Temporal sequence and kinetics of proinflammatory and anti-inflammatory cytokine secretion induced by toxic shock syndrome toxin 1 in human peripheral blood mononuclear cells

Infection and Immunity

Volumn 69, Issue 12, 2001, Pages 7544-7549

  Kum, W W S ^a   Cameron, S B ^a   Hung, R W Y ^a   Kalyan, S ^a   Chow, A W ^a  

^a VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; LYMPHOTOXIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; STAPHYLOCOCCUS TOXIN; T LYMPHOCYTE RECEPTOR; TOXIC SHOCK SYNDROME TOXIN 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; HUMAN; HUMAN CELL; INFLAMMATION; KINETICS; MAJOR HISTOCOMPATIBILITY COMPLEX; MONONUCLEAR CELL; MUTANT; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TOXIC SHOCK SYNDROME;

ADULT; BACTERIAL TOXINS; CYTOKINES; ENTEROTOXINS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKINS; LEUKOCYTES, MONONUCLEAR; LYMPHOTOXIN-ALPHA; MUTATION; SUPERANTIGENS; TH1 CELLS; TH2 CELLS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035179661     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.12.7544-7549.2001     Document Type: Article

References (50)

1. Functional diversity of helper T lymphocytes
2. Molecular mechanisms of the induction of IL-12 and its inhibition by IL-10
3. A new staphylococcal enterotoxin, enterotoxin F, associated with toxic-shock syndrome Staphylococcus aureus isolates
4. Immunomodulatory properties of interferon-gamma. An update
5. Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10
6. Toxicity of recombinant toxic shock syndrome toxin 1 and mutant toxins produced by Staphylococcus aureus in a rabbit infection model of toxic shock syndrome
7. A mutation at histidine residue 135 of toxic shock syndrome toxin yields an immunogenic protein with minimal toxicity
8. IL-2-independent activation and proliferation in human T cells induced by CD28
9. Regulation of helper T cell responses to staphylococcal superantigens
10. Direct effects of IL-10 on subsets of human CD4+ T cell clones and resting T cells. Specific inhibition of IL-2 production and proliferation
11. Differential regulation of murine T lymphocyte subsets
12. Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice
13. Immunoregulatory mechanisms of T-cell-dependent shock induced by a bacterial superantigen in mice
14. Leukemia inhibitory factor, interleukin 6, and other cytokines using the GP130 transducing receptor: Roles in inflammation and injury
15. Comparative cytokine release from human monocytes, monocyte-derived immature mast cells, and a human mast cell line (HMC-1)
16. Induction of human interleukin-1 by a product of Staphylococcus aureus associated with toxic shock syndrome
17. Toxic shock syndrome toxin 1 as an inducer of human tumor necrosis factors and gamma interferon
18. Vβ-specific stimulation of human T cells by staphylococcal toxins
19. The α1 domain of the HLA-DR molecule is essential for the high-affinity binding of the toxic shock syndrome toxin 1
20. Differential inhibitory effects of interleukin-10, interleukin-4, and dexamethasone on staphylococcal enterotoxin-induced cytokine production and T cell activation
21. Inhibition of toxic shock syndrome toxin-l-induced cytokine production and T cell activation by interleukin-10, interleukin-4, and dexamethasone
22. Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class 11 binding, superantigenic activity, and lethality
23. Improved purification and biologic activities of staphylococcal toxic shock syndrome toxin 1
24. A mutation at glycine residue 31 of toxic shock syndrome toxin-1 defines a functional site critical for major histocompatibility complex class 11 binding and superantigenic activity
25. IL-2, IL-4, and IFN-α gene expression versus secretion in superantigen-activated T cells
26. Anti-gamma interferon and anti-interleukin-6 antibodies affect staphylococcal enterotoxin B-induced weight loss, hypoglycemia, and cytokine release in D-galactosamine-sensitized and unsensitized mice
27. Effects of IL-12 on helper T cell-dependent immune responses in vivo
28. IL-12-induced IL-10 production by human T cells as a negative feedback for IL-12-induced immune responses
29. Pathogenesis of the toxic shock syndrome: T cell mediated lethal shock caused by the superantigen TSST-1
30. Superantigen mediated shock: A cytokine release syndrome
31. Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo
32. Development in vitro of human CD4+ thymocytes into functionally mature Th2 cells. Exogenous interleukin-12 is required for priming thymocytes to produce both Thl cytokines and interleukin-10
33. Interleukin-10
34. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
35. Hepatic injury and lethal shock in galactosamine-sensitized mice induced by the superantigen staphylococcal enterotoxin B
36. Chronic exposure to superantigen induces regulatory CD4+ T cells with IL-10-mediated suppressive activity
37. Cytokines induce the development of functionally heterogeneous T helper cell subsets
38. Mediators in the pathogenesis of TSS: Overview
39. A rabbit model of toxic shock syndrome that uses a constant, subcutaneous infusion of toxic shock syndrome toxin 1
40. Mechanisms of pathogenesis of staphylococcal and streptococcal superantigens
41. Induction of a cytokine network by superantigens with parallel TH1 and TH2 stimulation
42. Microbial superantigens stimulate T cells by the superantigen bridge and independently by a cytokine pathway
43. Lymphokine production by human T cells in disease states
44. Kinetics of intracytoplasmic Thl and Th2 cytokine production assessed by flow cytometry following in vitro activation of peripheral blood mononuclear cells
45. Pyrogenic toxin superantigen site specificity in toxic shock syndrome and food poisoning in animals
46. Induction of tumor necrosis factor and interleukin-1 by purified staphylococcal toxic shock syndrome toxin 1 requires the presence of both monocytes and T lymphocytes
47. Regulation of immunity to parasites by T cells and T cell-derived cytokines
48. Bacterial superantigeninduced human lymphocyte responses are nitric oxide dependent and mediated by IL-12 and IFN-gamma
49. Biological activity of toxic shock syndrome toxin 1 and a site-directed mutant, H135A, in a lipopolysaccharide-potentiated mouse lethality model
50. Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo