med. , vol.96 , pp. 572-574
    • Ceppellini, R.1    Polli, E.2    Celada, F.3
  • 3
    • 70449167140 scopus 로고
    • Demonstration in the blood of patients with disseminated lupus erythematosus a substance determining a precipitation reaction with desoxyribonucleic acid [in French]
    • Seligmann M. (1957) Demonstration in the blood of patients with disseminated lupus erythematosus a substance determining a precipitation reaction with desoxyribonucleic acid [in French]. C. R. Hebd. Seances Acad. Sci. 245:243-5.
    • (1957) C. R. Hebd. Seances Acad. Sci. , vol.245 , pp. 243-245
    • Seligmann, M.1
  • 4
    • 70449180551 scopus 로고
    • New serological methods for the detection of the L.E. factor
    • Miescher P, Strassle R. (1957) New serological methods for the detection of the L.E. factor. Vox Sang 2:283-7.
    • (1957) Vox Sang , vol.2 , pp. 283-287
    • Miescher, P.1    Strassle, R.2
  • 5
    • 0017704089 scopus 로고
    • Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides: Identificantion of circulating DNA and renal localization of DNA-anti-DNA complexes
    • Izui S, Lambert PH, Fournie GJ, Turler H, Miescher PA. (1977) Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides: identificantion of circulating DNA and renal localization of DNA-anti-DNA complexes. J. Exp. Med. 145:1115-30.
    • (1977) J. Exp. Med. , vol.145 , pp. 1115-1130
    • Izui, S.1    Lambert, P.H.2    Fournie, G.J.3    Turler, H.4    Miescher, P.A.5
  • 6
    • 0017084411 scopus 로고
    • In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA: A possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus
    • Izui S, Lambert PH, Miescher PA. (1976) In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA: a possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus. J. Exp. Med. 144:428-43.
    • (1976) J. Exp. Med. , vol.144 , pp. 428-443
    • Izui, S.1    Lambert, P.H.2    Miescher, P.A.3
  • 7
    • 0003129362 scopus 로고    scopus 로고
    • Anti-DNA antibodies
    • Lahita RG, Ed. Academic Press, San Diego, CA
    • Khalil M, Spatz L, Diamond B. (1999) Anti-DNA antibodies. In Systemic Lupus Erythematosus. Lahita RG, Ed. Academic Press, San Diego, CA, pp. 197-217.
    • (1999) Systemic Lupus Erythematosus , pp. 197-217
    • Khalil, M.1    Spatz, L.2    Diamond, B.3
  • 8
    • 0032493059 scopus 로고    scopus 로고
    • Antibodies to DNA
    • Hahn BH. (1998) Antibodies to DNA. N. Engl. J. Med. 338:1359-68.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1359-1368
    • Hahn, B.H.1
  • 9
    • 0042072897 scopus 로고    scopus 로고
    • Use of a novel elution regimen reveals the dominance of polyreactive antinuclear autoantibodies in lupus kidneys
    • Xie C, Liang Z, Chang S, Mohan C. (2003) Use of a novel elution regimen reveals the dominance of polyreactive antinuclear autoantibodies in lupus kidneys. Arthritis Rheum. 48:2343-52.
    • (2003) Arthritis Rheum. , vol.48 , pp. 2343-2352
    • Xie, C.1    Liang, Z.2    Chang, S.3    Mohan, C.4
  • 10
    • 33644925272 scopus 로고    scopus 로고
    • Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis
    • Kalaaji M, Sturfelt G, Mjelle JE, Nossent H, Rekvig OP. (2006) Critical comparative analyses of anti-alpha-actinin and glomerulus-bound antibodies in human and murine lupus nephritis. Arthritis Rheum. 54:914-26.
    • (2006) Arthritis Rheum. , vol.54 , pp. 914-926
    • Kalaaji, M.1    Sturfelt, G.2    Mjelle, J.E.3    Nossent, H.4    Rekvig, O.P.5
  • 11
    • 0030035657 scopus 로고    scopus 로고
    • Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis; a longitudinal study on plasma and glomerular eluates in MRL/l mice
    • Van Bruggen MC, Kramers C, Hylkema MN, Smeenk RJ, Berden JH. (1996) Significance of anti-nuclear and anti-extracellular matrix autoantibodies for albuminuria in murine lupus nephritis; a longitudinal study on plasma and glomerular eluates in MRL/l mice. Clin. Exp. Immunol. 105:132-9.
    • (1996) Clin. Exp. Immunol. , vol.105 , pp. 132-139
    • Van Bruggen, M.C.1    Kramers, C.2    Hylkema, M.N.3    Smeenk, R.J.4    Berden, J.H.5
  • 12
    • 0021342845 scopus 로고
    • The in vivo and in vitro glomerular deposition of isolated anti-double-stranded-DNA antibodies in NZB/W mice
    • Dang H, Harbeck RJ. (1984) The in vivo and in vitro glomerular deposition of isolated anti-double-stranded-DNA antibodies in NZB/W mice. Clin. Immunol. Immunopathol. 30:265-78.
