Combined discriminative stimulus effects of midazolam with other positive GABAA modulators and GABAA receptor agonists in rhesus monkeys

Psychopharmacology

Volumn 178, Issue 4, 2005, Pages 400-409

  McMahon, Lance R ^a   France, Charles P ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Additive; Barbiturate; Benzodiazepine; Drug discrimination; GABAA; Interaction; Muscimol; Neuroactive steroid; Progabide; Rhesus monkey

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; BENZODIAZEPINE DERIVATIVE; ELTANOLONE; GABAERGIC RECEPTOR AFFECTING AGENT; GABOXADOL; MIDAZOLAM; MUSCIMOL; PENTOBARBITAL; PROGABIDE; TRIAZOLAM;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENTIATION; FEMALE; MALE; NONHUMAN; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; REGULATORY MECHANISM; RHESUS MONKEY; STIMULUS;

ANIMALS; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; DISCRIMINATION LEARNING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ETHANOL; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; INJECTIONS, SUBCUTANEOUS; ISOXAZOLES; MACACA MULATTA; MALE; MIDAZOLAM; PENTOBARBITAL; PREGNANOLONE; RECEPTORS, GABA-A; TIME FACTORS; TRIAZOLAM; WOMEN;

EID: 16844371231     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-004-2022-4     Document Type: Article

References (36)

