The pathogenesis of pulmonary fibrosis: Is there a fibrosis gene?

International Journal of Biochemistry and Cell Biology

Volumn 29, Issue 1, 1997, Pages 107-120

  Marshall, Richard P ^a   McAnulty, Robin J ^a   Laurent, Geoffrey J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; LEUKOCYTE ANTIGEN; POLYPEPTIDE;

CELL INTERACTION; CELL PROLIFERATION; COLLAGEN METABOLISM; EXTRACELLULAR MATRIX; FIBROBLAST; FIBROSING ALVEOLITIS; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; HISTOLOGY; HUMAN; INFLAMMATORY CELL; INTERSTITIUM; LUNG FIBROSIS; NONHUMAN; PATHOGENESIS; REVIEW; RISK FACTOR;

ANIMALS; COLLAGEN; DISEASE MODELS, ANIMAL; HLA ANTIGENS; HUMANS; INFLAMMATION MEDIATORS; LINKAGE (GENETICS); MODELS, BIOLOGICAL; PULMONARY FIBROSIS;

ANIMALIA;

EID: 0031017141     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1357-2725(96)00141-0     Document Type: Review

References (129)

1. Adelman A. G., Chertkow G. and Hayton R. C. (1966) Familial fibrocystic pulmonary dysplasia. A detailed family study. Canad. Med. Ass. J 95, 603-610.
2. Adler K. B., Low R. B., Leslie K. O., Mitchell J. and Evans J. N. (1989) Contractile cells in normal and fibrotic lung. Lab. Invest. 60, 473-485.
3. Alton E. W. and Geddes D. M. (1995) Gene therapy for respiratory diseases potential applications and difficulties. Thorax 50, 484-486.
4. Amenta P. S., Gil J. and Martinez-Hernandez A. (1988) Connective tissue of rat lung II. Ultrastructral localisation of collagen types III, IV and VI. J. Histochem. Cytochem. 36, 1167-1173.
5. Appleman A. C. and Buytendijk H. J. (1961) Chronische interstitiele pneumonie/syndroom van Hamman Rich/in een familie. Ned. T. Geneesk. 105, 1928-1930.
6. Auwrex J., Demedts M., Bouillon R. and Desmet J. (1985a) Coexistence of hypocalcuric hypercalcaemia and interstitial lung disease in a family: a cross-sectional study. Eur. J. Clin. Invest. 15, 6-14.
7. Auwrex J., Boogaerts M., Ceuppens J. L. and Demedts M. (1985b) Defective host defence mechanisms in a family with hypocalcuric hypercalcaemia and coexisting interstitial lung disease. Clin. Exp. Immunol. 63, 57-64.
8. Baecher-Allan C. M. and Barth R. K. (1993) PCR analysis of cytokine induction profiles associated with mouse strain variation in susceptibility to pulmonary fibrosis. Reg. Immunol. 5, 207-217.
9. Barbera J. A., Hayashi S., Hegele R. G. and Hogg J. C. (1992) Detection of Epstein-Barr virus in lymphocytic interstitial pneumonia by in situ hybridisation. Am. Rev. Respir. Dis. 145, 940-946.
10. Barzo P. (1985) Familial idiopathic fibrosing alveolitis. Eur. J. Respir. Dis. 66, 350-352.
11. Bateman E. D., Turner Warwick M. and Adelmann-Grill B. C. (1981) Immunohistochemical study of collagen types in human foetal lung and fibrotic lung disease. Thorax 36, 645-653.
12. Beaumont F., Jansen H. M., Elema J. D., Ten Kate L. P. and Sluiter H. J. (1981) Simultaneous occurrence of pulmonary interstitial fibrosis and alveolar cell carcinoma in one family. Thorax 36, 252-258.
13. Bitterman P. B. and Rennard S. I. et al., (1986) Familial idopathic pulmonary fibrosis. NEJM 314, 1343-1347.
14. Bonnani P. P., Frymoyer J. W. and Jacox R. F. (1965) A family study of idiopathic pulmonary fibrosis. Am. J. Mcd. 39, 411-421.