    • (1984) Clin. Immunol. Immunopathol. , vol.30 , pp. 265-278
    • Dang, H.1    Harbeck, R.J.2
  • 13
    • 0020360240 scopus 로고
    • A comparison of anti-DNA antibodies from serum and kidney eluates of NZB x NZW F1 mice
    • Dang H, Harbeck RJ. (1982) A comparison of anti-DNA antibodies from serum and kidney eluates of NZB x NZW F1 mice. J. Clin. Lab. Immunol. 9:139-45.
    • (1982) J. Clin. Lab. Immunol. , vol.9 , pp. 139-145
    • Dang, H.1    Harbeck, R.J.2
  • 14
    • 0017337322 scopus 로고
    • Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus: Association of high avidity antinative DNA antibody with glomerulonephritis
    • Winfield JB, Faiferman I, Koffler D. (1977) Avidity of anti-DNA antibodies in serum and IgG glomerular eluates from patients with systemic lupus erythematosus: association of high avidity antinative DNA antibody with glomerulonephritis. J. Clin. Invest. 59:90-6.
    • (1977) J. Clin. Invest. , vol.59 , pp. 90-96
    • Winfield, J.B.1    Faiferman, I.2    Koffler, D.3
  • 15
    • 65249171440 scopus 로고    scopus 로고
    • Nephritogenic potential of anti-DNA antibodies against necrotic nucleosomes
    • Mortensen ES, Rekvig OP. (2009) Nephritogenic potential of anti-DNA antibodies against necrotic nucleosomes. J. Am. Soc. Nephrol. 20:696-704.
    • (2009) J. Am. Soc. Nephrol. , vol.20 , pp. 696-704
    • Mortensen, E.S.1    Rekvig, O.P.2
  • 16
    • 0037298948 scopus 로고    scopus 로고
    • Anti-DNA antibodies: Aspects of structure and pathogenicity
    • Jang YJ, Stollar BD. (2003) Anti-DNA antibodies: aspects of structure and pathogenicity. Cell. Mol. Life Sci. 60:309-20.
    • (2003) Cell. Mol. Life Sci. , vol.60 , pp. 309-320
    • Jang, Y.J.1    Stollar, B.D.2
  • 17
    • 79961212382 scopus 로고    scopus 로고
    • Lupus nephritis: Role of antinucleosome autoantibodies
    • van der Vlag J, Berden JH. (2011) Lupus nephritis: role of antinucleosome autoantibodies. Semin. Nephrol. 31:376-89.
    • (2011) Semin. Nephrol. , vol.31 , pp. 376-389
    • van der Vlag, J.1    Berden, J.H.2
  • 18
    • 66449089455 scopus 로고    scopus 로고
    • Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus
    • Munoz LE, et al. (2009) Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus. Arthritis Rheum. 60:1733-42.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1733-1742
    • Munoz, L.E.1
  • 19
    • 77956931638 scopus 로고    scopus 로고
    • Inefficient clearance of dying cells in patients with SLE: Anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players
    • Kruse K, et al. (2010) Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players. Apoptosis. 15:1098-113
    • (2010) Apoptosis. , vol.15 , pp. 1098-1113
    • Kruse, K.1
  • 21
    • 0942265440 scopus 로고    scopus 로고
    • The classification of glomerulonephritis in systemic lupus erythematosus revisited
    • Weening JJ, et al. (2004) The classification of glomerulonephritis in systemic lupus erythematosus revisited. J. Am. Soc. Nephrol. 15:241-50.
    • (2004) J. Am. Soc. Nephrol. , vol.15 , pp. 241-250
    • Weening, J.J.1
  • 22
    • 67650000223 scopus 로고    scopus 로고
    • Progression of murine lupus nephritis is linked to acquired renal Dnase1 deficiency and not to upregulated apoptosis
    • Seredkina N, Zykova SN, Rekvig OP. (2009) Progression of murine lupus nephritis is linked to acquired renal Dnase1 deficiency and not to upregulated apoptosis. Am. J. Pathol. 175:97-106.
    • (2009) Am. J. Pathol. , vol.175 , pp. 97-106
    • Seredkina, N.1    Zykova, S.N.2    Rekvig, O.P.3
  • 23
    • 80052841986 scopus 로고    scopus 로고
    • Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature in murine lupus nephritis
    • Seredkina S, Rekvig OP. (2011) Acquired loss of renal nuclease activity is restricted to DNaseI and is an organ-selective feature in murine lupus nephritis. Am. J. Pathol. 179:1120-8.
    • (2011) Am. J. Pathol. , vol.179 , pp. 1120-1128
    • Seredkina, S.1    Rekvig, O.P.2
  • 24
    • 77949535653 scopus 로고    scopus 로고
    • Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice
    • Fenton K, et al. (2009) Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice. PLoS One. 4:e8474.
