Mineralocorticoid receptor antagonism in experimental atherosclerosis

Circulation

Volumn 105, Issue 18, 2002, Pages 2212-2216

  Rajagopalan, Sanjay ^a,c   Duquaine, Damon ^a   King, Steven ^a   Pitt, Bertram ^a   Patel, Paresh ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c Women's Hospital   (United States)

Author keywords

Atherosclerosis; Endothelium; Nitric oxide; Superoxide

Indexed keywords

ACETYLCHOLINE; ALDOSTERONE; CHOLESTEROL; EPLERENONE; MINERALOCORTICOID RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL REACTIVITY; CELL FUNCTION; CONTROLLED STUDY; ENDOTHELIUM; ENZYME ACTIVITY; FAT INTAKE; HYPERLIPIDEMIA; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RADIOIMMUNOASSAY; RECEPTOR BLOCKING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

ALDOSTERONE ANTAGONISTS; ANIMALS; AORTA; ARTERIOSCLEROSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; MALE; MULTIENZYME COMPLEXES; NADH, NADPH OXIDOREDUCTASES; NADPH OXIDASE; ORGAN CULTURE TECHNIQUES; RABBITS; RECEPTORS, ALDOSTERONE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPIRONOLACTONE; SUPEROXIDES; VASOMOTOR SYSTEM;

EID: 0037035471     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000015854.60710.10     Document Type: Article

References (12)

1. Increased accumulation of tissue ACE in human atherosclerotic coronary artery disease
2. Increased NADH-oxidasemediated superoxide production in the early stages of atherosclerosis: Evidence for involvement of the renin-angiotensin system
3. Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin 1/angiotensin II conversion in patients with chronic heart failure
4. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: Contribution to alterations of vasomotor tone
5. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
6. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells
7. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats
8. Role of aldosterone in renal vascular injury in stroke-prone hypertensive rats
9. Increased angiotensin II type 1 receptor expression in hypercholesterolemic atherosclerosis in rabbits
10. High potassium diets protect against dysfunction of endothelial cells in stroke-prone spontaneously hypertensive rats
11. High K diets markedly reduce atherosclerotic cholesterol ester deposition in aortas of rats with hypercholesterolemia and hypertension
12. Mineralocorticoid receptor antagonists: The evolution of utility and pharmacology