15. Briggs D. C., Vaughan R. W., Welsh K. I., Myers A., duBois R. M. and Black C. M. (1991) Immunogenetic prediction of pulmonary fibrosis in systemic sclerosis. Lancet 338, 661-662.
16. 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc. Natl Acad. Sci. U.S.A. 88, 6642-6646.
17. Cernilas J., Lurie M., Topilsky M. and Spitzer S. (1978) Familial chronic diffuse interstitial pulmonary fibrosis of undetermined origin. Harefuah 95, 387-389.
18. Chapman J. R., Charles P. J., Venables P. J., Thompson P. J., Haslam P. L., Maini R. N. and Turner-Warwick M. E. (1984) Definition and clinical relevance of antibodies to nuclear ribonucleoprotein and other nuclear antigens in patients with cryptogenic fibrosing alveolitis. Am. Rev. Respir. Dis. 130, 439-443.
19. 2+)-sensing-receptor gene that causes familial hypocalcuric hypercalcaemia Am. J. Hum. Genet. 56, 1075-1079.
20. Coker R. K. and Laurent G. J. (1995) Pathogenesis of pulmonary fibrosis: implications for pharmacological intervention. In Immunology and Management of Interstitial Lung Disease (Eds Walters E. H. and duBois R. M.) Chapman and Hall, London.
21. Crouch E. (1990) Pathobiology of pulmonary fibrosis. Am. J. Physiol. 259, 159-184.
22. Crystal R. G., Fulmer J. D., Roberts W. C. and Moss M. L. B. R. Line and H. Y. Reynolds (1976) Idiopathic pulmonary fibrosis. Ann. Intern. Med. 85, 769-788.
23. Darke C., Wagner M. M. and McMillan G. H. (1979) HLA-A and B antigen frequencies in an asbestos exposed population with normal and abnormal chest radiographs. Tissue Antigens 13, 228-232.
24. Davies B. H. and Tuddenham E. G. D. (1976) Familial pulmonary fibrosis and occulocutaneous albinism and platelet function defect. Quat. J. Med. 45, 219-232.
25. Davies G. M. and Potts M. V. (1964) Chronic diffuse interstitial fibrosis in brothers. Guys Hsp. Rep. 113, 36.
26. Donohue W. L., Laski B., Uchida I. and Munn J. D. (1959) Familial pulmonary dysplasia and its relationship to the Hamman-Rich syndrome. Paediatrics 24, 786.
27. Driessen A. P. P. M. and Scherpenisse L. A. (1970) Familiair voorkomemde diffuse interstiele langfibrose gecompliceerd door alveolaire-cellencarcinoom. Ned. T. Geneesk. 114, 2041-2045.
28. Edwards D. R., Murphy G., Reynolds J. J., Whitham S. E., Docherty A. J. P., Angel P. and Heath J. K. (1987) Transforming growth factor β modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 6, 1899-1904.
29. Egan J. J., Stewart J. P., Hasleton P. S., Arrand J. R. and Carroll K. B. (1995) Epstein-Barr virus replication within pulmonary epithelial cells in cryptogenic fibrosing alveolitis. Thorax 50, 1234-1239.
30. Eitzmann D. T., McCoy R. D., Zheng X., Fay W. P., Shen T., Ginsburg D. and Simon R. H. (1996) Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or over express the murine plasminogen activator inhibitor-1 gene. Clin. Invest. 97, 232-237.
31. Ellis R. H. (1965) Familial incidence of diffuse pulmonary fibrosis. Postgrad. Med. J 41, 150-152.
32. Evans C. (1976) HLA antigens in diffuse fibrosing alveolitis. Thorax 31, 483.
33. Fabisiak J. P., Evans J. N. and Kelly J. (1989) Increased expression of platelet derived growth factor B (c-sis) mRNA in rat lung precedes DNA synthesis and tissue repair during chronic hypoxia. Am. J. Repir. Cell Mol. Biol. 1, 181-189.
34. Farrell P. M., Gilbert E. F., Zimmerman J. J., Warner T. F. and Saari T. N. (1986) Familial lung disease associated with proliferation and desquamation of type II pneumocytes. Am. J. Dis. Child 140, 262-266.