    • (2009) PLoS One. , vol.4
    • Fenton, K.1
  • 25
    • 20544472921 scopus 로고    scopus 로고
    • Cisplatin nephrotoxicity is mediated by deoxyribonuclease I
    • Basnakian AG, et al. (2005) Cisplatin nephrotoxicity is mediated by deoxyribonuclease I. J. Am. Soc. Nephrol. 16:697-702.
    • (2005) J. Am. Soc. Nephrol. , vol.16 , pp. 697-702
    • Basnakian, A.G.1
  • 26
    • 40549095677 scopus 로고    scopus 로고
    • Reduced fragmentation of apoptotic chromatin is associated with nephritis in lupusprone (NZB x NZW)F(1) mice
    • Zykova SN, Seredkina N, Benjaminsen J, Rekvig OP. (2008) Reduced fragmentation of apoptotic chromatin is associated with nephritis in lupusprone (NZB x NZW)F(1) mice. Arthritis Rheum. 58:813-25.
    • (2008) Arthritis Rheum. , vol.58 , pp. 813-825
    • Zykova, S.N.1    Seredkina, N.2    Benjaminsen, J.3    Rekvig, O.P.4
  • 27
    • 0035060979 scopus 로고    scopus 로고
    • Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: A case for tissue injury by molecular mimicry
    • Mostoslavsky G, et al. (2001) Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur. J. Immunol. 31:1221-7.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 1221-1227
    • Mostoslavsky, G.1
  • 28
    • 13444270344 scopus 로고    scopus 로고
    • Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential
    • Zhao Z, et al. (2005) Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential. Arthritis Rheum. 52:522-30.
    • (2005) Arthritis Rheum. , vol.52 , pp. 522-530
    • Zhao, Z.1
  • 29
    • 26844529249 scopus 로고    scopus 로고
    • Treatment with a lamininderived peptide suppresses lupus nephritis
    • Amital H, et al. (2005) Treatment with a lamininderived peptide suppresses lupus nephritis. J. Immunol. 175:5516-23.
    • (2005) J. Immunol. , vol.175 , pp. 5516-5523
    • Amital, H.1
  • 30
    • 0027518589 scopus 로고
    • Cross-reactions of anti-DNA autoantibodies with cell surface proteins
    • Raz E, Ben Bassat H, Davidi T, Shlomai Z, Eilat D. (1993) Cross-reactions of anti-DNA autoantibodies with cell surface proteins. Eur. J. Immunol. 23:383-90.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 383-390
    • Raz, E.1    Ben Bassat, H.2    Davidi, T.3    Shlomai, Z.4    Eilat, D.5
  • 31
    • 0029893337 scopus 로고    scopus 로고
    • Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens
    • D'Andrea DM, Coupaye Gerard B, Kleyman TR, Foster MH, Madaio MP. (1996) Lupus autoantibodies interact directly with distinct glomerular and vascular cell surface antigens. Kidney Int. 49:1214-21.
    • (1996) Kidney Int. , vol.49 , pp. 1214-1221
    • D'Andrea, D.M.1    Coupaye Gerard, B.2    Kleyman, T.R.3    Foster, M.H.4    Madaio, M.P.5
  • 32
    • 84863334924 scopus 로고    scopus 로고
    • Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice
    • Krishnan MR, Wang C, Marion TN. (2012) Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice. Kidney Int. 82:184-92.
    • (2012) Kidney Int. , vol.82 , pp. 184-192
    • Krishnan, M.R.1    Wang, C.2    Marion, T.N.3
  • 33
    • 75649096046 scopus 로고    scopus 로고
    • Relationship between anti-dsDNA, anti-nucleosome and anti-alphaactinin antibodies and markers of renal disease in patients with lupus nephritis: A prospective longitudinal study
    • Manson JJ, et al. (2009) Relationship between anti-dsDNA, anti-nucleosome and anti-alphaactinin antibodies and markers of renal disease in patients with lupus nephritis: a prospective longitudinal study. Arthritis Res. Ther. 11:R154.
    • (2009) Arthritis Res. Ther. , vol.11
    • Manson, J.J.1
  • 34
    • 33947660078 scopus 로고    scopus 로고
    • Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis
    • Kalaaji M, et al. (2007) Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis. Kidney Int. 71:664-72.
    • (2007) Kidney Int. , vol.71 , pp. 664-672
    • Kalaaji, M.1
  • 35
    • 33744756400 scopus 로고    scopus 로고
    • Nephritogenic lupus antibodies recognize glomerular basement membraneassociated chromatin fragments released from apoptotic intraglomerular cells
    • Kalaaji M, Mortensen E, Jorgensen L, Olsen R, Rekvig OP. (2006) Nephritogenic lupus antibodies recognize glomerular basement membraneassociated chromatin fragments released from apoptotic intraglomerular cells. Am. J. Pathol. 168:1779-92.
