Point mutations in human β cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: An ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly

Journal of Cell Biology

Volumn 137, Issue 1, 1997, Pages 131-140

  Becker, K David ^a   Gottshall, Kim R ^a   Hickey, Reed ^a   Perriard, Jean Claude ^b   Chien, Kenneth R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MYOSIN HEAVY CHAIN;

ARTICLE; BINDING SITE; CELL CLONE; CELL ISOLATION; GENETIC TRANSFECTION; HYPERTROPHIC CARDIOMYOPATHY; IMMUNOHISTOCHEMISTRY; MUSCLE FIBRIL; MYOFILAMENT; POINT MUTATION; PRIORITY JOURNAL; SARCOMERE; STRUCTURE ACTIVITY RELATION; THIN FILAMENT;

ACTINS; ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; ANIMALS, NEWBORN; BINDING SITES; CARDIOMYOPATHY, HYPERTROPHIC; CLONING, MOLECULAR; DNA, COMPLEMENTARY; EPITOPES; GENE EXPRESSION; HEART VENTRICLES; HUMANS; MOLECULAR SEQUENCE DATA; MUSCLE FIBERS; MYOSIN HEAVY CHAINS; POINT MUTATION; RATS; SARCOMERES; TRANSFECTION;

EID: 0030958086     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.137.1.131     Document Type: Article

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