35. Fukai K., Oh J., Frenk E., Almodovar C. and Spritz R. A. (1995) Linkage disequilibrium mapping of the gene for Hermansky-Pudlak syndrome to chromosome 10q23. Hum. Mol. Genet. 4, 1665-1669.
36. Garat S. M., Gardella A. E., Fazzini E. P. and Goldring R. M. (1979) Hermansky-Pudlak syndrome: manifestations of a ceroid storage disorder. Am. J. Med. 66, 737-747.
37. 1-Antitrypsin phenotypes in fibrosing alveolitis and rheumatoid arthritis. Lancet ii, 1049-1051.
38. Goldstein R. H., Poliks C. F., Pilch P. F., Smith B. D. and Fine A, (1989) Stimulation of collagen formation by insulin and insulin-like growth factor-1 in cultures of human lung fibroblasts. Endocrinology 124, 964-970.
39. Gray A. J., Reeves J. T., Harrison N. K., Winlove O. and Laurent G. J. (1990) Growth factors for human fibroblasts in the solute remaining after clot formation. J. Cell Sci. 96, 271-274.
40. Hakala M., Ruuska P., Hameenkorpi R., Tiilikainen A., Ilonen J. and Makitalo R. (1986) Diffuse interstitial lung disease in rheumatoid arthritis. Views on immunological and HLA findings. Scand. J. Rheumatol. 15, 368-376.
41. Hamman L. and Rich A. R. (1944) Acute diffuse interstitial fibrosis of the lungs. Bull. Johns Hopkins Hasp. 74, 177.
42. Harrison N. K. and Laurent G. J. Mechanisms for the pathogenesis of pulmonary fibrosis. In Respiratory Medicine (Ed. Barnes P. J.), pp. 190-210. Butterworth Heinmann, Oxford.
43. Harrison N. K., McAnulty R. J., Haslam P. L., Black C. M. and Laurent G. J. (1990) Evidence for protein oedema, neutrophil influx and enhanced procollagen production in the lungs of patients with systemic sclerosis. Thorax 45, 606-610.
44. Harrison N. K., Cambrey A. D., Myers A. R., Southcott A. M., Black C. M., duBois R. M. and Laurent G. J. (1994) Insulin-like growth factor is partially responsible for fibroblast proliferation induced by bronchoalveolar lavage fluid from patients with systemic sclerosis. Clin. Sci. 86, 141-148.
45. Hermasnky F. and Pudlak P. (1959) Albinism associated with hemorrhagic diathesis and unusual pigmented reticular cells in the bone marrow. Report of two cases with histochemical studies. Blood 14, 162.
46. Hernadez-Rodrigez N. A., Cambrey A. D., Harrison N. K., Chambers R. C., Gray A. J., Southcott A. M., duBois R. M., Black C. M., Scully M. F., McAnulty R. J. and Laurent G. J. (1995) Role of thrombin in pulmonary fibrosis. Lancet 346, 1071-1073.
47. Ho Y. S. (1994) Transgenic models for the study of lung biology and disease. Am. J. Physiol. 266, L139-L353.
48. Hoste P., Willems J., Devriendt J., Lamont H. and Straeten M. (1979) Familial diffuse interstitial pulmonary fibrosis associated with occulocutaneous albinism. Scand. J. Resp. Dis. 60, 128-134.
49. Hoyt D. G. and Lazo J. S. (1988) Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor β precede bleomycin-induced pulmonary fibrosis in mice. J. Pharmacol. Exp. Ther. 246, 765-771.
50. Hoyt D. G. and Lazo J. S. (1989) Early changes in pulmonary mRNA encoding procollagens and transforming growth factor β in mice sensitive to cyclophosphamide-induced pulmonary fibrosis. J. Pharmacol. Exp. Ther. 249, 38-43.
51. Hughes E. W. (1964) Familial interstitial pulmonary fibrosis. Thorax 19, 515-525.
52. Ignotz R. A. and Massague J. (1986) Transforming growth factor β stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. biol. Chem. 261, 4337-4345.