    • (2006) Am. J. Pathol. , vol.168 , pp. 1779-1792
    • Kalaaji, M.1    Mortensen, E.2    Jorgensen, L.3    Olsen, R.4    Rekvig, O.P.5
  • 36
    • 84873666705 scopus 로고    scopus 로고
    • The role of somatic hypermutation in the generation of pathogenic antibodies in SLE
    • Schroeder K, Herrmann M, Winkler TH. (2013) The role of somatic hypermutation in the generation of pathogenic antibodies in SLE. Autoimmunity. 46:121-7.
    • (2013) Autoimmunity. , vol.46 , pp. 121-127
    • Schroeder, K.1    Herrmann, M.2    Winkler, T.H.3
  • 37
    • 21544463136 scopus 로고    scopus 로고
    • The evolution of human anti-double-stranded DNA autoantibodies
    • Wellmann U, et al. (2005) The evolution of human anti-double-stranded DNA autoantibodies. Proc. Natl. Acad. Sci. U. S. A. 102:9258-63.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 9258-9263
    • Wellmann, U.1
  • 38
    • 84887081204 scopus 로고    scopus 로고
    • Garland Science, New York. Chapter 4, Antigen Recognition by B-cell and T-cell Receptors, Chapter 5, The Generation of Lymphocyte Antigen Receptors; pp. 157-200; Chapter 10, The Humoral Immune Response; pp. 387-428
    • Murphy K. (2011) Janeway's Immunobiology. Garland Science, New York. Chapter 4, Antigen Recognition by B-cell and T-cell Receptors; pp. 127-156; Chapter 5, The Generation of Lymphocyte Antigen Receptors; pp. 157-200; Chapter 10, The Humoral Immune Response; pp. 387-428.
    • (2011) Janeway's Immunobiology , pp. 127-156
    • Murphy, K.1
  • 39
    • 79959722590 scopus 로고    scopus 로고
    • High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice
    • Starke C, et al. (2011) High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice. Eur. J. Immunol. 41:2107-12.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 2107-2112
    • Starke, C.1
  • 40
    • 79960134114 scopus 로고    scopus 로고
    • Regulatory and pathogenetic mechanisms of autoantibodies in SLE
    • Radic M, Herrmann M, van der Vlag J, Rekvig OP. (2011) Regulatory and pathogenetic mechanisms of autoantibodies in SLE. Autoimmunity 44:349-56.
    • (2011) Autoimmunity , vol.44 , pp. 349-356
    • Radic, M.1    Herrmann, M.2    van der Vlag, J.3    Rekvig, O.P.4
  • 41
    • 0032487526 scopus 로고    scopus 로고
    • Regulation of anti-DNA B cells in recombination-activating gene-deficient mice
    • Xu H, Li H, Suri-Payer E, Hardy RR, Weigert M. (1998) Regulation of anti-DNA B cells in recombination-activating gene-deficient mice. J. Exp. Med. 188:1247-54.
    • (1998) J. Exp. Med. , vol.188 , pp. 1247-1254
    • Xu, H.1    Li, H.2    Suri-Payer, E.3    Hardy, R.R.4    Weigert, M.5
  • 42
    • 0028215530 scopus 로고
    • Deletion and editing of B cells that express antibodies to DNA
    • Chen C, et al. (1994) Deletion and editing of B cells that express antibodies to DNA. J. Immunol. 152:1970-82.
    • (1994) J. Immunol. , vol.152 , pp. 1970-1982
    • Chen, C.1
  • 44
    • 0022351071 scopus 로고
    • Murine monoclonal anti-DNA autoantibodies bind to endogenous bacteria
    • Carroll P, Stafford D, Schwartz RS, Stollar BD. (1985) Murine monoclonal anti-DNA autoantibodies bind to endogenous bacteria. J. Immunol. 135:1086-90.
    • (1985) J. Immunol. , vol.135 , pp. 1086-1090
    • Carroll, P.1    Stafford, D.2    Schwartz, R.S.3    Stollar, B.D.4
  • 45
    • 0020681076 scopus 로고
    • Polyspecificity of monoclonal lupus autoantibodies produced by humanhuman hybridomas
    • Shoenfeld Y, et al. (1983) Polyspecificity of monoclonal lupus autoantibodies produced by humanhuman hybridomas. N. Engl. J. Med. 308:414-20.
    • (1983) N. Engl. J. Med. , vol.308 , pp. 414-420
    • Shoenfeld, Y.1
  • 46
    • 0019364072 scopus 로고
    • Antigen-binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA
    • Andrzejewski C Jr, Rauch J, Lafer E, Stollar BD, Schwartz RS. (1981) Antigen-binding diversity and idiotypic cross-reactions among hybridoma autoantibodies to DNA. J. Immunol. 126:226-31.
    • (1981) J. Immunol. , vol.126 , pp. 226-231
    • Andrzejewski Jr., C.1    Rauch, J.2    Lafer, E.3    Stollar, B.D.4    Schwartz, R.S.5
  • 47
    • 0019430363 scopus 로고
    • Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids
    • Lafer EM, et al. (1981) Polyspecific monoclonal lupus autoantibodies reactive with both polynucleotides and phospholipids. J. Exp. Med. 153:897-909.
