Combinations of oxazepam and metyrapone attenuate cocaine and methamphetamine cue reactivity

Drug and Alcohol Dependence

Volumn 133, Issue 2, 2013, Pages 405-412

  Keller, Courtney M ^a   Cornett, Elyse M ^a   Guerin, Glenn F ^a   Goeders, Nicholas E ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Cocaine; Corticosterone; Cue reactivity; Methamphetamine; Metyrapone; Oxazepam

Indexed keywords

COCAINE; CORTICOSTERONE; METHAMPHETAMINE; METYRAPONE; OXAZEPAM;

ABSTINENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COCAINE DEPENDENCE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG SEEKING BEHAVIOR; INSTRUMENTAL CONDITIONING; LOW DRUG DOSE; MALE; METHAMPHETAMINE DEPENDENCE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT;

RATTUS;

COCAINE; CORTICOSTERONE; CUE REACTIVITY; METHAMPHETAMINE; METYRAPONE; OXAZEPAM;

AMPHETAMINE-RELATED DISORDERS; ANALYSIS OF VARIANCE; ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE-RELATED DISORDERS; CONDITIONING, OPERANT; CORTICOSTERONE; CUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INHIBITORS; FOOD; HYPNOTICS AND SEDATIVES; MALE; METHAMPHETAMINE; METYRAPONE; OXAZEPAM; PHARMACEUTICAL VEHICLES; RATS; RATS, WISTAR; SELF ADMINISTRATION; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84887020677     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2013.06.025     Document Type: Article

References (51)