1. Ator NA (2003) Selectivity in generalization to GABAergic drugs in midazolam-trained baboons. Pharmacol Biochem Behav 75:435-445
2. Ator NA, Griffiths RR (1986) Discriminative stimulus effects of atypical anxiolytics in baboons and rats. J Pharmacol Exp Ther 237:393-403
3. Bloss JL, Hammond DL (1985) Shock titration in the rhesus monkey: effects of opiate and nonopiate analgesics. J Pharmacol Exp Ther 235:423-430
4. 3H]diazepam binding at the benzodiazepine-GABA-receptor-ionophore complex. Eur J Pharmacol 67:325-326
5. A receptor in rat cerebral cortical synaptoneurosomes. Anesth Analg 7:598-605
6. De Vry J, Slangen JL (1986) Effects of training dose on discrimination and cross-generalization of chlordiazepoxide, pentobarbital and ethanol in the rat. Psychopharmacology 88:341-345
7. 50)? Mol Pharmacol 41:1124-1129
8. A receptor regulation: heterologous uncoupling of modulatory site interactions induced by chronic steroid, barbiturate, benzodiazepine, or GABA treatment in culture. Brain Res 707:100-109
9. Grant KA (1999) Strategies for understanding the pharmacological effects of ethanol with drug discrimination procedures. Pharmacol Biochem Behav 64:261-267
10. Grech DM, Balster RL (1997) The discriminative stimulus effects of muscimol in rats. Psychopharmacology 129:339-347
11. Harrison YE, Jenkins JA, Rocha BA, Lytle DA, Jung ME, Oglesby MW (1998) Discriminative stimulus effects of diazepam, ketamine and their mixture: ethanol substitution patterns. Behav Pharmacol 9:31-40
12. Honore T, Nielsen M, Braestrup C (1984) Barbiturate shift as a tool for determination of efficacy of benzodiazepine-receptor ligands. Eur J Pharmacol 100:103-107
13. Johno I, Bialer M, Nickelson SA, Levy RH (1984) Disposition of progabide and valproic acid following intraperitoneal administration in rhesus monkey. Epilepsia 25:578-585
14. Karobath M, Sperk G (1979) Stimulation of benzodiazepine receptor binding by gamma-aminobutyric acid. Proc Natl Acad Sci 76:1004-1006
15. Khan ZU, Gutierrez A, De Blas AL (1996a) The alpha 1 and alpha 6 subunits can coexist in the same cerebellar GABAA receptor maintaining their individual benzodiazepine-binding specificities. J Neurochem 66:685-691
16. A receptors from rat brain and retina. Neuropharmacology 35:1315-1322
17. Kissin I, Mason JO, Bradley EL (1987) Pentobarbital and thiopental anesthetic interactions with midazolam. Anesthesiology 67:26-31
18. Lelas S, Gerak LR, France CP (1999) Discriminative-stimulus effects of triazolam and midazolam in rhesus monkeys. Behav Pharmacol 10:39-50
19. Lelas S, Spealman RD, Rowlett JK (2000) Using behavior to elucidate receptor mechanisms: a review of the discriminative stimulus effects of benzodiazepines. Exp Clin Psychopharmacol 8:294-311
20. Lelas S, Rowlett JK, Spealman RD (2001) Isobolographic analysis of chlordiazepoxide and triazolam combinations in squirrel monkeys discriminating triazolam. Psychopharmacology 158:181-189
21. Lloyd KG, Arbilla S, Beaumont K, Briley M, De Montis G, Scatton B, Langer SZ, Bartholini G (1982) Gamma-aminobutyric acid (GABA) receptor stimulation. II. Specificity of progabide (SL 76002) and SL 75102 for the GABA receptor. J Pharmacol Exp Ther 220:672-677
22. Massey BW, Woolverton WL (1994) Discriminative stimulus effects of combinations of pentobarbital and ethanol in rhesus monkeys. Drug Alcohol Depend 35:37-43
23. A modulators and other anxiolytics, sedatives, and anticonvulsants in untreated and diazepam-treated monkeys. J Pharmacol Exp Ther 304:109-120
24. McMahon LR, Gerak LR, France CP (2001) Potency of positive gamma-aminobutyric acid(A) modulators to substitute for a midazolam discriminative stimulus in untreated monkeys does not predict potency to attenuate a flumazenil discriminative stimulus in diazepam-treated monkeys. J Pharmacol Exp Ther 298:1227-1235
25. A receptors. Brain Res Rev 29:196-217
26. Negus SS, Mello NK, Fivel PA (2000) Effects of GABA agonists and GABA-A receptor modulators on cocaine discrimination in rhesus monkeys. Psychopharmacology 152:398-407
27. Norberg L, Backstrom T, Wahlstrom G (1999) Anaesthetic effects of pregnanolone in combination with allopregnanolone, thiopental, hexobarbital and flurazepam: an EEG study in the rat. Br J Anaesth 82:731-737
28. Shannon HE, Herling S (1983) Discriminative stimulus effects of diazepam in rats: evidence for a maximal effect. J Pharmacol Exp Ther 227:160-166
29. Spealman RD (1985) Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788. J Pharmacol Exp Ther 235:456-462
30. Storustovu S, Ebert B (2003) Gaboxadol: in vitro interaction studies with benzodiazepines and ethanol suggest functional selectivity. Eur J Pharmacol 467:49-56
31. Tallarida RJ (2000) Drug synergism and dose-effect data analysis. Chapman and Hall/CRC, Boca Raton
32. Tallman JF, Thomas JW, Gallager DW (1978) GABAergic modulation of benzodiazepine binding site sensitivity. Nature 274:383-385
33. Tverskoy M, Ben-Shlomo I, Ezry J, Finger J, Fleyshman G (1989) Midazolam acts synergistically with methohexitone for induction of anaesthesia. Br J Anaesth 63:109-112
34. Van Gorder PN, Hoffman WE, Baughman V, Albrecht RF, Miletich DJ, Guzman F, Cook JM (1985) Midazolam-ethanol interactions and reversal with a benzodiazepine antagonist. Anesth Analg 64:129-135
35. Yang JS, Olsen RW (1987) Gamma-aminobutyric acid receptor binding in fresh mouse brain membranes at 22 degrees C: ligand-induced changes in affinity. Mol Pharmacol 32:266-277
36. Yang W, Drewe JA, Lan NC (1995) Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site. Eur J Pharmacol 291:319-325