    • (1981) J. Exp. Med. , vol.153 , pp. 897-909
    • Lafer, E.M.1
  • 49
    • 0025017688 scopus 로고
    • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
    • Shlomchik M, et al. (1990) Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J. Exp. Med. 171:265-92.
    • (1990) J. Exp. Med. , vol.171 , pp. 265-292
    • Shlomchik, M.1
  • 51
    • 0033577903 scopus 로고    scopus 로고
    • A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus
    • Chan OT, Hannum LG, Haberman AM, Madaio MP, Shlomchik MJ. (1999) A novel mouse with B cells but lacking serum antibody reveals an antibody-independent role for B cells in murine lupus. J. Exp. Med. 189:1639-48.
    • (1999) J. Exp. Med. , vol.189 , pp. 1639-1648
    • Chan, O.T.1    Hannum, L.G.2    Haberman, A.M.3    Madaio, M.P.4    Shlomchik, M.J.5
  • 52
    • 0030934956 scopus 로고    scopus 로고
    • Antibody independent crescentic glomerulonephritis in mu chain deficient mice
    • Li S, Holdsworth SR, Tipping PG. (1997) Antibody independent crescentic glomerulonephritis in mu chain deficient mice. Kidney Int. 51:672-8.
    • (1997) Kidney Int. , vol.51 , pp. 672-678
    • Li, S.1    Holdsworth, S.R.2    Tipping, P.G.3
  • 53
    • 1642540587 scopus 로고    scopus 로고
    • Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis
    • Waters ST, et al. (2004) Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J. Exp. Med. 199:255-64.
    • (2004) J. Exp. Med. , vol.199 , pp. 255-264
    • Waters, S.T.1
  • 54
    • 84866184129 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: The Lupus Nephritis Assessment with Rituximab study
    • Rovin BH, et al. (2012) Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study. Arthritis Rheum. 64:1215-26.
    • (2012) Arthritis Rheum. , vol.64 , pp. 1215-1226
    • Rovin, B.H.1
  • 55
    • 0029086996 scopus 로고
    • Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice
    • Ehrenstein MR, et al. (1995) Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice. Kidney Int. 48:705-11.
    • (1995) Kidney Int. , vol.48 , pp. 705-711
    • Ehrenstein, M.R.1
  • 56
    • 0031964947 scopus 로고    scopus 로고
    • Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis
    • Ravirajan CT, et al. (1998) Genetic, structural and functional properties of an IgG DNA-binding monoclonal antibody from a lupus patient with nephritis. Eur. J. Immunol. 28:339-50.
    • (1998) Eur. J. Immunol. , vol.28 , pp. 339-350
    • Ravirajan, C.T.1
  • 57
    • 84869881059 scopus 로고    scopus 로고
    • The pathogenesis of systemic lupus erythematosus: An update
    • Choi J, Kim ST, Craft J. (2012) The pathogenesis of systemic lupus erythematosus: an update. Curr. Opin. Immunol. 24:651-7.
    • (2012) Curr. Opin. Immunol. , vol.24 , pp. 651-657
    • Choi, J.1    Kim, S.T.2    Craft, J.3
  • 58
    • 77957797842 scopus 로고    scopus 로고
    • Renal Dnase1 enzyme activity and protein expression is selectively shut down in murine and human membranoproliferative lupus nephritis
    • Zykova SN, Tveita AA, Rekvig OP. (2010) Renal Dnase1 enzyme activity and protein expression is selectively shut down in murine and human membranoproliferative lupus nephritis. PLoS One. 10:5.
    • (2010) PLoS One. , vol.10 , pp. 5
    • Zykova, S.N.1    Tveita, A.A.2    Rekvig, O.P.3
  • 59
    • 0032813046 scopus 로고    scopus 로고
    • Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis
    • Berden JH, Licht R, Van Bruggen MC, Tax WJ. (1999) Role of nucleosomes for induction and glomerular binding of autoantibodies in lupus nephritis. Curr. Opin. Nephrol. Hypertens. 8:299-306.
    • (1999) Curr. Opin. Nephrol. Hypertens. , vol.8 , pp. 299-306
    • Berden, J.H.1    Licht, R.2    Van Bruggen, M.C.3    Tax, W.J.4
  • 60
    • 0030971352 scopus 로고    scopus 로고
    • Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo
    • Van Bruggen MC, et al. (1997) Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo. Eur. J. Immunol. 27:1564-9.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 1564-1569
    • Van Bruggen, M.C.1
  • 61
    • 27744455447 scopus 로고    scopus 로고
    • Trashing the genome: The role of nucleases during apoptosis
    • Samejima K, Earnshaw WC. (2005) Trashing the genome: the role of nucleases during apoptosis. Nat. Rev. Mol. Cell. Biol. 6:677-88.