1. Anderson, P.D., Bokor, G., 25(1), 2012, 41-9. Forensic aspects of drug-induced violence. J. Pharm. Pract.
2. Anker J.J., Holtz N.A., Zlebnik N., Carroll M.E. Effects of allopregnanolone on the reinstatement of cocaine-seeking behavior in male and female rats. Psychopharmacology (Berl.) 2009, 203:63-72.
3. Armario A. Activation of the hypothalamic-pituitary-adrenal axis by addictive drugs: different pathways, common outcome. Trends Pharmacol. Sci. 2010, 31:318-325.
4. Belelli D., Lambert J.J. Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat. Rev. Neurosci. 2005, 6:565-575.
5. Bradberry C.W., Roth R.H. Cocaine increases extracellular dopamine in rat nucleus accumbens and ventral tegmental area as shown by in vivo microdialysis. Neurosci. Lett. 1989, 103:97-102.
6. Carter B.L., Tiffany S.T. Meta-analysis of cue-reactivity in addiction research. Addiction 1999, 94:327-340.
7. Classically Conditioned Factors in Drug Dependence 1992, Williams and Wilkins, Baltimore. A.R. Childress, A.T. McLellan, R. Ehrman, C.P. O'Briem (Eds.).
8. Conrad K.L., McCutcheon J.E., Cotterly L.M., Ford K.A., Beales M., Marinelli M. Persistent increases in cocaine-seeking behavior after acute exposure to cold swim stress. Biol. Psychiatry 2010, 68:303-305.
9. Cruickshank C.C., Dyer K.R. A review of the clinical pharmacology of methamphetamine. Addiction 2009, 104:1085-1099.
10. Deroche V., Marinelli M., Le Moal M., Piazza P.V. Glucocorticoids and behavioral effects of psychostimulants. II: cocaine intravenous self-administration and reinstatement depend on glucocorticoid levels. J. Pharmacol. Exp. Ther. 1997, 281:1401-1407.
11. Doron R., Fridman L., Gispan-Herman I., Maayan R., Weizman A., Yadid G. DHEA, a neurosteroid, decreases cocaine self-administration and reinstatement of cocaine-seeking behavior in rats. Neuropsychopharmacology 2006, 31:2231-2236.
12. Drummond D.C. What does cue-reactivity have to offer clinical research?. Addiction 2000, 95(Suppl. 2):S129-S144.
13. Drummond D.C. Theories of drug craving, ancient and modern. Addiction 2001, 96:33-46.
14. Erb S., Shaham Y., Stewart J. Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period. Psychopharmacology (Berl.) 1996, 128:408-412.
15. Ghasemzadeh M.B., Vasudevan P., Mueller C., Seubert C., Mantsch J.R. Region specific alterations in glutamate receptor expression and subcellular distribution following extinction of cocaine self-administration. Brain Res. 2009, (epub ahead of print).
16. Goeders N.E. A neuroendocrine role in cocaine reinforcement. Psychoneuroendocrinology 1997, 22:237-259.
17. Goeders N.E. Stress and cocaine addiction. J. Pharmacol. Exp. Ther. 2002, 301:785-789.
18. Goeders N.E., Clampitt D.M. Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats. Psychopharmacology (Berl.) 2002, 161:222-232.
19. Goeders N.E., Clampitt D.M., Keller C., Sharma M., Guerin G.F. Alprazolam and oxazepam block the cue-induced reinstatement of extinguished cocaine seeking in rats. Psychopharmacology (Berl.) 2009, 201:581-588.
20. Goeders N.E., Cohen A., Fox B.S., Azar M.R., George O., Koob G.F. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology (Berl.) 2012, 223:17-25.
21. Goeders N.E., Guerin G.F. Effects of surgical and pharmacological adrenalectomy on the initiation and maintenance of intravenous cocaine self-administration in rats. Brain Res. 1996, 722:145-152.
22. Goeders N.E., Guerin G.F. Effects of the CRH receptor antagonist CP-154,526 on intravenous cocaine self-administration in rats. Neuropsychopharmacology 2000, 23:577-586.
23. Goeders N.E., Guerin G.F. Effects of the combination of metyrapone and oxazepam on cocaine and food self-administration in rats. Pharmacol. Biochem. Behav. 2008, 91:181-189.
24. Goeders N.E., McNulty M.A., Guerin G.F. Effects of alprazolam on intravenous cocaine self-administration in rats. Pharmacol. Biochem. Behav. 1993, 44:471-474.
25. Goeders N.E., McNulty M.A., Mirkis S., McAllister K.H. Chlordiazepoxide alters intravenous cocaine self-administration in rats. Pharmacol. Biochem. Behav. 1989, 33:859-866.
26. Goeders N.E., Peltier R.L., Guerin G.F. Ketoconazole reduces low dose cocaine self-administration in rats. Drug Alcohol Depend. 1998, 53:67-77.
27. Griffiths R.R., McLeod D.R., Bigelow G.E., Liebson I.A., Roache J.D. Relative abuse liability of diazepam and oxazepam: behavioral and subjective dose effects. Psychopharmacology (Berl.) 1984, 84:147-154.
