Cardiomyopathy mutations in the tail of β-cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes

Journal of Biological Chemistry

Volumn 288, Issue 44, 2013, Pages 31952-31962

  Wolny, Marcin ^a   Colegrave, Melanie ^a   Colman, Lucy ^a,b   White, Ed ^a   Knight, Peter J ^a   Peckham, Michelle ^a  

^a Chapel Allerton Hospital   (United Kingdom)

^b Southampton Science Park   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOMYOCYTES; COILED COIL; COILED-COIL STRUCTURE; DILATED CARDIOMYOPATHY; FLUORESCENCE RECOVERY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HELICAL CONTENT; MYOSIN HEAVY CHAIN;

CARDIOLOGY; FLUORESCENCE; PEPTIDES; PHOTOBLEACHING;

MUSCLE;

ADENOVIRUS VECTOR; BETA CARDIAC MYOSIN; CARDIAC MYOSIN; ENHANCED GREEN FLUORESCENT PROTEIN; MYOSIN HEAVY CHAIN BETA; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CARDIOMYOPATHY; CELL ISOLATION; CIRCULAR DICHROISM; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HEART MUSCLE CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERTROPHIC CARDIOMYOPATHY; IN VIVO STUDY; MUSCLE FIBRIL; MUTATIONAL ANALYSIS; MYH7 GENE; MYOFILAMENT; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; SARCOMERE; WILD TYPE;

ADENOVIRUS; CARDIAC HYPERTROPHY; CARDIOVASCULAR DISEASE; CELL BIOLOGY; CIRCULAR DICHROISM (CD); IMAGING; MYOSIN;

AMINO ACID SUBSTITUTION; ANIMALS; CARDIOMEGALY; GENETIC DISEASES, INBORN; MUTATION, MISSENSE; MYOSIN HEAVY CHAINS; PROTEIN STRUCTURE, SECONDARY; RATS; SARCOMERES;

EID: 84887031541     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.513291     Document Type: Article

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