    • (2005) Nat. Rev. Mol. Cell. Biol. , vol.6 , pp. 677-688
    • Samejima, K.1    Earnshaw, W.C.2
  • 62
    • 52049097489 scopus 로고    scopus 로고
    • Nucleases in programmed cell death
    • Kawane K, Nagata S. (2008) Nucleases in programmed cell death. Methods Enzymol. 442:271-87.
    • (2008) Methods Enzymol. , vol.442 , pp. 271-287
    • Kawane, K.1    Nagata, S.2
  • 64
    • 0029851318 scopus 로고    scopus 로고
    • The treatment of systemic lupus erythematosus (SLE) in NZB/W F1 hybrid mice: Studies with recombinant murine DNase and with dexamethasone
    • Macanovic M, et al. (1996) The treatment of systemic lupus erythematosus (SLE) in NZB/W F1 hybrid mice: studies with recombinant murine DNase and with dexamethasone. Clin. Exp. Immunol. 106:243-52.
    • (1996) Clin. Exp. Immunol. , vol.106 , pp. 243-252
    • McAnovic, M.1
  • 65
    • 0033043318 scopus 로고    scopus 로고
    • Recombinant human Dnase I (rhDNase) in patients with lupus nephritis
    • Davis JC Jr, et al. (1999) Recombinant human Dnase I (rhDNase) in patients with lupus nephritis. Lupus. 8:68-76.
    • (1999) Lupus. , vol.8 , pp. 68-76
    • Davis Jr., J.C.1
  • 66
    • 0031779647 scopus 로고    scopus 로고
    • DNAse treatment does not improve the survival of lupus prone (NZB x NZW)F1 mice
    • Verthelyi D, Dybdal N, Elias KA, Klinman DM. (1998) DNAse treatment does not improve the survival of lupus prone (NZB x NZW)F1 mice. Lupus. 7:223-30.
    • (1998) Lupus. , vol.7 , pp. 223-230
    • Verthelyi, D.1    Dybdal, N.2    Elias, K.A.3    Klinman, D.M.4
  • 67
    • 3042778187 scopus 로고    scopus 로고
    • Expression pattern of the deoxyribonuclease 1 gene: Lessons from the Dnase1 knockout mouse
    • Napirei M, Ricken A, Eulitz D, Knoop H, Mannherz HG. (2004) Expression pattern of the deoxyribonuclease 1 gene: lessons from the Dnase1 knockout mouse. Biochem. J. 380:929-37.
    • (2004) Biochem. J. , vol.380 , pp. 929-937
    • Napirei, M.1    Ricken, A.2    Eulitz, D.3    Knoop, H.4    Mannherz, H.G.5
  • 68
    • 84859118446 scopus 로고    scopus 로고
    • Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of toll like receptors and the Clec4e
    • Thiyagarajan D, et al. (2012) Silencing of renal DNaseI in murine lupus nephritis imposes exposure of large chromatin fragments and activation of toll like receptors and the Clec4e. PLoS One. 7:e34080.
    • (2012) PLoS One. , vol.7
    • Thiyagarajan, D.1
  • 69
    • 33746882098 scopus 로고    scopus 로고
    • Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity
    • Merrell MA, et al. (2006) Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity. Mol. Cancer Res. 4:437-47.
    • (2006) Mol. Cancer Res. , vol.4 , pp. 437-447
    • Merrell, M.A.1
  • 70
    • 33746346729 scopus 로고    scopus 로고
    • Activation of toll-like receptor-9 induces matrix metalloproteinase-9 expression through Akt and tumor necrosis factoralpha signaling
    • Lim EJ, et al. (2006) Activation of toll-like receptor-9 induces matrix metalloproteinase-9 expression through Akt and tumor necrosis factoralpha signaling. FEBS Lett. 580:4533-8.
    • (2006) FEBS Lett. , vol.580 , pp. 4533-4538
    • Lim, E.J.1
  • 71
    • 0035156633 scopus 로고    scopus 로고
    • TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP
    • Han YP, Tuan TL, Wu H, Hughes M, Garner WL. (2001) TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP. J. Cell Sci. 114:131-9.
    • (2001) J. Cell Sci. , vol.114 , pp. 131-139
    • Han, Y.P.1    Tuan, T.L.2    Wu, H.3    Hughes, M.4    Garner, W.L.5
  • 72
    • 42449158896 scopus 로고    scopus 로고
    • Exposure to pro-inflammatory cytokines upregulates MMP-9 synthesis by mesenchymal stem cells-derived osteoprogenitors
    • Ben DD, Reznick AZ, Srouji S, Livne E. (2008) Exposure to pro-inflammatory cytokines upregulates MMP-9 synthesis by mesenchymal stem cells-derived osteoprogenitors. Histochem. Cell. Biol. 129:589-97.
    • (2008) Histochem. Cell. Biol. , vol.129 , pp. 589-597
    • Ben, D.D.1    Reznick, A.Z.2    Srouji, S.3    Livne, E.4
  • 73
    • 77649267179 scopus 로고    scopus 로고
    • Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages
    • Triantafyllopoulou A, et al. (2010) Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages. Proc. Natl. Acad. Sci. U. S. A. 107:3012-7.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 3012-3017
    • Triantafyllopoulou, A.1
  • 74
    • 33744971173 scopus 로고    scopus 로고
    • Inefficient clearance of dying cells and autoreactivity
    • Gaipl US, et al. (2006) Inefficient clearance of dying cells and autoreactivity. Curr. Top. Microbiol. Immunol. 305:161-76.