28. Hirani K., Sharma A.N., Jain N.S., Ugale R.R., Chopde C.T. Evaluation of GABAergic neuroactive steroid 3alpha-hydroxy-5alpha-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats. Psychopharmacology (Berl.) 2005, 180:267-278.
29. Iguchi M.Y., Griffiths R.R., Bickel W.K., Handelsman L., Childress A.R., McLellan A.T. Relative abuse liability of benzodiazepines in methadone maintained populations in three cities. NIDA Res. Monogr. 1989, 95:364-365.
30. Kablinger A.S., Lindner M.A., Casso S., Hefti F., Demuth G., Fox B.S., McNair L.A., McCarthy B.G., Goeders N.E. Effects of the combination of metyrapone and oxazepam on cocaine craving and cocaine taking: a double-blind, randomized, placebo-controlled pilot study. J. Psychopharmacol. 2012, 26:973-981.
31. Katz J.L., Higgins S.T. The validity of the reinstatement model of craving and relapse to drug use. Psychopharmacology (Berl.) 2003, 168:21-30.
32. Koob G.F. A role for brain stress systems in addiction. Neuron 2008, 59:11-34.
33. Levy A.D., Li Q.A., Kerr J.E., Rittenhouse P.A., Milonas G., Cabrera T.M., Battaglia G., Alvarez Sanz M.C., Van de Kar L.D. Cocaine-induced elevation of plasma adrenocorticotropin hormone and corticosterone is mediated by serotonergic neurons. J. Pharmacol. Exp. Ther. 1991, 259:495-500.
34. Maayan R., Lotan S., Doron R., Shabat-Simon M., Gispan-Herman I., Weizman A., Yadid G. Dehydroepiandrosterone (DHEA) attenuates cocaine-seeking behavior in the self-administration model in rats. Eur. Neuropsychopharmacol. 2006, 16:329-339.
35. Mantsch J.R., Saphier D., Goeders N.E. Corticosterone facilitates the acquisition of cocaine self-administration in rats: opposite effects of the type II glucocorticoid receptor agonist dexamethasone. J. Pharmacol. Exp. Ther. 1998, 287:72-80.
36. Martin I.L. The benzodiazepines and their receptors: 25 years of progress. Neuropharmacology 1987, 26:957-970.
37. McMahon L.R., France C.P. Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys. Psychopharmacology (Berl.) 2005, 178:400-409.
38. Moffett M.C., Goeders N.E. CP-154,526, a CRF type-1 receptor antagonist, attenuates the cue-and methamphetamine-induced reinstatement of extinguished methamphetamine-seeking behavior in rats. Psychopharmacology (Berl.) 2007, 190:171-180.
39. Moldow R.L., Fischman A.J. Cocaine induced secretion of ACTH, beta-endorphin, and corticosterone. Peptides 1987, 8:819-822.
40. O'Brien C.P., Childress A.R., McLellan A.T., Ehrman R. Classical conditioning in drug-dependent humans. Ann. N.Y. Acad. Sci. 1992, 654:400-415.
41. Rothman R.B., Baumann M.H., Dersch C.M., Romero D.V., Rice K.C., Carroll F.I., Partilla J.S. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse 2001, 39:32-41.
42. SAMHSA Results from the 2008 National Survery on Drug Use and Health: National Findings. Office of Applied Studies, NSDUH Series H-36 2009.
43. See R.E., Elliott J.C., Feltenstein M.W. The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats. Psychopharmacology (Berl.) 2007, 194:321-331.
44. Shaham Y., Erb S., Leung S., Buczek Y., Stewart J. CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats. Psychopharmacology (Berl.) 1998, 137:184-190.
45. Simms J.A., Richards J.K., Mill D., Kanholm I., Holgate J.Y., Bartlett S.E. Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in Long-Evans rats by the alpha-2 adrenoreceptor antagonist yohimbine. Psychopharmacology (Berl.) 2011, 218:101-110.
46. Sinha R. Chronic stress, drug use, and vulnerability to addiction. Ann. N.Y. Acad. Sci. 2008, 1141:105-130.
47. Smagin G.N., Goeders N.E. Effects of acute and chronic ketoconazole administration on hypothalamo-pituitary-adrenal axis activity and brain corticotropin-releasing hormone. Psychoneuroendocrinology 2004, 29:1223-1228.
48. Ugale R.R., Sharma A.N., Kokare D.M., Hirani K., Subhedar N.K., Chopde C.T. Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats. Brain Res. 2007, 1184:193-201.
49. Visser S.A., Huntjens D.R., van der Graaf P.H., Peletier L.A., Danhof M. Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats. J. Pharmacol. Exp. Ther. 2003, 307:765-775.
50. Weiss F. Advances in animal models of relapse for addiction research. Advances in the Neuroscience of Addiction 2010, CRC Press, Boca Raton, FL. 2nd ed. C.M. Kuhn, G.F. Koob (Eds.).
51. Zavala A.R., Biswas S., Harlan R.E., Neisewander J.L. Fos and glutamate AMPA receptor subunit coexpression associated with cue-elicited cocaine-seeking behavior in abstinent rats. Neuroscience 2007, 145:438-452.