Perfusion defatting at subnormothermic temperatures in steatotic rat livers

Transplantation Proceedings

Volumn 45, Issue 9, 2013, Pages 3209-3213

  Liu, Q ^a   Berendsen, T ^a   Izamis, M L ^a   Uygun, B ^a   Yarmush, M L ^a,b   Uygun, K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FAT CONTENT; FATTY LIVER; HISTOPATHOLOGY; LIVER PERFUSION; LIVER PRESERVATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; ROOM TEMPERATURE; VASCULAR RESISTANCE;

ADIPOSE TISSUE; ANIMALS; BODY TEMPERATURE; FATTY LIVER; LIVER TRANSPLANTATION; RATS; RATS, ZUCKER;

EID: 84887053135     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2013.05.005     Document Type: Article

References (20)

1. R.A. Wolfe, R.M. Merion, and E.C. Roys Trends in organ donation and transplantation in the United States, 1998-2007 Am J Transplant 9 4 pt 2 2009 869 878
2. F. Durand, J.F. Renz, and B. Alkofer Report of the Paris consensus meeting on expanded criteria donors in liver transplantation Liver Transpl 14 12 2008 1694 1707
3. C.L. Berg, D.E. Steffick, and E.B. Edwards Liver and intestine transplantation in the United States 1998-2007 Am J Transplant 9 4 pt 2 2009 907 931
4. O. de Rougemont, K. Lehmann, and P.A. Clavien Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver Liver Transpl 15 2009 1172 1182
5. R.W. Jamieson, M. Zilvetti, and D. Roy Hepatic steatosis and normothermic perfusion-preliminary experiments in a porcine model Transplantation 92 3 2011 289 295
6. M. Vairetti, A. Ferrigno, and F. Carlucci Subnormothermic machine perfusion protects steatotic livers against preservation injury: a potential for donor pool increase? Liver Transpl 15 1 2009 20 29
7. E. Boncompagni, E. Gini, and A. Ferrigno Decreased apoptosis in fatty livers submitted to subnormothermic machine-perfusion respect to cold storage Eur J Histochem 55 4 2011 e40
8. M. Bessems, B.M. Doorschodt, and J.L. Kolkert Preservation of steatotic livers: a comparison between cold storage and machine perfusion preservation Liver Transpl 13 4 2007 497 504
9. D. Monbaliu, and J. Brassil Machine perfusion of the liver: past, present and future Curr Opin Organ Transplant 15 2 2010 160 166
10. J. Brockmann, S. Reddy, and C. Coussios Normothermic perfusion: a new paradigm for organ preservation Ann Surg 259 1 2009 1 6
11. C. Fondevila, A.J. Hessheimer, and M.H. Masthuis Superior preservation of DCD livers with continuous normothermic perfusion Ann Surg 254 6 2011 1000 1007
12. D. Nagrath, H. Xu, and Y. Tanimura Metabolic preconditioning of donor organs: defatting fatty livers by normothermic perfusion ex vivo Metab Eng 11 4-5 2009 274 283
13. M. Izamis, T. Berendsen, and K. Uygun Addressing the liver organ donor shortage with ex vivo organ perfusion J Healthcare Engineer 3 2012 279-98
14. A. Ferrigno, V. Rizzo, and E. Boncompagni Machine perfusion at 20 C reduces preservation damage to livers from non-heart beating donors Cryobiology 62 2 2011 152 158
15. H. Tolboom, M.L. Izamis, and N. Sharma Subnormothermic machine perfusion at both 20C and 30C recovers ischemic rat livers for successful transplantation J Surg Res 175 1 2012 149 156
16. T. Berendsen, B. Bruinsma, and J.W. Lee A simplified subnormothermic machine perfusion model restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation Transplant Res 1 1 2012 6
17. C.J. Imber, S.D. St Peter, and A. Handa Hepatotic steatosis and its relationship to transplantation Liver Transpl 8 5 2002 415 423
18. S. Ijaz, W. Yang, and M.C. Winslet Impairment of hepatic microcirculation in fatty liver Microcirculation 10 6 2003 447 456
19. I. Jochmans, C. Moers, and J.M. Smits The prognostic value of renal resistance during hypothermic machine perfusion of deceased donor kidneys Am J Transplant 11 10 2011 2214 2220
20. S. Fujita, I. Hamamoto, and K. Nakamura Isolated perfusion of rat livers: effect of temperature on O2 consumption, enzyme release, energy store, and morphology Nippon Geka Hokan 62 1993 58 70