53. Ignotz R. A., Endo T. and Massague J. (1987) Regulation of fibronectin and type I procollagen mRNA levels by transforming growth factor β. J. biol. Chem. 262, 6443-6446.
54. Irving W. L., Day S. and Johnston I. D. A. (1993) Idiopathic pulmonary fibrosis and hepatitis C virus infection. Am. Rev. Respir. Dis. 148, 1683-1684.
55. Javaheri S., Lederer D. H., Pella J. A., Mark G. J. and Levine B. W. (1980) Idiopathic pulmonary fibrosis in monozygotic twins. Chest 78, 591-594.
56. Johnston C. J., Piedboeuf B., Baggs R., Rubin P. and Finkelstein J. N. (1995) Differences in correlation of mRNA gene expression in mice sensitive to radiation-induced pulmonary fibrosis. Radiat. Res. 142, 197-203.
57. Khalil N., Bereznay O., Sporn M. and Greenburg A. H. (1989) Macrophage production of transforming growth factor β and fibroblast collagen synthesis in chronic pulmonary infammation. J. Exp. Med. 170, 727-737.
58. Kirk J. M. E., Herad B. E., Kerr I., Turner-Warwick M. and Laurent G. J. (1984) Quantification of types I and III collagen in biopsy lung samples from patients with cryptogenic fibrosing alveolitis. Coll. Rel. Res. 4, 169-182.
59. Koch B. (1965) Familial fibrocystic pulmonary dysplasia: observations in one family. Canad. Med. Ass. J 92, 801-808.
60. Laurent G. J. and McAnulty R. J. (1983) Protein metabolism during bleomycin induced lung fibrosis in rabbits: in vivo evidence for collagen accumulation because of increased synthesis and decreased degradation of the newly synthesised collagen. Am. Rev. Respir. Dis. 128, 82-88.
61. Laurent G. J., Harrison N. K. and McAnulty R. J. (1988) The regulation of collagen production in normal lung and during interstitial lung disease. Post Grad. Med. J 64, 26-34.
62. Madri J. A. and Furthmayr H. (1979) Isolation and tissue localisation of type AB2 collagen from normal lung parenchyma. Am. J. Pathol. 94, 323-330.
63. Manigrand G., Oury M., Faux N., Lemaigre G. and Thomas I. (1982) Fibrose pulmonaire interstitielle diffuse familiale. Nouv. Presse. Med. 11, 50.
64. Marsh P., Johnston I. and Britton J. (1994) Atopy as a risk factor for cryptogenic fibrosing alveolitis. Respir. Med. 88, 369-371.
65. McAnulty R. G. and Laurent G. J. (1987) Collagen synthesis and degradation in vivo. Evidence for rapid rates of collagen turnover with extensive degradation of newly synthesised collagen in tissues of the adult rat. Coll. Rel. Res. 7, 93-104.
66. McAnulty R. J., Campa J. S., Cambrey A. D. and Laurent G. J. (1991) The effect of transforming growth factor β on rates of procollagen synthesis and degradation in vitro. Bichem. Biophy. Acta 1091, 231-235.
67. McAnulty R. J., Chambers R. C. and Laurent G. J. (1995) Regulation of fibroblast procollagen production. Biochem. J. 307, 63-68.
68. McDonald J. A., Broekelmann T. J., Matheke M. L., Crouch E., Koo M. and Kuhn C. (1986) A monoclonal antibody to the carboxy-terminal domain of procollagen type I visualizes collagen synthesizing fibroblasts: detection of an altered fibroblast phenotype in patients with pulmonary fibrosis. J. Clin. Invest. 78, 1237-1244.
69. McDonnell L., Sweeney E. C., Jagoe W. S. and Fitzgerald M. X. (1982) Familial pulmonary fibrosis and lung cancer. Irish J. Med. Sci. 15, 315-317.
70. McKusick V. A. and Fischer A. M. (1958) Congenital cystic disease of the lung with progressive pulmonary fibrosis and carcinomatosis. Ann. Intern. Med. 48, 774-790.
71. McMillan J. M. (1951) Familial pulmonary fibrosis. Chest 20, 426-431.
72. 1 Antitrypsin phenotypes including M subtypes in pulmonary disease associated with rheumatoid arthritis and systemic sclerosis. Arthritis Rheum. 29, 586-591.