    • (2006) Curr. Top. Microbiol. Immunol. , vol.305 , pp. 161-176
    • Gaipl, U.S.1
  • 75
    • 52649166135 scopus 로고    scopus 로고
    • Sensing necrosis with Mincle
    • Brown GD. (2008) Sensing necrosis with Mincle. Nat. Immunol. 9:1099-100.
    • (2008) Nat. Immunol. , vol.9 , pp. 1099-1100
    • Brown, G.D.1
  • 76
    • 52549125928 scopus 로고    scopus 로고
    • Mincle is an ITAMcoupled activating receptor that senses damaged cells
    • Yamasaki S, et al. (2008) Mincle is an ITAMcoupled activating receptor that senses damaged cells. Nat. Immunol. 9:1179-88.
    • (2008) Nat. Immunol. , vol.9 , pp. 1179-1188
    • Yamasaki, S.1
  • 77
    • 67649840704 scopus 로고    scopus 로고
    • Signalling through C-type lectin receptors: Shaping immune responses
    • Geijtenbeek TB, Gringhuis SI. (2009) Signalling through C-type lectin receptors: shaping immune responses. Nat. Rev. Immunol. 9:465-79.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 465-479
    • Geijtenbeek, T.B.1    Gringhuis, S.I.2
  • 78
    • 35148883112 scopus 로고    scopus 로고
    • Protease yoga: Extreme flexibility of a matrix metalloproteinase
    • Overall CM, Butler GS. (2007) Protease yoga: extreme flexibility of a matrix metalloproteinase. Structure. 15:1159-61.
    • (2007) Structure. , vol.15 , pp. 1159-1161
    • Overall, C.M.1    Butler, G.S.2
  • 79
    • 84903184153 scopus 로고    scopus 로고
    • Complement and systemic lupus erythematosus
    • Walport MJ. (2002) Complement and systemic lupus erythematosus. Arthritis Res. 4 Suppl 3: S279-93.
    • (2002) Arthritis Res. , vol.4 , Issue.SUPPL. 3
    • Walport, M.J.1
  • 80
    • 77957942335 scopus 로고    scopus 로고
    • Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus
    • van Bavel CC, et al. (2011) Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus. Ann. Rheum. Dis. 70:201-7.
    • (2011) Ann. Rheum. Dis. , vol.70 , pp. 201-207
    • van Bavel, C.C.1
  • 81
    • 34447523785 scopus 로고    scopus 로고
    • Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus
    • Dieker JW, et al. (2007) Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus. Arthritis Rheum. 56:1921-33.
    • (2007) Arthritis Rheum. , vol.56 , pp. 1921-1933
    • Dieker, J.W.1
  • 82
    • 68049091014 scopus 로고    scopus 로고
    • Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17
    • Fransen JH, et al. (2009) Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17. Arthritis Rheum. 60:2304-13.
    • (2009) Arthritis Rheum. , vol.60 , pp. 2304-2313
    • Fransen, J.H.1
  • 83
    • 84872375049 scopus 로고    scopus 로고
    • RNA polymerase II transcript elongation
    • Svejstrup JQ. (2013) RNA polymerase II transcript elongation. Biochim. Biophys. Acta. 1829:1.
    • (2013) Biochim. Biophys. Acta. , vol.1829 , pp. 1
    • Svejstrup, J.Q.1
  • 84
    • 57849109058 scopus 로고    scopus 로고
    • Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters
    • Core LJ, Waterfall JJ, Lis JT. (2008) Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science. 322:1845-8.
    • (2008) Science. , vol.322 , pp. 1845-1848
    • Core, L.J.1    Waterfall, J.J.2    Lis, J.T.3
  • 85
    • 84869083002 scopus 로고    scopus 로고
    • RNA polymerase II collision interrupts convergent transcription
    • Hobson DJ, Wei W, Steinmetz LM, Svejstrup JQ. (2012) RNA polymerase II collision interrupts convergent transcription. Mol. Cell. 48:365-74.
    • (2012) Mol. Cell. , vol.48 , pp. 365-374
    • Hobson, D.J.1    Wei, W.2    Steinmetz, L.M.3    Svejstrup, J.Q.4
  • 86
    • 16244384503 scopus 로고    scopus 로고
    • A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation
    • Kizer KO, et al. (2005) A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Mol. Cell. Biol. 25:3305-16.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 3305-3316
    • Kizer, K.O.1
  • 87
    • 0037336041 scopus 로고    scopus 로고
    • Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast
    • Xiao T, et al. (2003) Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev. 17:654-63.