73. Muers M. F., Faux J. A., Ting A. and Morris P. J. (1982) HLA A, B, C and DR antigens in extrinsic allergic alveolitis. Clin. Allergy 12, 47-53.
74. Murphy G. and Docherty A. J. P. (1992) The matrix metalloproteinases and their inhibitors. Am. J. Respir. Cell Mol. Biol. 7, 120-125.
75. Murphy A. and O'Sullivan B. J. (1981) Familial fibrosing alveolitis. J. Med. Sci. 150, 204-209.
76. Musk A. W., Kilko P. J., Manners P., Kay P. H. and Kamboh M. I. (1986) Genetic studies in familial fibrosing alveolitis. Chest 89, 206-210.
77. Nezelof C., Brien A., Beal G., Meyer B., Paupe J. and Vialette J. (1974) Fibrose pulmonaire familiale. Ann. Pedieat. 21, 135-144.
78. Nowack D. and Goebel K. M. (1987) Genetic aspects of sarcoidosis. Class II histocompatibility antigens and a family study. Arch. Intern. Med. 147, 481-483.
79. Ohba T., McDonald J. K., Silver R. M., Strange C., LeRoy E. C. and Ludwicka A. (1994) Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet derived growth factor receptor. Am. J. Respir. Cell Mol. Biol. 10, 405-412.
80. Ohtsuka Y., Munakata M., Ukita H., Takahashi T., Satoh A., Homma Y. and Kawakami Y. (1995) Increased susceptibility to silicosis and TNF-α production in C57BL/6J mice. Am. J. Respir. Crit. Care Med. 152, 2144-2149.
81. Ostinell J., Valeyre D., Turbie P., Clerici C. and Battesti J. P. (1986) Familial primary diffuse pulmonary fibrosis with bullous emphysema. Presse-Med. 15, 1285-1286.
82. Overall C. M., Wrana J. L. and Sodek J. (1989) Independent regulation of collagenase. 72 kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor α. J. biol. Chem. 264, 1860-1869.
83. Peabody J. W., Peabody J. W. Jr., Hayes E. W. and Hayes E. W. Jr. (1950) Idiopathic pulmonary fibrosis: its occurence in identical twin sisters. Dis. Chest. 18, 330.
84. Peacock A. J., Dawes K. E., Shock A., Gray A. J., Reeves J. T. and Laurent G. J. (1992) Endothelin-1 and endothelin-3 induce chemotaxis and replication of pulmonary artery fibroblasts. Am. J. Respir. Cell Mol. Biol. 7, 492-499.
85. Penttinen R. P., Kobayashi S. and Bornstein P. (1988) Transforming growth factor β increases mRNA for matrix proteins both in the presence and in the absence of changes in mRNA stability. Proc. Natl Acad. Sci. U.S.A. 85, 1105-1108.
86. Phan S. H. and Thrall R, S. (eds) Pulmonary fibrosis. Marcel Dekker, New York.
87. 2+)-sensing receptor gene cause familial hypocalcuric hypercalcaemia and neonatal severe hyperparathyroidism. Cell 75, 1297-1303.
88. Pritchard M. G. and Musk A. W. (1984) Adverse effect of pregnancy on fibrosing alveolitis. Thorax 39, 319-320.
89. Raghow R., Postlethwaite A. E., Keski-Oja J., Moses H. L. and Kang A. H. (1987) Transforming growth factor γ increases steady state levels of type I procollagen and fibronectin messenger mRNAs post-transcriptionally in cultured human dermal fibroblasts. J. Clin. Invest. 79, 1285-1288.
90. Rezek Ph. R. and Tolbert W. M. (1962) Kongenitale/Familiare/zystische fibrose der lunge. Wien. Klin. Wochenschr. 74, 869-873.
91. Roberts A. B., Sporn A. B., Assoian R. K., Smith J. M., Roche N. S., Wakefiekd L. M., Heine U. I., Loitta L. A., Falanga V., Kehrl J. H. and Fauci A. S. (1986) Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl Acad. Sci. U.S.A. 83, 4167-4171.