    • (2003) Genes Dev. , vol.17 , pp. 654-663
    • Xiao, T.1
  • 88
    • 19444377759 scopus 로고    scopus 로고
    • Transcriptional interference: A crash course
    • Shearwin KE, Callen BP, Egan JB. (2005) Transcriptional interference: a crash course. Trends Genet. 21:339-45.
    • (2005) Trends Genet. , vol.21 , pp. 339-345
    • Shearwin, K.E.1    Callen, B.P.2    Egan, J.B.3
  • 89
    • 84874538904 scopus 로고    scopus 로고
    • Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis
    • Fismen S, et al. (2012) Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis. Am. J. Pathol. 182:688-700.
    • (2012) Am. J. Pathol. , vol.182 , pp. 688-700
    • Fismen, S.1
  • 91
  • 92
    • 4043079297 scopus 로고    scopus 로고
    • Apoptosis in systemic lupus erythematosus
    • Kaplan MJ. (2004) Apoptosis in systemic lupus erythematosus. Clin. Immunol. 112:210-8.
    • (2004) Clin. Immunol. , vol.112 , pp. 210-218
    • Kaplan, M.J.1
  • 93
    • 82255192363 scopus 로고    scopus 로고
    • Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus
    • Al-Mayouf SM, et al. (2011) Loss-of-function variant in DNASE1L3 causes a familial form of systemic lupus erythematosus. Nat. Genet. 43:1186-8.
    • (2011) Nat. Genet. , vol.43 , pp. 1186-1188
    • Al-Mayouf, S.M.1
  • 94
    • 0032581495 scopus 로고    scopus 로고
    • Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages
    • Baron WF, et al. (1998) Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. Gene. 215:291-301.
    • (1998) Gene. , vol.215 , pp. 291-301
    • Baron, W.F.1
  • 95
    • 34848887977 scopus 로고    scopus 로고
    • Glomerular expression of large polyomavirus T antigen in binary tetoff regulated transgenic mice induces apoptosis, release of chromatin and initiates a lupus-like nephritis
    • Bendiksen S, et al. (2008) Glomerular expression of large polyomavirus T antigen in binary tetoff regulated transgenic mice induces apoptosis, release of chromatin and initiates a lupus-like nephritis. Mol. Immunol. 45:728-39.
    • (2008) Mol. Immunol. , vol.45 , pp. 728-739
    • Bendiksen, S.1
  • 96
    • 43449096610 scopus 로고    scopus 로고
    • Renal expression of polyomavirus large T antigen is associated with nephritis in human systemic lupus erythematosus
    • Fenton KA, Mjelle JE, Jakobsen S, Olsen R, Rekvig OP. (2008) Renal expression of polyomavirus large T antigen is associated with nephritis in human systemic lupus erythematosus. Mol. Immunol. 45:3117-24.
    • (2008) Mol. Immunol. , vol.45 , pp. 3117-3124
    • Fenton, K.A.1    Mjelle, J.E.2    Jakobsen, S.3    Olsen, R.4    Rekvig, O.P.5
  • 97
    • 0037103423 scopus 로고    scopus 로고
    • BK virus nephropathy: Polyomavirus adding insult to injury
    • Fishman JA. (2002) BK virus nephropathy: polyomavirus adding insult to injury. N. Engl. J. Med. 347:527-30.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 527-530
    • Fishman, J.A.1
  • 98
    • 0034966564 scopus 로고    scopus 로고
    • Plasma levels of nucleosomes and nucleosome-autoantibody complexes in murine lupus: Effects of disease progression and lipopolyssacharide administration
    • Licht R, Van Bruggen MC, Oppers-Walgreen B, Rijke TP, Berden JH. (2001) Plasma levels of nucleosomes and nucleosome-autoantibody complexes in murine lupus: effects of disease progression and lipopolyssacharide administration. Arthritis Rheum. 44:1320-30.
    • (2001) Arthritis Rheum. , vol.44 , pp. 1320-1330
    • Licht, R.1    Van Bruggen, M.C.2    Oppers-Walgreen, B.3    Rijke, T.P.4    Berden, J.H.5
  • 99
    • 65649153698 scopus 로고    scopus 로고
    • Circulating chromatinanti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis
    • Fismen S, et al. (2009) Circulating chromatinanti-chromatin antibody complexes bind with high affinity to dermo-epidermal structures in murine and human lupus nephritis. Lupus. 18:597-607.
    • (2009) Lupus. , vol.18 , pp. 597-607
    • Fismen, S.1
  • 100
    • 77954838721 scopus 로고    scopus 로고
    • Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities
    • Hedberg A, Fismen S, Fenton KA, Mortensen ES, Rekvig OP. (2010) Deposition of chromatin-IgG complexes in skin of nephritic MRL-lpr/lpr mice is associated with increased local matrix metalloprotease activities. Exp. Dermatol. 19:e265-74.
    • (2010) Exp. Dermatol. , vol.19
    • Hedberg, A.1    Fismen, S.2    Fenton, K.A.3    Mortensen, E.S.4    Rekvig, O.P.5


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