92. Rom W. N., Basset P., Fells G. A., Nukiwa T., Trapnell B. C. and Crystal R. G. (1988) Alveolar macrophages release an insulin-like growth factor-1 type molecule. J. Clin. Invest. 82, 1685-1693.
93. Rosenfield M. A. and Collins F. S. (1996) Gene therapy for cystic fibrosis. Chest 109, 241-252.
94. Rossi G. A., Hunninghake G. W., Kawanami O., Ferrans V. J., Hansen C. T. and Crystal R. G. (1985) Motheaten mice an animal with an inherited form of interstitial lung disease. Am. Rev. Respir. Dis. 131, 150-158.
95. Rubin E. H. and Lubliner R. (1975) The Hamman-Rich syndrome. Review of the literature and analysis of 15 cases. Medicine Balt. 36, 397-463.
96. Sanderson N., Factor V., Nagy P., Kopp J., Kondaiah P., Wakefield L., Roberts A. B., Sporn M. B. and Thorgeirsson S. S. (1995) Hepatic expression of mature transforming growth factor β results in multiple tissue lesions. Proc. Natl Acad. Sci. U.S.A. 92, 2572-2576.
97. Sandford A. J., Shirakawa T., Moffatt M. F., Daniels S. E., Ra C. and Faux J. A. et al.. (1993) Localisation of atopy and subunit of high affinity IgE receptor on chromosome 11q. Lancet 341, 332-334.
98. Sandoz E. (1907) Uber zwei Falle von Fotaler Bronchektasie. Beitr. Path. Anat. 41, 495.
99. Sansonetti M., Sandron D., Pin I., Labrune S., Vervolet D., Dumur J. P., Charpin J. and Chretien J. (1985) Diffuse familial interstitial pulmonary fibrosis. Rev. Mal. Respir. 2, 75-81.
100. Schechter M. M. (1953) Diffuse interstitial fibrosis of the lungs. Am. Rev. Tuberc. 68, 603-614.
101. Schrier D. J., Kunkel R. G. and Phan S. H. (1983) The role of strain variation in murine bleomycin-induced pulmonary fibrosis. Am. Rev. Respir. Dis. 127, 63-66.
102. Seppa H., Grotedorst G., Seppa S., Schiffman E. and Martin G. R. (1982) Platelet derived growth factor is chemotactic for fibroblasts. J. Cell Biol. 92, 584-588.
103. Seyer J. M., Hutcheson E. T. and Kang A. H. (1976) Collagen polymorphism in idiopathic chronic pulmonary fibrosis. J. Clin. Invest. 57, 1498-1507.
104. Shih J. F., Hunnunghake G. W., Goeken N. E., Galvin J. R., Merchant J. A. and Schwartz D. A. (1993) The relationship between HLA-A, B, DQ and DR antigens and asbestos-induced lung disease. Chest 104, 26-31.
105. Smith M. J., Turton C. W., Mitchell D. N., Turner-Warwick M., Morris L. M. and Lawler S. D. (1981) Association of HLA B8 with spontaneous resolution in sarcoidosis. Thorax 36, 296-298.
106. Solliday N. H., Williams J. A., Gaensler E. A., Coutu R. E. and Carrington C. B. (1973) Familial chronic interstitial pneumonia. Am. Rev. Resp. Dis. 108, 193-204.
107. 1 antitrypsin PIZ allele with rheumatoid arthritis or with its extra-articular complications. Disease Markers 10, 151.
108. Stiles C. D., Capone G. T., Scher C. D., Antoniades H. N., Van Wyk J. J. and Pledger W. J. (1979) Dual control of cell growth by somatomedins and platelet derived growth factor. Proc. Natl Acad. Sci. U.S.A. 76, 1279-1283.
109. Stinson J. C. and Tompkin G. H. (1987) Familial cryptogenic fibrosing alveolitis. Irish J. Med. Sci. 161, 42-43.
110. Swaye P., Ordstrand H. S., McCormack L. J. and Wolpaw S. E. (1969) Familial Hamman-Rich syndrome. Chest 55, 7-12.
111. Tal A., Maor E., Bar-Ziv J. and Goroischer R. (1984) Fatal desquamative interstitial pneumonia in three infant siblings. J. Paed. 104, 873.
112. Tani K., Yasouka S., Ogushi F., Asada K., Fulisawa K., Ozaki T., Sano N. and Ogura T. (1991) Thrombin enhances lung fibroblast proliferation in bleomycin induced pulmonary fibrosis. Am. J. Respir. Cell Mol. Biol. 5, 34-40.
113. Tisdale J. E., Follin S. L., Ordelova A. and Webb C. R. (1995) Risk factors for the development of specific noncardiovascular adverse effects associated with amiodarone. J. Clin. Pharmacol. 35, 351-356.
114. Tran-van-Nhieu J., Valeyre D., Rainfray M., Daupleix D., Amouroux J., Meyrier A. and Battesti J. P. (1988) Idiopathic pulmonary fibrosis and benign familial hypercalcaemia syndrome without a deficiency in leucocyte myeloperoxidase. Presse Med. 17, 637-638.
115. Turton C. W. G., Morris L. M., Lawler S. D. and Turner-Warwick M. E., (1978) HLA in CFA. Lancet 1 507.
116. Ueda T., Ohta K., Suzuku N., Yamaguchi M., Hirai K., Horiuchi T., Wantanabe J., Miyamoto T. and Ito K. (1992) Idiopathic pulmonary fibrosis and high prevelance of serum antibodies to hepatitis C virus. Am. Rev. Repsir. Dis. 146, 266-268.
117. Vaclavik P. (1993) A rare occurence of familial idiopathic pulmonary fibrosis. Vnitr. Lek. 39, 54-58.
118. Varga J. and Jiminez S. A. (1986) Stimulation of normal human fibroblast procollagen production and processing by transforming growth factor β. Biochem. Biophys. Res. Comm. 138, 974-980.
119. Varpela E., Tiilikainen A., Varpela M. and Tukianen P. (1979) High prevelances of HLA B-15 and HLA Dw6 in patients with CFA. Tissue antigen 14, 68-71.
120. Villani F., Bacchella L., Bulgheroni A., Pizzini L., Galimberti M., Aprile C. and Luisetti M. (1992) Study of functional and biochemical indicators of subclinical lung damage in bleomycin-treated patients. Repir. Med. 86, 327-333.
121. Wagley P. F. (1972) A new look at the Hamman-Rich syndrome. Johns Hopkins Med. J 131, 412-424.
122. Wallace W. A. H., Schofield J. A., Lamb D. and Howie S. E. M. (1994a) Localisation of pulmonary auto-antigen in cryptogenic fibrosing alveolitis. Thorax 49, 1139-1145.
123. Wallace W. A. H., Roberts S. N., Caldwell H., Thornton E., Greening A. P. and Lamb D. (1994b) Circulating antibodies to lung protein(s) in patients with cryptogenic fibrosing alveolitis. Thorax 49, 218-224.
124. White D. A., Schwartzberg L. S., Kris M. G. and Bosl G. J. (1987) Acute chest pain syndromes during bleomycin infusions. Cancer 59, 1582-1585.
125. White D. A. and Stover D. E. (1984) Severe bleomycin-induced pneumonitis. Clinical features and response to corticosteroids. Chest 86, 723-728.
126. Wilborn J., Crofford L. J., Burdick M. D., Kunkel S. L., Streiter R. M. and Peters-Golden M. (1995) Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J. Clin. Invest. 95, 1861-1868.
127. Wildenberg S. C., Oetting W. S., Almodovar C., Krumwiede M., White J. G. and King R. A. (1995) A gene causing Hermansky-Pudlak syndrome in a Peurto-Rican population maps to chromosome 10q2. Am. J. Hum. Genet. 57, 755-765.
128. Young W. A. (1966) Familial fibrocystic dysplasia. Canad. Med. Ass. J. 94, 1059-1061.
129. Yu C. C., Tsui H. W., Ngan B. Y., Shulman M. J., Wu G. E. and Tsui F. W. (1996) B and T cells are not required for the viable motheaten phenotype. J. Exp. Med. 183, 371-380.